Temporal heterogeneity in oxygen tension in human melanoma xenografts

British Journal of Cancer

Volumn 89, Issue 2, 2003, Pages 350-356

  Brurberg, K G ^a   Graff, B A ^a   Rofstad, E K ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Acute hypoxia; Oxygen tension; pO2 fluctuations; Temporal heterogeneity in pO2

Indexed keywords

OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSENSOR; CANCER GRAFT; CANCER TISSUE; FIBER OPTICS; FOURIER ANALYSIS; HEMODYNAMICS; HUMAN; HUMAN TISSUE; HYPOXEMIA; MELANOMA; MICROVASCULATURE; MOUSE; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; TISSUE INJURY; TISSUE PERFUSION; TUMOR VASCULARIZATION; XENOGRAFT;

ANIMALS; CELL HYPOXIA; FEMALE; FIBER OPTICS; HEMODYNAMIC PROCESSES; HUMANS; KINETICS; MELANOMA; MICE; MICE, INBRED BALB C; OXYGEN; RADIOTHERAPY; SKIN NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0042575345     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601047     Document Type: Article

References (44)

1. Acker T, Plate KH (2002) A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology. J Mol Med 80: 562-575
2. Braun RD, Lanzen JL, Dewhirst MW (1999) Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats. Am J Physiol 277: H551-H568
3. Braun RD, Lanzen JL, Snyder SA, Dewhirst MW (2001) Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents. Am J Physiol 280: H2533-H2544
4. Brizel DM, Klitzman B, Cook JM, Edwards J, Rosner G, Dewhirst MW (1993) A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model. Int J Radiat Oncol Biol Phys 25: 269-276
5. Brown JM (1999) The hypoxic cell: a target for selective cancer therapy - eighteenth Bruce F. Cain memorial award lecture. Cancer Res 59: 5863-5870
6. Bussink J, Kaanders JHAM, Strik AM, van der Kogel AJ (2000) Effects of nicotinamide and carbogen on oxygenation in human tumor xenografts measured with luminescence based fiber-optic probes. Radiother Oncol 57: 21-30
7. Cairns RA, Kalliomaki T, Hill RP (2001) Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors. Cancer Res 61: 8903-8908
8. Chao KS, Bosch WR, Mutic S, Lewis JS, Dehdashti F, Mintun MA, Dempsey JF, Perez CA, Purdy JA, Welch MJ (2001) A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys 49: 1171-1182
9. Chaplin DJ, Hill SA (1995) Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours. Br J Cancer 71: 1210-1213
10. Chaplin DJ, Olive PL, Durand RE (1987) Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Res 47: 597-603
11. Collingridge DR, Young WK, Vojnovic B, Wardman P, Lynch EM, Hill SA, Chaplin DJ (1997) Measurement of tumor oxygenation: a comparison between polarographic needle electrodes and a time-resolved luminescence-based optical sensor. Radiat Res 147: 329-334
12. Demeure RJ, Jordan BF, Yang QX, Beghein N, Smith MB, Gregoire B, Gallez B (2002) Removal of local field gradient artefacts in BOLD contrast imaging of head and neck tumours. Phys Med Biol 47: 1819-1825
13. 2 of R3230Ac tumors in Fischer-334 rats. Int J Radiat Oncol Biol Phys 42: 723-726
14. Dewhirst MW, Kimura H, Rehmus SWE, Braun RD, Papahadjopoulos D, Hong K, Secomb TW (1996) Microvascular studies on the origins of perfusion-limited hypoxia. Br J Cancer 74(Suppl XXVII): S247-S251
15. Dewhirst MW, Klitzman B, Braun RD, Brizel DM, Haroon ZA, Secomb TW (2000) Review of methods used to study oxygen transport at the microcirculatory level. Int J Cancer Radiat Oncol Invest 90: 237-255
16. Endrich B, Intaglietta M, Reinhold HS, Gross JF (1979) Hemodynamic characteristics in microcirculatory blood channels during early tumor growth. Cancer Res 39: 17-23
17. Griffiths JR, Robinson P (1999) The OxyLite: a fibre-optic oxygen sensor. Br J Radiol 72: 627-630
18. Harris AL (2002) Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47
19. Hill SA, Pigott KH, Saunders MI, Powell MEB, Arnold S, Obeid A, Ward G, Leahy M, Hoskin PJ, Chaplin DJ (1996) Microregional blood flow in murine and human tumours assessed using laser Doppler microprobes. Br J Cancer 74(Suppl XXVII): S260-S263
