A critical role of non-active site residues on cyclooxygenase helices 5 and 6 in the control of prostaglandin stereochemistry at carbon 15

Journal of Biological Chemistry

Volumn 282, Issue 38, 2007, Pages 28157-28163

  Valmsen, Karin ^b   Boeglin, William E ^a   Järving, Reet ^b   Järving, Ivar ^b   Varvas, Külliki ^b   Brash, Alan R ^a   Samel, Nigulas ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TALLINN UNIVERSITY OF TECHNOLOGY   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING SITES; BIOACTIVITY; ENZYME ACTIVITY; HORMONES; STEREOCHEMISTRY; SUBSTITUTION REACTIONS;

CYCLOOXYGENASE; ENZYMATIC CONTROL; PROSTAGLANDINS;

FATTY ACIDS;

CARBON; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN SYNTHASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; ENZYME STRUCTURE; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY;

AMINO ACID SEQUENCE; ANIMALS; ANTHOZOA; BINDING SITES; CARBON; CELL LINE; INSECTS; KINETICS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; PROTEIN ISOFORMS; STEREOISOMERISM;

ANTHOZOA; PLEXAURA HOMOMALLA;

EID: 34948840083     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M704950200     Document Type: Article

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