Estrogen increases apoptosis in the arterial wall in a murine atherosclerosis model

Fertility and Sterility

Volumn 88, Issue 4 SUPPL., 2007, Pages 1190-1196

  Seli, Emre ^a   Guzeloglu Kayisli, Ozlem ^a   Kayisli, Umit A ^a   Kizilay, Gulnur ^a   Arici, Aydin ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; atherosclerosis; cardiovascular disease; estrogen; menopause

Indexed keywords

ESTRADIOL; ESTROGEN; LOW DENSITY LIPOPROTEIN RECEPTOR; PLACEBO;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; APOPTOSIS; ARTERY WALL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL PROLIFERATION; CHOLESTEROL DIET; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE MODEL; DNA STRAND BREAKAGE; FEMALE; HOMOZYGOSITY; IMPLANTATION; MITOSIS RATE; MOUSE; NONHUMAN; NULL ALLELE; OVARIECTOMY; PRIORITY JOURNAL;

ANIMALS; AORTA; APOPTOSIS; ATHEROSCLEROSIS; ENDOTHELIUM, VASCULAR; ESTROGENS; FEMALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OVARIECTOMY; RECEPTORS, LDL;

EID: 34848918453     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.01.132     Document Type: Article

References (48)

1. Mendelsohn M.E., and Karas R.H. Molecular and cellular basis of cardiovascular gender differences. Science 308 (2005) 1583-1587
2. Colditz G.A., Willett W.C., Stampfer M.J., Rosner B., Speizer F.E., and Hennekens C.H. Menopause and the risk of coronary heart disease in women. N Engl J Med 316 (1987) 1105-1110
3. Adams M.R., Kaplan J.R., Manuck S.B., Koritnik D.R., Parks J.S., Wolfe M.S., et al. Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys. Lack of an effect of added progesterone. Arteriosclerosis 10 (1990) 1051-1057
4. Sullivan T.R., Karas R.H., Aronovitz M., Faller G.T., Ziar J.P., Smith J.J., et al. Estrogen inhibits the response-to-injury in a mouse carotid artery model. J Clin Invest 96 (1995) 2482-2488
5. Stampfer M.J., and Colditz G.A. Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev Med 20 (1991) 47-63
6. Hulley S., Grady D., Bush T., Furberg C., Herrington D., Riggs B., et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 280 (1998) 605-613
7. Grady D., Herrington D., Bittner V., Blumenthal R., Davidson M., Hlatky M., et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). JAMA 288 (2002) 49-57
8. Rossouw J.E., Anderson G.L., Prentice R.L., LaCroix A.Z., Kooperberg C., Stefanick M.L., et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288 (2002) 321-333
9. Manson J.E., Hsia J., Johnson K.C., Rossouw J.E., Assaf A.R., Lasser N.L., et al. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 349 (2003) 523-534
10. Stary H.C. Macrophages, macrophage foam cells, and eccentric intimal thickening in the coronary arteries of young children. Atherosclerosis 64 (1987) 91-108
11. Aviram M. Low density lipoprotein modification by cholesterol oxidase induces enhanced uptake and cholesterol accumulation in cells. J Biol Chem 267 (1992) 218-225
12. Babaev V.R., Patel M.B., Semenkovich C.F., Fazio S., and Linton M.F. Macrophage lipo-protein lipase promotes foam cell formation and atherosclerosis in low density lipo-protein receptor-deficient mice. J Biol Chem 275 (2000) 26293-26299
13. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 340 (1999) 115-126
14. Katsuda S., Boyd H.C., Fligner C., Ross R., and Gown A.M. Human atherosclerosis. III. Immunocytochemical analysis of the cell composition of lesions of young adults. Am J Pathol 140 (1992) 907-914
15. Little W.C., and Applegate R.J. Coronary angiography before myocardial infarction: can the culprit site be prospectively recognized?. Am Heart J 136 (1998) 368-370
16. Koh K.K., Mincemoyer R., Bui M.N., Csako G., Pucino F., and Guetta V. Effects of hormone-replacement therapy on fibrinolysis in postmenopausal women. N Engl J Med 336 (1997) 683-690
17. Bennett M.R. Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture. Cardiovasc Res 41 (1999) 361-368
18. Wang B.Y., Ho H.K., Lin P.S., Schwarzacher S.P., Pollman M.J., Gibbons G.H., et al. Regression of atherosclerosis: role of nitric oxide and apoptosis. Circulation 99 (1999) 1236-1241
19. Kockx M.M., and Knaapen M.W. The role of apoptosis in vascular disease. J Pathol 190 (2000) 267-280
20. Caulin-Glaser T., Watson C.A., Pardi R., and Bender J.R. Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression. J Clin Invest 98 (1996) 36-42
21. Seli E., Kayisli U.A., Selam B., Seli M., and Arici A. Estradiol suppresses vascular monocyte chemotactic protein-1 expression during early atherogenesis. Am J Obstet Gynecol 187 (2002) 1544-1549
22. Foegh M.L., Asotra S., Howell M.H., and Ramwell P.W. Estradiol inhibition of arterial neointimal hyperplasia after balloon injury. J Vasc Surg 19 (1994) 722-726
23. Daly E., Vessey M.P., Hawkins M.M., Carson J.L., Gough P., and Marsh S. Risk of venous thromboembolism in users of hormone replacement therapy. Lancet 348 (1996) 977-980
