Inhibition of human immunodeficiency virus 1 protease in vitro: Rational design of substrate analogue inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 86, Issue 24, 1989, Pages 9752-9756

  Dreyer, G B ^a   Metcalf, B W ^a   Tomaszek Jr , T A ^a   Carr, T J ^a   Chandler III, A C ^a   Hyland, L ^a   Fakhoury, S A ^a   Magaard, V W ^a   Moore, M L ^a   Strickler, J E ^a   Debouck, C ^a   Meek, T D ^a  

^a SKF USA Inc   (United States)

Author keywords

antiviral agent; Aspartic protease; hydroxyethylene isostere; retroviral protease; transition state analogue

Indexed keywords

ASPARTIC PROTEINASE; PROTEINASE; PROTEINASE INHIBITOR; VIRUS PROTEIN;

ARTICLE; ENZYME INHIBITION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; DRUG DESIGN; ESCHERICHIA COLI; HIV-1; KINETICS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SUPPORT, U.S. GOV'T, P.H.S.;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0024792446     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.86.24.9752     Document Type: Article

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