Evolutionarily divergent type II protein arginine methyltransferase in Trypanosoma brucei

Eukaryotic Cell

Volumn 6, Issue 9, 2007, Pages 1665-1681

  Pasternack, Deborah A ^a   Sayegh, Joyce ^b   Clarke, Steven ^b   Read, Laurie K ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEAD BOX PROTEIN; N(G) METHYLARGININE; PROTEIN ARGININE METHYLTRANSFERASE; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOSYNTHESIS; CATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENE; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; METHYLATION; MOLECULAR EVOLUTION; MOLECULAR GENETICS; PHYLOGENY; TRYPANOSOMA BRUCEI;

AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; DEAD-BOX RNA HELICASES; EVOLUTION, MOLECULAR; GENES, PROTOZOAN; METHYLATION; MOLECULAR SEQUENCE DATA; OMEGA-N-METHYLARGININE; PHYLOGENY; PROTEIN-ARGININE N-METHYLTRANSFERASE; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRYPANOSOMA BRUCEI BRUCEI;

EUKARYOTA; HEXAPODA; KINETOPLASTIDA; MAMMALIA; SCHIZOSACCHAROMYCES POMBE; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 34748853038     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00133-07     Document Type: Article

References (99)

1. Abramovich, C., B. Yakobson, J. Chebath, and M. Revel. 1997. A protein-arginine methyltransferase binds to the intracytoplasmie domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16:260-266.
2. Anne, J., and B. M. Mechler. 2005. Valois, a component of the nuage and pole plasm, is involved in assembly of these structures, and binds to Tudor and the methyltransferase Capsuleen. Development 132:2167-2177.
3. Anne, J., R. Ollo, A. Ephrussi, and B. M. Mechler. 2007. Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila. Development 134:137-146.
4. Bachand, F., and P. A. Silver. 2004. PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits. EMBO J. 23:2641-2650.
5. Baldwin, G. S., and P. R. Carnegie. 1971. Isolation and partial characterization of methylated arginines from the eneephalitogenie basic protein of myelin. Biochem. J. 123:69-74.
6. Bedford, M. T., A. Frankel, M. B. Yaffe, S. Clarke, P. Leder, and S. Richard. 2000. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. J. Biol. Chem. 275:16030-16036.
7. Bedford, M. T., and S. Richard. 2005. Arginine methylation an emerging regulator of protein function. Mol. Cell 18:263-272.
8. Boisvert, F. M., J. Côte, M. C. Boulanger, P. Cléroux, F. Bachand, C. Autexier, and S. Richard. 2002. Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing. J. Cell Biol. 159:957-969.
9. Boisvert, F. M., J. Côte, M. C. Boulanger, and S. Richard. 2003. A proteomic analysis of arginine-methylated protein complexes. Mol. Cell Proteomics 2:1319-1330.
10. Boisvert, F. M., U. Déry, J. Y. Massen, and S. Richard. 2005. Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control. Genes Dev. 19:671-676.
11. Boulanger, M. C., T. B. Miranda, S. Clarke, M. Di Fruscio, B. Suter, P. Lasko, and S. Richard. 2004. Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4. Biochem. J. 379:283-289.
12. Brahms, H., L. Meheus, V. de Brabandere, U. Fischer, and R. Lührmann. 2001. Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein. RNA 7:1531-1542.
13. Branscombe, T. L., A. Frankel, J. H. Lee, J. R. Cook, Z. Yang, S. Pestka, and S. Clarke. 2001. PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins. J. Biol. Chem. 276:32971-32976.
14. Brostoff, S., and E. H. Eylar. 1971. Localization of methylated arginine in the A1 protein from myelin. Proc. Natl. Acad. Sci. USA 68:765-769.
15. Brun, R., and M. Schonenberger. 1979. Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Acta Trop. 36:289-292.
16. Carrera, P., O. Johnstone, A. Nakamura, J. Casanova, H. Jackle, and P. Lasko. 2000. VASA mediates translation through interaction with a Drosophila yIF2 homolog. Mol. Cell 5:181-187.
17. Cavey, M., S. Hijal, X. Zhang, and B. Suter. 2005. Drosophila valois encodes a divergent WD protein that is required for Vasa localization and Oskar protein accumulation. Development 132:459-168.
