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Fan J., and Posner M. Human attentional networks. Psychiatr Prax 31 Suppl 2 (2004) S210-S214
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Fan, J.1
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Task-modulated 'what' and 'where' pathways in human auditory cortex
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Human neuroimaging study of selective attention to auditory object identification and localization using dual approaches (fMRI and MEG). Subjects were asked to attend either to the phonetic content of sound pairs or to their location. The key finding was a double dissociation in response adaptation to sound pairs with phonetic versus spatial sound changes dependent upon attentive focus, and the demonstration of parallel 'what' and 'where' pathways for sound processing. Further, with the time resolution of MEG, it was possible to show that activation of these parallel pathways occurred as early as 70-150 ms from stimulus onset and that the 'where' pathway was activated ∼30 ms earlier than the 'what' pathway. These results suggest that auditory selective attention effects are feature specific and also that they may arise from enhanced tuning of receptive fields of task-relevant neuronal populations.
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Ahveninen J., Jaaskelainen I.P., Raij T., Bonmassar G., Devore S., Hamalainen M., Levanen S., Lin F.H., Sams M., Shinn-Cunningham B.G., et al. Task-modulated 'what' and 'where' pathways in human auditory cortex. Proc Natl Acad Sci USA 103 (2006) 14608-14613. Human neuroimaging study of selective attention to auditory object identification and localization using dual approaches (fMRI and MEG). Subjects were asked to attend either to the phonetic content of sound pairs or to their location. The key finding was a double dissociation in response adaptation to sound pairs with phonetic versus spatial sound changes dependent upon attentive focus, and the demonstration of parallel 'what' and 'where' pathways for sound processing. Further, with the time resolution of MEG, it was possible to show that activation of these parallel pathways occurred as early as 70-150 ms from stimulus onset and that the 'where' pathway was activated ∼30 ms earlier than the 'what' pathway...
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Ahveninen, J.1
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33745190251
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Neural substrates for dividing and focusing attention between simultaneous auditory and visual events
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In order to map the neural basis of bimodal divided attention-attending to one sense while ignoring another - an fMRI study was conducted in which subjects simultaneously heard novel melodies and viewed geometric shapes, and in different conditions, were instructed to attend to only one sense (bimodal selective attention) or to both senses at the same time (bimodal divided attention). Bimodal selective attention lead to increased activity in relevant sensory cortices and simultaneous decrease in irrelevant sensory cortex. Thus top-down attentional effects modulate the interaction of sensory cortical areas by enhancing processing in one modality at the expense of the other. Subjects with the best performance during the selective-attention task showed the greatest enhancement of activity in relevant sensory cortices. However, unlike the selective-attention conditions, divided attention recruited heteromodal areas in dorsolateral prefrontal cortex (DLPFC).
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Johnson J.A., and Zatorre R.J. Neural substrates for dividing and focusing attention between simultaneous auditory and visual events. Neuroimage 31 (2006) 1673-1681. In order to map the neural basis of bimodal divided attention-attending to one sense while ignoring another - an fMRI study was conducted in which subjects simultaneously heard novel melodies and viewed geometric shapes, and in different conditions, were instructed to attend to only one sense (bimodal selective attention) or to both senses at the same time (bimodal divided attention). Bimodal selective attention lead to increased activity in relevant sensory cortices and simultaneous decrease in irrelevant sensory cortex. Thus top-down attentional effects modulate the interaction of sensory cortical areas by enhancing processing in one modality at the expense of the other. Subjects with the best performance during the selective-attention task showed the greatest enhancement of activity in relevant sensory cortices. However, unlike the selective-attention conditions, divided attention recruited heteromodal areas in dorsolateral prefrontal cortex (DLPFC). These results suggest that selective attention was achieved by a different neural set of neural processes. Selective attention acted by modulation of sensory cortices, whereas bimodal attention recruited DLPFC.
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Neuroimage
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Johnson, J.A.1
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This study developed an innovative approach that made it possible to simultaneously measure spectral-temporal receptive fields (STRFs) with task performance, providing multiple snapshots of the dynamically changing STRF during ongoing behavior. Ferrets were trained on a generalized tone detection task, in which they learned to detect tones of any frequency, in the context of background noisy stimuli. Attending to a specific target frequency during the detection task consistently induced localized facilitative changes in STRF shape, which were swift in onset (<2 min) and could persist for hours, and provide a form of sensory memory. The authors propose that such modulatory changes could enhance overall cortical responsiveness to the target tone and increase the likelihood of 'capturing' the attended target during the task.
