메뉴 건너뛰기




Volumn 8, Issue 10, 2007, Pages 814-820

Genetic variation of estrogen metabolism and the risks of cardiovascular disease

Author keywords

Cardiovascular disease; Estrogen metabolism; Estrogen receptor; Genetic variant; Hormonal replacement therapy; Pharmacogenetics

Indexed keywords

4 HYDROXYESTRADIOL; ANDROSTENEDIONE; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; ATORVASTATIN; CYTOCHROME P450 19A1; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; DRUG METABOLIZING ENZYME; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTRONE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

EID: 34848826824     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (14)

References (54)
  • 1
    • 0242574365 scopus 로고    scopus 로고
    • Controversy of hormone treatment and cardiovascular function: Need for strengthened collaborations between preclinical and clinical scientists
    • Miller VM, Shuster LT, Hayes SN: Controversy of hormone treatment and cardiovascular function: Need for strengthened collaborations between preclinical and clinical scientists. Curr Opin Investig Drugs (2003) 4(10):1220-1232.
    • (2003) Curr Opin Investig Drugs , vol.4 , Issue.10 , pp. 1220-1232
    • Miller, V.M.1    Shuster, L.T.2    Hayes, S.N.3
  • 2
    • 0033542402 scopus 로고    scopus 로고
    • The protective effects of estrogen on the cardiovascular system
    • Mendelsohn ME, Karas RH: The protective effects of estrogen on the cardiovascular system. N Engl J Med (1999) 340(23):1801-1811.
    • (1999) N Engl J Med , vol.340 , Issue.23 , pp. 1801-1811
    • Mendelsohn, M.E.1    Karas, R.H.2
  • 3
    • 0032547326 scopus 로고    scopus 로고
    • Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E: Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/Progestin Replacement Study (HERS) Research Group. J Am Med Assoc (1998) 280(7):605-613. • This was the first randomized trial to consider the clinical cardiovascular effect of HRT in postmenopausal women with established CVD.
    • Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E: Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/Progestin Replacement Study (HERS) Research Group. J Am Med Assoc (1998) 280(7):605-613. • This was the first randomized trial to consider the clinical cardiovascular effect of HRT in postmenopausal women with established CVD.
  • 4
    • 0037125379 scopus 로고    scopus 로고
    • Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. J Am Med Assoc (2002) 288(3):321-333. • This is the largest prospective randomized controlled trial of clinical cardiovascular effects of HRT in healthy postmenopausal women.
    • Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. J Am Med Assoc (2002) 288(3):321-333. • This is the largest prospective randomized controlled trial of clinical cardiovascular effects of HRT in healthy postmenopausal women.
  • 5
    • 0035656115 scopus 로고    scopus 로고
    • Invited review: Pharmacogenetics of estrogen replacement therapy
    • Herrington DM, Klein KP: Invited review: Pharmacogenetics of estrogen replacement therapy. J Appl Physiol (2001) 91(6):2776-2784.
    • (2001) J Appl Physiol , vol.91 , Issue.6 , pp. 2776-2784
    • Herrington, D.M.1    Klein, K.P.2
  • 6
    • 0038407701 scopus 로고    scopus 로고
    • ER-α variants and the cardiovascular effects of hormone replacement therapy
    • Herrington DM, Howard TD: ER-α variants and the cardiovascular effects of hormone replacement therapy. Pharmacogenomics (2003) 4(3):269-277.
    • (2003) Pharmacogenomics , vol.4 , Issue.3 , pp. 269-277
    • Herrington, D.M.1    Howard, T.D.2
  • 7
    • 33644638521 scopus 로고    scopus 로고
    • Deroo BJ, Korach KS: Estrogen receptors and human disease. J Clin Invest (2006) 116(3):561-570. •• This review describes diseases in which estrogen, via action at ERs, plays a role in the development or severity of disease.
    • Deroo BJ, Korach KS: Estrogen receptors and human disease. J Clin Invest (2006) 116(3):561-570. •• This review describes diseases in which estrogen, via action at ERs, plays a role in the development or severity of disease.
  • 8
    • 0022653964 scopus 로고
    • Human oestrogen receptor cDNA: Sequence, expression and homology to v-erb-I
    • Green S, Walter P, Kumar V, Krust A, Bornert J-M, Argos P, Chambon P: Human oestrogen receptor cDNA: Sequence, expression and homology to v-erb-I. Nature (1986) 320(6058):134-139.
