Genitourinary tract patent update

Expert Opinion on Therapeutic Patents

Volumn 11, Issue 1, 2001, Pages 17-31

  Smith, C P ^a   Chancellor, M B ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Gene therapy; Stem cells; Stress urinary incontinence; Tissue engineering; Urge urinary incontinence; Urinary incontinence

Indexed keywords

ACETYLCHOLINE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ANILINE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; BENZYLAMINE DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; CARBACHOL; COLLAGEN; CYCLOALKANE DERIVATIVE; DRUG METABOLITE; IMIDAZOLE DERIVATIVE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M1 RECEPTOR ANTAGONIST; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NEUROTRANSMITTER; OXYBUTYNIN; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; PYRROLIDINE DERIVATIVE; QUINUCLIDINE; RADIOLIGAND; TACHYKININ RECEPTOR ANTAGONIST; THIADIAZOLE DERIVATIVE; TOLTERODINE; UNINDEXED DRUG;

ACCOMMODATION PARALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICHOLINERGIC EFFECT; BIOMEDICAL ENGINEERING; BLADDER MUSCLE; CARTILAGE CELL; CELL CULTURE; COMMERCIAL PHENOMENA; CONSTIPATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG METABOLISM; DRUG RESEARCH; DRUG SELECTIVITY; ELECTROSTIMULATION; FEMALE; GUINEA PIG; HEALTH CARE COST; HUMAN; MAGNETIC STIMULATION; MALE; MICTURITION DISORDER; NONHUMAN; PATENT; RABBIT; RAT; REVIEW; SIDE EFFECT; SMOOTH MUSCLE FIBER; STEM CELL; STRESS INCONTINENCE; TACHYCARDIA; URGE INCONTINENCE; URINE INCONTINENCE; UROGENITAL SYSTEM; VISUAL IMPAIRMENT; XEROSTOMIA;

EID: 0035192011     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.11.1.17     Document Type: Review

References (74)

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2. Current concepts in the treatment of disorders of micturition
3. Selective muscarinic receptor agonists and antagonists
4. Muscarinic receptor subtypes modulating smooth muscle contractility in the urinary bladder
5. Function, signal transduction mechanisms and plasticity of presynaptic muscarinic receptors in the urinary bladder
6. Tolterodine, a new antimuscarinic agent: As effective but better tolerated than oxybutynin in patients with an overactive bladder
7. Comparison of urge incontinence treatments
8. Intravesical oxybutynin hydrochloride: Experience with 42 patients
9. The sympathetic innervation of the urinary bladder and urethra in the normal state and after parasympathetic denervation at the spinal root level
10. Type of neurogenic bladder in children with spina bifida and response to treatment with phenoxybenzamine
11. Adrenergic response of bladder muscle in prostatic obstruction
12. The effect of terazosin on bladder function in the spinal cord injured
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17. Identification of receptor subtypes in the rabbit and human urinary bladder by selective radioligand binding
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19. Alpha and Beta-adrenoceptors in the detrusor muscle and bladder base of the pig and β-adrenoceptors in the detrusor of man
20. Functional and molecular biological evidence of β3-adrenoceptors in the human detrusor
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30. Characterization of tachykinin NK-2 receptors in human urinary bladder
31. Pharmacological characterization of tachykinin NK-2 receptors on isolated human urinary bladder, prostatic urethra and prostate
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33. Nitric oxide synthase in pig lower urinary tract: Immunohistochemistry, NADPH diaphorase histochemistry and functional effects
34. Electrically induced nerve mediated relaxation of rabbit urethra involves nitric oxide
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39. Brain stem influences on the parasympathetic supply to the urinary bladder of the cat
40. Effects of serotonergic agonists on micturition and sexual function in the rat
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42. Pharmacological modulation of the pontine micturition center
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46. Endothelin-1-induced contractions of isolated pig detrusor and vesical arterial smooth muscle: Calcium dependence and phosphoinositide hydrolysis
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48. Endoscopic treatment of vesicoureteral reflux with chondrocyte-alginate suspension
49. Construction of artificial organs and tissue using autologous cells
50. Treatment of reflux and incontinence with autologous chondrocytes and bladder muscle cells
51. The standardization of terminology of lower urinary tract dysfunction
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53. Frequency dependence of muscarinic facilitation of transmitter release in urinary bladder strips from neurally intact or chronic spinal cord transected rats
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55. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo
56. Effects of selective β2 and β3-adrenoceptor agonists on prostaglandin-E2 induced bladder hyperactivity and cardiovascular system in conscious rats
57. Zeneca ZD6169: A novel Katp channel opener with in vivo selectivity for urinary bladder
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60. Effects of ZD6169, a K+(ATP) channel opener, on the micturition reflex in the rat
61. + channel openers, KRN2391 and Ki1769 and nitroglycerin on the urinary tract of rats in vivo
62. Neurophysiology of micturition and its modification in animal models of human disease
63. MEN 11,420, a peptide tachykinin NK-2 receptor antagonist, reduces motor responses induced by the intravesical administration of capsaicin in vivo
64. Role of intrathecal tachykinins for micturition in unanaesthetized rats with and without bladder outlet obstruction
65. Effects of neurokinin receptor antagonists on l-dopa induced bladder hyperactivity in normal conscious rats
66. Involvement of spinal tachykinin NK-1 and NK-2 receptors in detrusor hyperreflexia during chemical cystitis in anaesthetized rats
67. Evaluation of flurbiprofen in detrusor instability
68. A comparison between bromocriptine and indomethacin in the treatment of detrusor instability
69. 2 receptor antagonist in overactive bladder in the chronic spinal rats
70. Atropine-resistant excitation of the urinary bladder: Possibility of transmission via nerves releasing a purine nucleotide
71. Receptors for purines and pyrimidines
72. Development of approaches to improve cell survival in myoblast transfer therapy