Constitutive phosphorylation of Janus kinase 2 in the GL15 glioblastoma derived human cell line

Oncology Reports

Volumn 17, Issue 1, 2007, Pages 17-23

  Sciaccaluga, Miriam ^a   Gianfranceschi, Gian Luigi ^a   Rocco, Simone ^a   Germano, Giovanni ^a   Roti, Giovanni ^a   Gorello, Paolo ^a   La Starza, Roberta ^a   Castigli, Emilia ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Glioblastoma; Janus kinase 2; Tyrphostin AG490

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; INTERMEDIATE FILAMENT PROTEIN; JAK2 PROTEIN, HUMAN; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NERVE PROTEIN; NESTIN; TYRPHOSTIN; TYRPHOSTIN AG-490; VIMENTIN;

ARTICLE; BIOSYNTHESIS; CELL CYCLE; CELL DIFFERENTIATION; CELL GROWTH; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GLIOBLASTOMA; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

CELL CYCLE; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; CELL LINE, TUMOR; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; JANUS KINASE 2; NERVE TISSUE PROTEINS; PHOSPHORYLATION; TYRPHOSTINS; VIMENTIN;

EID: 34848907237     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.17.1.17     Document Type: Article

References (37)

1. Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK and DePinho RA: Malignant glioma: genetics and biology of a grave matter. Genes Dev 15: 1311-1333, 2001. (Pubitemid 32524640)
2. Holland EC: Gliomagenesis: genetic alterations and mouse models. Nat Rev Genet 2: 120-129, 2001.
3. Rane GS and Reddy EP: Janus kinases: components of multiple signaling pathways. Oncogene 19: 5662-5679, 2000.
4. Cattaneo E, Conti L and De-Fraja C: Signalling through the JAK-STAT pathway in developing brain. Trends Neurosci 22: 365-369, 1999. (Pubitemid 29339250)
5. He F, Ge W, Martinowich K, Becker-Catania S, Coskun V, Zhu W, Wu H, Castro D, Guillemot F, Fan G, de Vellis J and Sun YE: A positive autoregolatory loop of Jak-STAT signalling controls the onset of astrogliogenesis. Nat Neurosci 8: 616-625, 2005. (Pubitemid 40594203)
6. De-Fraja C, Conti L, Magrassi L, Covoni S and Cattaneo E: Members of the JAK-STAT proteins are expressed and regulated during development in the mammalian forebrain. J Neurosci Res 54: 320-330, 1998. (Pubitemid 28493942)
7. Arai K, Lee F, Miyajima A, Miyatake S, Arai N and Yokota T: Cytokines: coordinator of immune and inflammatory response. Annu Rev Biochem 59: 783-836, 1990.
8. Merrill JE and Benveniste EN: Cytokines in inflammatory brain lesion: helpful and harmful. Trends Neurosci 19: 331-338, 1996. (Pubitemid 26349062)
9. Natarajan C, Sriram S, Muthian G and Bright JJ: Signaling through JAK2-STAT5 pathway is essential for IL-3-induced activation of microglia. Glia 47: 188-196, 2004. (Pubitemid 38196995)
10. Swanson RA, Ying W and Kauppinen TM: Astrocyte influences on ischemic neuronal death. Curr Mol Med 4: 193-205, 2004. (Pubitemid 38425914)
11. Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, Leeder JS, Freedman M, Cohen A, Gazit A, Levitzki A and Roifman CM: Inibition of acute lymphoblastic leukaemia by a JAK-2 inhibitor. Nature 379: 645-648, 1996. (Pubitemid 26053453)
12. Bocchini V, Beccari T, Arcuri C, Bruyere L, Fages C and Tardy M: Glial fibrillary acidic protein and its encoding mRNA exibit mosaic expression in a glioblastoma multiform cell line of clonal origin. Int J Dev Neurosci 11: 485-492, 1993.
13. Arcuri C, Bocchini V, Guerrieri P, Fages C and Tardy M: PKA and PKC activation induces opposite glial fibrillary acidic protein (GFAP) expression and morphology changes in a glioblastoma multiform cell line of clonal origin. J Neurosci Res 40: 622-631, 1995.
14. Moretto G, Brutti N, De Andelis V, Arcuri C and Bocchini V: A time-dependent increase in glial fibrillary acidic protein expression and glutammine synthetase activity in long-term subculture of the GL15 glioma cell line. Cell Mol Neurobiol 17: 509-519, 1997. (Pubitemid 27451246)
15. Castigli E, Arcuri C, Giovagnoli L, Luciani R, Giovagnoli L, Secca T, Gianfranceschi GL and Bocchini V: Interleukin-1β induces apoptosis in GL15 glioblastoma-derived human cell line. Am J Physiol Cell Physiol 279: C2043-C2049, 2000.
16. Lee JC, Mayer-Proschel M and Rao MS: Gliogenesis in the central nervous system. Glia 30: 105-121, 2000. (Pubitemid 30199425)
17. Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, Mauchauffe M, Berthou C, Lessard M, Berger R, Ghysdael J and Bernard OA: A TEL-JAK2 fusion protein with constitutive kinase activity in human leukaemia. Science 278: 1309-1312, 1997. (Pubitemid 27495745)
18. Miyamoto N, Sugita K, Goi K, Inukai T, Lijima K, Tezuka T, Kojika S, Nakamura M, Kagami K and Nakazawa S: The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome. Leukemia 15: 1758-1768, 2001. (Pubitemid 33061844)
19. Laemmli UK: Cleavage of structural protein during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
20. Towbin H, Staelin T and Gordon J: Electrophoretic transfer of protein from polyacrylamide gels in nitrocellulose sheets. Procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354, 1979. (Pubitemid 9256559)
21. Tognon M, Casalone R, Martini F, De Mattei M, Granata P, Minelli E, Arcuri C, Collini P and Bocchini V: Large T antigen coding sequences of two DNA tumor viruses, BK and SV40, and nonrandom chromosome changes in two glioblastoma cell lines. Cancer Genet Cytogenet 90: 17-23, 1996. (Pubitemid 26316416)
22. Dierlamm J, Wlodarska I, Michaux R, La Starza R, Zeller W, Mecucci C and Van den Berghe H: Successful use of the same slide for consecutive fluorescence in situ hybridization (FISH) experiments. Genes Chromosomes Cancer 16: 261-264, 1996. (Pubitemid 26299981)
23. Guillamo JS, Lisovoski F, Christov C, Le Guerinel C, Defer GL, Peschanski M and Lefrancois T: Migration pathways of human glioblastoma cells xenografted into the immunosuppressed rat brain. J Neurooncol 52: 205-215, 2001. (Pubitemid 33638519)
24. Rahaman SO, Harbor PC, Chernova O, Barnett GH, Vogelbaum MA and Haque SJ: Inhibition of costitutive active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 21: 8404-8413, 2002. (Pubitemid 36054883)
25. Bignami A, Eng LF, Dahl D and Uyeda CT: Localization of the glial fibrillary acidic protein in astrocytes by immunoflorescence. Brain Res 43: 429-435, 1972.
26. Eng LF: Glial fibrillary acidic protein: The major protein of glia intermediate filament in differentiated astrocytes. J Neuroimmunol 8: 203-214, 1985.
27. Paillaud E, Costa S, Fages C, Plassat JL, Rochette-Egly C, Monville C and Tardy M: Retinoic acid increases proliferation rate of GL15 glioma cells, involving activation of STAT-3 transcription factor. J Neurosci Res 67: 670-679, 2002. (Pubitemid 34207680)
28. Watanabe S and Arai K: Roles of the JAK-STAT system in signal transduction via cytokine receptors. Differentiation and gene regulation. Curr Opin Genet Dev 6: 587-596, 1996. (Pubitemid 26372155)
29. Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD and Greenberg ME: Regulation of gliogenesis in the central nervous system by the JAK-STAT signalling pathway. Science 278: 477-483, 1997. (Pubitemid 27454434)
30. Rajan P and McKay RD: Multiple routes to astrocytic differentiation in the CNS. J Neurosci 18: 3620-3629, 1998. (Pubitemid 28225670)
31. Tarasenko YI, Yu Y, Jordan PM, Bottenstein J and Wu P: Effect of growth factors on proliferation and phenotypic differentiation of human fetal neural stem cells. J Neurosci Res 78: 625-636, 2004. (Pubitemid 39657580)
32. Fukuda S and Taga T: Cell fate determination regulated by a transcriptional signal network in the developing mouse brain. Anat Sci Int 80: 12-18, 2005. (Pubitemid 40425962)
33. Adachi T, Takanaga H, Kunimoto M and Asou H: Influence of LIF and BMP-2 on differentiation and development of glial cells in primary cultures of embryonic rat cerebral hemisphere. J Neurosci Res 79: 608-615, 2005. (Pubitemid 40476439)
34. Gregg C and Weiss S: CNTF/LIF/gp130 receptor complex signalling maintains a VZ precursor differentiation gradient in the developing ventral forebrain. Development 132: 565-578, 2005. (Pubitemid 40277696)
35. Andl CL, Mizushima T, Oyama K, Bowser M, Nakagawa H and Rustgi AK: EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes. Am J Physiol Gastrointest Liver Physiol 287: G1227-1237, 2004. (Pubitemid 39551854)
36. Savell J, Ma Y, Morrow KS, Jove R, Olashaw N, Moseley PL, Cress WD and Wharton W: AG490 inhibits G1-S traverse in BALB/c-3T3 cells following either mitogenic stimulation or exogenous expression of E2F-1. Mol Cancer Ther 3: 205-213, 2004. (Pubitemid 39193695)
37. Kleinberger-Doron N, Shelah N, Capone R, Gazit A and Levitzki A: Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase. Exp Cell Res 241: 340-351, 1998. (Pubitemid 28366560)