메뉴 건너뛰기




Volumn 9, Issue SUPPL. 2, 2007, Pages 99-108

New insights into the molecular mechanisms of priming of insulin exocytosis

Author keywords

Diacylglycerol; Insulin exocytosis; Munc13 1; Priming; Readily releasable pool; Soluble N ethylmaleimide sensitive factor attachment protein (SNAP) receptor (SNARE)

Indexed keywords

BINDING PROTEIN; DIACYLGLYCEROL; MEMBRANE PROTEIN; MUNC 13 PROTEIN; MUNC18 PROTEIN; NEUROTRANSMITTER; PHORBOL ESTER; SNARE PROTEIN; SOLUBLE N ETHYLMALEIMIDE SENSITIVE FACTOR ATTACHMENT PROTEIN; SYNTAXIN 1A; TOMOSYN; UNCLASSIFIED DRUG;

EID: 35148845162     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2007.00788.x     Document Type: Conference Paper
Times cited : (9)

References (65)
  • 1
    • 0024917106 scopus 로고
    • Electrophysiology of the pancreatic beta-cell
    • Ashcroft FM, Rorsman P. Electrophysiology of the pancreatic beta-cell. Prog Biophys Mol Biol 1989; 54: 87-143.
    • (1989) Prog Biophys Mol Biol , vol.54 , pp. 87-143
    • Ashcroft, F.M.1    Rorsman, P.2
  • 2
    • 2942556680 scopus 로고    scopus 로고
    • The synaptic vesicle cycle
    • Sudhof TC. The synaptic vesicle cycle. Annu Rev Neurosci 2004; 27: 509-547.
    • (2004) Annu Rev Neurosci , vol.27 , pp. 509-547
    • Sudhof, T.C.1
  • 3
    • 33646185099 scopus 로고    scopus 로고
    • Fusion pores and fusion machines in Ca2+-triggered exocytosis
    • Jackson MB, Chapman ER. Fusion pores and fusion machines in Ca2+ -triggered exocytosis. Annu Rev Biophys Biomol Struct 2006; 35: 135-160.
    • (2006) Annu Rev Biophys Biomol Struct , vol.35 , pp. 135-160
    • Jackson, M.B.1    Chapman, E.R.2
  • 5
    • 0036868797 scopus 로고    scopus 로고
    • Glucose-stimulated signaling pathways in biphasic insulin secretion
    • Straub SG, Sharp GW. Glucose-stimulated signaling pathways in biphasic insulin secretion. Diabetes Metab Res Rev 2002; 18: 451-463.
    • (2002) Diabetes Metab Res Rev , vol.18 , pp. 451-463
    • Straub, S.G.1    Sharp, G.W.2
  • 6
    • 0036261251 scopus 로고    scopus 로고
    • Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells
    • Olofsson CS, Gopel SO, Barg S et al. Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells. Pflugers Arch 2002; 444: 43-51.
    • (2002) Pflugers Arch , vol.444 , pp. 43-51
    • Olofsson, C.S.1    Gopel, S.O.2    Barg, S.3
  • 7
    • 0032081255 scopus 로고    scopus 로고
    • Cytosolic Ca2+ acts by two separate pathways to modulate the supply of release-competent vesicles in chromaffin cells
    • Smith C, Moser T, Xu T, Neher E. Cytosolic Ca2+ acts by two separate pathways to modulate the supply of release-competent vesicles in chromaffin cells. Neuron 1998; 20: 1243-1253.
    • (1998) Neuron , vol.20 , pp. 1243-1253
    • Smith, C.1    Moser, T.2    Xu, T.3    Neher, E.4
  • 8
    • 0030874610 scopus 로고    scopus 로고
    • Rapid ATP-dependent priming of secretory granules precedes Ca2+-induced exocytosis in mouse pancreatic B-cells
    • Eliasson L, Rorsman P. Rapid ATP-dependent priming of secretory granules precedes Ca2+-induced exocytosis in mouse pancreatic B-cells. J Physiol 1997; 503: 399-412.
    • (1997) J Physiol , vol.503 , pp. 399-412
    • Eliasson, L.1    Rorsman, P.2
  • 9
    • 0042879951 scopus 로고    scopus 로고
    • Insulin granule dynamics in pancreatic beta cells
    • Rorsman P, Renstrom E. Insulin granule dynamics in pancreatic beta cells. Diabetologia 2003; 46: 1029-1045.