24. The Writing Group for the PEPI Trial. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. JAMA 273 (1995) 199-208
25. Seli E., Guzeloglu-Kayisli O., Cakmak H., Kayisli U.A., Selam B., and Arici A. Estradiol increases apoptosis in human coronary artery endothelial cells (HCAEC) by up-regulating Fas and Fas ligand expression. J Clin Endocrinol Metab 91 (2006) 4995-5001
26. Ishibashi S., Brown M.S., Goldstein J.L., Gerard R.D., Hammer R.E., and Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 92 (1993) 883-893
27. Somers K.D., Koenig M., and Schechter G.L. Growth of head and neck squamous cell carcinoma in nude mice: potentiation of laryngeal carcinoma by 17 beta-estradiol. J Natl Cancer Inst 80 (1988) 688-691
28. Segars J.H., and Driggers P.H. Estrogen action and cytoplasmic signaling cascades. Part I: membrane-associated signaling complexes. Trends Endocrinol Metab 13 (2002) 349-354
29. Hall J.M., Couse J.F., and Korach K.S. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276 (2001) 36869-36872
30. Guzeloglu Kayisli O., Kayisli U.A., Luleci G., and Arici A. In vivo and in vitro regulation of Akt activation in human endometrial cells is estrogen dependent. Biol Reprod 71 (2004) 714-721
31. Guzeloglu-Kayisli O., Kayisli U.A., Al-Rejjal R., Zheng W., Luleci G., and Arici A. Regulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression by estradiol and progesterone in human endometrium. J Clin Endocrinol Metab 88 (2003) 5017-5026
32. Seval Y., Cakmak H., Kayisli U.A., and Arici A. Estrogen-mediated regulation of p38 mitogen-activated protein kinase (MAPK) in human endometrium. J Clin Endocrinol Metab 91 (2006) 2349-2357
33. Speir E., Yu Z.X., Takeda K., Ferrans V.J., and Cannon R.O. Antioxidant effect of estrogen on cytomegalovirus-induced gene expression in coronary artery smooth muscle cells. Circulation 102 (2000) 2990-2996
34. Zacharia L.C., Gogos J.A., Karayiorgou M., Jackson E.K., Gillespie D.G., Barchiesi F., et al. Methoxyestradiols mediate the antimitogenic effects of 17beta-estradiol: direct evidence from catechol-O-methyltransferase-knockout mice. Circulation 108 (2003) 2974-2978
35. Alvarez R.J., Gips S.J., Moldovan N., Wilhide C.C., Milliken E.E., Hoang A.T., et al. 17beta-estradiol inhibits apoptosis of endothelial cells. Biochem Biophys Res Commun 237 (1997) 372-381
36. Spyridopoulos I., Sullivan A.B., Kearney M., Isner J.M., and Losordo D.W. Estrogen-receptor-mediated inhibition of human endothelial cell apoptosis. Estradiol as a survival factor. Circulation 95 (1997) 1505-1514
37. Mori-Abe A., Tsutsumi S., Takahashi K., Toya M., Yoshida M., Du B., et al. Estrogen and raloxifene induce apoptosis by activating p38 mitogen-activated protein kinase cascade in synthetic vascular smooth muscle cells. J Endocrinol 178 (2003) 417-426
38. Tsukamoto A., Kaneko Y., Yoshida T., Han K., Ichinose M., and Kimura S. 2-Methoxyestradiol, an endogenous metabolite of estrogen, enhances apoptosis and beta-galactosidase expression in vascular endothelial cells. Biochem Biophys Res Commun 248 (1998) 9-12
39. Yue T.L., Wang X., Louden C.S., Gupta S., Pillarisetti K., Gu J.L., et al. 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression. Mol Pharmacol 51 (1997) 951-962
40. LaVallee T.M., Zhan X.H., Herbstritt C.J., Kough E.C., Green S.J., and Pribluda V.S. 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta. Cancer Res 62 (2002) 3691-3697
41. Appt S.E., Clarkson T.B., Lees C.J., and Anthony M.S. Low dose estrogens inhibit coronary artery atherosclerosis in postmenopausal monkeys. Maturitas 55 (2006) 187-194
42. Hampton R.Y. Proteolysis and sterol regulation. Annu Rev Cell Dev Biol 18 (2002) 345-378
43. Helguero L.A., Faulds M.H., Gustafsson J.A., and Haldosen L.A. Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene 24 (2005) 6605-6616
44. Huang E.J., Wu C.C., Lee S.D., Chen J.H., Liu J.Y., Ko J.L., et al. Opposing action of estrogen receptors alpha and beta on tumor necrosis factor-alpha gene expression and caspase-8-mediated apoptotic effects in HA22T cells. Mol Cell Biochem 290 (2006) 1-7
45. Wada-Hiraike O., Imamov O., Hiraike H., Hultenby K., Schwend T., Omoto Y., et al. Role of estrogen receptor beta in colonic epithelium. Proc Natl Acad Sci USA 103 (2006) 2959-2964
46. Imamov O., Morani A., Shim G.J., Omoto Y., Thulin-Andersson C., Warner M., et al. Estrogen receptor beta regulates epithelial cellular differentiation in the mouse ventral prostate. Proc Natl Acad Sci USA 101 (2004) 9375-9380
47. Amant C., Holm P., Xu S.H., Tritman N., Kearney M., and Losordo D.W. Estrogen receptor-mediated, nitric oxide-dependent modulation of the immunologic barrier function of the endothelium: regulation of fas ligand expression by estradiol. Circulation 104 (2001) 2576-2581
48. Anderson G.L., Limacher M., Assaf A.R., Bassford T., Beresford S.A., Black H., et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 291 (2004) 1701-1712