Strategy for allergenicity assessment of 'natural novel foods': Clinical and molecular investigation of exotic vegetables (water spinach, hyacinth bean and Ethiopian eggplant)

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 62, Issue 11, 2007, Pages 1243-1250

  Gubesch, M ^a   Theler, B ^b   Dutta, M ^b   Baumer, B ^c   Mathis, A ^c   Holzhauser, T ^a   Vieths, S ^a   Ballmer Weber, B K ^b,d  

^a PAUL EHRLICH INSTITUT   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c ZURICH UNIVERSITY OF APPLIED SCIENCES   (Switzerland)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Allergenic potential; Exotic vegetable; Food allergy; Novel food; Pollen cross reactivity

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; LIPID TRANSFER PROTEIN; PROFILIN;

ADULT; ALLERGENICITY; ARTICLE; BINDING AFFINITY; CLINICAL ASSESSMENT; ENZYME ALLERGOSORBENT TEST; ETHIOPIAN EGGPLANT; EXTRACT; FOOD ALLERGY; FOOD ANALYSIS; HUMAN; HYACINTH BEAN; IMMUNOBLOTTING; MAJOR CLINICAL STUDY; PEANUT ALLERGY; POLLEN ALLERGY; PRICK TEST; PRIORITY JOURNAL; PROVOCATION TEST; RISK ASSESSMENT; SCREENING TEST; SEQUENCE HOMOLOGY; SOYBEAN; TOMATO; VEGETABLE; WATER SPINACH;

ALLERGENS; CARRIER PROTEINS; EUROPEAN UNION; FABACEAE; FOOD HYPERSENSITIVITY; HUMANS; IMMUNOASSAY; IMMUNOGLOBULIN E; IPOMOEA; PROFILINS; SKIN TESTS; SOLANUM; VEGETABLES;

EID: 35148856207     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2007.01474.x     Document Type: Article

References (28)

