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Baillargeon J, Rose DP. Obesity, adipokines, and prostate cancer [review]. Int J Oncol 2006; 28:737-745.
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Baillargeon, J.1
Rose, D.P.2
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Angiogenic factors are elevated in overweight and obese individuals
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Silha JV, Krsek M, Sucharda P, Murphy LJ. Angiogenic factors are elevated in overweight and obese individuals. Int J Obes (Lond) 2005; 29:1308-1314.
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Silha, J.V.1
Krsek, M.2
Sucharda, P.3
Murphy, L.J.4
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57
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Biological action of leptin as an angiogenic factor
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Sierra-Honigmann MR, Nath AK, Murakami C, et al. Biological action of leptin as an angiogenic factor. Science 1998; 281:1683-1686.
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(1998)
Science
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Sierra-Honigmann, M.R.1
Nath, A.K.2
Murakami, C.3
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Kitade M, Yoshiji H, Kojima H, et al. Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats. Hepatology 2006; 44:983-991. In this study, Zucker rats (which develop spontaneous mutations in the leptin receptor) were used to investigate the effects of leptin in liver fibrosis and hepatocarcinoma-induced angiogenesis. The study showed that lack of leptin signaling is associated with reduced levels of VEGF as well as fibrosis and carcinogenesis in the obese animals when compared to their lean nonmutated littermates.
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Kitade M, Yoshiji H, Kojima H, et al. Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats. Hepatology 2006; 44:983-991. In this study, Zucker rats (which develop spontaneous mutations in the leptin receptor) were used to investigate the effects of leptin in liver fibrosis and hepatocarcinoma-induced angiogenesis. The study showed that lack of leptin signaling is associated with reduced levels of VEGF as well as fibrosis and carcinogenesis in the obese animals when compared to their lean nonmutated littermates.
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Mu H, Ohashi R, Yan S, et al. Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc Res 2006; 70:146-157. This describes another study that associated an adipocytokine found increased in obese patients with increased angiogenesis. Here, the investigators demonstrated that resistin increases endothelial cell proliferation and migration in a MAPK-dependent manner. Furthermore, they demonstrated the ability of resistin to induce the formation of capillary-like tube when added to HCAEC cells (human coronary artery endothelial cells) as well as to upregulate the expression of several potent angiogenic factors.
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Mu H, Ohashi R, Yan S, et al. Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc Res 2006; 70:146-157. This describes another study that associated an adipocytokine found increased in obese patients with increased angiogenesis. Here, the investigators demonstrated that resistin increases endothelial cell proliferation and migration in a MAPK-dependent manner. Furthermore, they demonstrated the ability of resistin to induce the formation of capillary-like tube when added to HCAEC cells (human coronary artery endothelial cells) as well as to upregulate the expression of several potent angiogenic factors.
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Wang Y, Xu LY, Lam KS, et al. Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectin. Proteomics 2006; 6:3862-3870. This presents an analysis of human serum proteins and identifies binding partners for adiponectin. Binding of adiponectin to thrombospondin-1 (TSP-1) and α2M (both involved in inflammation and angiogenesis) is verified with the use of co-immunoprecipitation and radioligand competitive-binding assays.
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Wang Y, Xu LY, Lam KS, et al. Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectin. Proteomics 2006; 6:3862-3870. This presents an analysis of human serum proteins and identifies binding partners for adiponectin. Binding of adiponectin to thrombospondin-1 (TSP-1) and α2M (both involved in inflammation and angiogenesis) is verified with the use of co-immunoprecipitation and radioligand competitive-binding assays.
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Role of neuropeptides in inflammatory bowel disease
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Gross KJ, Pothoulakis C. Role of neuropeptides in inflammatory bowel disease. Inflamm Bowel Dis 2007; 13:918-932.
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(2007)
Inflamm Bowel Dis
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Gross, K.J.1
Pothoulakis, C.2
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Karagiannides I, Kokkotou E, Tansky M, et al. Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A 2006; 103:5207-5212. The authors describe the first observation that colonic mucosal inflammation signals inflammatory changes in mesenteric fat. This study also showed that human mesenteric preadipocytes possess receptors for the neuropeptide SP (a potent proinflammatory regulator of intestinal inflammation) which can mediate pro-inflammatory responses (such as expression of IL-8) in an NF-κB-dependent manner.
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Karagiannides I, Kokkotou E, Tansky M, et al. Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A 2006; 103:5207-5212. The authors describe the first observation that colonic mucosal inflammation signals inflammatory changes in mesenteric fat. This study also showed that human mesenteric preadipocytes possess receptors for the neuropeptide SP (a potent proinflammatory regulator of intestinal inflammation) which can mediate pro-inflammatory responses (such as expression of IL-8) in an NF-κB-dependent manner.
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Duarte-Rojo A, Lezama-Barreda A, Ramirez-Iglesias MT, et al. Is leptin related to systemic inflammatory response in acute pancreatitis? World J Gastroenterol 2006; 12:4392-4396. This study linked increased adipocity with the severity of pancreatitis.
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Duarte-Rojo A, Lezama-Barreda A, Ramirez-Iglesias MT, et al. Is leptin related to systemic inflammatory response in acute pancreatitis? World J Gastroenterol 2006; 12:4392-4396. This study linked increased adipocity with the severity of pancreatitis.
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