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Volumn 53, Issue 5, 2007, Pages 173-175

KCNJ11 E23K polymorphism and diabetes mellitus with adult onset in Czech patients

Author keywords

C peptide; Diabetes mellitus; Insulin; Kir6.2

Indexed keywords

C PEPTIDE; GLUTAMATE DECARBOXYLASE ANTIBODY; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2;

EID: 35248887041     PISSN: 00155500     EISSN: 25337602     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (22)

References (11)
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    • Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
    • Gloyn, A. L., Weedon, M. N., Owen, K. R., Turner, M. J., Knight, B. A., Hitman, G., Walker, M., Levy, J. C., Sampson, M., Halford, S., McCarthy, M. I., Hattersley, A. T., Frayling, T. M. (2003) Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52, 568-572.
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    • Gloyn, A.L.1    Weedon, M.N.2    Owen, K.R.3    Turner, M.J.4    Knight, B.A.5    Hitman, G.6    Walker, M.7    Levy, J.C.8    Sampson, M.9    Halford, S.10    McCarthy, M.I.11    Hattersley, A.T.12    Frayling, T.M.13
  • 3
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    • Missense mutations in the pancreatic islet β-cell inwardly rectifying K+ channel gene (KIR6.2/BIR): A meta-analysis suggests a role in the polygenic basis of type II diabetes mellitus in Caucasians
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    • (1998) Diabetologia , vol.41 , pp. 1511-1515
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  • 4
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    • The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of type 2 diabetes
    • Kahn, S. E. (2003) The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46, 3-19.
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    • Kahn, S.E.1
  • 5
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    • E23K Single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of type 11 diabetes in caucasians as the PPARγ Pro 12Ala variant
    • Love-Gregory, L., Wasson, J., Lin, J., Skolnick, G., Suarez, B., Permutt, M. A. (2003) E23K Single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of type 11 diabetes in caucasians as the PPARγ Pro 12Ala variant. Diabetologia 46, 136-137.
    • (2003) Diabetologia , vol.46 , pp. 136-137
    • Love-Gregory, L.1    Wasson, J.2    Lin, J.3    Skolnick, G.4    Suarez, B.5    Permutt, M.A.6
  • 6
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    • β-cell dysfunction and failure in type 2 diabetes - potential mechanisms
    • Porte, D., Kahn, S. E. (2001) β-cell dysfunction and failure in type 2 diabetes - potential mechanisms. Diabetes 50, S160-S163.
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    • Schwanstecher, C., Meyer, U., Schwanstecher, M. (2002) K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic β-cell ATP-sensitive K(+) channels. Diabetes 51, 875-879.
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    • Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: Population-based studies and meta-analyses
    • van Dam, R. M., Hoebee, B., Seidell, J. C., Schaap, M. M., de Bruin, T. W. A., Feskens, E. J. M. (2005) Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses. Diabet. Med. 22, 590-598.
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    • Willer, C. J., Bonnycastle, L. L., Conneely, K. N., Duren, W. L., Jackson, A. U., Scott, L. J., Narisu, N., Chines, P. S., Skol, A., Stringham, H. M., Petrie, J., Erdos, M. R., Shift, A. J., Enloe, S. T., Sprau, A. G., Smith, E., Tong, M., Doheny, K. F., Pugh, E. W., Watanabe, R. M., Buchanan, T. A., Valle, T. T., Bergman, R. N., Tuomilehto, J., Mohike, K. L. Collins, F. S., Boehnke, M. (2007) Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. Diabetes 56, 256-264


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.