1. Lucas JS, Lewis SA, Hourihane JO. Kiwi fruit allergy: a review. Pediatr Allergy Immunol 2003 14 : 420 428.
2. Lucas JS, Grimshaw KE, Collins K, Warner JO, Hourihane JO. Kiwi fruit is a significant allergen and is associated with differing patterns of reactivity in children and adults. Clin Exp Allergy 2004 34 : 1115 1121.
3. Regulation (EC) No 258/97 of the European Parliament and of the Council of 27 January 1997 concerning novel foods and novel food ingredients. Official Journal of the European Communities, 1997: No L 43/1.
4. FAO & WHO. Evaluation of allergenicity of genetically modified foods. Report of a joint FAO/WHA Expert Consultation on allergenicity of foods derived from biotechnology. Rome, Italy : Food and Agriculture Organization of the United Nations, 2001 : 22 25. http://www.fao.org/docrep/007/y0820e/y0820e00.htm ; accessed 10 July 2007.
5. Codex Alimentarius. Codex principles and guidelines on foods derived from biotechnology. Rome : Codex Alimentarius Commission, Joint FAO/WHO Food Standards Programme, Food and Agriculture Organisation, 2003. http://www.fao.org/documents/show_cdr.asp?url_file=/docrep/007/y5819e/y5819e00. htm
6. European Food Safety Authority. Guidance document of the Scientific panel on Genetically Modified Organisms for the risk assessment of genetically modified microorganisms and their derived products intended for food and feed use. The EFSA Journal 2006 347 : 1 115. http://www.efsa.europa.eu
7. Meredith C. Allergenic potential of novel foods. Proc Nutr Soc 2005 64 : 487 490.
8. Poulsen LK. Allergy assessment of foods or ingredients derived from biotechnology, gene-modified organisms, or novel foods (Review). Mol Nutr Food Res 2004 48 : 413 423.
9. Sten E, Stahl Skov P, Torp AM, Olesen A, Bindslev-Jensen U, Poulsen LK et al. Allergenic components of a novel food, Micronesian nut Nangai (Canariumindicum), shows IgE cross-reactivity in pollen allergic patients. Allergy 2002 57 : 398 404.
10. 97/618/EC: Commission Recommendation of 29 July 1997 concerning the scientific aspects and the presentation of information necessary to support applications for the placing on the market of novel foods and novel food ingredients and the preparation of initial assessment reports under Regulation (EC) No 258/97 of the European Parliament and of the Council (Text with EEA relevance). Official Journal of the European Communities, 1997: L 253/1.
11. Vieths S, Scheurer S, Ballmer-Weber B. Current understanding of cross-reactivity of food allergens and pollen. Ann NY Acad Sci 2002 964 : 47 68.
12. Scheurer S, Lauer I, Foetisch K, San Miguel Moncin M, Retzek M, Hartz C et al. Strong allergenicity of Pru av 3, the lipid transfer protein from cherry, is related to high stability against thermal processing and digestion. J Allergy Clin Immunol 2004 114 : 900 907.
13. Pastorello EA, Robino AM. Clinical role of lipid transfer proteins in food allergy. Mol Nutr Food Res 2004 48 : 356 362.
14. Vieths S, Schöning B, Petersen A. Characterisation of the 18 kDa apple allergen by two-dimensional immunoblotting and microsequencing. Int Arch Allergy Immunol 1994 104 : 399 404.
15. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970 227 : 680 685.
16. Kyhse-Andersen J. Elektroblotting of multiple gel: a simple horizontal apparatus without buffer tank for electrophoretic transfer of proteins from polyacrylamide to nitrocellulose. J Biochem Biophys Methods 1984 10 : 203 209.
17. Malling H.J. Methods of skin testing. In EAACI position paper on allergen standardization and skin tests. Allergy 1993 48 : 49 82.
18. Lidholm J, Ballmer-Weber BK, Mari A, Vieths S. Component-resolved diagnostics in food allergy. Curr Opin Allergy Clin Immunol 2006 6 : 234 240.
19. Mittag D, Vieths S, Vogel L, Wagner-Löw D, Starke A, Hunziker P et al. Birch pollen-related food allergy to legumes: identification and characterisation of the Bet v 1 homologue in mungbean (Vigna radiate) Vig r 1. Clin Exp Allergy 2005 35 : 1049 1055.
20. Scheurer S, Wangorsch A, Nerkamp J, Stahl Skov P, Ballmer-Weber B, Wüthrich B et al. Cross-reactivity within the profilin panallergen family investigated by comparison of recombinant profilins from pear (Pyr c 4), cherry (Pru av 4) and celery (Api g 4) with birch pollen profilin Bet v 2. J Chromatogr B Biomed Sci Appl 2001 756 : 315 325.
21. Wensing M, Akkerdaas JH, van Leeuwen WA, Stapel SO, Bruijnzeel-Koomen CA, Aalberse RC et al. IgE to Bet v 1 and profilin: cross-reactivity patterns and clinical relevance. J Allergy Clin Immunol 2002 110 : 435 442.
22. van Ree R, Voitenko V, van Leeuwen WA, Aalberse RC. Profilin is a cross-reactive allergen in pollen and vegetable food. Int Arch Allergy Immunol 1992 98 : 97 104.
23. Sancho AI, Rigby NM, Zuidmeer L, Asero R, Mistrello G, Amato S et al. The effect of thermal processing on the IgE reactivity of the non-specific lipid transfer protein from apple, Mal d 3. Allergy 2005 60 : 1262 1268.
24. Asero R, Mistrello G, Roncarolo D, de Vries SC, Gautier M-F, Ciurana CLF et al. Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int Arch Allergy Immunol 2000 122 : 20 32.
25. Asero R, Amato S, Alfieri B, Folloni S, Mistrello G. Rice: another potential cause of food allergy in patients sensitized to lipid transfer protein. Int Arch Allergy Immunol 2006 143 : 69 74. [Epub ahead of print]
26. Mittag D, Vieths S, Vogel L, Becker WM, Rhis HP, Helbling A et al. Soybean allergy in patients allergic to birch pollen: clinical investigation and molecular characterization of allergens. J Allergy Clin Immunol 2004 113 : 148 154.
27. Aalberse RC, Akkerdaas JH, van Ree R. Cross-reactivity of IgE antibodies to allergens (Review Article). Allergy 2001 56 : 478 490.
28. Fötisch K, Westphal S, Lauer I, Retzek M, Altmann F, Kolarich D et al. Biological activity of IgE specific for cross-reactive carbohydrate determinants. J Allergy Clin Immunol 2003 111 : 889 896.