Localized vs. systemic inflammation in guinea pigs: A role for prostaglandins at distinct points of the fever induction pathways?

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 289, Issue 2 58-2, 2005, Pages

  Rummel, Christoph ^a   Barth, Stephan W ^b   Voss, Thilo ^a   Korte, Stefan ^a   Gerstberger, Rüdiger ^a   Hübschle, Thomas ^a   Roth, Joachim ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b FEDERAL RESEARCH INSTITUTE OF NUTRITION AND FOOD   (Germany)

Author keywords

Cyclooxygenase 2; Febrile response; Immune system to brain communication; Lipopolysaccharide; Prostaglandin E2

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYCLOOXYGENASE 2; DICLOFENAC; MESSENGER RNA; PROSTAGLANDIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEVER; GENE EXPRESSION; GUINEA PIG; HUMORAL IMMUNITY; IN SITU HYBRIDIZATION; INFLAMMATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRAIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; FEVER; GUINEA PIGS; INFLAMMATION; INJECTIONS, INTRA-ARTERIAL; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; IRRIGATION; LIPOPOLYSACCHARIDES; MALE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; PROSTHESES AND IMPLANTS; RNA, MESSENGER; SUBCUTANEOUS TISSUE;

EID: 23044473662     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00104.2005     Document Type: Article

References (39)