    • (2003) Diabetologia , vol.46 , pp. 1029-1045
    • Rorsman, P.1    Renstrom, E.2
  • 10
    • 0029906237 scopus 로고    scopus 로고
    • Ca(2+)- and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps
    • Proks P, Eliasson L, Ammala C, Rorsman P, Ashcroft FM. Ca(2+)- and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps. J Physiol 1996; 496: 255-264.
    • (1996) J Physiol , vol.496 , pp. 255-264
    • Proks, P.1    Eliasson, L.2    Ammala, C.3    Rorsman, P.4    Ashcroft, F.M.5
  • 11
    • 0038303159 scopus 로고    scopus 로고
    • Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells
    • Olsen HL, Hoy M, Zhang W et al. Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells. Proc Natl Acad Sci U S A 2003; 100: 5187-5192.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 5187-5192
    • Olsen, H.L.1    Hoy, M.2    Zhang, W.3
  • 12
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006; 444: 840-846.
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 13
    • 0034082054 scopus 로고    scopus 로고
    • Regulation of transmitter release by Unc-13 and its homologues
    • Brose N, Rosenmund C, Rettig J. Regulation of transmitter release by Unc-13 and its homologues. Curr Opin Neurobiol 2000; 10: 303-311.
    • (2000) Curr Opin Neurobiol , vol.10 , pp. 303-311
    • Brose, N.1    Rosenmund, C.2    Rettig, J.3
  • 14
    • 0033349884 scopus 로고    scopus 로고
    • UNC-13 is required for synaptic vesicle fusion in C. elegans
    • Richmond JE, Davis WS, Jorgensen EM. UNC-13 is required for synaptic vesicle fusion in C. elegans. Nat Neurosci 1999; 2: 959-964.
    • (1999) Nat Neurosci , vol.2 , pp. 959-964
    • Richmond, J.E.1    Davis, W.S.2    Jorgensen, E.M.3
  • 15
    • 0034235922 scopus 로고    scopus 로고
    • Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform
    • Koch H, Hofmann K, Brose N. Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform. Biochem J 2000; 349: 247-253.
    • (2000) Biochem J , vol.349 , pp. 247-253
    • Koch, H.1    Hofmann, K.2    Brose, N.3
  • 16
    • 10744224641 scopus 로고    scopus 로고
    • Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3)
    • Feldmann J, Callebaut I, Raposo G et al. Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3). Cell 2003; 115: 461-473.
    • (2003) Cell , vol.115 , pp. 461-473
    • Feldmann, J.1    Callebaut, I.2    Raposo, G.3
  • 17
    • 0028791349 scopus 로고
    • Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins
    • Brose N, Hofmann K, Hata Y, Sudhof TC. Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins. J Biolumin Chemilumin 1995; 270: 25273-25280.
    • (1995) J Biolumin Chemilumin , vol.270 , pp. 25273-25280
    • Brose, N.1    Hofmann, K.2    Hata, Y.3    Sudhof, T.C.4
  • 18
    • 0033084096 scopus 로고    scopus 로고
    • Differential expression of two novel Munc13 proteins in rat brain
    • Augustin I, Betz A, Herrmann C, Jo T, Brose N. Differential expression of two novel Munc13 proteins in rat brain. Biochem J 1999; 337: 363-371.
    • (1999) Biochem J , vol.337 , pp. 363-371
    • Augustin, I.1    Betz, A.2    Herrmann, C.3    Jo, T.4    Brose, N.5
  • 19
    • 0041344686 scopus 로고    scopus 로고
    • Regulation of insulin exocytosis by Munc13-1
    • Sheu L, Pasyk EA, Ji J et al. Regulation of insulin exocytosis by Munc13-1. J Biol Chem 2003; 278: 27556-27563.
    • (2003) J Biol Chem , vol.278 , pp. 27556-27563
    • Sheu, L.1    Pasyk, E.A.2    Ji, J.3
  • 20
    • 0034679721 scopus 로고    scopus 로고
    • Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells
    • Ashery U, Varoqueaux F, Voets T et al. Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells. EMBO J 2000; 19: 3586-3596.
    • (2000) EMBO J , vol.19 , pp. 3586-3596
    • Ashery, U.1    Varoqueaux, F.2    Voets, T.3
  • 21
    • 0031750748 scopus 로고    scopus 로고
    • Cloning of a novel gene in the human kidney homologous to rat munc13s: Its potential role in diabetic nephropathy
    • Song Y, Ailenberg M, Silverman M. Cloning of a novel gene in the human kidney homologous to rat munc13s: Its potential role in diabetic nephropathy. Kidney Int 1998; 53: 1689-1695.