18. Chen, D., H. Ma, H. Hong, S. S. Koh, S. M. Huang, B. T. Schulter, D. W. Aswad, and M. R. Stallcup. 1999. Regulation of transcription by a protein methyltransferase. Science 284:2174-2177.
19. Chen, H., Y. Xue, N. Huang, X. Yao, and Z. Sun. 2006. MeMo: a web tool for prediction of protein methylation modifications. Nucleic Acids Res. 34: W249-W253.
20. Chern, M. K., K. N. Chang, L. F. Liu, T. C. Tam, Y. C. Liu, Y. L. Liang, and M. F. Tam. 2002. Yeast ribosomal protein L12 is a substrate of protein-arginine methyltransferase 2. J. Biol. Chem. 277:15345-15353.
21. Chuang, R. Y., P. L. Weaver, Z. Liu, and T. H. Chang. 1997. Requirement of the DEAD-Box protein ded1p for messenger RNA translation. Science 275:1468-1471.
22. Cimato, T. R., J. Tang, Y. Xu, C. Guarnaccia, H. R. Herschman, S. Pongor, and J. M. Aletta. 2002. Nerve growth factor-mediated increases in protein methylation occur predominantly at type I arginine methylation sites and involve protein arginine methyltransferase 1. J. Neurosei. Res. 67:435-142.
23. Clayton, C. E. 2002. Life without transcriptional control? From fly to man and back again. EMBO J. 21:1881-1888.
24. Das, A., H. Li, T. Liu, and V. Bellofatto. 2006. Biochemical characterization of Trypanosoma brucei RNA polymerase II. Mol. Biochem. Parasitol. 150: 201-210.
25. De Gaudenzi, J., A. C. Frasch, and C. Clayton. 2005. RNA-binding domain proteins in kinetoplastids: a comparative analysis. Eukaryot. Cell 4:2106-2114.
26. de la Cruz, J., I. Iost, D. Kressler, and P. Linder. 1997. The p20 and Ded1 proteins have antagonistic roles in eIF4E-dependent translation in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 94:5201-5206.
27. Denman, R. B. 2002. Methylation of the arginine-glycine-rich region in the fragile X mental retardation protein FMRP differentially affects RNA binding. Cell. Mol. Biol. Lett. 7:877-883.
28. Dolzhanskaya, N., G. Merz, J. M. Aletta, and R. B. Denman. 2006. Methylation regulates the intracellular protein-protein and protein-RNA interactions of FMRP. J. Cell Sci. 119:1933-1946.
29. Doyle, J. J., H. Hirumi, K. Hirumi, E. N. Lupton, and G. A. Cross. 1980. Antigenic variation in clones of animal-infective Trypanosoma brucei derived and maintained in vitro. Parasitology 80:359-369.
30. Estevez, A. M., T. Kempf, and C. Clayton. 2001. The exosome of Trypanosoma brucei. EMBO J. 20:3831-3839.
31. Friesen, W. J., S. Massenet, S. Paushkin, A. Wyce, and G. Dreyfuss. 2001. SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets. Mol. Cell 7:1111-1117.
32. Friesen, W. J., S. Paushkin, A. Wyce, S. Massenet, G. S. Pesiridis, G. Van Duyne, J. Rappsilber, M. Mann, and G. Dreyfuss. 2001. The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins. Mol. Cell. Biol. 21:8289-8300.
33. Friesen, W. J., A. Wyce, S. Paushkin, L. Abel, J. Rappsilber, M. Mann, and G. Dreyfuss. 2002. A novel WD repeat protein component of the methylosome binds Sm proteins. J. Biol. Chem. 277:8243-8247.
34. Gary, J. D., and S. Clarke. 1998. RNA and protein interactions modulated by protein arginine methylation. Prog. Nucleic Acid Res. Mol. Biol. 61:65-131.
35. Gary, J. D., W. J. Lin, M. C. Yang, H. R. Herschman, and S. Clarke. 1996. The predominant protein-arginine methyltransferase from Saccharomyces cerevisiae. J. Biol. Chem. 271:12585-12594.
36. Gavis, E. R., L. Lunsford, S. E. Bergsten, and R. Lehmann. 1996. A conserved 90 nucleotide element mediates translational repression of nanos RNA. Development 122:2791-2800.
37. Gibson, W. C., B. W. Swinkels, and P. Borst. 1988. Post-transcriptional control of the differential expression of phosphoglyeerate kinase genes in Trypanosoma brucei. J. Mol. Biol. 201:315-325.
38. Gilbreth, M., P. Yang, D. Wang, J. Frost, A. Polverino, M. H. Cobb, and S. Marcus. 1996. The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog. Proc. Natl. Acad. Sci. USA 93:13802-13807.
39. Gonsalvez, G. B., T. K. Rajendra, L. Tian, and A. G. Matera. 2006. The Sm-protein methyltransferase, dart5, is essential for germ-cell specification and maintenance. Curr. Biol. 16:1077-1089.