1. Barth SW, Riediger T, Lutz TA, and Rechkemmer G. Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat. Brain Res 997: 97-102, 2004.
2. Blatteis CM. The cytokine-prostaglandin cascade in fever production: fact or fancy? J Therm Biol 29: 359-368, 2004.
3. Blatteis CM, Feleder C, Perlik V, and Li S. Possible sequence of pyrogenic afferent processing in the POA. J Therm Biol 29: 391-400, 2004.
4. Braun HA, Bade H, and Hensel H. Static and dynamic discharge patterns of bursting cold fibers related to hypothetical receptor mechanisms. Pflügers Arch 386: 1-9, 1980.
5. Breder CD and Saper CB. Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide. Brain Res 713: 64-69, 1996.
6. Cao C, Matsumura K, Yamagata K, and Watanabe Y. Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain: its possible role in the febrile response. Brain Res 697: 187-196, 1995.
7. Cao C, Matsumura K, Yamagata K, and Watanabe Y. Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in the rat brain. Am J Physiol Regul Integr Comp Physiol 272: R1712-R1725, 1997.
8. Cartmell T, Luheshi GN, Hopkins SJ, Rothwell NJ, and Poole S. Role of endogenous interleukin-1 receptor antagonist in regulating fever induced by localised inflammation in the rat. J Physiol 531: 171-180, 2001.
9. Cartmell T, Poole S, Turnbull AV, Rothwell NJ, and Luheshi GN. Circulating interleukin-6 mediates the febrile response to localised inflammation in rats. J Physiol 526: 653-661, 2000.
10. Givalois L, Dornand J, Mekaouche M, Solier MD, Bristow AF, Ixart G, Siaud P, Assenmacher I, and Barbanel G. Temporal cascade of plasma level surges in ACTH, corticosterone, and cytokines in endotoxin-challenged rats. Am J Physiol Regul Integr Comp Physiol 267: R164-R170, 1994.
11. Goldbach JM, Roth J, and Zeisberger E. Fever suppression by subdiaphragmatic vagotomy in guinea pigs depends on the route of pyrogen administration. Am J Physiol Regul Integr Comp Physiol 272: R675-R681, 1997.
12. 2-synthesizing enzymes in fever: differential transcriptional regulation. Am J Physiol Regul Integr Comp Physiol 283: R1104-R1117, 2002.
13. 2 as a mediator of fever: synthesis and catabolism. Front Biosci 9: 1977-1993, 2004.
14. Johnson JD, O'Connor KA, Hansen MK, Watkins LR, and Maier SF. Effects of prior stress on LPS-induced cytokine and sickness response. Am J Physiol Regul Integr Comp Physiol 284: R422-R432, 2003.
15. Konsman JP, Vigues S, Mackerlova L, Bristow A, and Blomqvist A. Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli. J Comp Neurol 472: 113-129, 2004.
16. Lacroix S and Rivest S. Effects of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain. J Neurochem 70: 452-466, 1998.
17. Lenczowski MJP, Van Dam AM, Poole S, Larrick JW, and Tilders FJH. Role of circulating endotoxin and interleukin-6 in the ACTH and corticosterone response to intraperitoneal LPS. Am J Physiol Regul Integr Comp Physiol 273: R1870-R1877, 1997.
18. -/- mice. Brain Res 825: 86-94, 1999.
19. Li Z and Blatteis CM. Fever onset is linked to the appearance of lipopolysaccharide in the liver. J Endotoxin Res 10: 39-53, 2004.
20. Machida H, Limviphuvadh V, Okazawa M, Shiraki T, Matsumura K, and Kobayashi S. PGE2 selectively activates peripheral cold-sensitive neurons (Abstract). Proc Austr Physiol Pharmacol Soc 32 Suppl: 92P, 2001.
21. McCleskey EW and Gold MS. Ion channels of nociception. Annu Rev Physiol 61: 835-856, 1999.
22. Miller AJ, Hopkins SJ, and Luheshi GN. Sites of action of IL-1 in the development of fever and cytokine responses to tissue inflammation in the rat. Br J Pharmacol 120: 1274-1279, 1997.
23. Miller AJ, Luheshi GN, Rothwell NJ, and Hopkins SJ. Local cytokine induction by LPS in the rat air pouch and its relation to the febrile response. Am J Physiol Regul Integr Comp Physiol 272: R857-R861, 1997.
24. Mouihate A, Clerget-Froidevaux MS, Nakamura K, Negeshi M, Wallace JL, and Pittman QJ. Suppression of fever at near term is associated with reduced COX-2 protein expression in rat hypothalamus. Am J Physiol Regul Integr Comp Physiol 283: R800-R805, 2002.
25. Quan N, Whiteside M, and Herkenham M. Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide. Brain Res 802: 189-197, 1998.
26. Romanovsky AA. Signaling the brain in the early sickness syndrome: are sensory nerves involved? Front Biosci 9: 494-504, 2004.
27. 2 may be involved in fever. Am J Physiol Regul Integr Comp Physiol 276: R1840-R1844, 1999.
28. Romanovsky AA, Ivanov AI, Lenczowski MJP, Kulchitsky VA, Van Dam AM, Poole S, Homer LD, and Tilders FJH. Lipopolysaccharide transport from the peritoneal cavity to the blood: is it controlled by the vagus nerve? Auton Neurosci 85: 133-140, 2000.
29. Ross G, Hübschle T, Pehl U, Braun HA, Voigt K, Gerstberger R, and Roth J. Fever induction by localized subcutaneous inflammation in guinea pigs: the role of cytokines and prostaglandins. J Appl Physiol 94: 1395-1402, 2003.
30. Ross G, Roth J, Störr B, Voigt K, and Zeisberger E. Afferent nerves are involved in the febrile response to injection of LPS into artificial subcutaneous chambers in guinea pigs. Physiol Behav 71: 305-313, 2000.
31. Roth J, Hübschle T, Pehl U, Ross G, and Gerstberger R. Influence of systemic treatment with cyclooxygenase inhibitors on lipopolysaccharide-induced fever and circulating levels of cytokines and cortisol in guinea pigs. Pflügers Arch 443: 411-417, 2002.
32. Roth J, Martin D, Störr B, and Zeisberger E. Neutralization of pyrogen-induced tumour necrosis factor by its type 1 soluble receptor in guinea-pigs: effects on fever and interleukin-6 release. J Physiol 509: 267-275, 1998.
33. 2 in the blood simultaneously with the onset of fever. Eur J Pharmacol 154: 145-152, 1988.
34. Rummel C, Hübschle T, Gerstberger R, and Roth J. Nuclear translocation of the transcription factor STAT3 in the guinea pig brain during systemic or localized inflammation. J Physiol 557: 671-687, 2004.
35. Schiltz JC and Savchenko PE. Distinct brain vascular cell types manifest inducible cyclooxygenase expression as a function of the strength and nature of immune insults. J Neurosci 22: 5606-5618, 2002.
36. Steiner AA, Li S, Llanos QJ, and Blatteis CM. Differential inhibition by nimesulide of the early and late phases of intravenous- and intracerebro- ventricular-LPS-induced fever in guinea pigs. Neuroimmunomodulation 9: 263-275, 2001.
37. Takahashi Y, Smith P, Fergusson A, and Pittman QJ. Circumventricular organs and fever. Am J Physiol Regul Integr Comp Physiol 273: R1690-R1695, 1997.
38. Turnbull AV, Prehar S, Kennedy AR, Little RA, and Hopkins SJ. Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice. Endocrinology 144: 1894-1906, 2003.
39. Zhang YH, Lu J, Elmquist JK, and Saper CB. Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain. J Comp Neurol 463: 3-12, 2003.