    • (1998) Kidney Int , vol.53 , pp. 1689-1695
    • Song, Y.1    Ailenberg, M.2    Silverman, M.3
  • 22
    • 33744504875 scopus 로고    scopus 로고
    • Munc13-1 is required for the sustained release of insulin from pancreatic beta cells
    • Kang L, He Z, Xu P et al. Munc13-1 is required for the sustained release of insulin from pancreatic beta cells. Cell Metab 2006; 3: 463-468.
    • (2006) Cell Metab , vol.3 , pp. 463-468
    • Kang, L.1    He, Z.2    Xu, P.3
  • 23
    • 0026053020 scopus 로고
    • A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans
    • Mavuyama IN, Brenner S. A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans. Proc Natl Acad Sci U S A 1991; 88: 5729-5733.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 5729-5733
    • Mavuyama, I.N.1    Brenner, S.2
  • 25
    • 0037204063 scopus 로고    scopus 로고
    • Differential control of vesicle priming and short-term plasticity by Munc13 isoforms
    • Rosenmund C, Sigler A, Augustin I, Reim K, Brose N, Rhee JS. Differential control of vesicle priming and short-term plasticity by Munc13 isoforms. Neuron 2002; 33: 411-424.
    • (2002) Neuron , vol.33 , pp. 411-424
    • Rosenmund, C.1    Sigler, A.2    Augustin, I.3    Reim, K.4    Brose, N.5    Rhee, J.S.6
  • 26
    • 0033615054 scopus 로고    scopus 로고
    • Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles
    • Augustin I, Rosenmund C, Sudhof TC, Brose N. Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles. Nature 1999; 400: 457-461.
    • (1999) Nature , vol.400 , pp. 457-461
    • Augustin, I.1    Rosenmund, C.2    Sudhof, T.C.3    Brose, N.4
  • 27
    • 4043075637 scopus 로고    scopus 로고
    • Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticity
    • Junge HJ, Rhee JS, Jahn O et al. Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticity. Cell 2004; 118: 389-401.
    • (2004) Cell , vol.118 , pp. 389-401
    • Junge, H.J.1    Rhee, J.S.2    Jahn, O.3
  • 28
    • 33745835747 scopus 로고    scopus 로고
    • Binding to RAB3a-interacting-molecule rim regulates the presynaptic recruitment of MUNC13-1 and ubMUNC13-2
    • Andrews-Zwilling YS, Kawabe H, Reim K, Varoqueaux F, Brose N. Binding to RAB3a-interacting-molecule rim regulates the presynaptic recruitment of MUNC13-1 and ubMUNC13-2. J Biol Chem 2006; 281: 19720-19731.
    • (2006) J Biol Chem , vol.281 , pp. 19720-19731
    • Andrews-Zwilling, Y.S.1    Kawabe, H.2    Reim, K.3    Varoqueaux, F.4    Brose, N.5
  • 29
    • 0035030935 scopus 로고    scopus 로고
    • Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming
    • Betz A, Thakur P, Junge HJ et al. Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming. Neuron 2001; 30: 183-196.
    • (2001) Neuron , vol.30 , pp. 183-196
    • Betz, A.1    Thakur, P.2    Junge, H.J.3
  • 30
    • 18544399674 scopus 로고    scopus 로고
    • Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release
    • Betz A, Ashery U, Rickmann M et al. Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release. Neuron 1998; 21: 123-136.
    • (1998) Neuron , vol.21 , pp. 123-136
    • Betz, A.1    Ashery, U.2    Rickmann, M.3
  • 31
    • 18244389735 scopus 로고    scopus 로고
    • Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs
    • Rhee JS, Betz A, Pyott S. Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell 2002; 108: 121-133.
    • (2002) Cell , vol.108 , pp. 121-133
    • Rhee, J.S.1    Betz, A.2    Pyott, S.3
  • 32
    • 1642275392 scopus 로고    scopus 로고
    • Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets
    • Shirakawa R, Higashi T, Tabuchi A et al. Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets. J Biol Chem 2004; 279: 10730-10737.
    • (2004) J Biol Chem , vol.279 , pp. 10730-10737
    • Shirakawa, R.1    Higashi, T.2    Tabuchi, A.3
  • 33
    • 29044435309 scopus 로고    scopus 로고
    • Identification of the minimal protein domain required for priming activity of Munc13-1
    • Stevens DR, Wu ZX, Matti U et al. Identification of the minimal protein domain required for priming activity of Munc13-1. Curr Biol 2005; 15: 2243-2248.
