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Volumn 16, Issue 3, 2007, Pages 251-256

MTHFR polymorphisms as prognostic factors in sporadic colorectal cancer

Author keywords

Colorectal cancer; MTHFR polymorphism; Prognosis

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

EID: 34948905809     PISSN: 18418724     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (24)

References (40)
  • 1
    • 0027326933 scopus 로고
    • DNA methylation in folate deficiency: Use of CpG methylase
    • Balaghi M, Wagner C. DNA methylation in folate deficiency: use of CpG methylase. Biochem Biophys Res Commun 1993; 193: 1184-1190.
    • (1993) Biochem Biophys Res Commun , vol.193 , pp. 1184-1190
    • Balaghi, M.1    Wagner, C.2
  • 2
    • 0031816123 scopus 로고    scopus 로고
    • Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women
    • Jacob RA, Gretz DM, Taylor PC et al. Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr 1998; 128: 1204-1212.
    • (1998) J Nutr , vol.128 , pp. 1204-1212
    • Jacob, R.A.1    Gretz, D.M.2    Taylor, P.C.3
  • 3
    • 0028229675 scopus 로고
    • Analysis of uracil in DNA by gas chromatography - mass spectrometry
    • Blount BC, Ames BN. Analysis of uracil in DNA by gas chromatography - mass spectrometry. Anal Biochem 1994; 219: 195-200.
    • (1994) Anal Biochem , vol.219 , pp. 195-200
    • Blount, B.C.1    Ames, B.N.2
  • 4
    • 0030979178 scopus 로고    scopus 로고
    • Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
    • Blount BC, Mack MM, Wehr CM et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A 1997; 94: 3290-3295.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3290-3295
    • Blount, B.C.1    Mack, M.M.2    Wehr, C.M.3
  • 5
    • 0036328028 scopus 로고    scopus 로고
    • Choi SW, Mason JB. Folate status: effects on pathways of colorectal carcinogenesis. J Nutr 2002; 132(8S): 2413S-2418S.
    • Choi SW, Mason JB. Folate status: effects on pathways of colorectal carcinogenesis. J Nutr 2002; 132(8S): 2413S-2418S.
  • 6
    • 0033007272 scopus 로고    scopus 로고
    • Folate and carcinogenesis: Evidence, mechanisms, and implications
    • Kim YI. Folate and carcinogenesis: evidence, mechanisms, and implications. J Nutr Biochem 1999; 10: 66-88.
    • (1999) J Nutr Biochem , vol.10 , pp. 66-88
    • Kim, Y.I.1
  • 7
    • 17144460958 scopus 로고
    • Hypomethylation of DNA: A nongenotoxic mechanism involved in tumor promotion
    • Counts JL, Goodman JI. Hypomethylation of DNA: a nongenotoxic mechanism involved in tumor promotion. Toxicol Lett 1995; 82-83: 663-672.
    • (1995) Toxicol Lett
    • Counts, J.L.1    Goodman, J.I.2
  • 8
    • 0031149098 scopus 로고    scopus 로고
    • Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat
    • Pogribny IP, Miller BJ, James SJ. Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat. Cancer Lett 1997; 115: 31-38.
    • (1997) Cancer Lett , vol.115 , pp. 31-38
    • Pogribny, I.P.1    Miller, B.J.2    James, S.J.3
  • 9
    • 0033587747 scopus 로고    scopus 로고
    • CpG island methylator phenotype in colorectal cancer
    • Toyota M, Ahuja N, Ohe-Toyota M et al. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 1999; 96: 8681-8686.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8681-8686
    • Toyota, M.1    Ahuja, N.2    Ohe-Toyota, M.3
  • 10
    • 0035117307 scopus 로고    scopus 로고
    • Methylation of 0-6-methylguanine DNA methyltransferase characterises a subset of colorectal cancer with low level DNA microsatellite instability
    • Whitehall V, Walsh MD, Young J et al. Methylation of 0-6-methylguanine DNA methyltransferase characterises a subset of colorectal cancer with low level DNA microsatellite instability. Cancer Res 2001; 61: 827-830.
    • (2001) Cancer Res , vol.61 , pp. 827-830
    • Whitehall, V.1    Walsh, M.D.2    Young, J.3
  • 11
    • 19244370208 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene 0-6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis
    • Esteller M, Toyota M, Sanchez-Cespedes M et al. Inactivation of the DNA repair gene 0-6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res 2000; 60: 2368-2371.
    • (2000) Cancer Res , vol.60 , pp. 2368-2371
    • Esteller, M.1    Toyota, M.2    Sanchez-Cespedes, M.3
  • 12
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/ p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman JG, Merlo A, Mao L et al. Inactivation of the CDKN2/ p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 1995; 55: 4525-4530.
    • (1995) Cancer Res , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3
  • 13
    • 0031577160 scopus 로고    scopus 로고
    • CpG methylation inactivates the transcriptional activity of the promoter of the human p53 tumor suppressor gene
