Aging attenuates dynactin-dynein interaction: Down-regulation of dynein causes accumulation of endogenous tau and amyloid precursor protein in human neuroblastoma cells

Journal of Neuroscience Research

Volumn 85, Issue 13, 2007, Pages 2909-2916

  Kimura, Nobuyuki ^a   Imamura, Osamu ^b   Ono, Fumiko ^a,c   Terao, Keiji ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

^c The Corporation for Production and Research of Laboratory Primates   (Japan)

Author keywords

Accumulation of disease proteins; Aging; Axonal transport; Dynactin dynein interaction; RNA interference

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DYNACTIN; DYNEIN ADENOSINE TRIPHOSPHATASE; KINESIN; TAU PROTEIN;

AGING; ANIMAL TISSUE; ARTICLE; DOWN REGULATION; HUMAN; HUMAN CELL; NERVE FIBER TRANSPORT; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RNA INTERFERENCE; WESTERN BLOTTING;

AGING; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CELL LINE, TUMOR; DOWN-REGULATION; DYNEIN ATPASE; HAPLORHINI; HUMANS; IMMUNOPRECIPITATION; MICROTUBULE-ASSOCIATED PROTEINS; NEUROBLASTOMA; RNA, SMALL INTERFERING; TAU PROTEINS;

EID: 34948859426     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21408     Document Type: Article

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