    • (2005) Curr Biol , vol.15 , pp. 2243-2248
    • Stevens, D.R.1    Wu, Z.X.2    Matti, U.3
  • 34
    • 29044447583 scopus 로고    scopus 로고
    • UNC-13 interaction with syntaxin is required for synaptic transmission
    • Madison JM, Nurrish S, Kaplan JM. UNC-13 interaction with syntaxin is required for synaptic transmission. Curr Biol 2005; 15: 2236-2242.
    • (2005) Curr Biol , vol.15 , pp. 2236-2242
    • Madison, J.M.1    Nurrish, S.2    Kaplan, J.M.3
  • 35
    • 33645014145 scopus 로고    scopus 로고
    • A minimal domain responsible for Munc13 activity
    • Basu J, Shen N, Dulubova I et al. A minimal domain responsible for Munc13 activity. Nat Struct Mol Biol 2005; 12: 1017-1018.
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 1017-1018
    • Basu, J.1    Shen, N.2    Dulubova, I.3
  • 36
    • 0034917524 scopus 로고    scopus 로고
    • alpha-Latrotoxin and its receptors: Neurexins and CIRL/latrophilins
    • Sudhof TC. alpha-Latrotoxin and its receptors: Neurexins and CIRL/ latrophilins. Annu Rev Neurosci 2001; 24: 933-962.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 933-962
    • Sudhof, T.C.1
  • 37
    • 0035141520 scopus 로고    scopus 로고
    • The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice
    • Augustin I, Korte S, Rickmann M et al. The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice. J Neurosci 2001; 21: 10-17.
    • (2001) J Neurosci , vol.21 , pp. 10-17
    • Augustin, I.1    Korte, S.2    Rickmann, M.3
  • 38
    • 0036827802 scopus 로고    scopus 로고
    • Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment
    • Gaisano HY, Ostenson CG, Sheu L, Wheeler MB, Efendic S. Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment. Endocrinology 2002; 143: 4218-4226.
    • (2002) Endocrinology , vol.143 , pp. 4218-4226
    • Gaisano, H.Y.1    Ostenson, C.G.2    Sheu, L.3    Wheeler, M.B.4    Efendic, S.5
  • 39
    • 33644772589 scopus 로고    scopus 로고
    • Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients
    • Ostenson CG, Gaisano H, Sheu L, Tibell A, Bartfai T. Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients. Diabetes 2006; 55: 435-440.
    • (2006) Diabetes , vol.55 , pp. 435-440
    • Ostenson, C.G.1    Gaisano, H.2    Sheu, L.3    Tibell, A.4    Bartfai, T.5
  • 40
    • 33745291822 scopus 로고    scopus 로고
    • Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance
    • Kwan EP, Xie L, Sheu L. Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes 2006; 55: 1421-1429.
    • (2006) Diabetes , vol.55 , pp. 1421-1429
    • Kwan, E.P.1    Xie, L.2    Sheu, L.3
  • 41
    • 85073763929 scopus 로고    scopus 로고
    • Munc13-1 interactions with cAMP pathways in insulin exocytosis
    • (Abstract)
    • Kwan EP, Xie L, Sheu L, Brose N, Gaisano HY. Munc13-1 interactions with cAMP pathways in insulin exocytosis. Diabetes 2006; 55 (Suppl. 1) (Abstract) A44.
    • (2006) Diabetes , vol.55 , Issue.SUPPL. 1
    • Kwan, E.P.1    Xie, L.2    Sheu, L.3    Brose, N.4    Gaisano, H.Y.5
  • 42
    • 0037040238 scopus 로고    scopus 로고
    • Imaging exocytosis of single insulin secretory granules with evanescent wave microscopy
    • Ohara-Imaizumi M, Nakamichi Y, Tanaka T, Ishida H, Nagamatsu S. Imaging exocytosis of single insulin secretory granules with evanescent wave microscopy. J Biol Chem 2002; 277: 3805-3808.