    • (1986) Nature , vol.320 , Issue.6058 , pp. 134-139
    • Green, S.1    Walter, P.2    Kumar, V.3    Krust, A.4    Bornert, J.-M.5    Argos, P.6    Chambon, P.7
  • 10
    • 0028204074 scopus 로고
    • Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women
    • Losordo DW, Kearney M, Kim EA, Jekanowski J, Isner JM: Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women. Circulation (1994) 89(4):1501-1510.
    • (1994) Circulation , vol.89 , Issue.4 , pp. 1501-1510
    • Losordo, D.W.1    Kearney, M.2    Kim, E.A.3    Jekanowski, J.4    Isner, J.M.5
  • 13
    • 0036093816 scopus 로고    scopus 로고
    • Association of estrogen receptor-α gene polymorphisms with coronary artery disease in patients with familial hypercholesterolemia
    • Lu H, Higashikata T, Inazu A, Nohara A, Yu W, Shimizu M, Mabuchi H: Association of estrogen receptor-α gene polymorphisms with coronary artery disease in patients with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol (2002) 22(5):817-823.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , Issue.5 , pp. 817-823
    • Lu, H.1    Higashikata, T.2    Inazu, A.3    Nohara, A.4    Yu, W.5    Shimizu, M.6    Mabuchi, H.7
  • 17
    • 33847102728 scopus 로고    scopus 로고
    • Kjaergaard AD, Ellervik C, Tybjaerg-Hansen A, Axelsson CK, Grønholdt ML, Grande P, Jensen GB, Nordestgaard BG: Estrogen receptor α polymorphism and risk of cardiovascular disease, cancer, and hip fracture: Cross-sectional, cohort, and case-control studies and a meta-analysis. Circulation (2007) 115(7):861-871. •• This paper reviews the main findings of association studies between the ESR1 gene and several diseases (mainly CVD).
    • Kjaergaard AD, Ellervik C, Tybjaerg-Hansen A, Axelsson CK, Grønholdt ML, Grande P, Jensen GB, Nordestgaard BG: Estrogen receptor α polymorphism and risk of cardiovascular disease, cancer, and hip fracture: Cross-sectional, cohort, and case-control studies and a meta-analysis. Circulation (2007) 115(7):861-871. •• This paper reviews the main findings of association studies between the ESR1 gene and several diseases (mainly CVD).
  • 20
    • 23744466600 scopus 로고    scopus 로고
    • de Padua Mansur, Nogueira CC, Strunz CM, Aldrighi JM, Ramires JA: Genetic polymorphisms of estrogen receptors in patients with premature coronary artery disease. Arch Med Res (2005) 36(5):511-517.
    • de Padua Mansur, Nogueira CC, Strunz CM, Aldrighi JM, Ramires JA: Genetic polymorphisms of estrogen receptors in patients with premature coronary artery disease. Arch Med Res (2005) 36(5):511-517.
  • 21
    • 33747873901 scopus 로고    scopus 로고
    • Sex steroid hormone polymorphisms, high-density lipoprotein cholesterol, and apolipoprotein A-1 from the Study of Women's Health Across the Nation (SWAN)
    • Sowers MR, Symons JP, Jannausch ML, Chu J, Kardia SR: Sex steroid hormone polymorphisms, high-density lipoprotein cholesterol, and apolipoprotein A-1 from the Study of Women's Health Across the Nation (SWAN). Am J Med (2006) 119(9 Suppl 1):S61-S68.
    • (2006) Am J Med , vol.119 , Issue.9 SUPPL. 1
    • Sowers, M.R.1    Symons, J.P.2    Jannausch, M.L.3    Chu, J.4    Kardia, S.R.5
  • 22
    • 33751086418 scopus 로고    scopus 로고
    • Estrogen receptor α gene polymorphism associated with type 2 diabetes mellitus and the serum lipid concentration in Chinese women in Guangzhou
    • Huang Q, Wang TH, Lu WS, Mu PW, Yang YF, Liang WW, Li CX, Lin GP: Estrogen receptor α gene polymorphism associated with type 2 diabetes mellitus and the serum lipid concentration in Chinese women in Guangzhou. Chin Med J (Engl) (2006) 119(21):1794-1801.
