Expression of p27KIP1 and p21WAF1/CIP1 in primary hepatocellular carcinoma: Clinicopathologic correlation and survival analysis

Human Pathology

Volumn 32, Issue 8, 2001, Pages 778-785

  Qin, Lan Fang ^a   Ng, Irene Oi lin ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

Expression; Hepatocellular carcinoma; Prognosis

Indexed keywords

PROTEIN P21; PROTEIN P27;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CORRELATION FUNCTION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PROGNOSIS; PROTEIN EXPRESSION;

EID: 0034869599     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2001.27105     Document Type: Article

References (33)

1. p27Kip1: Chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors
2. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
3. Inhibitors of mammalian G1 cyclin-dependent kinases
4. CDK inhibitors: Positive and negative regulators of G1-phase progression
5. The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2
6. Translational control of p27Kip1 accumulation during the cell cycle
7. Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest
8. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
9. Regulation of the Cdk inhibitor p27 and its deregulation in cancer
10. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
11. Loss of P27Kip1 expression correlates with tumor grade and with reduced disease-free survival in primary superficial bladder cancers
12. Expression of the cell cycle inhibitor p27KIP1 is a new prognostic marker associated with survival in epithelial ovarian tumors
13. WAF1, a potential mediator of p53 tumor suppression
14. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
15. Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation
16. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
17. p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation
18. Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: p27 independently predicts the recurrence
19. Acquired expression of p27 is a favorable prognostic indicator in patients with hepatocellular carcinoma
20. Decreased expression of p27 protein is associated with advanced tumor stage in hepatocellular carcinoma
21. p21, p53 and PCNA expression and p53 mutation status in hepatocellular carcinoma
22. Prognostic significance of pathologic features of hepatocellular carcinoma - A multivariate analysis of 278 patients
23. Reduced expression of p27(Kip1) correlates with an early stage of cancer invasion in oral squamous cell carcinoma
24. Cyclin D 2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases
25. Mutational analysis of the p27(kip1) gene in hepatocellular carcinoma
26. High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers
27. WAF1/CIP1 expression and p53 mutation in hepatocellular carcinomas
28. Decreased expression and rare somatic mutation of the CIP1/WAF1 gene in human hepatocellular carcinoma
29. Absence of WAF1 mutations in a variety of human malignancies
30. Posttranscriptional stabilization underlies p53-independent induction of p21WAF1/CIP1/SDI1 in differentiating human leukemic cells
31. Regulation of cyclin-dependent kinase inhibitor p21(WAF1/Cip1/Sdi1) gene expression in hepatic regeneration
32. Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells
33. Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation