-
3
-
-
0033985191
-
The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation
-
Baroja ML, Luxenberg D, Chau T, et al. The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation. J Immunol 2000;164:49-55.
-
(2000)
J Immunol
, vol.164
, pp. 49-55
-
-
Baroja, M.L.1
Luxenberg, D.2
Chau, T.3
-
5
-
-
1842854703
-
Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo
-
Yi LA, Hajialiasgar S, Chuang E. Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo. Int Immunol 2004;16:539-47.
-
(2004)
Int Immunol
, vol.16
, pp. 539-547
-
-
Yi, L.A.1
Hajialiasgar, S.2
Chuang, E.3
-
8
-
-
0037093856
-
Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A
-
Baroja ML, Vijayakrishnan L, Bettelli E, et al. Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A. J Immunol 2002;168:5070-8.
-
(2002)
J Immunol
, vol.168
, pp. 5070-5078
-
-
Baroja, M.L.1
Vijayakrishnan, L.2
Bettelli, E.3
-
9
-
-
0033662376
-
The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A
-
Chuang E, Fisher TS, Morgan RW, et al. The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A. Immunity 2000;13:313-22.
-
(2000)
Immunity
, vol.13
, pp. 313-322
-
-
Chuang, E.1
Fisher, T.S.2
Morgan, R.W.3
-
10
-
-
0036687077
-
CTLA-4 engagement regulates NF-κB activation in vivo
-
Harlin H, Hwang KW, Palucki DA, et al. CTLA-4 engagement regulates NF-κB activation in vivo. Eur J Immunol 2002;32:2095-104.
-
(2002)
Eur J Immunol
, vol.32
, pp. 2095-2104
-
-
Harlin, H.1
Hwang, K.W.2
Palucki, D.A.3
-
11
-
-
0029120245
-
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
-
Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995;182:459-65.
-
(1995)
J Exp Med
, vol.182
, pp. 459-465
-
-
Krummel, M.F.1
Allison, J.P.2
-
12
-
-
0028484545
-
CTLA-4 can function as a negative regulator of T cell activation
-
Walunas TL, Lenschow DJ, Bakker CY, et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994;1:405-13.
-
(1994)
Immunity
, vol.1
, pp. 405-413
-
-
Walunas, T.L.1
Lenschow, D.J.2
Bakker, C.Y.3
-
13
-
-
0036180686
-
CTLA-4 regulates cell cycle progression during a primary immune response
-
Greenwald RJ, Oosterwegel MA, van der Woude D, et al. CTLA-4 regulates cell cycle progression during a primary immune response. Eur J Immunol 2002;32:366-73.
-
(2002)
Eur J Immunol
, vol.32
, pp. 366-373
-
-
Greenwald, R.J.1
Oosterwegel, M.A.2
van der Woude, D.3
-
14
-
-
33749038866
-
Reversal of the TCR stop signal by CTLA-4
-
Schneider H, Downey J, Smith A, et al. Reversal of the TCR stop signal by CTLA-4. Science 2006;313:1972-5.
-
(2006)
Science
, vol.313
, pp. 1972-1975
-
-
Schneider, H.1
Downey, J.2
Smith, A.3
-
15
-
-
16844362608
-
Mechanisms of suppression by suppressor T cells
-
von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol 2005;6:338-44.
-
(2005)
Nat Immunol
, vol.6
, pp. 338-344
-
-
von Boehmer, H.1
-
16
-
-
0033682056
-
+ immunoregulatory T cells that control autoimmune diabetes
-
+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000;12:431-40.
-
(2000)
Immunity
, vol.12
, pp. 431-440
-
-
Salomon, B.1
Lenschow, D.J.2
Rhee, L.3
-
17
-
-
14544296063
-
CD4(+) CD25(+) regulatory T cell selection
-
Caton AJ, Cozzo C, Larkin J III, Lerman MA, Boesteanu A, Jordan MS. CD4(+) CD25(+) regulatory T cell selection. Ann N Y Acad Sci 2004;1029:101-14.
-
(2004)
Ann N Y Acad Sci
, vol.1029
, pp. 101-114
-
-
Caton, A.J.1
Cozzo, C.2
Larkin III, J.3
Lerman, M.A.4
Boesteanu, A.5
Jordan, M.S.6
-
19
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
-
Waterhouse P, Penninger JM, Timms E, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995;270:985-8.
