Fungal infections in primary immunodeficiencies

European Journal of Pediatrics

Volumn 166, Issue 11, 2007, Pages 1099-1117

  Antachopoulos, Charalampos ^a,b   Walsh, Thomas J ^a   Roilides, Emmanuel ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Antifungal agents; Aspergillus; Candida; Fungal infections; Primary immunodeficiencies

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B CHOLESTEROL SULFATE; AMPHOTERICIN B DEOXYCHOLATE; AMPHOTERICIN B LIPID COMPLEX; ANTIFUNGAL AGENT; CASPOFUNGIN; ECHINOCANDIN; FLUCONAZOLE; FLUCYTOSINE; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOLOGIC AGENT; INFLIXIMAB; ITRACONAZOLE; KETOCONAZOLE; LIVER ENZYME; MICONAZOLE; POSACONAZOLE; RAVUCONAZOLE; STEROID; TERBINAFINE; TRIAZOLE; TRIAZOLE DERIVATIVE; VORICONAZOLE;

ADAPTIVE IMMUNITY; ASPERGILLOSIS; ASPERGILLUS; BRAIN ABSCESS; CANDIDA; CENTRAL NERVOUS SYSTEM INFECTION; CHEDIAK HIGASHI SYNDROME; CHRONIC GRANULOMATOUS DISEASE; CLINICAL TRIAL; COMBINED IMMUNODEFICIENCY; COMMON VARIABLE IMMUNODEFICIENCY; COMPLEMENT DEFICIENCY; CRYPTOCOCCUS; DIAGNOSTIC ERROR; DIAGNOSTIC IMAGING; DIGEORGE SYNDROME; DISEASE ASSOCIATION; DISORDERS OF DNA SYNTHESIS AND REPAIR; DRUG ERUPTION; DRUG FEVER; DRUG INDUCED HEADACHE; FATALITY; HUMAN; HYPERIMMUNOGLOBULINEMIA M; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOGLOBULIN A DEFICIENCY; IMMUNOTHERAPY; INFECTION RISK; INFECTION SENSITIVITY; INJECTION SITE REACTION; INNATE IMMUNITY; LEUKOCYTE ADHESION DEFICIENCY; LUNG ABSCESS; LUNG ASPERGILLOSIS; LUNG INFECTION; MORBIDITY; MORTALITY; MUCOCUTANEOUS CANDIDIASIS; MYCETOMA; MYCOSIS; MYELOPEROXIDASE DEFICIENCY; NEPHROTOXICITY; NEUTROPENIA; NONHUMAN; OSTEOMYELITIS; PERICARDITIS; PLEURISY; PNEUMOCYSTIS CARINII; PNEUMOCYSTIS JIROVECI; PNEUMONIA; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; REVIEW; SIDE EFFECT; SKIN INFECTION; SOFT TISSUE INFECTION; SPLEEN ABSCESS; STATISTICAL SIGNIFICANCE; THERAPEUTIC ERROR; TRICHOSPORON; X LINKED AGAMMAGLOBULINEMIA;

ANTIBODY FORMATION; ASPERGILLOSIS; DISEASE SUSCEPTIBILITY; GRANULOMATOUS DISEASE, CHRONIC; HUMANS; IMMUNITY, CELLULAR; IMMUNOLOGIC DEFICIENCY SYNDROMES; MYCOSES;

EID: 34748907802     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00431-007-0527-7     Document Type: Review

References (196)

1. Aguilar C, Pujol I, Sala J, Guarro J (1998) Antifungal susceptibilities of Paecilomyces species. Antimicrob Agents Chemother 42:1601-1604
2. Aihara Y, Mori M, Yokota S (1996) Successful treatment of onychomycosis with fluconazole in two patients with hyperimmunoglobulin E syndrome. Pediatr Dermatol 13:493-495
3. Alberti-Flor JJ, Granda A (1986) Ileocecal histoplasmosis mimicking Crohn's disease in a patient with Job's syndrome. Digestion 33:176-180
4. Almyroudis NG, Holland SM, Segal BH (2005) Invasive aspergillosis in primary immunodeficiencies. Med Mycol 43(1):S247-259
5. Alsultan A, Williams MS, Lubner S, Goldman FD (2006) Chronic granulomatous disease presenting with disseminated intracranial aspergillosis. Pediatr Blood Cancer 47:107-110
6. Antachopoulos C, Roilides E (2005) Cytokines and fungal infections. Br J Haematol 129:583-596
7. Aratani Y, Koyama H, Nyui S, Suzuki K, Kura F, Maeda N (1999) Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect Immun 67:1828-1836
8. Aratani Y, Kura F, Watanabe H, Akagawa H, Takano Y, Suzuki K, Maeda N, Koyama H (2000) Differential host susceptibility to pulmonary infections with bacteria and fungi in mice deficient in myeloperoxidase. J Infect Dis 182:1276-1279
9. Assari T (2006) Chronic granulomatous disease; fundamental stages in our understanding of CGD. Med Immunol 5:4
10. Bakir M, Cerikcioglu N, Tirtir A, Berrak S, Ozek E, Canpolat C (2004) Pichia anomala fungaemia in immunocompromised children. Mycoses 47:231-235
11. Bernhisel-Broadbent J, Camargo EE, Jaffe HS, Lederman HM (1991) Recombinant human interferon-gamma as adjunct therapy for Aspergillus infection in a patient with chronic granulomatous disease. J Infect Dis 163:908-911
12. Bhat SV, Paterson DL, Rinaldi MG, Veldkamp PJ (2007) Scedosporium prolificans brain abscess in a patient with chronic granulomatous disease: successful combination therapy with voriconazole and terbinafine. Scand J Infect Dis 39:87-90
13. Bielorai B, Toren A, Wolach B, Mandel M, Golan H, Neumann Y, Kaplinisky C, Weintraub M, Keller N, Amariglio N, Paswell J, Rechavi G (2000) Successful treatment of invasive aspergillosis in chronic granulomatous disease by granulocyte transfusions followed by peripheral blood stem cell transplantation. Bone Marrow Transplant 26:1025-1028
14. Bode CP, Schroten H, Koletzko S, Lubke H, Wahn V (1996) Transient achalasia-like esophageal motility disorder after Candida esophagitis in a boy with chronic granulomatous disease. J Pediatr Gastroenterol Nutr 23:320-323
15. Boltansky H, Kwon-Chung KJ, Macher AM, Gallin JI (1984) Acremonium strictum-related pulmonary infection in a patient with chronic granulomatous disease. J Infect Dis 149:653
