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Volumn 31, Issue 2, 2007, Pages 389-396

Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-κB in human osteoblastic osteosarcoma MG63 cells

Author keywords

Apoptosis; Calyculin A; NF B; Phosphatase; Phosphorylation

Indexed keywords

CALYCULIN A; ENZYME INHIBITOR; OXAZOLE DERIVATIVE; SERINE; TRANSCRIPTION FACTOR RELA;

EID: 35148842580     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.31.2.389     Document Type: Article
Times cited : (13)

References (45)
  • 1
    • 0025932984 scopus 로고
    • Apoptosis: Mechanisms and roles in pathology
    • Arends MJ and Wyllie AH: Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol 32: 223-254, 1991.
    • (1991) Int Rev Exp Pathol , vol.32 , pp. 223-254
    • Arends, M.J.1    Wyllie, A.H.2
  • 2
    • 0030947095 scopus 로고    scopus 로고
    • Programmed cell death in animal development
    • DOI 10.1016/S0092-8674(00)81873-5
    • Jacobson MD, Weil M and Raff MC: Programmed cell death in animal development. Cell 88: 347-354, 1997. (Pubitemid 27131376)
    • (1997) Cell , vol.88 , Issue.3 , pp. 347-354
    • Jacobson, M.D.1    Weil, M.2    Raff, M.C.3
  • 4
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-κB in cancer development and progression
    • Karin M: Nuclear factor-κB in cancer development and progression. Nature 441: 431-436, 2006.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 5
    • 33644798457 scopus 로고    scopus 로고
    • Role of MAPKs and NF-κB in diosgenin-induced megakaryocytic differentiation and subsequent apoptosis in HEL cells
    • Leger DY, Liagre B and Beneytout JL: Role of MAPKs and NF-κB in diosgenin-induced megakaryocytic differentiation and subsequent apoptosis in HEL cells. Int J Oncol 28: 201-207, 2006.
    • (2006) Int J Oncol , vol.28 , pp. 201-207
    • Leger, D.Y.1    Liagre, B.2    Beneytout, J.L.3
  • 6
    • 34250698168 scopus 로고    scopus 로고
    • NF-κB, inflammation and pancreatic carcinogenesis: NF-κB as a chemoprevention target
    • Zhang Z and Rigas B: NF-κB, inflammation and pancreatic carcinogenesis: NF-κB as a chemoprevention target. Int J Oncol 29: 185-192, 2006.
    • (2006) Int J Oncol , vol.29 , pp. 185-192
    • Zhang, Z.1    Rigas, B.2
  • 7
    • 27244433443 scopus 로고    scopus 로고
    • Pro-apoptotic and anti-apoptotic effects of tumor necrosis factor in tumor cells. Role of nuclear transcription factor NF-κB
    • Aggarwal BB and Takada Y: Pro-apoptotic and anti-apoptotic effects of tumor necrosis factor in tumor cells. Role of nuclear transcription factor NF-κB. Cancer Treat Res 126: 103-127, 2005.
    • (2005) Cancer Treat Res , vol.126 , pp. 103-127
    • Aggarwal, B.B.1    Takada, Y.2
  • 8
    • 26444538871 scopus 로고    scopus 로고
    • The two faces of NFκB in cell survival responses
    • Graham B and Gibson SB: The two faces of NF-κB in cell survival responses. Cell Cycle 4: 1342-1345, 2005. (Pubitemid 41437117)
    • (2005) Cell Cycle , vol.4 , Issue.10 , pp. 1342-1345
    • Graham, B.1    Gibson, S.B.2
  • 9
    • 33646103893 scopus 로고    scopus 로고
    • Caspases leave the beaten track: Caspase-mediated activation of NF-κB
    • Lamkanfi M, Declercq W, Vanden Berghe T and Vandenabeele P: Caspases leave the beaten track: caspase-mediated activation of NF-κB. J Cell Biol 173: 165-171, 2006.