-
(1995)
Science
, vol.270
, pp. 985-988
-
-
Waterhouse, P.1
Penninger, J.M.2
Timms, E.3
-
20
-
-
0028867420
-
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
-
Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995;3:541-7.
-
(1995)
Immunity
, vol.3
, pp. 541-547
-
-
Tivol, E.A.1
Borriello, F.2
Schweitzer, A.N.3
Lynch, W.P.4
Bluestone, J.A.5
Sharpe, A.H.6
-
21
-
-
0031405867
-
-
+ T cells. Immunity 1997;7:885-95.
-
+ T cells. Immunity 1997;7:885-95.
-
-
-
-
22
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996;271:1734-6.
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
23
-
-
0033517152
-
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
-
van Elsas A, Hurwitz AA, Allison JP. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med 1999;190:355-66.
-
(1999)
J Exp Med
, vol.190
, pp. 355-366
-
-
van Elsas, A.1
Hurwitz, A.A.2
Allison, J.P.3
-
24
-
-
0034194329
-
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
-
Hurwitz AA, Foster BA, Kwon ED, et al. Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res 2000;60:2444-8.
-
(2000)
Cancer Res
, vol.60
, pp. 2444-2448
-
-
Hurwitz, A.A.1
Foster, B.A.2
Kwon, E.D.3
-
25
-
-
0032544067
-
CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
-
Hurwitz AA, Yu TF, Leach DR, Allison JP. CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma. Proc Natl Acad Sci U S A 1998;95:10067-71.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 10067-10071
-
-
Hurwitz, A.A.1
Yu, T.F.2
Leach, D.R.3
Allison, J.P.4
-
26
-
-
0030743846
-
Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer
-
Kwon ED, Hurwitz AA, Foster BA, et al. Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer. Proc Natl Acad Sci U S A 1997;94:8099-103.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 8099-8103
-
-
Kwon, E.D.1
Hurwitz, A.A.2
Foster, B.A.3
-
27
-
-
17944364189
-
Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: Comparison of prophylaxis and therapy
-
van Elsas A, Sutmuller RP, Hurwitz AA, et al. Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J Exp Med 2001;194:481-9.
-
(2001)
J Exp Med
, vol.194
, pp. 481-489
-
-
van Elsas, A.1
Sutmuller, R.P.2
Hurwitz, A.A.3
-
29
-
-
33745851479
-
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
-
Quezada SA, Peggs KS, Curran MA, Allison JP. CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J Clin Invest 2006;116:1935-45.
-
(2006)
J Clin Invest
, vol.116
, pp. 1935-1945
-
-
Quezada, S.A.1
Peggs, K.S.2
Curran, M.A.3
Allison, J.P.4
-
30
-
-
0344341626
-
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
-
Hodi FS, Mihm MC, Soiffer RJ, et al. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci US A 2003;100:4712-7.
-
(2003)
Proc Natl Acad Sci US A
, vol.100
, pp. 4712-4717
-
-
Hodi, F.S.1
Mihm, M.C.2
Soiffer, R.J.3
-
31
-
-
0038153907
-
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
-
Phan GQ, Yang JC, Sherry RM, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci U S A 2003;100:8372-7.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8372-8377
-
-
Phan, G.Q.1
Yang, J.C.2
Sherry, R.M.3
-
32
-
-
20044395957
-
Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma
-
Sanderson K, Scotland R, Lee P, et al. Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma. JClin Oncol 2005;23:741-50.
-
(2005)
JClin Oncol
, vol.23
, pp. 741-750
-
-
Sanderson, K.1
Scotland, R.2
Lee, P.3
-
33
-
-
24944459890
-
Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
-
Attia P, Phan GQ, Maker AV, et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol 2005;23:6043-53.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6043-6053
-
-
Attia, P.1
Phan, G.Q.2
Maker, A.V.3
-
34
-
-
28244492012
-
Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade
-
Maker AV, Attia P, Rosenberg SA. Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade. J Immunol 2005;175:7746-54.
-
(2005)
J Immunol
, vol.175
, pp. 7746-7754
-
-
Maker, A.V.1
Attia, P.2
Rosenberg, S.A.3
-
35
-
-
27844458057
-
Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: A phase I/II study
-
Maker AV, Phan GQ, Attia P, et al. Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ann Surg Oncol 2005;12:1005-16.
