Peritubular endothelium: The Achilles heel of the kidney?

Kidney International

Volumn 72, Issue 8, 2007, Pages 926-930

  Rabelink, T J ^a   Wijewickrama, D C ^a   De Koning, E J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

End stage renal disease; Endothelium; Tubular epithelium; Vascular

Indexed keywords

CELL ACTIVATION; CELL REGENERATION; DISEASE COURSE; ENDOTHELIUM; HUMAN; KIDNEY; KIDNEY DISEASE; KIDNEY FAILURE; KIDNEY ISCHEMIA; KIDNEY PERFUSION; KIDNEY TUBULE; LEUKOSTASIS; NEPHRON; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PERITUBULAR ENDOTHELIUM; PRIORITY JOURNAL; RISK FACTOR; SHORT SURVEY; TUBE FLOW;

ANIMALS; CAPILLARIES; DISEASE PROGRESSION; ENDOTHELIUM, VASCULAR; HUMANS; ISCHEMIA; KIDNEY DISEASES; KIDNEY MEDULLA; KIDNEY TUBULES;

EID: 34948888238     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5002414     Document Type: Short Survey

References (36)

1. Rookmaaker MB, Smits AM, Tolboom H et al. Bone-marrow-derived cells contribute to glomerular endothelial repair in experimental glomerulonephritis. Am J Pathol 2003; 163: 553-562.
2. Fioretto P, Steffes MW, Sutherland DE et al. Reversal of lesions of diabetic nephropathy after pancreas transplantation. N Engl J Med 1998; 339: 69-75.
3. Hauer HA, Bajema IM, Hagen EC et al. Long-term renal injury in ANCA-associated vasculitis: an analysis of 31 patients with follow-up biopsies. Nephrol Dial Transplant 2002; 17: 587-596.
4. Pallone TL, Zhang Z, Rhinehart K. Physiology of the renal medullary microcirculation. Am J Physiol Renal Physiol 2003; 284: F253-F266.
5. Manotham K, Tanaka T, Matsumoto M et al. Evidence of tubular hypoxia in the early phase in the remnant kidney model. J Am Soc Nephrol 2004; 15: 1277-1288.
6. Nadasdy T, Laszik Z, Blick KE et al. Proliferative activity of intrinsic cell populations in the normal human kidney. J Am Soc Nephrol 1994; 4: 2032-2039.
7. Oliver JA, Maarouf O, Cheema FH et al. The renal papilla is a niche for adult kidney stem cells. J Clin Invest 2004; 114: 795-804.
8. Melk A, Schmidt BM, Takeuchi O et al. Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney. Kidney Int 2004; 65: 510-520.
9. Rabelink TJ, Luscher TF. Endothelial nitric oxide synthase: host defense enzyme of the endothelium? Arterioscler Thromb Vasc Biol 2006; 26: 267-271.
10. Johannes T, Mik EG, Nohe B et al. Acute decrease in renal microvascular PO2 during acute normovolemic hemodilution. Am J Physiol Renal Physiol 2007; 292: F796-F803.
11. Chen J, Goligorsky MS. Premature senescence of endothelial cells: Methusaleh's dilemma. Am J Physiol Heart Circ Physiol 2006; 290: H1729-H1739.
12. Yang J, Nagavarapu U, Relloma K et al. Telomerized human microvasculature is functional in vivo. Nat Biotechnol 2001; 19: 219-224.
13. Minamino T, Komuro I. Role of telomere in endothelial dysfunction in atherosclerosis. Curr Opin Lipidol 2002; 13: 537-543.
14. Hillebrands JL, Klatter FA, van Dijk WD, Rozing J. Bone marrow does not contribute substantially to endothelial-cell replacement in transplant arteriosclerosis. Nat Med 2002; 8: 194-195.
15. van Poelgeest EP, Baelde HJ, Lagaaij EL et al. Endothelial cell chimerism occurs more often and earlier in female than in male recipients of kidney transplants. Kidney Int 2005; 68: 847-853.
16. Yoder MC, Mead LE, Prater D et al. Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 2007; 109: 1801-1809.
17. Rabelink TJ, de Boer HC, de Koning EJ, Van Zonneveld AJ. Endothelial progenitor cells: more than an inflammatory response? Arterioscler Thromb Vasc Biol 2004; 24: 834-838.
18. Loomans CJ, Wan H, de Crom R et al. Angiogenic murine endothelial progenitor cells are derived from a myeloid bone marrow fraction and can be identified by endothelial NO synthase expression. Arterioscler Thromb Vasc Biol 2006; 26: 1760-1767.
19. Li J, Deane JA, Campanale NV et al. Blockade of p38 mitogen-activated protein kinase and TGF-beta1/Smad signaling pathways rescues bone marrow-derived peritubular capillary endothelial cells in adriamycin-induced nephrosis. J Am Soc Nephrol 2006; 17: 2799-2811.
20. Norman JT, Fine LG. Intrarenal oxygenation in chronic renal failure. Clin Exp Pharmacol Physiol 2006; 33: 989-996.
21. Eremina V, Sood M, Haigh J et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 2003; 111: 707-716.
22. Tanaka T, Kojima I, Ohse T et al. Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model. Lab Invest 2005; 85: 1292-1307.
23. Ishii Y, Sawada T, Kubota K et al. Loss of peritubular capillaries in the development of chronic allograft nephropathy. Transplant Proc 2005; 37: 981-983.
24. Kairaitis LK, Wang Y, Gassmann M et al. HIF-1alpha expression follows microvascular loss in advanced murine adriamycin nephrosis. Am J Physiol Renal Physiol 2005; 288: F198-F206.
25. Sun D, Feng J, Dai C et al. Role of peritubular capillary loss and hypoxia in progressive tubulointerstitial fibrosis in a rat model of aristolochic acid nephropathy. Am J Nephrol 2006; 26: 363-371.
26. Basile DP, Donohoe D, Roethe K, Osborn JL. Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function. Am J Physiol Renal Physiol 2001; 281: F887-F899.
27. Matsumoto M, Tanaka T, Yamamoto T et al. Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis. J Am Soc Nephrol 2004; 15: 1574-1581.
28. Yamamoto Y, Kato I, Doi T et al. Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. J Clin Invest 2001; 108: 261-268.
29. Nakagawa T, Sato W, Glushakova O et al. Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy. J Am Soc Nephrol 2007; 18: 539-550.
30. Brodsky SV, Yamamoto T, Tada T et al. Endothelial dysfunction in ischemic acute renal failure: rescue by transplanted endothelial cells. Am J Physiol Renal Physiol 2002; 282: F1140-F1149.
31. Deanfield JE, Halcox JP, Rabelink TJ. Endothelial function and dysfunction: testing and clinical relevance. Circulation 2007; 115: 1285-1295.
32. London GM, Pannier B, Agharazii M et al. Forearm reactive hyperemia and mortality in end-stage renal disease. Kidney Int 2004; 65: 700-704.
33. Gschwend S, Buikema H, Navis G et al. Endothelial dilatory function predicts individual susceptibility to renal damage in the 5/6 nephrectomized rat. J Am Soc Nephrol 2002; 13: 2909-2915.
34. Nieuwdorp M, Mooij HL, Kroon J et al. Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes. Diabetes 2006; 55: 1127-1132.
35. Werner N, Kosiol S, Schiegl T et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005; 353: 999-1007.
36. Aicher A, Heeschen C, Mildner-Rihm C et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003; 9: 1370-1376.