16. Borges WG, Augustine NH, Hill HR (2000) Defective interleukin-12/ interferon-gamma pathway in patients with hyperimmunoglobulinemia E syndrome. J Pediatr 136:176-180
17. Briones MA, Josephson CD, Hillyer CD (2003) Granulocyte transfusion: revisited. Curr Hematol Rep 2:522-527
18. Brown JR, Goldblatt D, Buddle J, Morton L, Thrasher AJ (2003) Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD). J Leukoc Biol 73:591-599
19. Buckley RH (2002) Primary cellular immunodeficiencies. J Allergy Clin Immunol 109:747-757
20. Buckley RH (2000) Primary immunodeficiency diseases due to defects in lymphocytes. N Engl J Med 343:1313-1324
21. Cappell MS, Manzione NC (1991) Recurrent colonic histoplasmosis after standard therapy with amphotericin B in a patient with Job's syndrome. Am J Gastroenterol 86:119-120
22. Carlsson G, Fasth A (2001) Infantile genetic agranulocytosis, morbus Kostmann: presentation of six cases from the original "Kostmann family" and a review. Acta Paediatr 90:757-764
23. Carrillo AJ, Guarro J (2001) In vitro activities of four novel triazoles against Scedosporium spp. Antimicrob Agents Chemother 45:2151-2153
24. Casadevall A, Cassone A, Bistoni F, Cutler JE, Magliani W, Murphy JW, Polonelli L, Romani L (1998) Antibody and/or cell-mediated immunity, protective mechanisms in fungal disease: an ongoing dilemma or an unnecessary dispute? Med Mycol 36(1):95-105
25. Casson DH, Riordan FA, Ladusens EJ (1996) Aspergillus endocarditis in chronic granulomatous disease. Acta Paediatr 85:758-759
26. Cassone A, De Bernardis F, Torososantucci A (2005) An outline of the role of anti-Candida antibodies within the context of passive immunization and protection from candidiasis. Curr Mol Med 5:377-382
27. Cech P, Stalder H, Widmann JJ, Rohner A, Miescher PA (1979) Leukocyte myeloperoxidase deficiency and diabetes mellitus associated with Candida albicans liver abscess. Am J Med 66:149-153
28. Chakrabarti A, Marhawa RK, Mondal R, Trehan A, Gupta S, Rao Raman DS, Sethi S, Padhyet AA (2002) Generalized lymphadenopathy caused by Trichosporon asahii in a patient with Job's syndrome. Med Mycol 40:83-86
29. Chamilos G, Kontoyiannis DP (2005) Voriconazole-resistant disseminated Paecilomyces variotii infection in a neutropenic patient with leukaemia on voriconazole prophylaxis. J Infect 51:e225-e228
30. Chehimi J, Elder M, Greene J, Noroski L, Stiehm ER, Winkelstein JA, Sullivan KE (2001) Cytokine and chemokine dysregulation in hyper-IgE syndrome. Clin Immunol 100:49-56
31. Chiang AK, Chan GC, Ma SK, Ng YK, Ha SY, Lau YL (2000) Disseminated fungal infection associated with myeloperoxidase deficiency in a premature neonate. Pediatr Infect Dis J 19:1027-1029
32. Cohen MS, Isturiz RE, Malech HL, Root RK, Wilfert CM, Gutman L, Buckley RH (1981) Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi. Am J Med 71:59-66
33. Cohen-Abbo A, Edwards KM (1995) Multifocal osteomyelitis caused by Paecilomyces variotii in a patient with chronic granulomatous disease. Infection 23:55-57
34. Couch JR, Romyg DA (1977) Histoplasma meningitis with common variable hypogammaglobulinemia. Neurol Neurocir Psiquiatr 18:403-412
35. Cramer R, Soranzo MR, Dri P, Rottini GD, Bramezza M, Cirielli S, Patriarca P (1982) Incidence of myeloperoxidase deficiency in an area of northern Italy: histochemical, biochemical and functional studies. Br J Haematol 51:81-87
36. Cutler JE, Deepe GS Jr, Klein BS (2007) Advances in combating fungal diseases: vaccines on the threshold. Nat Rev Microbiol 5:13-28
37. Dallorso S, Manzitti C, Dodero P, Faraci M, Rosanda C, Castagnola E (2003) Uneventful outcome of unrelated hematopoietic stem cell transplantation in a patient with leukemic transformation of Kostmann syndrome and long-lasting invasive pulmonary mycosis. Eur J Haematol 70:322-325
38. Del Poeta M, Schell WA, Perfect JR (1997) In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds. Antimicrob Agents Chemother 41:1835-1836
39. Dennis CG, Greco WR, Brun Y, Youn R, Slocum HK, Bernacki RJ, Lewis R, Wiederhold N, Holland SM, Petraitiene R, Walsh TJ, Segal BH (2006) Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease. Antimicrob Agents Chemother 50:422-427
40. Diamond RD, Clark RA (1982) Damage to Aspergillus fumigatus and Rhizopus oryzae hyphae by oxidative and nonoxidative microbicidal products of human neutrophils in vitro. Infect Immun 38:487-495
41. Djalilian AR, Smith JA, Walsh TJ, Malech HL, Robinson MR (2001) Keratitis caused by Candida glabrata in a patient with chronic granulomatous disease. Am J Ophthalmol 132:782-783
42. Dotis J, Panagopoulou P, Filioti J, Winn R, Toptsis C, Panteliadis C, Roilides E (2003) Femoral osteomyelitis due to Aspergillus nidulans in a patient with chronic granulomatous disease. Infection 31:121-124
43. Dotis J, Roilides E (2004) Osteomyelitis due to Aspergillus spp. in patients with chronic granulomatous disease: comparison of Aspergillus nidulans and Aspergillus fumigatus. Int J Infect Dis 8:103-110
