NMR study of the inhibition of pepsin by glyoxal inhibitors: Mechanism of tetrahedral intermediate stabilization by the aspartyl proteases

Biochemistry

Volumn 46, Issue 39, 2007, Pages 11205-11215

  Cosgrove, Sonya ^a   Rogers, Louis ^a   Hewage, Chandralal M ^a   Malthouse, J Paul G ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE CARBONS; ASPARTYL PROTEASES; GLYOXAL INHIBITORS; HEMIACETAL HYDROXYL GROUPS; OXYANIONS; PEPSIN;

ALDEHYDES; CARBON; CATALYSIS; HYDROGEN BONDS; KETONES; NUCLEAR MAGNETIC RESONANCE;

ENZYME INHIBITION;

ALDEHYDE; ASPARTIC PROTEINASE; BENZYLOXYCARBONYLALANYLALANYLPHENYLGLYOXAL; CARBON; CARBON 13; GLYOXAL; HYDROXYL GROUP; KETONE; PEPSIN A; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; WATER;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; COMPETITIVE INHIBITION; COMPLEX FORMATION; ENZYME ACTIVE SITE; HYDROGEN BOND; IONIZATION; PKA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STABILITY; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL DETECTION;

ASPARTIC ENDOPEPTIDASES; CATALYSIS; ENZYME INHIBITORS; GLYOXAL; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PEPSIN A; PEPSTATINS; TEMPERATURE;

EID: 34848920136     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701000k     Document Type: Article

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