Efficient growth inhibition of ErbB2-overexpressing tumor cells by anti-ErbB2 ScFv-Fc-IL-2 fusion protein in vitro and in vivo

Acta Pharmacologica Sinica

Volumn 28, Issue 10, 2007, Pages 1611-1620

  Shi, Ming ^a   Zhang, Ling ^b   Gu, Hong Tao ^b   Jiang, Feng Qin ^b   Qian, Lu ^a   Yu, Ming ^a   Chen, Guo Jiang ^a   Luo, Qun ^c   Shen, Bei Fen ^a   Guo, Ning ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Antibody; ErbB2; Fusion protein; Interleukin 2; Tumor

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; HERCEPTIN IMMUNOGLOBULIN FC FRAGMENT INTERLEUKIN 2 FUSION PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; LACTATE DEHYDROGENASE; RECOMBINANT INTERLEUKIN 2; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CANCER INHIBITION; CANCER MODEL; COLORIMETRY; CONTROLLED STUDY; COVALENT BOND; CYTOLYSIS; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SPECIFICITY; ENZYME ASSAY; ENZYME RELEASE; FEMALE; GENETIC ENGINEERING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OVARY CARCINOMA; PROTEIN EXPRESSION; PROTEIN FOLDING; TUMOR CELL; TUMOR XENOGRAFT;

ANIMALS; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CELL LINE, TUMOR; FEMALE; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN VARIABLE REGION; INTERLEUKIN-2; MICE; MICE, INBRED BALB C; MICE, NUDE; OVARIAN NEOPLASMS; RECEPTOR, ERBB-2; RECOMBINANT FUSION PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 34848817958     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00622.x     Document Type: Article

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