44. Edman JC, Kovacs JA, Masur H, Santi DV, Elwood HJ, Sogin ML (1988) Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the fungi. Nature 334:519-522
45. Estrada B, Mancao MY, Polski JM, Figarola MS (2006) Candida lusitaniae and chronic granulomatous disease. Pediatr Infect Dis J 25:758-759
46. Ezekowitz RA, Dinauer MC, Jaffe HS, Orkin SH, Newburger PE (1988) Partial correction of the phagocyte defect in patients with X-linked chronic granulomatous disease by subcutaneous interferon gamma. N Engl J Med 319:146-151
47. Ezekowitz RA, Orkin SH, Newburger PE (1987) Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease. J Clin Invest 80:1009-1016
48. Fischer A, Lisowska-Grospierre B, Anderson DC, Springer TA (1988) Leukocyte adhesion deficiency: molecular basis and functional consequences. Immunodefic Rev 1:39-54
49. Fleischmann J, Church JA, Lehrer RI (1986) Primary Candida meningitis and chronic granulomatous disease. Am J Med Sci 291:334-341
50. Fogarty L (1996) Thrush and septic shock in a two-month-old. Pediatr Infect Dis J 15:553-554, 559-560
51. Freeman AF, Kleiner DE, Nadiminti H, Davis J, Quezado M, Anderson V, Puck JM, Holland SM (2007) Causes of death in hyper-IgE syndrome. J Allergy Clin Immunol 119:1234-1240
52. Galimberti R, Kowalczuk A, Hidalgo Parra I, Gonzalez Ramos M, Flores V (1998) Cutaneous aspergillosis: a report of six cases. Br J Dermatol 139:522-526
53. Gallin JI, Alling DW, Malech HL, Wesley R, Koziol D, Marciano B, Eisenstein EM, Turner ML, DeCarlo ES, Starling JM, Holland SM (2003) Itraconazole to prevent fungal infections in chronic granulomatous disease. N Engl J Med 348:2416-2422
54. Garty BZ, Wolach B, Ashkenazi S, Weismart Y, Rachmel A, Nitzan M (1995) Cryptococcal meningitis in a child with hyperimmunoglobulin E syndrome. Pediatr Allergy Immunol 6:175-177
55. Goldman DL, Khine H, Abadi J, Lindenberg DJ, Pirofski L, Niang R, Casadevall A (2001) Serologic evidence for Cryptococcus neoformans infection in early childhood. Pediatrics 107:E66
56. Gompels MM, Bethune CA, Jackson G, Spickett GP (2002) Scedosporium apiospermum in chronic granulomatous disease treated with an HLA matched bone marrow transplant. J Clin Pathol 55:784-786
57. Grimbacher B, Holland SM, Gallin JI, Greenberg F, Hill SC, Malech HL, Miller JA, O'Connell AC, Puck JM (1999) Hyper-IgE syndrome with recurrent infections-an autosomal dominant multisystem disorder. N Engl J Med 340:692-702
58. Hall RA, Salhany KE, Lebel E, Bavaria JE, Kaiser LR (1995) Fungal pulmonary abscess in an adult secondary to hyperimmunoglobulin E (Job's) syndrome. Ann Thorac Surg 59:759-761
59. Haslett RS, Moriarty AP, Vijayadurai P, McGalliard JN, Chandna A (1996) Candida endophthalmitis in Job syndrome. Arch Ophthalmol 114:617-618
60. Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, Oestmann JW, Kern WV, Marr KA, Ribaud P, Lortholary O, Sylvester R, Rubin RH, Wingard JR, Stark P, Durand C, Caillot D, Thiel E, Chandrasekar PH, Hodges MR, Schlamm HT, Troke PF, de Pauw B (2002) Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med 347:408-415
61. Herbrecht R, Letscher-Bru V, Oprea C, Lioure B, Waller J, Campos F, Villard O, Liu KL, Natarajan-Ame S, Lutz P, Dufour P, Bergerat JP, Candolfi E (2002) Aspergillus galactomannan detection in the diagnosis of invasive aspergillosis in cancer patients. J Clin Oncol 20:1898-1906
62. Heyworth PG, Cross AR, Curnutte JT (2003) Chronic granulomatous disease. Curr Opin Immunol 15:578-584
63. Hostoffer RW, Berger M, Clark HT, Schreiber JR (1994) Disseminated Histoplasma capsulatum in a patient with hyper IgM immunodeficiency. Pediatrics 94:234-236
64. Huffnagle GB, Deepe GS (2003) Innate and adaptive determinants of host susceptibility to medically important fungi. Curr Opin Microbiol 6:344-350
65. Hutto JO, Bryan CS, Greene FL, White CJ, Gallin JI (1988) Cryptococcosis of the colon resembling Crohn's disease in a patient with the hyperimmunoglobulinemia E-recurrent infection (Job's) syndrome. Gastroenterology 94:808-812
66. Ikinciogullari A, Dogu F, Solaz N, Reisli I, Kemahli S, Cin S, Babacan E (2005) Granulocyte transfusions in children with chronic granulomatous disease and invasive aspergillosis. Ther Apher Dial 9:137-141
67. Illerhaus G, Wirth K, Dwenger A, Waller CF, Garbe A, Brass V, Lang H, Lange W (2002) Treatment and prophylaxis of severe infections in neutropenic patients by granulocyte transfusions. Ann Hematol 81:273-281
68. Imai K, Morio T, Zhu Y, Jin Y, Itoh S, Kajiwara M, Yata J, Mizutani S, Ochs HD, Nonoyama S (2004) Clinical course of patients with WASP gene mutations. Blood 103:456-464
69. Iseki M, Anzo M, Yamashita N, Matsuo N (1994) Hyper-IgM immunodeficiency with disseminated cryptococcosis. Acta Paediatr 83:780-782
70. Jabado N, Casanova JL, Haddad E, Dulieu F, Fournet JC, Dupont B, Fischer A, Hennequin C, Blanche S (1998) Invasive pulmonary infection due to Scedosporium apiospermum in two children with chronic granulomatous disease. Clin Infect Dis 27:1437-1441
