Quaternized chitosan/alginate nanoparticles for protein delivery

Journal of Biomedical Materials Research - Part A

Volumn 83, Issue 2, 2007, Pages 383-390

  Li, Tao ^a   Shi, Xiao Wen ^b   Du, Yu Min ^b   Tang, Yu Feng ^b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

Bovine serum albumin; Degree of substitution; Nanoparticles; Quaternized chitosan; Weight average molecular weight

Indexed keywords

INFRARED SPECTROSCOPY; MOLECULAR WEIGHT; NANOPARTICLES; PROTEINS;

BOVINE SERUM ALBUMIN; DEGREE OF SUBSTITUTION; QUATERNIZED CHITOSAN; WEIGHT-AVERAGE MOLECULAR WEIGHT;

DRUG DELIVERY;

ALGINIC ACID; BOVINE SERUM ALBUMIN; BUFFER; CHITOSAN; NANOPARTICLE; PHOSPHATE;

ARTICLE; DRUG DELIVERY SYSTEM; ENCAPSULATION; INFRARED SPECTROSCOPY; MOLECULAR WEIGHT; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; SURFACE CHARGE; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

ALGINATES; ANIMALS; CATTLE; CHITOSAN; DRUG DELIVERY SYSTEMS; GLUCURONIC ACID; HEXURONIC ACIDS; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR WEIGHT; NANOPARTICLES; PARTICLE SIZE; SERUM ALBUMIN, BOVINE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 35048879814     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31322     Document Type: Article

References (27)

1. Takakura Y, Kaneko Y, Fujita T, Hashita M, Maeda H, Sezaki H. Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. I. Synthesis and characterization. J Pharm Sci 1989;78:117-121.
2. Castro GR, Kamdar RR, Panilaitis B, Kaplan DL. Triggered release of proteins from emulsan-alginate beads. J Control Release 2005;109:149-157.
3. Ponchel G, Irache JM. Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract. Adv Drug Deliv Rev 1998;34:191-219.
4. Russell Jones GJ. Oral vaccine delivery. J Control Release 2000;65:49-54.
5. Sood A, Panchagnula R. Peroral route: An opportunity for protein and peptide drug delivery. Chem Rev 2001;101:3275-3303.
6. Bodmeier R, Chen HG, Paeratakul O. A novel approach to the oral delivery of micro- or nanoparticles. Pharm Res 1989;6:413-417.
7. Aboubakar M, Couvreur P, Pinto-Alphandary H, Gouritin B, Lacour B, Farinotti R, Puisieux F, Vauthier C. Insulin-loaded nanocapsules for oral administration: In vitro and in vivo investigation. Drug Dev Res 2000,49:109-117.
8. Jani PU, McCarthy DE, Florence AT. Nanosphere and microsphere uptake via Peyer's patches: Observation of the rate of uptake in the rat after a single oral dose. Int J Pharm 1992;86:239-246.
9. Ermak TH, Giannasca PJ. Microparticle targeting to M cells. Adv Drug Deliv Rev 1998;34:261-283.
10. Zambaux MF, Bonneaux F, Gref R, Dellacherie E, Vigneron C. Preparation and characterization of protein C-loaded PLA nanoparticles. J Control Release 1999;60:179-188.
11. Fonseca C, Simoes S, Gaspar R. Paclitaxel-loaded PLGA nanoparticles: Preparation, physicochemical characterization and in vitro anti-tumoral activity. J Control Release 2002;83:273-286.
12. Liu Y, Guo LK, Huang L, Deng XM. Preparation and properties of a biodegradable polymer as a novel drug delivery system. J Appl Polym Sci 2003;90:3150-3156.
13. Gombotz WR, Wee SF. Protein release from alginate matrices. Adv Drug Deliv Rev 1998;31:267-285.
14. Rajaonarivony M, Vauthier C, Couarraze G. Development of a new drug carrier made from alginate. J Pharm Sci 1993;82:912-917.
15. Bowersock TL, HogenEsch H, Suckow M, Porter RE, Jackson R, Park K. Oral vaccination with alginate microsphere systems. J Control Release 1996;39:209-220.
16. De S, Robinson D. Polymer relationships during preparation of chitosan-alginate and poly-L-lysine-alginate nanospheres. J Control Release 2003;89:101-112.'
17. Illum L. Chitosan and its use as a pharmaceutical excipient. Pharm Res 1998;15:1326-1331.
18. Thanou M, Verhoef JC, Junginger HE. Oral drug absorption enhancement by chitosan and its derivatives. Adv Drug Deliv Rev 2001;52:117-126.
19. van der Merwe SM, Verhoef JC, Verheijden JH, Kotze AF, Junginger HE. Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs. Eur J Pharm Biopharm 2004;58:225-235.
20. Kotze AF, Thanou MM, Luebetaen HL, de Boer AG, Verhoef IC, Junginger HE. Enhancement of paracellular drug transport with highly quaternized N-trimethyl chitosan chloride in neutral environments: In vitro evaluation in intestinal epithelial cells (Caco-2). J Pharm Sci 1999;88:253-257.
21. Li HB, Du YM, Wu XJ, Zhan HY. Effect of molecular weight and degree of substitution of quaternary chitosan on its adsorption and flocculation properties for potential retention-aids in alkaline papermaking. Colloid Surf A: Physicochem Eng Asp 2004;242:1-8.
22. Domard A, Rinaudo M, Terrassin C. New method for the quaternization of chitosan. Int J Biol Macromol 1986;8:105-107.
23. John MW. The Protein Protocols Handbook. Totowa, NJ: Humana; 2002. p 15.
24. Xu YM, Du YM, Huang RH, Gao LP. Preparation and modification of N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride nanoparticle as a protein carrier. Biomaterials 2003;24:5015-5022.
25. Sartori C, Finch DS, Ralph B. Determination of the cation content of alginate thin films by FTIR spectroscopy. Polymer 1997;38:43-51.
26. Xu YM, Du YM. Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. Int J Pharm 2003;250:215-226.
27. Quong D, Neufeld RJ. DNA protection from extracapsular nucleases, within chitosan- or poly-L-lysine-coated alginate beads. Biotechnol Bioeng 1998;60:124-134.