Mediation of the positive chronotropic effect of CGP 12177 and cyanopindolol in the pithed rat by atypical β-adrenoceptors, different from β3-adrenoceptors

British Journal of Pharmacology

Volumn 117, Issue 5, 1996, Pages 943-949

  Malinowska, Barbara ^a   Schlicker, Eberhard ^b  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Atypical adrenaceptors; BRL 37344; Bupranolol; CGP 12177; CGP 20712; Cyanopindolol; Pithed rat; Positive chronotropic effect; ZD 2079; 3 adrenoceptors

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 [2 [(2 HYDROXY 2 PHENYLETHYL)AMINO]ETHOXY]PHENYLACETIC ACID; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; BETA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BUPRANOLOL; CYANOPINDOLOL; FENOTEROL; ISOPRENALINE; PRENALTEROL;

ANIMAL EXPERIMENT; ARTICLE; CHRONOTROPISM; DIASTOLIC BLOOD PRESSURE; DRUG ANTAGONISM; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL ANIMAL;

EID: 0029873068     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15285.x     Document Type: Article

References (13)

1. 3 and atypical β-adrenoceptors. Med. Res. Rev., 13, 663-729.
2. BERLAN, M., GALITZKY, J., BOUSQUET-MELOU, A., LAFONTAN, M. & MONTASTRUC, J.L. (1994). Beta-3 adrenoceptor-mediated increase in cutaneous blood flow in the dog. J. Pharmacol. Exp. Ther., 268, 1444-1451.
3. 3-adrenergic receptor. Mol. Pharmacol., 44, 1094-1104.
4. 3-adrenergic receptor. Science, 245, 1118-1121.
5. 3-adrenergic receptor. Mol. Pharmacol., 40, 895-899.
6. KAUMANN, A.J. (1989). Is there a third heart β-adrenoceptor? Trends Pharmacol. Sci., 10, 316-320.
7. KAUMANN, A.J. (1995). (-)-CGP 12177 increases human atrial contraction through a putative third β-adrenoceptor. Br. J. Pharmacol., (in press).
8. 3-adrenoceptors, mediate the positive chronotropic effect of CGP 12177 and cyanopindolol in the pithed rat. Pol. J. Pharmacol., 47, (Suppl.) 38-39.
9. 3 receptors in the pithed rat. Naunyn-Schmied. Arch. Pharmacol., 347, 55-60.
10. ORIOWO, M.A., SENNITT, M.V., SMITH, S.A., RUFFOLO, R.R. & CAWTHORNE, M.A. (1994). The β-adrenoceptor selectivity profile of BRL 37344 in the pithed rat. J. Auton. Pharmacol., 14, 337-344.
11. SHEN, Y.T., ZHANG, H. & VATNER, S.F. (1994). Peripheral vascular effects of beta-3 adrenergic receptor stimulation in conscious dogs. J. Pharmacol. Exp. Ther., 268, 466-473.
12. TAVERNIER, G., GALITZKY, J., BOUSQUET-MELOU, A., MONTASTRUC, J.L. & BERLAN, M. (1992). The positive chronotropic effect induced by BRL 37344 and CGP 12177, two beta-3 adrenergic agonists, does not involve cardiac beta adrenoceptors but baroreflex mechanisms. J. Pharmacol. Exp. Ther., 263, 1083-1090.
13. WALTER, M., LEMOINE, H. & KAUMANN, A.J. (1984). Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of β-adrenoceptor subtypes in the dissociation between blockade and stimulation. Naunyn-Schmied. Arch. Pharmacol., 327, 159-175.