71. Jacobs DH, Macher AM, Handler R, Bennett JE, Collen MJ, Gallin JI (1984) Esophageal cryptococcosis in a patient with the hyperimmunoglobulin E-recurrent infection (Job's) syndrome. Gastroenterology 87:201-203
72. Johnston RB Jr, Baehner RL (1971) Chronic granulomatous disease: correlation between pathogenesis and clinical findings. Pediatrics 48:730-739
73. Kane S, Brasitus T (2000) Histoplasmosis capsulatum as a cause of lower gastrointestinal bleeding in common variable immunodeficiency. Dig Dis Sci 45:2133-2135
74. Kenney RT, Kwon-Chung KJ, Waytes AT, Melnick DA, Pass HI, Merino MJ, Gallin JI (1992) Successful treatment of systemic Exophiala dermatitidis infection in a patient with chronic granulomatous disease. Clin Infect Dis 14:235-242
75. Kenney RT, Kwon-Chung KJ, Witebsky FG, Melnick DA, Malech HL, Gallin JI (1990) Invasive infection with Sarcinosporon inkin in a patient with chronic granulomatous disease. Am J Clin Pathol 94:344-350
76. Kim M, Shin JH, Suh SP, Ryang DW, Park CS, Kim C, Kook H, Kim J (1997) Aspergillus nidulans infection in a patient with chronic granulomatous disease. J Korean Med Sci 12:244-248
77. Kirkpatrick CH (2001) Chronic mucocutaneous candidiasis. Pediatr Infect Dis J 20:197-206
78. Kobayashi S, Murayama S, Tatsuzawa O, Koinuma G, Kawasaki K, Kiyotani C, Kumagai M (2006) X-linked severe combined immunodeficiency (X-SCID) with high blood levels of immunoglobulins and Aspergillus pneumonia successfully treated with micafangin followed by unrelated cord blood stem cell transplantation. Eur J Pediatr 166:207-210
79. Kosut JS, Kamani NR, Jantausch BA (2006) One-month-old infant with multilobar round pneumonias. Pediatr Infect Dis J 25:95-97
80. Kuijpers TW, van Bruggen R, Kamerbeek N, Tool AT, Hicsonmez G, Gurgey A, Karow A, Verhoeven AJ, Seeger K, Sanal O, Niemeyer C, Roos D (2007) Natural history and early diagnosis of LAD-1/variant syndrome. Blood 109:3529-3537
81. Kumar A, Teuber SS, Gershwin ME (2006) Current perspectives on primary immunodeficiency diseases. Clin Dev Immunol 13:223-259
82. Lanza F (1998) Clinical manifestation of myeloperoxidase deficiency. J Mol Med 76:676-681
83. Lau YL, Yuen KY, Lee CW, Chan CF (1995) Invasive Acremonium falciforme infection in a patient with severe combined immunodeficiency. Clin Infect Dis 20:197-198
84. Lazarus GM, Neu HC (1975) Agents responsible for infection in chronic granulomatous disease of childhood. J Pediatr 86:415-417
85. Lee MY, Chung JH, Shin JH, Hwang TJ, Kim KS, Lee JH, Nam JH, Lee MC, Park CS, Juhng SW, Choi C (2001) Lymphonodular cryptococcosis diagnosed by fine needle aspiration cytology in hyper-IgM syndrome. A case report. Acta Cytol 45:241-244
86. Lehrer RI, Cline MJ (1969) Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection. J Clin Invest 48:1478-1488
87. Lekstrom-Himes JA, Gallin JI (2000) Immunodeficiency diseases caused by defects in phagocytes. N Engl J Med 343:1703-1714
88. Lestini BJ, Church JA (2006) Trichosporon pullulans as a complication of chronic granulomatous disease in a patient undergoing immunosuppressive therapy for inflammatory bowel disease. Pediatr Infect Dis J 25:87-89
89. Levy O, Bourquin JP, McQueen A, Cantor AB, Lachenauer C, Malley R (2002) Fatal disseminated Candida lusitaniae infection in an infant with chronic granulomatous disease. Pediatr Infect Dis J 21:262-264
90. Liese J, Kloos S, Jendrossek V, Petropoulou T, Wintergerst U, Notheis G, Gahr M, Belohradsky BH (2000) Long-term follow-up and outcome of 39 patients with chronic granulomatous disease. J Pediatr 137:687-693
91. Lilic D (2002) New perspectives on the immunology of chronic mucocutaneous candidiasis. Curr Opin Infect Dis 15:143-147
92. Lin WC, Dai YS, Tsai MJ, Huang LM, Chiang BL (1998) Systemic Penicillium marneffei infection in a child with common variable immunodeficiency. J Formos Med Assoc 97:780-783
93. Lindegren ML, Kobrynski L, Rasmussen SA, Moore CA, Grosse SD, Vanderford ML, Spira TJ, McDougal JS, Vogt RF Jr, Hannon WH, Kalman LV, Chen B, Mattson M, Baker TG, Khoury M (2004) Applying public health strategies to primary immunodeficiency diseases: a potential approach to genetic disorders. MMWR Recomm Rep 53:1-29
94. Ludviksson BR, Thorarensen O, Gudnason T, Halldorsson S (1993) Candida albicans meningitis in a child with myeloperoxidase deficiency. Pediatr Infect Dis J 12:162-164
95. Macura AB, Macura-Biegun A, Pawlik B (2003) Susceptibility to fungal infections of nails in patients with primary antibody deficiency. Comp Immunol Microbiol Infect Dis 26:223-232
96. Maertens J, Raad I, Petrikkos G, Boogaerts M, Selleslag D, Petersen FB, Sable CA, Kartsonis NA, Ngai A, Taylor A, Patterson TF, Denning DW, Walsh TJ (2004) Efficacy and safety of caspofungin for treatment of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapy. Clin Infect Dis 39:1563-1571
