Liver X receptor-α gene expression is positively regulated by thyroid hormone

Endocrinology

Volumn 148, Issue 10, 2007, Pages 4667-4675

  Hashimoto, Koshi ^a   Matsumoto, Shunichi ^a   Yamada, Masanobu ^a   Satoh, Teturou ^a   Mori, Masatomo ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LIOTHYRONINE; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; LUCIFERASE; MESSENGER RNA; RETINOID X RECEPTOR ALPHA; THYROID HORMONE; THYROID HORMONE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; C57BL 6 MOUSE; CELL STRAIN HEPG2; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DELETION MUTANT; DNA RESPONSIVE ELEMENT; DYSLIPIDEMIA; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HORMONAL REGULATION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; WESTERN BLOTTING;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CHOLESTEROL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; PROMOTER REGIONS (GENETICS); PROTEIN ISOFORMS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, THYROID HORMONE; RETINOID X RECEPTORS; RNA, MESSENGER; TRANSFECTION; TRIIODOTHYRONINE; UP-REGULATION;

EID: 34748897091     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0150     Document Type: Article

References (38)

1. Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P 2003 Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 9:213-219
2. Stulnig TM, Steffensen KR, Gao H, Reimers M, Dahlman-Wright K, Schuster GU, Gustafsson JA 2002 Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue. Mol Pharmacol 62:1299-1305
3. Zelcer N, Tontonoz P 2006 Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 116:607-614
4. Apfel R, Benbrook D, Lernhardt E, Ortiz MA, Salbert G, Pfahl M 1994 A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol Cell Biol 14:7025-7035
5. Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ 1995 LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev 9:1033-1045
6. Repa JJ, Mangelsdorf DJ 2000 The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol 16:459-481
7. Umesono K, Murakami KK, Thompson CC, Evans RM 1991 Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell 65:1255-1266
8. Tamura K, Chen YE, Horiuchi M, Chen Q, Daviet L, Yang Z, Lopez-Ilasaca M, Mu H, Pratt RE, Dzau VJ 2000 LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression. Proc Natl Acad Sci USA 97:8513-8518
9. Lazar MA 1993 Thyroid hormone receptors: multiple forms, multiple possibilities. Endocr Rev 14:184-193
10. Flamant F, Samarut J 2003 Thyroid hormone receptors: lessons from knockout and knock-in mutant mice. Trends Endocrinol Metab 14:85-90
11. Enmark E, Gustafsson JA 2001 Comparing nuclear receptors in worms, flies and humans. Trends Pharmacol Sci 22:611-615
12. Berkenstam A, Farnegardh M, Gustafsson JA 2004 Convergence of lipid homeostasis through liver X and thyroid hormone receptors. Mech Ageing Dev 125:707-717
13. Berkenstam A, Gustafsson JA 2005 Nuclear receptors and their relevance to diseases related to lipid metabolism. Curr Opin Pharmacol 5:171-176
14. Quack M, Frank C, Carlberg C 2002 Differential nuclear receptor signalling from DR4-type response elements. J Cell Biochem 86:601-612
15. Hashimoto K, Cohen RN, Yamada M, Markan KR, Monden T, Satoh T, Mori M, Wondisford, FE 2006 Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model. J Biol Chem 281:295-302
16. Huuskonen J, Vishnu M, Pullinger CR, Fielding PE, Fielding CJ 2004 Regulation of ATP-binding cassette transporter A1 transcription by thyroid hormone receptor. Biochemistry 43:1626-1632
17. Whitney KD, Watson MA, Goodwin B, Galardi CM, Maglich JM, Wilson JG, Willson TM, Collins JL, Kliewer SA 2001 Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages. J Biol Chem 276:43509-43515
18. Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P 2003 Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci USA 100:5419-5424