    • (2002) J Biol Chem , vol.277 , pp. 3805-3808
    • Ohara-Imaizumi, M.1    Nakamichi, Y.2    Tanaka, T.3    Ishida, H.4    Nagamatsu, S.5
  • 43
    • 3142758492 scopus 로고    scopus 로고
    • TIRF imaging of docking and fusion of single insulin granule motion in primary rat pancreatic beta-cells: Different behaviour of granule motion between normal and Goto-Kakizaki diabetic rat beta-cells: Different behaviour of granule motion between normal and Goto-Kakizaki diabetic rat beta-cells
    • Ohara-Imaizumi M, Nishiwaki C, Kikuta T, Nagai S, Nakamichi Y, Nagamatsu S. TIRF imaging of docking and fusion of single insulin granule motion in primary rat pancreatic beta-cells: Different behaviour of granule motion between normal and Goto-Kakizaki diabetic rat beta-cells. Biochem J 2004; 381: 13-18.
    • (2004) Biochem J , vol.381 , pp. 13-18
    • Ohara-Imaizumi, M.1    Nishiwaki, C.2    Kikuta, T.3    Nagai, S.4    Nakamichi, Y.5    Nagamatsu, S.6
  • 44
    • 0036314213 scopus 로고    scopus 로고
    • Beta-cell protein kinases and the dynamics of the insulin response to glucose
    • Nesher R, Anteby E, Yedovizky M. Beta-cell protein kinases and the dynamics of the insulin response to glucose. Diabetes 2002; 51 (Suppl. 1): S68-S73.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 1
    • Nesher, R.1    Anteby, E.2    Yedovizky, M.3
  • 45
    • 0037172972 scopus 로고    scopus 로고
    • Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming
    • Varoqueaux F, Sigler A, Rhee JS et al. Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc Natl Acad Sci U S A 2002; 99: 9037-9042.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 9037-9042
    • Varoqueaux, F.1    Sigler, A.2    Rhee, J.S.3
  • 46
    • 33846794400 scopus 로고    scopus 로고
    • Munc13-1C1 domain activation lowers the energy barrier for synaptic vesicle fusion
    • Basu J, Betz A, Brose N, Rosenmund C. Munc13-1C1 domain activation lowers the energy barrier for synaptic vesicle fusion. J Neurosci 2007; 27: 1200-1210.
    • (2007) J Neurosci , vol.27 , pp. 1200-1210
    • Basu, J.1    Betz, A.2    Brose, N.3    Rosenmund, C.4
  • 47
    • 0031027591 scopus 로고    scopus 로고
    • Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin
    • Betz A, Okamoto M, Benseler F, Brose N. Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. J Biol Chem 1997; 272: 2520-2526.
    • (1997) J Biol Chem , vol.272 , pp. 2520-2526
    • Betz, A.1    Okamoto, M.2    Benseler, F.3    Brose, N.4
  • 48
    • 0033575749 scopus 로고    scopus 로고
    • A conformational switch in syntaxin during exocytosis: Role of munc18
    • Dulubova I, Sugita S, Hill S. A conformational switch in syntaxin during exocytosis: Role of munc18. EMBO J 1999; 18: 4372-4382.
    • (1999) EMBO J , vol.18 , pp. 4372-4382
    • Dulubova, I.1    Sugita, S.2    Hill, S.3
  • 50
    • 0035913332 scopus 로고    scopus 로고
    • An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming
    • Richmond JE, Weimer RM, Jorgensen EM. An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming. Nature 2001; 412: 338-341.
    • (2001) Nature , vol.412 , pp. 338-341
    • Richmond, J.E.1    Weimer, R.M.2    Jorgensen, E.M.3
  • 51
    • 28844459957 scopus 로고    scopus 로고
    • RIM function in short- and long-term synaptic plasticity
    • Kaeser PS, Sudhof TC. RIM function in short- and long-term synaptic plasticity. Biochem Soc Trans 2005; 33: 1345-1349.
    • (2005) Biochem Soc Trans , vol.33 , pp. 1345-1349
    • Kaeser, P.S.1    Sudhof, T.C.2
  • 52
    • 0035974886 scopus 로고    scopus 로고
    • Munc18-1 promotes large dense-core vesicle docking
    • Voets T, Toonen RF, Brian EC et al. Munc18-1 promotes large dense-core vesicle docking. Neuron 2001; 31: 581-591.
    • (2001) Neuron , vol.31 , pp. 581-591
    • Voets, T.1    Toonen, R.F.2    Brian, E.C.3
  • 54
    • 33745834309 scopus 로고    scopus 로고
    • The stimulus-induced tyrosine phosphorylation of Munc18c facilitates vesicle exocytosis
    • Oh E, Thurmond DC. The stimulus-induced tyrosine phosphorylation of Munc18c facilitates vesicle exocytosis. J Biol Chem 2006; 281: 17624-17634.