97. Malmvall BE, Follin P (1993) Successful interferon-gamma therapy in a chronic granulomatous disease (CGD) patient suffering from Staphylococcus aureus hepatic abscess and invasive Candida albicans infection. Scand J Infect Dis 25:61-66
98. Mamishi S, Fattahi F, Radmanesh A, Mahjoub F, Pourpak Z (2005) Anterior chest wall protrusion as initial presentation of chronic granulomatous disease: a case report. Pediatr Allergy Immunol 16:685-687
99. Mamishi S, Parvaneh N, Salavati A, Abdollahzadeh S, Yeganeh M (2007) Invasive aspergillosis in chronic granulomatous disease: report of 7 cases. Eur J Pediatr 166:83-84
100. Mamishi S, Zomorodian K, Saadat F, Gerami-Shoar M, Tarazooie B, Siadati SA (2005) A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-gamma. Ann Clin Microbiol Antimicrob 4:4
101. Mansour MK, Levitz SM (2002) Interactions of fungi with phagocytes. Curr Opin Microbiol 5:359-365
102. Marciano BE, Wesley R, De Carlo ES, Anderson VL, Barnhart LA, Darnell D, Malech HL, Gallin JI, Holland SM (2004) Long-term interferon-gamma therapy for patients with chronic granulomatous disease. Clin Infect Dis 39:692-699
103. Marcinkowski M, Bauer K, Stoltenburg-Didinger G, Vogel M, Versmold H (2000) Fatal aspergillosis with brain abscesses in a neonate with DiGeorge syndrome. Pediatr Infect Dis J 19:1214-1216
104. Margolis DM, Melnick DA, Alling DW, Gallin JI (1990) Trimethoprim- sulfamethoxazole prophylaxis in the management of chronic granulomatous disease. J Infect Dis 162:723-726
105. Marques AR, Kwon-Chung KJ, Holland SM, Turner ML, Gallin JI (1995) Suppurative cutaneous granulomata caused by Microascus cinereus in a patient with chronic granulomatous disease. Clin Infect Dis 20:110-114
106. Martin Mateos MA, Alvaro M, Giner MT, Plaza AM, Sierra JI, Munoz-Lopez F (1998) Chronic granulomatous disease: six new cases. Allergol Immunopathol (Madr) 26:241-249
107. Meletiadis J, Meis JF, Mouton JW, Rodriquez-Tudela JL, Donnelly JP, Verweij PE (2002) In vitro activities of new and conventional antifungal agents against clinical Scedosporium isolates. Antimicrob Agents Chemother 46:62-68
108. Meletiadis J, Mouton JW, Meis JF, Verweij PE (2003) In vitro drug interaction modeling of combinations of azoles with terbinafine against clinical Scedosporium prolificans isolates. Antimicrob Agents Chemother 47:106-117
109. Mencacci A, Cenci E, Bacci A, Montagnoli C, Bistoni F, Romani L (2000) Cytokines in candidiasis and aspergillosis. Curr Pharm Biotechnol 1:235-251
110. Miron D, Horowitz Y, Lumelsky D, Hanania S, Colodner R (2005) Dual pulmonary infection with Candida dubliniensis and Aspergillus fumigatus in a child with chronic granulomatous disease. J Infect 50:72-75
111. Moraes-Vasconcelos D, Grumach AS, Yamaguti A, Andrade ME, Fieschi C, Beaucoudrey L, Casanova JL, Duarte AJ (2005) Paracoccidioides brasiliensis disseminated disease in a patient with inherited deficiency in the beta1 subunit of the interleukin (IL)-12/IL-23 receptor. Clin Infect Dis 41:e31-e37
112. Mouy R, Fischer A, Vilmer E, Seger R, Griscelli C (1989) Incidence, severity, and prevention of infections in chronic granulomatous disease. J Pediatr 114:555-560
113. Mouy R, Veber F, Blanche S, Donadieu J, Brauner R, Levron JC, Griscelli C, Fischer A (1994) Long-term itraconazole prophylaxis against Aspergillus infections in thirty-two patients with chronic granulomatous disease. J Pediatr 125:998-1003
114. Muhlebach TJ, Gabay J, Nathan CF, Erny C, Dopfer G, Schroten H, Wahn V, Seger RA (1992) Treatment of patients with chronic granulomatous disease with recombinant human interferon-gamma does not improve neutrophil oxidative metabolism, cytochrome b558 content or levels of four anti-microbial proteins. Clin Exp Immunol 88:203-206
115. Mussa AY, Singh VK, Randhawa HS, Khan ZU (1998) Disseminated fatal trichosporonosis: first case due to Trichosporon inkin. J Mycol Med 8:196-199
116. Netea MG, Kullberg BJ, van der Meer JW (2005) Severely impaired IL-12/IL-18/IFNgamma axis in patients with hyper IgE syndrome. Eur J Clin Invest 35:718-721
117. Netea MG, Van der Graaf C, Van der Meer JW, Kullberg BJ (2004) Recognition of fungal pathogens by Toll-like receptors. Eur J Clin Microbiol Infect Dis 23:672-676
118. Nguyen C, Katner HP (1997) Myeloperoxidase deficiency manifesting as pustular candidal dermatitis. Clin Infect Dis 24:258-260
119. Okuda T, Yasuoka T, Oka N (1991) Myeloperoxidase deficiency as a predisposing factor for deep mucocutaneous candidiasis: a case report. J Oral Maxillofac Surg 49:183-186
120. Orson JM, Greco RG (1985) Chronic granulomatous disease and Torulopsis infections. Am J Dis Child 139:545
121. Ostrosky-Zeichner L, Marr KA, Rex JH, Cohen SH (2003) Amphotericin B: time for a new "gold standard". Clin Infect Dis 37:415-425