    • Schroeder M, Mass MJ. CpG methylation inactivates the transcriptional activity of the promoter of the human p53 tumor suppressor gene. Biochem Biophys Res Commun 1997; 235: 403-406.
    • (1997) Biochem Biophys Res Commun , vol.235 , pp. 403-406
    • Schroeder, M.1    Mass, M.J.2
  • 14
    • 0030887086 scopus 로고    scopus 로고
    • Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma
    • Hiltunen MO, Alhonen L, Koistinaho J et al. Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma. Int J Cancer 1997; 70: 644-648.
    • (1997) Int J Cancer , vol.70 , pp. 644-648
    • Hiltunen, M.O.1    Alhonen, L.2    Koistinaho, J.3
  • 15
    • 20144371859 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides
    • Quinlivan EP, Davis SR, Shelnutt KP et al. Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides. J Nutr 2005; 135: 389-396.
    • (2005) J Nutr , vol.135 , pp. 389-396
    • Quinlivan, E.P.1    Davis, S.R.2    Shelnutt, K.P.3
  • 16
    • 22844440731 scopus 로고    scopus 로고
    • Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms. A pilot study
    • Kapiszewska M, Kalemba M, Wojciech U, Milewicz T. Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms. A pilot study. J Nutr Biochem 2005; 16: 467-478.
    • (2005) J Nutr Biochem , vol.16 , pp. 467-478
    • Kapiszewska, M.1    Kalemba, M.2    Wojciech, U.3    Milewicz, T.4
  • 17
    • 0031687887 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg I, Tran P, Christensen B, Sibani S, Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 1998; 64: 169-172.
    • (1998) Mol Genet Metab , vol.64 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3    Sibani, S.4    Rozen, R.5
  • 18
    • 33747881743 scopus 로고    scopus 로고
    • Localized depletion: The key to colorectal cancer risk mediated by MTHFR genotype and folate?
    • Brockton NT. Localized depletion: the key to colorectal cancer risk mediated by MTHFR genotype and folate? Cancer Causes Control 2006; 17: 1005-1016.
    • (2006) Cancer Causes Control , vol.17 , pp. 1005-1016
    • Brockton, N.T.1
  • 19
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, Goyette P et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3    Goyette, P.4
  • 20
    • 0031971515 scopus 로고    scopus 로고
    • A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects?
    • van der Put NM, Gabreels F, Stevens EM et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 1998; 62: 1044-1051.
    • (1998) Am J Hum Genet , vol.62 , pp. 1044-1051
    • van der Put, N.M.1    Gabreels, F.2    Stevens, E.M.3
  • 21
    • 0034064209 scopus 로고    scopus 로고
    • Lack of association between the C677T MTHFR polymorphism and colorectal hyperplastic polyps
    • Ulrich CM, Kampman E, Bigler J et al. Lack of association between the C677T MTHFR polymorphism and colorectal hyperplastic polyps. Cancer Epidemiol Biomarkers Prev 2000; 9: 427-433.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 427-433
    • Ulrich, C.M.1    Kampman, E.2    Bigler, J.3
  • 22
    • 0029855024 scopus 로고    scopus 로고
    • A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer
    • Chen J, Giovannucci E, Kelsey K et al. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res 1996; 56: 4862-4864.
    • (1996) Cancer Res , vol.56 , pp. 4862-4864
    • Chen, J.1    Giovannucci, E.2    Kelsey, K.3
  • 23
    • 0031611631 scopus 로고    scopus 로고
    • Whole-blood folate values in subjects with different methylenetetrahydrofolate reductase genotypes: Differences between the radioassay and microbiological assays
    • Molloy AM, Mills JL, Kirke PN et al. Whole-blood folate values in subjects with different methylenetetrahydrofolate reductase genotypes: differences between the radioassay and microbiological assays. Clin Chem 1998; 44: 186-188.
    • (1998) Clin Chem , vol.44 , pp. 186-188
    • Molloy, A.M.1    Mills, J.L.2    Kirke, P.N.3
  • 24
    • 27144526086 scopus 로고    scopus 로고
    • Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma
    • Kono S, Chen K. Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma. Cancer Sci 2005; 96: 535-542.
    • (2005) Cancer Sci , vol.96 , pp. 535-542
    • Kono, S.1    Chen, K.2
  • 25
    • 0030615085 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer
    • Ma J, Stampfer Mj, Hennekens CH et al. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 1997; 57: 1098-1102.
    • (1997) Cancer Res , vol.57 , pp. 1098-1102
    • Ma, J.1    Stampfer, M.2    Hennekens, C.H.3
  • 26
    • 0032434823 scopus 로고    scopus 로고
    • A prospective study of methylenetetra-hydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
    • Chen J, Giovannucci E, Hankinson SE, et al. A prospective study of methylenetetra-hydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma. Carcinogenesis 1998; 19: 2129-2132.