    • (2006) J Biol Chem , vol.281 , pp. 17624-17634
    • Oh, E.1    Thurmond, D.C.2
  • 55
    • 0032472409 scopus 로고    scopus 로고
    • ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner
    • Wu MN, Littleton JT, Bhat MA, Prokop A, Bellen HJ. ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner. EMBO J 1998; 17: 127-139.
    • (1998) EMBO J , vol.17 , pp. 127-139
    • Wu, M.N.1    Littleton, J.T.2    Bhat, M.A.3    Prokop, A.4    Bellen, H.J.5
  • 56
    • 0034731521 scopus 로고    scopus 로고
    • Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta-cell
    • Zhang W, Efanov A, Yang SN et al. Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta-cell. J Biol Chem 2000; 275: 41521-41527.
    • (2000) J Biol Chem , vol.275 , pp. 41521-41527
    • Zhang, W.1    Efanov, A.2    Yang, S.N.3
  • 57
    • 14644408047 scopus 로고    scopus 로고
    • Munc18c heterozygous knockout mice display increased susceptibility for severe glucose intolerance
    • Oh E, Spurlin BA, Pessin JE, Thurmond DC. Munc18c heterozygous knockout mice display increased susceptibility for severe glucose intolerance. Diabetes 2005; 54: 638-647.
    • (2005) Diabetes , vol.54 , pp. 638-647
    • Oh, E.1    Spurlin, B.A.2    Pessin, J.E.3    Thurmond, D.C.4
  • 58
    • 0036673069 scopus 로고    scopus 로고
    • Snares and Munc18 in synaptic vesicle fusion
    • Rizo J, Sudhof TC. Snares and Munc18 in synaptic vesicle fusion. Nat Rev Neurosci 2002; 3: 641-653.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 641-653
    • Rizo, J.1    Sudhof, T.C.2
  • 59
    • 33845987734 scopus 로고    scopus 로고
    • Selective activation of cognate SNAREpins by Sec1/Munc18 proteins
    • Shen J, Tareste DC, Paumet F, Rothman JE, Melia TJ. Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell 2007; 128: 183-495.
    • (2007) Cell , vol.128 , pp. 183-495
    • Shen, J.1    Tareste, D.C.2    Paumet, F.3    Rothman, J.E.4    Melia, T.J.5
  • 60
    • 33750241320 scopus 로고    scopus 로고
    • Munc18-bound syntaxin readily forms SNARE complexes with synaptobrevin in native plasma membranes
    • e330
    • Zilly FE, Sorensen JB, Jahn R, Lang T. Munc18-bound syntaxin readily forms SNARE complexes with synaptobrevin in native plasma membranes. PLoS Biol 2006; 4: E330, 1789-1797.
    • (2006) PLoS Biol , vol.4 , pp. 1789-1797
    • Zilly, F.E.1    Sorensen, J.B.2    Jahn, R.3    Lang, T.4
  • 62
    • 33746726458 scopus 로고    scopus 로고
    • Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13
    • McEwen JM, Madison JM, Dybbs M, Kaplan JM. Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13. Neuron 2006; 51: 303-315.
    • (2006) Neuron , vol.51 , pp. 303-315
    • McEwen, J.M.1    Madison, J.M.2    Dybbs, M.3    Kaplan, J.M.4
  • 63
    • 17344376286 scopus 로고    scopus 로고
    • Tomosyn: A syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process
    • Fujita Y, Shirataki H, Sakisaka T et al. Tomosyn: A syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Neuron 1998; 20: 905-915.
    • (1998) Neuron , vol.20 , pp. 905-915
    • Fujita, Y.1    Shirataki, H.2    Sakisaka, T.3
  • 64
    • 33644783907 scopus 로고    scopus 로고
    • Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis
    • Zhang W, Lilja L, Mandic SA et al. Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis. Diabetes 2006; 55: 574-581.
    • (2006) Diabetes , vol.55 , pp. 574-581
    • Zhang, W.1    Lilja, L.2    Mandic, S.A.3
  • 65
    • 33747364921 scopus 로고    scopus 로고
    • Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans
    • Gracheva EO, Burdina AO, Holgado AM et al. Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans. PLoS Biol 2006; 4: E261.
    • (2006) PLoS Biol , vol.4
    • Gracheva, E.O.1    Burdina, A.O.2    Holgado, A.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.