    • (2006) J Cell Biol , vol.173 , pp. 165-171
    • Lamkanfi, M.1    Declercq, W.2    Vanden Berghe, T.3    Vandenabeele, P.4
  • 10
    • 33646705888 scopus 로고    scopus 로고
    • NF-κB: A stress-regulated switch for cell survival
    • DOI 10.1089/ars.2006.8.478
    • Piva R, Belardo G and Santoro MG: NF-κB: a stress-regulated switch for cell survival. Antioxid Redox Signal 8: 478-486, 2006. (Pubitemid 43741316)
    • (2006) Antioxidants and Redox Signaling , vol.8 , Issue.3-4 , pp. 478-486
    • Piva, R.1    Belardo, G.2    Santoro, M.G.3
  • 12
    • 33750443289 scopus 로고    scopus 로고
    • IκB kinase complexes: Gateways to NF-κB activation and transcription
    • DOI 10.1038/sj.onc.1209934, PII 1209934
    • Scheidereit C: IκB kinase complexes: gateways to NF-κB activation and transcription. Oncogene 25: 6685-6705, 2006. (Pubitemid 44657846)
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6685-6705
    • Scheidereit, C.1
  • 13
    • 11844269840 scopus 로고    scopus 로고
    • Phosphorylation of NF-κB and IκB proteins: Implications in cancer and inflammation
    • DOI 10.1016/j.tibs.2004.11.009, PII S0968000404002993
    • Viatour P, Merville MP, Bours V and Chariot A: Phosphorylation of NF-κB proteins: implications in cancer and inflammation. Trends Biochem Sci 30: 43-52, 2005. (Pubitemid 40093740)
    • (2005) Trends in Biochemical Sciences , vol.30 , Issue.1 , pp. 43-52
    • Viatour, P.1    Merville, M.-P.2    Bours, V.3    Chariot, A.4
  • 14
    • 33750457370 scopus 로고    scopus 로고
    • Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway
    • DOI 10.1038/sj.onc.1209937, PII 1209937
    • Perkins ND: Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. Oncogene 25: 6717-6730, 2006. (Pubitemid 44657848)
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6717-6730
    • Perkins, N.D.1
  • 15
    • 0025181418 scopus 로고
    • Okadaic acid: A new probe for the study of cellular regulation
    • Cohen P, Holmes CFB and Tsukitani Y: Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem Sci 15: 98-102, 1990. (Pubitemid 20067990)
    • (1990) Trends in Biochemical Sciences , vol.15 , Issue.3 , pp. 98-102
    • Cohen, P.1    Holmes, C.F.B.2    Tsukitani, Y.3
  • 18
    • 0346789063 scopus 로고    scopus 로고
    • Okadaic acid stimulates expression of Fas receptor and Fas ligand by activation of nuclear factor kappa-B in human oral squamous carcinoma cells
    • Fujita M, Goto K, Yoshida K, Okamura H, Morimoto H, Kito S, Fukuda J and Haneji T: Okadaic acid stimulates expression of Fas receptor and Fas ligand by activation of nuclear factor kappa-B in human oral squamous carcinoma cells. Oral Oncol 40: 199-206, 2004.
    • (2004) Oral Oncol , vol.40 , pp. 199-206
    • Fujita, M.1    Goto, K.2    Yoshida, K.3    Okamura, H.4    Morimoto, H.5    Kito, S.6    Fukuda, J.7    Haneji, T.8
  • 19
    • 17644394184 scopus 로고    scopus 로고
    • Association of protein phosphatase 1 delta with nucleolin in osteoblastic cells and cleavage of nucleolin in apoptosis-induced osteoblastic cells
    • Haneji T: Association of protein phosphatase 1 delta with nucleolin in osteoblastic cells and cleavage of nucleolin in apoptosis-induced osteoblastic cells. Acta Histochem Cytochem 38: 1-8, 2005.