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Fritz J., Shamma S., Elhilali M., and Klein D. Rapid task-related plasticity of spectrotemporal receptive fields in primary auditory cortex. Nat Neurosci 6 (2003) 1216-1223. This study developed an innovative approach that made it possible to simultaneously measure spectral-temporal receptive fields (STRFs) with task performance, providing multiple snapshots of the dynamically changing STRF during ongoing behavior. Ferrets were trained on a generalized tone detection task, in which they learned to detect tones of any frequency, in the context of background noisy stimuli. Attending to a specific target frequency during the detection task consistently induced localized facilitative changes in STRF shape, which were swift in onset (<2 min) and could persist for hours, and provide a form of sensory memory. The authors propose that such modulatory changes could enhance overall cortical responsiveness to the target tone and increase the likelihood of 'capturing' the attended target during the task.
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Fritz, J.1
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In this behavioral physiology study, ferrets were initially trained on generalized frequency-independent tasks - a single-tone detection task, and a two-tone discrimination task. While recording from the same neurons, spectral-temporal receptive fields (STRFs) were measured in A1 under resting (non-task conditions) and also while ferrets successively performed frequency discrimination or tone detection tasks. Both tasks enhanced STRFs at the target frequency. In the discrimination task, however, STRF suppression was observed at the reference frequency. STRF changes were rapid and frequency-selective for both task conditions. In successive tasks, neurons responded differentially to identical tones, depending upon whether the tone was a reference or target. These task-dependent differences in receptive-field plasticity reflect differences in the meaning attributed to identical stimuli according to the context in which they were presented.
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Fritz J.B., Elhilali M., and Shamma S.A. Differential dynamic plasticity of A1 receptive fields during multiple spectral tasks. J Neurosci 25 (2005) 7623-7635. In this behavioral physiology study, ferrets were initially trained on generalized frequency-independent tasks - a single-tone detection task, and a two-tone discrimination task. While recording from the same neurons, spectral-temporal receptive fields (STRFs) were measured in A1 under resting (non-task conditions) and also while ferrets successively performed frequency discrimination or tone detection tasks. Both tasks enhanced STRFs at the target frequency. In the discrimination task, however, STRF suppression was observed at the reference frequency. STRF changes were rapid and frequency-selective for both task conditions. In successive tasks, neurons responded differentially to identical tones, depending upon whether the tone was a reference or target. These task-dependent differences in receptive-field plasticity reflect differences in the meaning attributed to identical stimuli according to the context in which they were presented.
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J Neurosci
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Fritz, J.B.1
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A neuroimaging approach was used to test the prediction that differential attentional focus on the same stimulus set would differentially activate auditory cortex. Subjects were presented with the same set of frequency-modulated tone sweeps, which the subjects were asked to categorize, either in pitch direction (rising or falling), or in duration (short or long). When the task involved attention to pitch direction, there was greater activation in right posterior auditory cortex than passive stimulus exposure. By contrast, there was greater left posterior auditory cortex activation when the task involved attention to sweep duration. These results provide strong evidence that top-down influences can differentially shape responses in the two hemispheres, leading to lateralized patterns of activation, dependent upon task constraints and attentional focus.
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Brechmann A., and Scheich H. Hemispheric shifts of sound representation in auditory cortex with conceptual listening. Cereb Cortex 15 (2005) 578-587. A neuroimaging approach was used to test the prediction that differential attentional focus on the same stimulus set would differentially activate auditory cortex. Subjects were presented with the same set of frequency-modulated tone sweeps, which the subjects were asked to categorize, either in pitch direction (rising or falling), or in duration (short or long). When the task involved attention to pitch direction, there was greater activation in right posterior auditory cortex than passive stimulus exposure. By contrast, there was greater left posterior auditory cortex activation when the task involved attention to sweep duration. These results provide strong evidence that top-down influences can differentially shape responses in the two hemispheres, leading to lateralized patterns of activation, dependent upon task constraints and attentional focus.
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