A differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal women

Human Heredity

Volumn 65, Issue 1, 2007, Pages 1-8

  Cheung, Ching Lung ^a   Chan, Vivian ^a   Kung, Annie W C ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

ALOX15; Association study; BMD; Chinese; Gene environment interaction; Genetic association; Haplotype; Osteoporosis; SNP

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE;

3' UNTRANSLATED REGION; ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BODY HEIGHT; BODY WEIGHT; BONE DENSITY; CHINESE; EXON; FEMALE; GENE LOCUS; GENETIC RISK; GENOTYPE; HAPLOTYPE; HIP; HUMAN; INTRON; MUTATIONAL ANALYSIS; NORMAL HUMAN; POSTMENOPAUSE; PREMENOPAUSE; PROMOTER REGION; RISK REDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SPINE;

ADULT; AGED; ALLELES; ARACHIDONATE 15-LIPOXYGENASE; BONE DENSITY; CHROMOSOMES, HUMAN, PAIR 17; FEMALE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTMENOPAUSE; PREMENOPAUSE;

MUS;

EID: 35148830836     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000106057     Document Type: Article

References (28)

1. Ng MYM, Sham PC, Paterson AD, Chan V, Kung AWC: Effect of environmental factors and gender on the heritability of bone mineral density and bone size. Ann Hum Genet 2006;70:428-438.
2. Livshits G, Deng H-W, Nguyen TV, Yakovenko K, Recker RR, Eisman JA: Genetics of bone mineral density: Evidence for a major pleiotropic effect from an intercontinental study. J Bone Miner Research 2004;19:914-923.
3. Flicker L, Hopper JL, Rodgers L, Kaymakci B, Green RM, Wark JD: Bone density determinants in elderly women: A twin study. J Bone Miner Res 1995;10:1607-1613.
4. Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S: Genetic determinants of bone mass in adults. A twin study. J Clin Invest 1987;80:706-710.
5. Smith DM, Nance WE, Kang KW, Christian JC, Johnston CC Jr: Genetic factors in determining bone mass. J Clin Invest 1973;52:2800-2808.
6. Eisman JA: Genetics of osteoporosis. Endocr Rev 1999;20:788-804.
7. Klein RF, Allard J, Avnur Z, Nikolcheva T, Rotstein D, Carlos AS, Shea M, Waters RV, Belknap JK, Peltz G, Orwoll ES: Regulation of bone mass in mice by the lipoxygenase gene alox15. Science 2004;303:229-232.
8. Serhan CN, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B, Colgan SP, Stahl GL, Merched A, Petasis NA, Chan L, Van Dyke TE: Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol 2003;171:6856-6865.
9. Ioannidis JP, Ng MY, Sham PC, Zintzaras E, Lewis CM, Deng HW, Econs MJ, Karasik D, Devoto M, Kammerer CM, Spector T, Andrew T, Cupples LA, Foroud T, Kiel DP, Koller D, Langdahl B, Mitchell BD, Peacock M, Recker R, Shen H, Sol-Church K, Spotila LD, Uitterlinden AG, Wilson SG, Kung AW, Ralston SH: Meta-analysis of genome wide scans provides evidence for gender and site specific regulation of bone mass. J Bone Miner Res 2007;22:173-183.
10. Urano T, Shiraki M, Fujita M, Hosoi T, Orimo H, Ouchi Y, Inoue S: Association of a single nucleotide polymorphism in the lipoxygenase alox15 5′ flanking region (-5229g/a) with bone mineral density. J Bone Miner Metab 2005;23:226.
11. Ichikawa S, Koller DL, Johnson ML, Lai D, Xuei X, Edenberg HJ, Klein RF, Orwoll ES, Hui SL, Foroud TM, Peacock M, Econs MJ: Human alox12, but not alox15, is associated with bmd in white men and women. J Bone Miner Res 2006;21:556-564.
12. Hanson RL, Looker HC, Ma L, Muller YL, Baier LJ, Knowler WC: Design and analysis of genetic association studies to finely map a locus identified by linkage analysis: Sample size and power calculations. Ann Hum Genet 2006;70:332-349.
13. Schork NJ, Nath SK, Fallin D, Chakravarti A: Linkage disequilibrium analysis of biallelic DNA markers, human quantitative trait loci, and threshold-defined case and control subjects. Am J Hum Genet 2000;67:1208-1218.
14. Kung AW, Luk KD, Chu LW, Tang GW: Quantitative ultrasound and symptomatic vertebral fracture risk in chinese women. Osteoporos Int 1999;10:456-461.
15. Kung AWC, Lai BMH, Ng MYM, Chan V, Sham PC: T-1213C polymorphism of estrogen receptor beta is associated with low bone mineral density and osteoporotic fractures. Bone 2006;39:1097-106.
16. Hirakawa M, Tanaka T, Hashimoto Y, Kuroda M, Takagi T, Nakamura Y: Jsnp: A database of common gene variations in the japanese population. Nucleic Acids Res 2002;30:158-162.
17. The international hapmap project. Nature 2003;426:789-796.
18. Barrett JC, Fry B, Maller J, Daly MJ: Haploview: Analysis and visualization of ld and haplotype maps. Bioinformatics 2005;21:263-265.
19. North BV, Curtis D, Sham PC: Application of logistic regression to case-control association studies involving two causative loci. Hum Hered 2005;59:79.
20. Fallin D, Schork NJ: Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data. Am J Hum Genet 2000;67:947-959.
21. Purcell S, Cherny SS, Sham PC: Genetic power calculator: Design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003;19:149-150.
22. Weitzmann MN, Pacifici R: Estrogen deficiency and bone loss: An inflammatory tale. J Clin Invest 2006;116:1186-1194.
23. Xiong M, Jin L: Comparison of the power and accuracy of biallelic and microsatellite markers in population-based gene-mapping methods. Am J Hum Genet 1999;64:629-640.
24. Chapman JM, Cooper JD, Todd JA, Clayton DG: Detecting disease associations due to linkage disequilibrium using haplotype tags: A class of tests and the determinants of statistical power. Hum Hered 2003;56:18-31.
25. Doecke JD, Day CJ, Stephens AS, Carter SL, van Daal A, Kotowicz MA, Nicholson GC, Morrison NA: Association of functionally different runx2 p2 promoter alleles with bmd. J Bone Miner Res 2006;21:265-273.
26. Zhu X, Fejerman L, Luke A, Adeyemo A, Cooper RS: Haplotypes produced from rare variants in the promoter and coding regions of angiotensinogen contribute to variation in angiotensinogen levels. Hum Mol Genet 2005;14:639-643.
27. Emilsson L, Saetre P, Jazin E: Low mRNA levels of rgs4 splice variants in Alzheimer's disease: Association between a rare haplotype and decreased mRNA expression. Synapse 2006;59:173-176.
28. Cheung CL, Huang QY, Ng MY, Chan V, Sham PC, Kung AW: Confirmation of linkage to chromosome 1q for spine bone mineral density in Southern Chinese. Hum Genet 2006;120:354-359.