    • (2005) Acta Histochem Cytochem , vol.38 , pp. 1-8
    • Haneji, T.1
  • 20
    • 13644269374 scopus 로고    scopus 로고
    • Okadaic acid induces apoptosis through double-stranded RNA-dependent protein kinase/eukaryotic initiation factor-2α pathway in human osteoblastic MG63 cells
    • DOI 10.1093/jb/mvh144
    • Morimoto H, Okamura H, Yoshida K, Kitamura S and Haneji T: Okadaic acid induces apoptosis through double-stranded RNA-dependent protein kinase/eukaryotic initiation factor-2α pathway in human osteoblastic MG63 cells. J Biochem 136: 433-438, 2004. (Pubitemid 40228340)
    • (2004) Journal of Biochemistry , vol.136 , Issue.4 , pp. 433-438
    • Morimoto, H.1    Okamura, H.2    Yoshida, K.3    Kitamura, S.4    Haneji, T.5
  • 21
    • 33751182874 scopus 로고    scopus 로고
    • Okadaic acid induces phosphorylation of p65NF-B on serine 536 and activates NF-κB transcriptional activity in human osteoblastic MG63 cells
    • Ozaki A, Morimoto H, Tanaka H, Okamura H, Yoshida K, Amorim BR and Haneji T: Okadaic acid induces phosphorylation of p65NF-B on serine 536 and activates NF-κB transcriptional activity in human osteoblastic MG63 cells. J Cell Biochem 99: 1275-1284, 2006.
    • (2006) J Cell Biochem , vol.99 , pp. 1275-1284
    • Ozaki, A.1    Morimoto, H.2    Tanaka, H.3    Okamura, H.4    Yoshida, K.5    Amorim, B.R.6    Haneji, T.7
  • 22
    • 0031080389 scopus 로고    scopus 로고
    • The protein phosphatase inhibitors okadaic acid and calyculin a induce apoptosis in human osteoblastic cells
    • DOI 10.1006/excr.1996.3404
    • Morimoto Y, Ohba T, Kobayashi S and Haneji T: The protein phosphatase inhibitors okadaic acid and calyculin A induce apoptosis in human osteoblastic cells. Exp Cell Res 230: 181-186, 1997. (Pubitemid 27190638)
    • (1997) Experimental Cell Research , vol.230 , Issue.2 , pp. 181-186
    • Morimoto, Y.1    Ohba, T.2    Kobayashi, S.3    Haneji, T.4
  • 23
    • 16544395969 scopus 로고    scopus 로고
    • Transcription factor NF-Y regulates mdr1 expression through binding to inverted CCAAT sequence in drug-resistant human squamous carcinoma cells
    • Okamura H, Yoshida K, Sasaki E, Morimoto H and Haneji T: Transcription factor NF-Y regulates mdr1 expression through binding to inverted CCAAT sequence in drug-resistant human squamous carcinoma cells. Int J Oncol 25: 1031-1037, 2004.
    • (2004) Int J Oncol , vol.25 , pp. 1031-1037
    • Okamura, H.1    Yoshida, K.2    Sasaki, E.3    Morimoto, H.4    Haneji, T.5
  • 24
    • 17644370362 scopus 로고    scopus 로고
    • PTEN expression elicited by EGR-1 transcription factor in calyculin A-induced apoptotic cells
    • DOI 10.1002/jcb.20283
    • Okamura H, Yoshida K, Morimoto H and Haneji T: PTEN expression elicited by EGR-1transcription factor in calyculin A-induced apoptotic cells. J Cell Biochem 94: 117-125, 2005. (Pubitemid 41420330)
    • (2005) Journal of Cellular Biochemistry , vol.94 , Issue.1 , pp. 117-125
    • Okamura, H.1    Yoshida, K.2    Morimoto, H.3    Haneji, T.4
  • 25
    • 0025823502 scopus 로고
    • The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells
    • Bøe R, Gjertsen BT, Vintermyr OK, Houge G, Lanotte M and Døskeland SO: The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp Cell Res 195: 237-246, 1991.