122. Pachl J, Svoboda P, Jacobs F, Vandewoude K, van der Hoven B, Spronk P, Masterson G, Malbrain M, Aoun M, Garbino J, Takala J, Drgona L, Burnie J, Matthews R (2006) A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis. Clin Infect Dis 42:1404-1413
123. Pappas PG, Rex JH, Sobel JD, Filler SG, Dismukes WE, Walsh TJ, Edwards JE (2004) Guidelines for treatment of candidiasis. Clin Infect Dis 38:161-189
124. Parry MF, Root RK, Metcalf JA, Delaney KK, Kaplow LS, Richar WJ (1981) Myeloperoxidase deficiency: prevalence and clinical significance. Ann Intern Med 95:293-301
125. Pastor FJ, Guarro J (2006) Clinical manifestations, treatment and outcome of Paecilomyces lilacinus infections. Clin Microbiol Infect 12:948-960
126. Perheentupa J (2006) Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab 91:2843-2850
127. Phillips P, Forbes JC, Speert DP (1991) Disseminated infection with Pseudallescheria boydii in a patient with chronic granulomatous disease: response to gamma-interferon plus antifungal chemotherapy. Pediatr Infect Dis J 10:536-539
128. Pistono PG, Rapetti I, Stacchini E, Guasco C (1989) Clinical case of mycetoma caused by Scedosporium apiospermum. G Batteriol Virol Immunol 82:88-91
129. Piwoz JA, Stadtmauer GJ, Bottone EJ, Weitzman I, Shlasko E, Cummingham-Rundles C (2000) Trichosporon inkin lung abscesses presenting as a penetrating chest wall mass. Pediatr Infect Dis J 19:1025-1027
130. Porter SR, Scully C (1993) Orofacial manifestations in primary immunodeficiencies: common variable immunodeficiencies. J Oral Pathol Med 22:157-158
131. Rachid A, Rezende LS, de Moura SF, Loffy PC, Magalhaes FL (2003) A case study of disseminated histoplasmosis linked to common variable immunodeficiency. Braz J Infect Dis 7:268-272
132. Reeves EP, Lu H, Jacobs HL, Messina CG, Bolsover S, Gabella G, Potma EO, Warley A, Roes J, Segal AW (2002) Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 416:291-297
133. Renner ED, Puck JM, Holland SM, Schmitt M, Weiss M, Frosch M, Bergmann M, Davis J, Belohradsky BH, Grimbacher B (2004) Autosomal recessive hyperimmunoglobulin E syndrome: a distinct disease entity. J Pediatr 144:93-99
134. Rex JH, Bennett JE, Gallin JI, Malech HL, DeCarlo ES, Melnick DA (1991) In vivo interferon-gamma therapy augments the in vitro ability of chronic granulomatous disease neutrophils to damage Aspergillus hyphae. J Infect Dis 163:849-852
135. Rex JH, Bennett JE, Gallin JI, Malech HL, Melnick DA (1990) Normal and deficient neutrophils can cooperate to damage Aspergillus fumigatus hyphae. J Infect Dis 162:523-528
136. Roilides E (2006) Early diagnosis of invasive aspergillosis in infants and children. Med Mycol 44(Suppl):199-205
137. Roilides E, Sigler L, Bibashi E, Katsifa H, Flaris N, Panteliadis C (1999) Disseminated infection due to Chrysosporium zonatum in a patient with chronic granulomatous disease and review of non-Aspergillus fungal infections in patients with this disease. J Clin Microbiol 37:18-25
138. Romani L (2004) Immunity to fungal infections. Nat Rev Immunol 4:1-23
139. Rosen-Wolff A, Koch A, Friedrich W, Hahn G, Gahr M, Roesler J (2004) Successful elimination of an invasive Aspergillus nidulans lung infection by voriconazole after failure of a combination of caspofungin and liposomal amphotericin B in a boy with chronic granulomatous disease. Pediatr Infect Dis J 23:584-586
140. Salzer U, Grimbacher B (2006) Common variable immunodeficiency: The power of co-stimulation. Semin Immunol 18:337-346
141. Santambrogio L, Nosotti M, Pavoni G, Harte M, Pietogrande MC (1997) Pneumatocele complicated by fungal lung abscess in Job's syndrome. Successful lobectomy with the aid of videothoracoscopy. Scand Cardiovasc J 31:177-179
142. Santos PE, Piontelli E, Shea YR, Galluzzo ML, Holland SM, Zelazko ME, Rosenzweig SD (2006) Penicillium piceum infection: diagnosis and successful treatment in chronic granulomatous disease. Med Mycol 44:749-753
143. Saulsbury FT (2001) Successful treatment of aspergillus brain abscess with itraconazole and interferon-gamma in a patient with chronic granulomatous disease. Clin Infect Dis 32:E137-E139
144. Sechler JM, Malech HL, White CJ, Gallin JI (1988) Recombinant human interferon-gamma reconstitutes defective phagocyte function in patients with chronic granulomatous disease of childhood. Proc Natl Acad Sci USA 85:4874-4878
145. Segal AW (2006) How superoxide production by neutrophil leukocytes kills microbes. Novartis Found Symp 279:92-98, discussion 98-100, 216-109
146. Segal BH, Barnhart LA, Anderson VL, Walsh TJ, Malech HL, Holland SM (2005) Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection. Clin Infect Dis 40:1684-1688
147. Segal BH, DeCarlo ES, Kwon-Chung KJ, Malech HL, Gallin JI, Holland SM (1998) Aspergillus nidulans infection in chronic granulomatous disease. Medicine (Baltimore) 77:345-354
148. Segal BH, Leto TL, Gallin JI, Malech HL, Holland SM (2000) Genetic, biochemical, and clinical features of chronic granulomatous disease. Medicine (Baltimore) 79:170-200