19. Li Y, Bolten C, Bhat BG, Woodring-Dietz J, Li S, Prayaga SK, Xia C, Lala DS 2002 Induction of human liver X receptor α gene expression via an autoregulatory loop mechanism. Mol Endocrinol 16:506-514
20. Repa JJ, Turley SD, Lobaccaro JA, Medina J, Li L, Lustig K, Shan B, Heyman RA, Dietschy JM, Mangelsdorf DJ 2000 Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289:1524-1529
21. Chisholm JW, Hong J, Mills SA, Lawn RM 2003 The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. J Lipid Res 44:2039-2048
22. Theodossiou C, Skrepnik N, Robert EG, Prasad C, Schapira DV, Hunt JD 1999 Propylthiouracil-induced hypothyroidism reduces xenograft tumor growth in athymic nude mice. Cancer 86:1596-1601
23. Wolf B, Aratan-Spire S, Czernichow P 1984 Hypothalamo-pituitary regulation of thyrotrophin secretion in chronically catheterized Brattleboro rats. Endocrinology 114:1334-1337
24. Hashimoto K, Yamada M, Matsumoto S, Monden T, Satoh T, Mori M 2006 Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone. Endocrinology 147:4292-4302
25. Janowski BA, Grogan MJ, Jones SA, Wisely GB, Kliewer SA, Corey EJ, Mangelsdorf DJ 1999 Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ. Proc Natl Acad Sci USA 96:266-271
26. Ren Y, Satoh T, Yamada M, Hashimoto K, Konaka S, Iwasaki T, Mori M 1998 Stimulation of the preprothyrotropin-releasing hormone gene by epidermal growth factor. Endocrinology 139:195-203
27. Hashimoto K, Yamada M, Monden T, Satoh T, Wondisford FE, Mori M 2005 Thyrotropin-releasing hormone (TRH) specific interaction between amino terminus of P-Lim and CREB binding protein (CBP). Mol Cell Endocrinol 229:11-20
28. Alberti S, Schuster G, Parini P, Feltkamp D, Diczfalusy U, Rudling M, Angelin B, Bjorkhem I, Pettersson S, Gustafsson JA 2001 Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRβ-deficient mice. J Clin Invest 107:565-573
29. Hashimoto K, Curty FH, Borges PP, Lee CE, Abel ED, Elmquist JK, Cohen RN, Wondisford FE 2001 An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci USA 98:3998-4003
30. Drover VAB, Norman CW, Agellon LB 2002 A distinct thyroid hormone response element mediates repression of the human cholesterol 7α-hydroxylase (CYP7A1) gene promoter. Mol Endocrinol 16:14-23
31. Ness GC, Lopez D 1995 Transcriptional regulation of rat hepatic low-density lipoprotein receptor and cholesterol 7 α hydroxylase by thyroid hormone. Arch Biochem Biophys 323:404-408
32. Ness GC, Pendlton LC, Zhao Z 1994 Thyroid hormone rapidly increases cholesterol 7 alpha-hydroxylase mRNA levels in hypophysectomized rats. Biochim Biophys Acta 1214: 229-233
33. Ness GC, Pendlton LC, Li YC, Chiang JY 1990 Effect of thyroid hormone on hepatic cholesterol 7 alpha hydroxylase, LDL receptor, HMG-CoA reductase, farnesyl pyrophosphate synthetase and apolipoprotein A-I mRNA levels in hypophysectomized rats. Biochem Biophys Res Commun 172:1150-1156
34. Shin D-J, Plateroti M, Samarut J, Osborne TF 2006 Two uniquely arranged thyroid hormone response elements in the far upstream 5′ flanking region confer direct thyroid hormone regulation to the murine cholesterol 7α hydroxylase gene. Nucleic Acids Res 34:3853-3861
35. Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, Schwendner S, Wang S, Thoolen M, Mangelsdorf DJ, Lustig KD, Shan B 2000 Role of LXRs in control of lipogenesis. Genes Dev 14:2831-2838
36. Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N 2001 Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol Cell Biol 21:2991-3000
37. Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ 2000 Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 14:2819-2830
38. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ 2001 Nuclear receptors and lipid physiology: opening the X-files. Science 294:1866-1870