-
(2005)
Ann Surg Oncol
, vol.12
, pp. 1005-1016
-
-
Maker, A.V.1
Phan, G.Q.2
Attia, P.3
-
36
-
-
32644467549
-
Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206
-
Ribas A, Camacho LH, Lopez-Berestein G, et al. Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206. J Clin Oncol 2005;23:8968-77.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8968-8977
-
-
Ribas, A.1
Camacho, L.H.2
Lopez-Berestein, G.3
-
37
-
-
34848893696
-
-
Weber J, Targan S, Scotland R, et al. Phase II trial of extended dose anti-CTLA-4 antibody ipilimumab (formerly MDX-010) with a multi-peptide vaccine for resected stages IIIC and IV melanoma. 2006 ASCO annual meeting proceedings part I. J Clin Oncol 2006;24(No.18S):2510.
-
Weber J, Targan S, Scotland R, et al. Phase II trial of extended dose anti-CTLA-4 antibody ipilimumab (formerly MDX-010) with a multi-peptide vaccine for resected stages IIIC and IV melanoma. 2006 ASCO annual meeting proceedings part I. J Clin Oncol 2006;24(No.18S):2510.
-
-
-
-
38
-
-
27444440093
-
Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer
-
Blansfield JA, Beck KE, Tran K, et al. Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. J Immunother 2005;28:593-8.
-
(2005)
J Immunother
, vol.28
, pp. 593-598
-
-
Blansfield, J.A.1
Beck, K.E.2
Tran, K.3
-
39
-
-
34848840711
-
-
Fong L, Kavanagh B, Rini B, Shaw V, Weinberg V, Small EJ. A phase I trial of combination immunotherapy with CTLA-4 blockade and GM-CSF in hormone-refractory prostate cancer. 2006 ASCO annual meeting proceedings part I. J Clin Oncol 2006;24(No.18S):2508.
-
Fong L, Kavanagh B, Rini B, Shaw V, Weinberg V, Small EJ. A phase I trial of combination immunotherapy with CTLA-4 blockade and GM-CSF in hormone-refractory prostate cancer. 2006 ASCO annual meeting proceedings part I. J Clin Oncol 2006;24(No.18S):2508.
-
-
-
-
40
-
-
34848820991
-
CTLA-4 blockade-based immunotherapy for hormone-refractory prostate cancer [abstract]
-
Kavanagh B, Rini B, Weinberg V, Shaw V, Small E, Fong L. CTLA-4 blockade-based immunotherapy for hormone-refractory prostate cancer [abstract]. ASCO prostate cancer symposium; 2006.
-
(2006)
ASCO prostate cancer symposium
-
-
Kavanagh, B.1
Rini, B.2
Weinberg, V.3
Shaw, V.4
Small, E.5
Fong, L.6
-
41
-
-
34848857425
-
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) antibody blockade in previously vaccinated melanoma and ovarian cancer patients [abstract]
-
January 18-23
-
Hodi F, Seiden M, Butler M, et al. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) antibody blockade in previously vaccinated melanoma and ovarian cancer patients [abstract]. Keystone symposia: advances in the understanding and treatment of melanoma, January 18-23, 2006; 2006.
-
(2006)
Keystone symposia: Advances in the understanding and treatment of melanoma
-
-
Hodi, F.1
Seiden, M.2
Butler, M.3
-
42
-
-
34848884613
-
-
Vonderheide R, Flaherty K, Khalil M, et al. Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. 2006 ASCO annual meeting proceedings part I. J Clin Oncol 2006;24(No. 18S):2507.
-
Vonderheide R, Flaherty K, Khalil M, et al. Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. 2006 ASCO annual meeting proceedings part I. J Clin Oncol 2006;24(No. 18S):2507.
-
-
-
-
43
-
-
33747661085
-
Update on immunotherapy for melanoma
-
Ribas A. Update on immunotherapy for melanoma. J Natl Compr Canc Netw 2006;4:687-94.
-
(2006)
J Natl Compr Canc Netw
, vol.4
, pp. 687-694
-
-
Ribas, A.1
-
44
-
-
33746924449
-
Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity
-
Kocak E, Lute K, Chang X, et al. Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity. Cancer Res 2006;66:7276-84.
-
(2006)
Cancer Res
, vol.66
, pp. 7276-7284
-
-
Kocak, E.1
Lute, K.2
Chang, X.3
|