    • (2006) Chin Med J (Engl) , vol.119 , Issue.21 , pp. 1794-1801
    • Huang, Q.1    Wang, T.H.2    Lu, W.S.3    Mu, P.W.4    Yang, Y.F.5    Liang, W.W.6    Li, C.X.7    Lin, G.P.8
  • 25
    • 33645812891 scopus 로고    scopus 로고
    • Estrogen receptor 1 gene polymorphisms and coronary artery disease in the Brazilian population
    • Almeida S, Hutz MH: Estrogen receptor 1 gene polymorphisms and coronary artery disease in the Brazilian population. Braz J Med Biol Res (2006) 39(4):447-454.
    • (2006) Braz J Med Biol Res , vol.39 , Issue.4 , pp. 447-454
    • Almeida, S.1    Hutz, M.H.2
  • 27
    • 26944461954 scopus 로고    scopus 로고
    • No replication of association between estrogen receptor α gene polymorphisms and susceptibility to myocardial infarction in a large sample of patients of European descent
    • Koch W, Hoppmann P, Pfeufer A, Mueller JC, Schömig A, Kastrati A: No replication of association between estrogen receptor α gene polymorphisms and susceptibility to myocardial infarction in a large sample of patients of European descent. Circulation (2005) 112(14):2138- 2142.
    • (2005) Circulation , vol.112 , Issue.14 , pp. 2138-2142
    • Koch, W.1    Hoppmann, P.2    Pfeufer, A.3    Mueller, J.C.4    Schömig, A.5    Kastrati, A.6
  • 28
    • 33745474648 scopus 로고    scopus 로고
    • Estrogen receptor 1 haplotype does not regulate oral contraceptive-induced changes in haemostasis and inflammation risk factors for venous and arterial thrombosis
    • de Maat MP, Bladbjerg EM, Kluft C, Winkler UH, Rekers H, Skouby SO, Jespersen J: Estrogen receptor 1 haplotype does not regulate oral contraceptive-induced changes in haemostasis and inflammation risk factors for venous and arterial thrombosis. Hum Reprod (2006) 21(6):1473-1476.
    • (2006) Hum Reprod , vol.21 , Issue.6 , pp. 1473-1476
    • de Maat, M.P.1    Bladbjerg, E.M.2    Kluft, C.3    Winkler, U.H.4    Rekers, H.5    Skouby, S.O.6    Jespersen, J.7
  • 29
    • 2942735177 scopus 로고    scopus 로고
    • Sex differences and genetic associations with myocardial infarction
    • Newton-Cheh C, O'Donnell CJ: Sex differences and genetic associations with myocardial infarction. J Am Med Assoc (2004) 291(24):3008-3010.
    • (2004) J Am Med Assoc , vol.291 , Issue.24 , pp. 3008-3010
    • Newton-Cheh, C.1    O'Donnell, C.J.2
  • 32
    • 24944512406 scopus 로고    scopus 로고
    • Estrogen-induced changes in IGF-I, Myb family and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines
    • Swartz CD, Afshari CA, Yu L, Hall KE, Dixon D: Estrogen-induced changes in IGF-I, Myb family and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines. Mol Hum Reprod (2005) 11(6):441-450.
    • (2005) Mol Hum Reprod , vol.11 , Issue.6 , pp. 441-450
    • Swartz, C.D.1    Afshari, C.A.2    Yu, L.3    Hall, K.E.4    Dixon, D.5
  • 33
  • 34
    • 33745264409 scopus 로고    scopus 로고
    • Estrogen receptor α and β polymorphisms: Is there an association with bone mineral density, plasma lipids, and response to postmenopausal hormone therapy?
    • Silvestri S, Thomsen AB, Gozzini A, Bagger Y, Christiansen C, Brandi ML: Estrogen receptor α and β polymorphisms: Is there an association with bone mineral density, plasma lipids, and response to postmenopausal hormone therapy? Menopause (2006) 13(3):451-461.
    • (2006) Menopause , vol.13 , Issue.3 , pp. 451-461
    • Silvestri, S.1    Thomsen, A.B.2    Gozzini, A.3    Bagger, Y.4    Christiansen, C.5    Brandi, M.L.6
  • 36
    • 33745439481 scopus 로고    scopus 로고
    • The association of oestrogen receptor α-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study
    • Lawlor DA, Timpson N, Ebrahim S, Day IN, Smith GD: The association of oestrogen receptor α-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study. Eur Heart J (2006) 27(13):1597-1604.