    • (1998) Carcinogenesis , vol.19 , pp. 2129-2132
    • Chen, J.1    Giovannucci, E.2    Hankinson, S.E.3
  • 27
    • 0032799527 scopus 로고    scopus 로고
    • The 677C > T mutation in 5,10- methylenetetrahydrofolate reductase and colorectal cancer risk
    • Park KS, Mok JW, Kim JC. The 677C > T mutation in 5,10- methylenetetrahydrofolate reductase and colorectal cancer risk. Genet Test 1999; 3: 233-236.
    • (1999) Genet Test , vol.3 , pp. 233-236
    • Park, K.S.1    Mok, J.W.2    Kim, J.C.3
  • 29
    • 0033370552 scopus 로고    scopus 로고
    • Colorectal adenomas and the C677T MTHFR polymorphism: Evidence for gene-environment interaction?
    • Ulrich CM, Kampman E, Bigler J et al. Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction? Cancer Epidemiol Biomarkers Prev 1999; 8: 659-668.
    • (1999) Cancer Epidemiol Biomarkers Prev , vol.8 , pp. 659-668
    • Ulrich, C.M.1    Kampman, E.2    Bigler, J.3
  • 30
    • 0033942127 scopus 로고    scopus 로고
    • The methylenetetrahydrofolate reductase 677C->T polymorphism and distal colorectal adenoma risk
    • Levine AJ, Siegmund KD, Ervin CM, et al. The methylenetetrahydrofolate reductase 677C->T polymorphism and distal colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev 2000; 9: 657-663.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 657-663
    • Levine, A.J.1    Siegmund, K.D.2    Ervin, C.M.3
  • 31
    • 0034647021 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas
    • Marugame T, Tsuji E, Inoue H et al. Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas. Cancer Lett 2000; 151: 181-186.
    • (2000) Cancer Lett , vol.151 , pp. 181-186
    • Marugame, T.1    Tsuji, E.2    Inoue, H.3
  • 32
    • 0036230697 scopus 로고    scopus 로고
    • B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)
    • Le Marchand L, Donion T, Hankin JH et al. B-vitamin intake, metabolic genes, and colorectal cancer risk (United States). Cancer Causes Control 2002; 13: 239-248.
    • (2002) Cancer Causes Control , vol.13 , pp. 239-248
    • Le Marchand, L.1    Donion, T.2    Hankin, J.H.3
  • 33
    • 0036016321 scopus 로고    scopus 로고
    • Linkage disequilibrium between the 677C7gt;T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer
    • Chen J, Ma J, Stampfer MJ et al. Linkage disequilibrium between the 677C7gt;T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer. Pharmacogenetics 2002; 12: 339-342.
    • (2002) Pharmacogenetics , vol.12 , pp. 339-342
    • Chen, J.1    Ma, J.2    Stampfer, M.J.3
  • 34
    • 34948861286 scopus 로고    scopus 로고
    • Sharp L, Little J, Brockton et al. Dietary intake of folate and related micronutrients, genetic polymorphisms in MTHFR and colorectal cancer: a population-based case-control study in Scotland J Nutr 2002; 132(11S): 3542S.
    • Sharp L, Little J, Brockton et al. Dietary intake of folate and related micronutrients, genetic polymorphisms in MTHFR and colorectal cancer: a population-based case-control study in Scotland J Nutr 2002; 132(11S): 3542S.
  • 35
    • 0036907435 scopus 로고    scopus 로고
    • 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites
    • Keku T, Millikan R, Worley K et al. 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites. Cancer Epidemiol Biomarkers Prev 2002; 11: 1611-1621.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 1611-1621
    • Keku, T.1    Millikan, R.2    Worley, K.3
  • 37
    • 7744244730 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea
    • Kim DH, Ahn YO, Lee BH et al. Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea. Cancer Lett 2004; 216: 199-205.
    • (2004) Cancer Lett , vol.216 , pp. 199-205
    • Kim, D.H.1    Ahn, Y.O.2    Lee, B.H.3
  • 38
    • 0346103808 scopus 로고    scopus 로고
    • The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase
    • Kawakami K, Ruszkiewicz A, Bennett G et al. The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase. Clin Cancer Res 2003; 9: 5860-5865.
    • (2003) Clin Cancer Res , vol.9 , pp. 5860-5865
    • Kawakami, K.1    Ruszkiewicz, A.2    Bennett, G.3
  • 39
    • 0037990003 scopus 로고    scopus 로고
    • Cohen V, Panel-Raymond V, Sabbaghian N et al. Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy. Clin Cancer Res 2003; 9: 1611-1615.
    • Cohen V, Panel-Raymond V, Sabbaghian N et al. Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy. Clin Cancer Res 2003; 9: 1611-1615.
  • 40
    • 19944428095 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients
    • Etienne MC, Formento JL, Chazal M et al. Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients. Pharmacogenetics 2004; 14: 785-792.
    • (2004) Pharmacogenetics , vol.14 , pp. 785-792
    • Etienne, M.C.1    Formento, J.L.2    Chazal, M.3


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