20. Horsman MR (1995) Nicotinamide and other benzamide analogs as agents for overcoming hypoxic cell radiation resistance in tumours. Acta Oncol 34: 571-587
21. Höckel M, Vaupel P (2001) Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 93: 266-276
22. Jarm T, Sersa G, Miklavcic D (2002) Oxygenation and blood flow in tumors treated with hydralazine: evaluation with a novel luminescence-based fiber-optic sensor. Technol Health Care 10: 363-380
23. Jordan BF, Grégoire V, Demeure RJ, Sonveaux P, Feron O, O'Hara J, Vanhulle VP, Delzenne N, Gallez B (2002) Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption. Cancer Res 62: 3555-3561
24. Kimura H, Braun RD, Ong ET, Hsu R, Secomb TW, Papahadjopoulos D, Hong K, Dewhirst MW (1996) Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res 56: 5522-5528
25. Linsenmeier RA, Yancey CM (1987) Improved fabrication of double-barreled recessed cathode oxygen microelectrodes. J Appl Physiol 63: 2554-2557
26. Overgaard J, Horsman MR (1996) Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Semin Radiat Oncol 6: 10-21
27. Pettersen EO, Wang H (1996) Radiation-modifying effect of oxygen in synchronized cells pre-treated with acute or prolonged hypoxia. Int J Radiat Biol 70: 319-326
28. Popple RA, Ove R, Shen S (2002) Tumor control probability for selective boosting of hypoxic subvolumes, including the effect of reoxygenation. Int J Radiat Oncol Biol Phys 54: 921-927
29. Rofstad EK (1994) Orthotopic human melanoma xenograft model systems for studies of tumour angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern. Br J Cancer 70: 804-812
30. Rofstad EK (2000) Microenvironment-induced cancer metastasis. Int J Radiat Biol 76: 589-605
31. Rofstad EK, Halsør EF (2002) Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8. Br J Cancer 86: 301-308
32. Rofstad EK, Måseide K (1999) Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours. Int J Radiat Biol 75: 1377-1393
33. Rofstad EK, Rasmussen H, Galappathi K, Mathiesen B, Nilsen K, Graff BA (2002) Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor. Cancer Res 62: 1847-1853
34. Seddon BM, Honess DJ, Vojnovic B, Tozer GM, Workman P (2001) Measurement of tumor oxygenation: in vivo comparison of a luminescence fiber-optic sensor and a polarographic electrode in the P22 tumor. Radiat Res 155: 837-846
35. Tome WA, Fowler JF (2000) Selective boosting of tumor subvolumes. Int J Radiat Oncol Biol Phys 48: 593-599
36. Urano M, Chen Y, Humm J, Koutcher JA, Zanzonico P, Ling C (2002) Measurements of tumor tissue oxygen tension using a time-resolved luminescence-based optical OxyLite probe: comparison with a paired survival assay. Radiat Res 158: 167-173
37. Vaupel P (1990) Oxygenation of human tumors. Strahlenther Onkol 166: 377-386
38. Vaupel P, Kallinowski F, Okunieff P (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49: 6449-6465
39. Workman P, Twentyman P, Balkwill F, Balmain A, Chaplin D, Double J, Embleton J, Newell D, Raymond R, Stables J, Stephens T, Wallace J (1998) United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition). Br J Cancer 77: 1-10
40. Wouters BG, Brown JM (1997) Cells at intermediate oxygen levels can be more important than the 'hypoxic fraction' in determining tumor response to fractionated radiotherapy. Radiat Res 147: 541-550
41. Wouters BG, Weppler SA, Koritzinsky M, Landuyt W, Nuyts S, Theys J, Chiu RK, Lambin P (2002) Hypoxia as a target for combined modality treatments. Eur J Cancer 38: 240-257
42. Yamaura H, Matsuzawa T (1979) Tumour regrowth after irradiation: an experimental approach. Int J Radiat Biol 35: 201-219
43. Young WK, Vojnovic B, Wardman P (1996) Measurement of oxygen tension in tumours by time-resolved fluorescence. Br J Cancer 74(Suppl XXVII): S256-S259
44. Zölzer F, Streffer C (2002) Increased radiosensitivity with chronic hypoxia in four human tumor cell lines. Int J Radiat Oncol Biol Phys 54: 910-920