    • (2006) Eur Heart J , vol.27 , Issue.13 , pp. 1597-1604
    • Lawlor, D.A.1    Timpson, N.2    Ebrahim, S.3    Day, I.N.4    Smith, G.D.5
  • 37
    • 13244249775 scopus 로고    scopus 로고
    • Gender-specific effects of estrogen receptor α gene haplotype on high-density lipoprotein cholesterol response to atorvastatin: Interaction with apolipoprotein AI gene polymorphism
    • Kajinami K, Brousseau ME, Lamon-Fava S, Ordovas JM, Schaefer EJ: Gender-specific effects of estrogen receptor α gene haplotype on high-density lipoprotein cholesterol response to atorvastatin: Interaction with apolipoprotein AI gene polymorphism. Atherosclerosis (2005) 178(2):331-338.
    • (2005) Atherosclerosis , vol.178 , Issue.2 , pp. 331-338
    • Kajinami, K.1    Brousseau, M.E.2    Lamon-Fava, S.3    Ordovas, J.M.4    Schaefer, E.J.5
  • 39
    • 13544274426 scopus 로고    scopus 로고
    • Estrogen receptor 2 and progesterone receptor gene polymorphisms and lipid levels in women with different hormonal status
    • Almeida S, Franken N, Zandoná MR, Osório-Wender MC, Hutz MH: Estrogen receptor 2 and progesterone receptor gene polymorphisms and lipid levels in women with different hormonal status. Pharmacogenomics J (2005) 5(1):30-34.
    • (2005) Pharmacogenomics J , vol.5 , Issue.1 , pp. 30-34
    • Almeida, S.1    Franken, N.2    Zandoná, M.R.3    Osório-Wender, M.C.4    Hutz, M.H.5
  • 41
    • 0036344440 scopus 로고    scopus 로고
    • No major effect of estrogen receptor β gene RsaI polymorphism on bone mineral density and response to alendronate therapy in postmenopausal osteoporosis
    • Arko B, Prezelj J, Komel R, Kocijancic A, Marc J: No major effect of estrogen receptor β gene RsaI polymorphism on bone mineral density and response to alendronate therapy in postmenopausal osteoporosis. J Steroid Biochem Mol Biol (2002) 81(2):147-152.
    • (2002) J Steroid Biochem Mol Biol , vol.81 , Issue.2 , pp. 147-152
    • Arko, B.1    Prezelj, J.2    Komel, R.3    Kocijancic, A.4    Marc, J.5
  • 42
    • 0037320652 scopus 로고    scopus 로고
    • Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor
    • Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV: Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet (2003) 12(3):205-216.
    • (2003) Hum Mol Genet , vol.12 , Issue.3 , pp. 205-216
    • Duan, J.1    Wainwright, M.S.2    Comeron, J.M.3    Saitou, N.4    Sanders, A.R.5    Gelernter, J.6    Gejman, P.V.7
  • 43
    • 0034807672 scopus 로고    scopus 로고
    • Dubey RK, Jackson EK: Cardiovascular protective effects of 17β-estradiol metabolites. J Appl Physiol (2001) 91(4):1868-1883. • The effects of estrogen metabolites on the cardiovascular system are reported and discussed in this paper
    • Dubey RK, Jackson EK: Cardiovascular protective effects of 17β-estradiol metabolites. J Appl Physiol (2001) 91(4):1868-1883. • The effects of estrogen metabolites on the cardiovascular system are reported and discussed in this paper.
  • 44
    • 0036753586 scopus 로고    scopus 로고
    • The origin of postmenopausal oestrogens
    • Neven P: The origin of postmenopausal oestrogens. Eur J Cancer (2002) 38(Suppl 6):S29-S30.
    • (2002) Eur J Cancer , vol.38 , Issue.SUPPL. 6
    • Neven, P.1
  • 45
    • 0034800442 scopus 로고    scopus 로고
    • Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16α-hydroxylation of 17β-estradiol
    • Badawi AF, Cavalieri EL, Rogan EG: Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16α-hydroxylation of 17β-estradiol. Metabolism (2001) 50(9):1001-1003.