149. Sergi C, Serpi M, Muller-Navia J, Schnabel PA, Hagl S, Otto HF, Ulmer HE (1999) CATCH 22 syndrome: report of 7 infants with follow-up data and review of the recent advancements in the genetic knowledge of the locus 22q11. Pathologica 91:166-172
150. Shoham S, Levitz SM (2005) The immune response to fungal infections. Br J Haematol 129:569-582
151. Siemann M, Koch-Dorfler M, Gaude M (1998) False-positive results in premature infants with the Platelia Aspergillus sandwich enzyme-linked immunosorbent assay. Mycoses 41:373-377
152. Sillevis Smitt JH, Leusen JH, Stas HG, Teeuw AH, Weening RS (1997) Chronic bullous disease of childhood and a paecilomyces lung infection in chronic granulomatous disease. Arch Dis Child 77:150-152
153. Silliman CC, Lawellin DW, Lohr JA, Rodgers BM, Donowitz LG (1992) Paecilomyces lilacinus infection in a child with chronic granulomatous disease. J Infect 24:191-195
154. Smego RA Jr, Devoe PW, Sampson HA, Perfect JR, Wilfert CM, Buckley RH (1984) Candida meningitis in two children with severe combined immunodeficiency. J Pediatr 104:902-904
155. Souto JT, Figueiredo F, Furlanetto A, Pfeffer K, Rossi MA, Silva JS (2000) Interferon-gamma and tumor necrosis factor-alpha determine resistance to Paracoccidioides brasiliensis infection in mice. Am J Pathol 156:1811-1820
156. Spanakis EK, Aperis G, Mylonakis E (2006) New agents for the treatment of fungal infections: clinical efficacy and gaps in coverage. Clin Infect Dis 43:1060-1068
157. Stergiopoulou T, Meletiadis J, Roilides E, Kleiner DE, Schaufele R, Roden M, Harrington S, Dad L, Segal B, Walsh TJ (2007) Host-dependent patterns of tissue injury in invasive pulmonary aspergillosis. Am J Clin Pathol 127:1-7
158. Sutton DA, Thompson EH, Rinaldi MG, Iwen PC, Nakasone KK, Jung HS, Rosenblatt HM, Paul ME (2005) Identification and first report of Inonotus (Phellinus) tropicalis as an etiologic agent in a patient with chronic granulomatous disease. J Clin Microbiol 43:982-987
159. Tabone MD, Leverger G, Landman J, Aznar C, Boccon-Gibod L, Lasfargues G (1994) Disseminated lymphonodular cryptococcosis in a child with X-linked hyper-IgM immunodeficiency. Pediatr Infect Dis J 13:77-79
160. The International Chronic Granulomatous Disease Cooperative Study Group (1991) A controlled trial of interferon gamma to prevent infection in chronic granulomatous disease. The International Chronic Granulomatous Disease Cooperative Study Group. N Engl J Med 324:509-516
161. Thomas KE, Owens CM, Veys PA, Novelli V, Costoli V (2003) The radiological spectrum of invasive aspergillosis in children: a 10-year review. Pediatr Radiol 33:453-460
162. Tinelli M, Zambelli A, Cavanna C, Michelone G (1987) Pulmonary aspergillosis in a case of humoral immunodeficiency. Microbiologica 10:235-240
163. Tkalcevic J, Novelli M, Phylactides M, Iredale JP, Segal AW, Roes J (2000) Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity 12:201-210
164. Trachana M, Roilides E, Gompakis N, Kanellopoulou K, Mpantouraki M, Kanakoudi-Tsakalidou F (2001) Case report. Hepatic abscesses due to Aspergillus terreus in an immunodeficient child. Mycoses 44:415-418
165. van 't Hek LG, Verweij PE, Weemaes CM, van Dalen R, Yntema JB, Meis JF (1998) Successful treatment with voriconazole of invasive aspergillosis in chronic granulomatous disease. Am J Respir Crit Care Med 157:1694-1696
166. van der Meer JW, Bont L, Verhage J (1998) Aspergillus infection in patients with hyperimmunoglobulin E syndrome. Clin Infect Dis 27:1337
167. Vazquez JA, Sobel JD (2002) Mucosal candidiasis. Infect Dis Clin North Am 16:793-820
168. Verweij PE, Mellado E, Melchers WJ (2007) Multiple-triazole-resistant aspergillosis. N Engl J Med 356:1481-1483
169. Verweij PE, Weemaes CM, Curfs JH, Bretagne S, Meis JF (2000) Failure to detect circulating Aspergillus markers in a patient with chronic granulomatous disease and invasive aspergillosis. J Clin Microbiol 38:3900-3901
170. Walcott DW, Linehan Tt, Hilman BC, Hershfield MS, el Dahr J (1994) Failure to thrive, diarrhea, cough, and oral candidiasis in a three-month-old boy. Ann Allergy 72:408-414
171. Walsh TJ, Adamson PC, Seibel NL, Flynn PM, Neely MN, Schwartz C, Shad A, Kaplan SL, Roden MM, Stone JA, Miller A, Bradshaw SK, Li SX, Sable CA, Kartsonis NA (2005) Pharmacokinetics, safety, and tolerability of caspofungin in children and adolescents. Antimicrob Agents Chemother 49:4536-4545
172. Walsh TJ, Driscoll TA, Arietta AC, Klein N, Bradley J, Hafri HS, Schlamm H, Wood N, Milligan P, Lutsar I (2006) Pharmacokinetics, safety and tolerability of voriconazole in hospitalized children. In: Proceedings of the 46th Interscience conference on antimicrobial agents and chemotherapy, San Francisco, CA, 27-30 September
173. Walsh TJ, Karlsson MO, Driscoll T, Arguedas AG, Adamson P, Saez-Llorens X, Vora AJ, Arrieta AC, Blumer J, Lutsar I, Milligan P, Wood N (2004) Pharmacokinetics and safety of intravenous voriconazole in children after single- or multiple-dose administration. Antimicrob Agents Chemother 48:2166-2172
