Potent oxindole based human β3 adrenergic receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 22, 2007, Pages 6270-6273

  Stevens, F Craig ^a   Bloomquist, William E ^a   Borel, Anthony G ^a   Cohen, Marlene L ^a   Droste, Christine A ^a   Heiman, Mark L ^a   Kriauciunas, Aidas ^a   Sall, Daniel J ^a   Tinsley, Frank C ^a   Jesudason, Cynthia D ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

3 adrenergic receptors; 3 agonists; Tacyhcardia

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; OXINDOLE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; NONHUMAN; QUANTUM YIELD; RAT; REACTION ANALYSIS; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; SUPRAVENTRICULAR TACHYCARDIA;

ADRENERGIC BETA-AGONISTS; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HUMANS; INDOLES; MOLECULAR STRUCTURE; RATS; RATS, LONG-EVANS; RECEPTORS, ADRENERGIC, BETA-3; TACHYCARDIA;

RATTUS;

EID: 35048833716     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.09.011     Document Type: Article

References (37)

1. Germack R., Starzec A.B., Vassy R., and Perret G.Y. Br. J. Pharmacol. 120 (1997) 201
2. Llado I., Estrany M.E., Rodriguez E., Amengual B., Roca P., and Palou A. Int. J. Obes. 24 (2000) 1396
3. Lowell B.B., and Flier J.S. Annu. Rev. Med. 48 (1997) 307
4. Himms-Hagen J. In: Strasborg A.D. (Ed). The Beta 3-Adrenoreceptor 125-166 (2000), Taylor & Francis Ltd, London 97-119
5. Collins S., and Surwit R.S. Recent Prog. Horm. Res. 56 (2001) 309
6. Sell H., Deshaies Y., and Richard D. Int. J. Biochem. Cell Biol. 36 (2004) 2098
7. Hatakeyama Y., Sakata Y., Takakura S., Manda T., and Mutoh S. Am. J. Physiol. 287 (2004) R336
8. Kiso T., Namikawa T., Tokunaga T., Sawada K., Kakita T., Shogaki T., and Ohtsubo Y. Biol. Pharm. Bull. 22 (1999) 1073
9. Atgie C., Faintrenie G., Carpene C., Bukowiecki L.J., and Geloen A. Comp. Biochem. Physiol. A: Physiol. A (1998) 629
10. Van Baak M.A., Hul G.B.J., Toubro S., Astrup A., Gottesdiener K.M., DeSmet M., and Saris W.H.M. Clin. Pharmacol. Ther. 71 (2002) 272
11. Larsen T.M., Toubro S., van Baak M.A., Gottesdiener K.M., Larson P., Saris W.H.M., and Astrup A. Am. J. Clin. Nutr. 76 (2002) 780
12. McLaughlin D.P., and MacDonald A. Br. J. Pharmacol. 101 (1990) 569
13. Kreif S., Lonnqvist F., Raimbault S., Baude B., Van Spronsen A., Arner P., Strosberg A.D., Ricquier D., and Emorine L.J. J. Clin. Invest. 91 (1993) 344
14. Takeda M., Obara K., Mizusawa T., Tomita Y., Arai K., Tsutsui K., Hatano A., Takahashi K., and Nomura S. J. Pharmacol. Exp. Ther. 288 (1999) 1367
15. Fletcher D.S., Candelore M.R., Grujic D., Lowell B.B., Luell S., Susulic V.S., and Macintyre D.E. J. Pharmacol. Exp. Ther. 287 (1998) 720
16. Summers R.J., Roberts S.J., Hutchinson D.S., and Evans B.A. Proc. West. Pharmacol. Soc. 42 (1999) 115
17. Fujimura T., Tamura K., Tsutsumi T., Yamamoto T., Nakamura K., Koibuchi Y., Kobayashi M., and Yamaguchi O. J. Urol. 161 (1999) 680
18. Smith C.P., and Chancellor M.B. Expert Opin. Ther. Patient 11 (2001) 17
19. Kaumann A.J., and Molenaar P. Br. J. Pharmacol. 118 (1996) 2085
20. Malinowska B., and Schlicker E. Br. J. Pharmacol. 117 (1996) 943
21. Cohen M.L., Bloomquist W., Shuker A., Kriauciunas A., and Calligaro D. Br. J. Pharmacol. 126 (1999) 1018
22. Cohen M.L., Bloomquist W., Ito M., and Lowell B.B. Ion Channels 7 (2000) 17
23. Brahmadevara N., Shaw A.M., and MacDonald A.. Br. J. Pharmacol. 138 (2003) 99
24. Sarsero D., Molenaar P., and Kaumann A.J. Br. J. Pharmacol. 123 (1998) 371
25. Kaumann A.J., Preitner F., Sarsero D., Molenaar P., Revelli J.-P., and Giacobino J.P. Mol. Pharmacol. 53 (1998) 670
26. Kaumann A.J., Engelhardt S., Hein L., Molenaar P., and Lohse M. Naunyn-Schmiedeberg's Arch. Pharmacol. 363 (2001) 87
27. Rohrer D.K., Chruscinski A., Schauble E.H., Bernstein D., and Kobilka B.K. J. Biol. Chem. 274 (1999) 16701
28. Konkar A.A., Shu Z.X., and Granneman J.G. J. Pharmacol. Exp. Ther. 294 (2000) 923
29. Finley D.R., Bell M.G., Borel A.G., Bloomquist W.E., Cohen M.L., Heiman M.L., Kriauciunas A., Matthews D.P., Miles T., Neel D.A., Rito C.J., Sall D.J., Shuker A.J., Stephens T.W., Tinlsey F.C., Winter M.A., and Jesudason C.D. Bioorg. Med. Chem. Lett. 16 (2006) 5691
30. Modi S.P., Oglesby C., and Archer S. Org. Synth. 72 (1998) 125
31. Beckett A.H., Daisley R.W., and Walker J. Tetrahedron 24 (1968) 6093
32. Kende A.S., and Hodges J.C. Synth. Commun. 12 (1982) 1
33. Jesudason C. D.; Sall, D. J.; Stevens, F. C.; Werner, J. A. U.S. Patent 7, 122, 680, 2006.
34. Karp G.M. J. Org. Chem. 57 (1992) 4765
35. Karp G.M., and Condon M.L. J. Het. Chem. 31 (1994) 1513
36. Rat atrial tachycardia was measured as described in Ref. 9c.
37. Chen Y., and Heiman M.L. Regul. Pept. 92 (2000) 113