Altered cellular distribution of phospho-Tau proteins coincides with impaired retrograde axonal transport in neurons of aged rats

Annals of the New York Academy of Sciences

Volumn 1048, Issue , 2005, Pages 287-295

  Niewiadomska, Grazyna ^a   Baksalerska Pazera, Marta ^a   Riedel, Gernot ^b  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Aging; Axonal transport; Cholinergic system; Hyperphosphorylation; Neurodegeneration; NGF; Rat; Tau protein

Indexed keywords

CYTOSKELETON PROTEIN; FLUOROGOLD; NERVE GROWTH FACTOR; PHOSPHOPROTEIN; PROTEIN TYROSINE KINASE A; TAU PHOSPHOPROTEIN ANTIBODY 231; TAU PHOSPHOPROTEIN ANTIBODY 404; TAU PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; AGED; ANIMAL CELL; ANIMAL TISSUE; BRAIN CORTEX; CHOLINERGIC NERVE CELL; CONFERENCE PAPER; CONTROLLED STUDY; CYTOSKELETON; FOREBRAIN; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NERVE CELL; NERVE FIBER TRANSPORT; NONHUMAN; PROTEIN LOCALIZATION; RAT;

ANIMALIA;

EID: 25144517127     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1342.026     Document Type: Conference Paper

References (38)

1. GIACOBINI, E. 2003. Cholinergic function and Alzheimer's disease. Int. J. Geriatr. Psychiatry. Suppl. 1: S1-5.
2. SMITH, D.E. et al. 2004. Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons. J. Neurosci. 24: 4373-4381.
3. NIEWIADOMSKA, G., J. WYRZYKOWSKA & M. CHECHLACZ. 2000. Does senile impairment of cholinergic system in rats concern only disturbances in cholinergic phenotype or the progressive degeneration of neuronal cell bodies? Acta Biochim. Pol. 47: 313-330.
4. BRIERER, L.M. et al. 1995. Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits. J. Neurochem. 64: 749-760.
5. ARCINIEGAS, D.B. 2003. The cholinergic hypothesis of cognitive impairment caused by traumatic brain injury. Curr. Psychiatry Rep. 5: 391-399.
6. SALEHI, A., V. GONZALEZ MARTINEZ & D.F. SWAAB. 1998. A sex difference and no effect of ApoE type on the amount of cytoskeletal alterations in the nucleus basalis of Meynert in Alzheimer's disease. Neurobiol. Aging. 19: 505-510.
7. SASSIN, I. et al. 2000. Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert. Acta Neuropathol. (Berl). 100: 259-269.
8. SOFRONIEW, M.V., C.L. HOWE & W.C. MOBLEY. 2001. Nerve growth factor signaling, neuroprotection, and neural repair. Annu. Rev. Neurosci. 24: 1217-1281.
9. HENDRY, I.A. et al. 1974. The retrograde axonal transport of nerve growth factor. Brain Res. 68: 103-121.
10. WATSON, F.L. et al. 1999. Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex. J. Neurosci. 19: 7889-7900.
11. BHATTACHARYYA, A. et al. 2002. High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors. Neurobiol. 51: 302-312.
12. GOODE, P.L. et al. 1997. Functional interactions between the proline-rich and repeat regions of Tau enhance microtubule binding and assembly. Mol. Biol. Cell. 8: 353-365.
13. HERNANDEZ, F. et al. 2003. GSK-3 dependent phosphoepitopes recognized by PHF-1 and AT-8 antibodies are present in different Tau isoforms. Neurobiol. Aging 24: 1087-1094.
14. BUEE, L. et al. 2000. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res. Rev. 33: 95-130.
15. HAFEZPARAST, M. et al. 2003. Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science 300: 808-812.
16. MUFSON, E.J. et al. 1994. Nerve growth factor-like immunoreactive profiles in the primate basal forebrain and hippocampal formation. J. Comp. Neurol. 341: 507-519.
17. PENG, S. et al. 2004. Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease. J. Neuropathol. Exp. Neurol. 63: 641-649.
18. LAD, S.P., K.F. NEET & E.J. MUFSON. 2003. Nerve growth factor: structure, function and therapeutic implications for Alzheimer's disease. Curr. Drug Targets CNS Neurol. Disord. 2: 315-334.
19. SALEHI, A. et al. 2000. P75 neurotrophin receptor in the nucleus basalis of Meynert in relation to age, sex, and Alzheimer's disease. Exp. Neurol. 161: 245-258.
20. SALEHI, A. et al. 1996. Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease. Neuroscience 75: 373-387.
21. MUFSON, E.J. et al. 1997. Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease. Exp. Neurol. 146: 91-103.
22. DELCROIX, J.D. et al. 2004. Trafficking the NGF signal: implications for normal and degenerating neurons. Prog. Brain Res. 146: 3-23.
23. SALEHI, A., J.D. DELCROIX & W.C. MOBLEY. 2003. Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends Neurosci. 26: 73-80.
24. PAXINOS, G. & C. WATSON. 1997. The rat brain in stereotaxic coordinates. Academic Press.
25. NIEWIADOMSKA, G., S. KOMOROWSKI & M. BAKSALERSKA-PAZERA. 2002. Amelioration of cholinergic neurons dysfunction in aged rats by NGF depends on the continuous supply of the trophic factor. Neurobiol. Aging 23: 601-613.
26. ETUENNE, P. 1986. Nucleus basalis neuronal loss, neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's disease. Neuroscience 19: 279-291.
27. PERRY, E.K. 1986. The cholinergic hypothesis-ten years on. Br. Med. Bull. 42: 3-9.
28. WHITEHOUSE, P.J., D.T. PRICE, R.G. STRUBLE, et al. 1982. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215: 1237-1239.
29. MUFSON, E.J., J.M. CONNOR, & J.H. KORDOWER. 1995. NGF and Alzheimer's disease: Defective retrograde transport to the nucleus basalis. Neuroreport 6: 1063-1066.
30. SCOTT, S.A. et al. 1995. Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. J. Neurosci. 15: 6213-6221.
31. MUFSON, E.J. et al. 1993. Galaninergic innervation of the cholinergic vertical limb of the diagonal band (Ch2) and bed nucleus of the stria terminalis in aging, Alzheimer's disease and Down's syndrome. Dementia 4: 237-250.
32. CAPSONI, S. et al. 2000. Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. Proc. Natl. Acad. Sci. USA 97: 6826-6831.
33. BOISSIERE, B., Y. et al. 1996. Decrease of trkA mRNA level in cholinergic neurons of the striatum and basal forebrain in Alzheimer's disease. Soc. Neurosci. Abstr. 22: 210.
34. MUFSON, E.J. et al. 1994. Apolipoprotein E-immunoreactivity in aged rhesus monkey cortex: Colocalization with amyloid plaques. Neurobiol. Aging 15: 621-627.
35. MUKAI, F. et al. 2002. Alternative splicing isoform of Tau protein kinase I/glycogen synthase kinase 3beta. J. Neurochem. 81: 1073-1083.
36. PEI, J.J. et al. 1999. Distribution of active glycogen synthase kinase (GSK3-beta) in brains staged for Alzheimer disease neurofibrillary changes. J. Neuropathol. Exp. Neurol. 58: 1010-1019.
37. SHIURBA, R.A. et al. 1996. Immunocytochemistry of Tau phosphoserine 413 and Tau protein kinase I in Alzheimer pathology. Brain Res. 737: 119-132.
38. LI, Y. et al. 1995. Regulation of trkA and ChAT expression in developing rat basal forebrain: Evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. J. Neurosci. 15: 2888-2905.