    • (2001) Metabolism , vol.50 , Issue.9 , pp. 1001-1003
    • Badawi, A.F.1    Cavalieri, E.L.2    Rogan, E.G.3
  • 46
    • 0042315387 scopus 로고    scopus 로고
    • Lee AJ, Cai MX, Thomas PE, Conney AH, Zhu BT: Characterization of the oxidative metabolites of 17β-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology (2003) 144(8):3382-3398. •• In this paper, the oxidative metabolites of 17 β-estradiol and estrone formed by 15 human CYP isoforms are characterized. Many human CYP isoforms are involved in the oxidative metabolism of endogenous estrogen, with a varying degree of catalytic activity and distinct regioselectivity.
    • Lee AJ, Cai MX, Thomas PE, Conney AH, Zhu BT: Characterization of the oxidative metabolites of 17β-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology (2003) 144(8):3382-3398. •• In this paper, the oxidative metabolites of 17 β-estradiol and estrone formed by 15 human CYP isoforms are characterized. Many human CYP isoforms are involved in the oxidative metabolism of endogenous estrogen, with a varying degree of catalytic activity and distinct regioselectivity.
  • 47
    • 0034047067 scopus 로고    scopus 로고
    • Progression of human breast cancers to the metastatic state is linked to genotypes of catechol-Omethyltransferase
    • Matsui A, Ikeda T, Enomoto K, Nakashima H, Omae K, Watanabe M, Hibi T, Kitajima M: Progression of human breast cancers to the metastatic state is linked to genotypes of catechol-Omethyltransferase. Cancer Lett (2000) 150(1):23-31.
    • (2000) Cancer Lett , vol.150 , Issue.1 , pp. 23-31
    • Matsui, A.1    Ikeda, T.2    Enomoto, K.3    Nakashima, H.4    Omae, K.5    Watanabe, M.6    Hibi, T.7    Kitajima, M.8
  • 49
    • 33644675781 scopus 로고    scopus 로고
    • Almeida S, Zandoná MR, Franken N, Callegari-Jacques SM, Osório-Wender MC, Hutz MH: Estrogen-metabolizing gene polymorphisms and lipid levels in women with different hormonal status. Pharmacogenomics J (2005) 5(6):346-351. •• This paper was the first to suggest that estrogen-metabolizing genes might be associated with lipid levels and CVD.
    • Almeida S, Zandoná MR, Franken N, Callegari-Jacques SM, Osório-Wender MC, Hutz MH: Estrogen-metabolizing gene polymorphisms and lipid levels in women with different hormonal status. Pharmacogenomics J (2005) 5(6):346-351. •• This paper was the first to suggest that estrogen-metabolizing genes might be associated with lipid levels and CVD.
  • 50
    • 0032547341 scopus 로고    scopus 로고
    • Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
    • Rebbeck TR, Jaffe JM, Walker AH, Wein AJ, Malkowicz SB: Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4. J Natl Cancer Inst (1998) 90(16): 1225-1229.
    • (1998) J Natl Cancer Inst , vol.90 , Issue.16 , pp. 1225-1229
    • Rebbeck, T.R.1    Jaffe, J.M.2    Walker, A.H.3    Wein, A.J.4    Malkowicz, S.B.5
  • 52
    • 0025737529 scopus 로고
    • PCR detection of an A/G polymorphism within exon 7 of the CYP1A1 gene
    • Hayashi S, Watanabe J, Nakachi K, Kawajiri K: PCR detection of an A/G polymorphism within exon 7 of the CYP1A1 gene. Nucleic Acids Res (1991) 19(17):4797.
    • (1991) Nucleic Acids Res , vol.19 , Issue.17 , pp. 4797
    • Hayashi, S.1    Watanabe, J.2    Nakachi, K.3    Kawajiri, K.4
  • 53
    • 0031715548 scopus 로고    scopus 로고
    • The role of ethnicity in cancer susceptibility gene polymorphisms: The example of CYP1A1
    • Garte S: The role of ethnicity in cancer susceptibility gene polymorphisms: The example of CYP1A1. Carcinogenesis (1998) 19(8):1329-1332.
    • (1998) Carcinogenesis , vol.19 , Issue.8 , pp. 1329-1332
    • Garte, S.1
  • 54
    • 0031848636 scopus 로고    scopus 로고
    • Functional role of estrogen metabolism in target cells: Review and perspectives
    • Zhu BT, Conney AH: Functional role of estrogen metabolism in target cells: Review and perspectives. Carcinogenesis (1998) 19(1):1-27.
    • (1998) Carcinogenesis , vol.19 , Issue.1 , pp. 1-27
    • Zhu, B.T.1    Conney, A.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.