    • (1991) Exp Cell Res , vol.195 , pp. 237-246
    • Bøe, R.1    Gjertsen, B.T.2    Vintermyr, O.K.3    Houge, G.4    Lanotte, M.5    Døskeland, S.O.6
  • 26
    • 2442572230 scopus 로고    scopus 로고
    • Identification of a p65 Peptide That Selectively Inhibits NF-κB Activation Induced by Various Inflammatory Stimuli and Its Role in Down-regulation of NF-κB-mediated Gene Expression and Up-regulation of Apoptosis
    • DOI 10.1074/jbc.M311192200
    • Tanaka Y, Singh S and Aggarwal BB: Identification of a p65 peptide that selectively inhibits NF-κB activation induced by various inflammatory stimuli and its role in down-regulation of NF-κB-mediated gene expression and up-regulation of apoptosis. J Biol Chem 279: 15096-15104, 2004. (Pubitemid 38618904)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.15 , pp. 15096-15104
    • Takada, Y.1    Singh, S.2    Aggarwal, B.B.3
  • 27
    • 33646434222 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3′-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells
    • Bertram J, Peacock JW, Tan C, Mui AL, Chung SW, Gleave ME, Dedhar S, Cox ME and Ong CJ: Inhibition of the phosphatidylinositol 3′-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells. Cancer Res 66: 4781-4788, 2006.
    • (2006) Cancer Res , vol.66 , pp. 4781-4788
    • Bertram, J.1    Peacock, J.W.2    Tan, C.3    Mui, A.L.4    Chung, S.W.5    Gleave, M.E.6    Dedhar, S.7    Cox, M.E.8    Ong, C.J.9
  • 28
    • 0037851769 scopus 로고    scopus 로고
    • IKKβ plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide
    • Yang F, Tang E, Guan K and Wang CY: IKKβ plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J Immunol 170: 5630-5635, 2003. (Pubitemid 36617854)
    • (2003) Journal of Immunology , vol.170 , Issue.11 , pp. 5630-5635
    • Yang, F.1    Tang, E.2    Guan, K.3    Wang, C.-Y.4
  • 29
    • 21244503601 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFκB activation by lipopolysaccharide
    • Doyle SL, Jefferies CA and O'Neill LA: Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFκB activation by lipopolysaccharide. J Biol Chem 280: 23496-23501, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 23496-23501
    • Doyle, S.L.1    Jefferies, C.A.2    O'Neill, L.A.3
  • 33
    • 0032589462 scopus 로고    scopus 로고
    • IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain
    • Sakurai H, Chiba H, Miyoshi H, Sugita T and Toriumi W: IκB kinases phosphorylate NF-κB p65 subunit on serine 536 in the transactivation domain. J Biol Chem 274: 30353-30356, 1999. (Pubitemid 129576764)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.43 , pp. 30353-30356
    • Sakurai, H.1    Chiba, H.2    Miyoshi, H.3    Sugita, T.4    Toriumi, W.5
  • 34
    • 0035379555 scopus 로고    scopus 로고
    • Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38
    • DOI 10.1074/jbc.M101103200
    • Madrid LV, Mayo MW, Reuther JY and Baldwin AS Jr: Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem 276: 18934-18940, 2001. (Pubitemid 37411214)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.22 , pp. 18934-18940
    • Madrid, L.V.1    Mayo, M.W.2    Reuther, J.Y.3    Baldwin Jr., A.S.4
  • 35
    • 0037039665 scopus 로고    scopus 로고
    • Distinct roles of the IκB kinase α and β subunits in liberating nuclear factor κB (NF-κB) from IκB and in phosphorylating the p65 subunit of NF-κB
    • DOI 10.1074/jbc.M110572200
    • Sizemore N, Lerner N, Dombrowski N, Sakurai H and Stark GR: Distinct roles of the IκB kinase α and β subunits in liberating nuclear factor κB (NF-κB) from IκB and in phosphorylating the p65 subunit of NF-κB. J Biol Chem 277: 3863-3869, 2002. (Pubitemid 34968637)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.6 , pp. 3863-3869
    • Sizemore, N.1    Lerner, N.2    Dombrowski, N.3    Sakurai, H.4    Stark, G.R.5
  • 36
    • 0141703513 scopus 로고    scopus 로고
    • Tumor necrosis factor-α-induced IKK phosphorylation of NF-κB p65 on serine 536 is mediated though the TRAF2, TRAF5, and TAK1 signaling pathway
    • Sakurai H, Suzuki S, Kawasaki N, Nakano H, Okazaki T, Chino A, Doi T and Saiki I: Tumor necrosis factor-α-induced IKK phosphorylation of NF-κB p65 on serine 536 is mediated though the TRAF2, TRAF5, and TAK1 signaling pathway. J Biol Chem 278: 36916-36923, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 36916-36923
    • Sakurai, H.1    Suzuki, S.2    Kawasaki, N.3    Nakano, H.4    Okazaki, T.5    Chino, A.6    Doi, T.7    Saiki, I.8
  • 37
    • 27144459692 scopus 로고    scopus 로고
    • Phosphorylation of Re1A/p65 on serine 536 defines an IκBα- Independent NF-κB pathway
    • DOI 10.1074/jbc.M504943200
    • Sasaki CY, Barberi TJ, Ghosh P and Longo DL: Phosphorylation of RelA/p65 on serine 536 defines an IκBα-independent NF-κB pathway. J Biol Chem 280: 34538-34547, 2005. (Pubitemid 41504584)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.41 , pp. 34538-34547
    • Sasaki, C.Y.1    Barberi, T.J.2    Ghosh, P.3    Longo, D.L.4
  • 38
    • 24144451830 scopus 로고    scopus 로고
    • Okadaic acid induces tyrosine phosphorylation of IκBα that mediated by PKR pathway in human osteoblastic MG63 cells
    • DOI 10.1007/s11010-005-4440-y
    • Morimoto H, Ozaki A, Okamura H, Yoshida K, Kitamura S and Haneji T: Okadaic acid induces tyrosine phosphorylation of IκBα that mediated by PKR pathway in human osteoblastic MG63 cells. Mol Cell Biochem 276: 211-217, 2005. (Pubitemid 41236227)
    • (2005) Molecular and Cellular Biochemistry , vol.276 , Issue.1-2 , pp. 211-217
    • Morimoto, H.1    Ozaki, A.2    Okamura, H.3    Yoshida, K.4    Kitamura, S.5    Haneji, T.6
  • 39
    • 0033038491 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase in response to interleukin- 1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit
    • Sizemore N, Leung S and Stark GR: Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit. Mol Cell Biol 19: 4798-4805, 1999. (Pubitemid 29289518)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.7 , pp. 4798-4805
    • Sizemore, N.1    Leung, S.2    Stark, G.R.3
  • 40
    • 0033531795 scopus 로고    scopus 로고
    • rasand protein kinase Cæ in primary endothelial cells
    • Anrather J, Csizmadia V, Soares MP and Winkler H: Regulation of NF-κB RelA phosphorylation and transcriptional activity by p21ras and protein kinase Cæ in primary endothelial cells. J Biol Chem 274: 13594-13603, 1999. (Pubitemid 129518578)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.19 , pp. 13594-13603
    • Anrather, J.1    Csizmadia, V.2    Soares, M.P.3    Winkler, H.4
  • 42
    • 0037223086 scopus 로고    scopus 로고
    • NF-κB activation by protein kinase C isoforms and B-cell function
    • DOI 10.1038/sj.embor.embor704
    • Mascat J, Diaz-Meco MT and Rennert P: NF-κB activation by protein kinase C isoforms and B-cell function. EMBO Rep 4: 31-36, 2003. (Pubitemid 36305374)
    • (2003) EMBO Reports , vol.4 , Issue.1 , pp. 31-36
    • Moscat, J.1    Diaz-Meco, M.T.2    Rennert, P.3


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