174. Walsh TJ, Melcher GP, Rinaldi MG, Lecciones J, McGough DA, Kelly P, Lee J, Callender D, Rubin M, Pizzo PA (1990) Trichosporon beigelii, an emerging pathogen resistant to amphotericin B. J Clin Microbiol 28:1616-1622
175. Walsh TJ, Raad I, Patterson TF, Chandrasekar P, Donowitz GR, Graybill R, Greene RE, Hachem R, Hadley S, Herbrecht R, Langston A, Louie A, Ribaud P, Segal BH, Stevens DA, van Burik JA, White CS, Corcoran G, Gogate J, Krishna G, Pedicone L, Hardalo C, Perfect JR (2007) Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial. Clin Infect Dis 44:2-12
176. Walsh TJ, Schaufele RL, Sein T, Gea-Banacloche J, Bishop M, Young N, Childs R, Barrett J, Malech HL, Holland SM (2002) Reduced expression of galactomannan antigenemia in patients with invasive aspergillosis and chronic granulomatous disease or Job's syndrome. In: Proceedings of the 40th annual meeting of the Infectious Disease Society of America, Chicago, IL, 24-27 October
177. Wang SM, Shieh CC, Liu CC (2005) Successful treatment of Paecilomyces variotii splenic abscesses: a rare complication in a previously unrecognized chronic granulomatous disease child. Diagn Microbiol Infect Dis 53:149-152
178. Weber ML, Abela A, de Repentigny L, Garel L, Lapointe N (1987) Myeloperoxidase deficiency with extensive candidal osteomyelitis of the base of the skull. Pediatrics 80:876-879
179. White CJ, Kwon-Chung KJ, Gallin JI (1988) Chronic granulomatous disease of childhood. An unusual case of infection with Aspergillus nidulans var. echinulatus. Am J Clin Pathol 90:312-316
180. Williamson PR, Kwon-Chung KJ, Gallin JI (1992) Successful treatment of Paecilomyces variotii infection in a patient with chronic granulomatous disease and a review of Paecilomyces species infections. Clin Infect Dis 14:1023-1026
181. Winkelstein JA, Marino MC, Johnston RB Jr, Boyle J, Curnutte J, Gallin JI, Malech HL, Holland SM, Ochs H, Quie P, Buckley RH, Foster CB, Chanock SJ, Dickler H (2000) Chronic granulomatous disease. Report on a national registry of 368 patients. Medicine (Baltimore) 79:155-169
182. Winkelstein JA, Marino MC, Ochs H, Fuleihan R, Scholl PR, Geha R, Stiehm ER, Conley ME (2003) The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients. Medicine (Baltimore) 82:373-384
183. Wolach B, Eliakim A, Gottesman G, Yellin A (1998) Pulmonary aspergillosis in a child with hyperimmunoglobulin E syndrome. Clin Infect Dis 26:204-205
184. Woodman RC, Erickson RW, Rae J, Jaffe HS, Curnutte JT (1992) Prolonged recombinant interferon-gamma therapy in chronic granulomatous disease: evidence against enhanced neutrophil oxidase activity. Blood 79:1558-1562
185. Wright DG, Robichaud KJ, Pizzo PA, Deisseroth AB (1981) Lethal pulmonary reactions associated with the combined use of amphotericin B and leukocyte transfusions. N Engl J Med 304:1185-1189
186. Wynne SM, Kwon-Chung KJ, Shea YR, Filie AC, Varma A, Lupo P, Holland SM (2004) Invasive infection with Trichosporon inkin in 2 siblings with chronic granulomatous disease. J Allergy Clin Immunol 114:1418-1424
187. Yates AB, Mehrotra D, Moffitt JE (1997) Candida endocarditis in a child with hyperimmunoglobulinemia E syndrome. J Allergy Clin Immunol 99:770-772
188. Yilmaz E (2004) Disseminated pulmonary candidiasis complicating hyperimmunoglobulin E (Job's) syndrome. J Thorac Imaging 19:48-51
189. Yilmaz GG, Yilmaz E, Coskun M, Karpuzoglu G, Gelen T, Yegin O (1995) Cutaneous histoplasmosis in a child with hyper-IgM. Pediatr Dermatol 12:235-238
190. Yin EZ, Frush DP, Donnelly LF, Buckley RH (2001) Primary immunodeficiency disorders in pediatric patients: clinical features and imaging findings. AJR Am J Roentgenol 176:1541-1552
191. Yoshihara T, Morimoto A, Nakauchi S, Fujii N, Tsunamoto K, Misawa A, Hibi S, Imashuku S (2002) Successful transplantation of haploidentical CD34+ selected bone marrow cells for an infantile case of severe combined immunodeficiency with Aspergillus pneumonia. Pediatr Hematol Oncol 19:439-443
192. Zaoutis TE, Heydon K, Chu JH, Walsh TJ, Steinbach WJ (2006) Epidemiology, outcomes, and costs of invasive aspergillosis in immunocompromised children in the United States, 2000. Pediatrics 117:e711-e716
193. Zeidler C (2005) Congenital neutropenias. Hematology 10(1):306-311
194. Zeidler C, Welte K, Barak Y, Barriga F, Bolyard AA, Boxer L, Cornu G, Cowan MJ, Dale DC, Flood T, Freedman M, Gadner H, Mandel H, O'Reilly RJ, Ramenghi U, Reiter A, Skinner R, Vermylen C, Levine JE (2000) Stem cell transplantation in patients with severe congenital neutropenia without evidence of leukemic transformation. Blood 95:1195-1198
195. Zerbe CS, Holland SM (2005) Disseminated histoplasmosis in persons with interferon-gamma receptor 1 deficiency. Clin Infect Dis 41:e38-e41
196. Zhou P, Sieve MC, Tewari RP, Seder RA (1997) Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulatum. Infect Immun 65:936-942