40. Gottschling, H., and E. Freese. 1962. A tritium isotope effect on ion exchange chromatography. Nature 196:829-831.
41. Goulah, C. C., M. Pelletier, and L. K. Read. 2006. Arginine methylation regulates mitochondrial gene expression in Trypanosoma brucei through multiple effector proteins. RNA 12:1545-1555.
42. Goulah, C. C., and L. K. Read. 2007. Differential effects of arginine methylation on RBP16 mRNA binding, gRNA binding, and gRNP formation. J. Biol. Chem. 282:7181-7190.
43. Grallert, B., S. E. Kearsey, M. Lenhard, C. R. Carlson, P. Nurse, E. Boye, and K. Labib. 2000. A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls. J. Cell Sci. 113:1447-1458.
44. Green, D. M., K. A. Marfatia, E. B. Crafton, X. Zhang, X. Cheng, and A. H. Corbett. 2002. Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p. J. Biol. Chem. 277:7752-7760.
45. Hayman, M. L., and L. K. Read. 1999. Trypanosoma brucei RBP16 is a mitochondrial Y-box family protein with guide RNA binding activity. J. Biol. Chem. 274:12067-12074.
46. Hirumi, H., and K. Hirumi. 1989. Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers. J. Parasitol. 75:985-989.
47. Hirumi, H., K. Hirumi, J. J. Doyle, and G. A. Cross. 1980. In vitro cloning of animal-infective bloodstream forms of Trypanosoma brucei. Parasitology 80: 371-382.
48. Janzen, C. J., J. P. Fernandez, H. Deng, R. Diaz, S. B. Hake, and G. A. Cross. 2006. Unusual histone modifications in Trypanosoma brucei. FEBS Lett. 580:2306-2310.
49. Johnson, J. G., and G. A. Cross. 1979. Selective cleavage of variant surface glycoproteins from Trypanosoma brucei. Biochem. J. 178:689-697.
50. Krause, C. D., Z. H. Yang, Y. S. Kim, J. H. Lee, J. R. Cook, and S. Pestka. 2007. Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential. Pharmacol. Ther. 113:50-87.
51. LaCount, D. J., B. Barrett, and J. E. Donelson. 2002. Trypanosoma brucei FLA1 is required for flagellum attachment and cytokinesis. J. Biol. Chem. 277:17580-17588.
52. Lee, J. H., J. R. Cook, B. P. Pollack, T. G. Kinzy, D. Norris, and S. Pestka. 2000. Hs17p, the yeast homologue of human JBP1, is a protein methyltransferase. Biochem. Biophys. Res. Commun. 274:105-111.
53. Liang, X. H., A. Haritan, S. Uliel, and S. Michaeli. 2003. trans and cis splicing in trypanosomatids: mechanism, factors, and regulation. Eukaryot. Cell 2:830-840.
54. Lim, Y., Y. H. Kwon, N. H. Won, B. H. Min, I. S. Park, W. K. Paik, and S. Kim. 2005. Multimerization of expressed protein-arginine methyltransferases during the growth and differentiation of rat liver. Biochim. Biophys. Acta 1723:240-247.
55. Lin, W. J., J. D. Gary, M. C. Yang, S. Clarke, and H. R. Herschman. 1996. The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. J. Biol. Chem. 271:15034-15044.
56. Linder, P. 2003. Yeast RNA helieases of the DEAD-box family involved in translation initiation. Biol. Cell 95:157-167.
57. Liu, Q., and G. Dreyfuss. 1995. In vivo and in vitro arginine methylation of RNA-binding proteins. Mol. Cell. Biol. 15:2800-2808.
58. Mandelboim, M., S. Barth, M. Biton, X. H. Liang, and S. Michaeli. 2003. Silencing of Sm proteins in Trypanosoma brucei by RNA interference captured a novel cytoplasmic intermediate in spliced leader RNA biogenesis. J. Biol. Chem. 278:51469-51478.
59. Markussen, F. H., W. Breitwieser, and A. Ephrussi. 1997. Efficient translation and phosphorylation of Oskar require Oskar protein and the RNA helicase Vasa. Cold Spring Harbor Symp. Quant. Biol. 62:13-17.
60. McBride, A. E., and P. A. Silver. 2001. State of the arg: protein methylation at arginine comes of age. Cell 106:5-8.
61. Meister, G., C. Eggert, D. Buhler, H. Brahms, C. Kambach, and U. Fischer. 2001. Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln. Curr. Biol. 11:1990-1994.
62. Meister, G., and U. Fischer. 2002. Assisted RNP assembly: SMN and PRMT5 complexes cooperate in the formation of spliceosomal UsnRNPs. EMBO J. 21:5853-5863.
63. Miller, M. M., and L. K. Read. 2003. Trypanosoma brucei: functions of RBP16 cold shock and RGG domains in macromolecular interactions. Exp. Parasitol. 105:140-148.
64. Motyka, S. A., M. E. Drew, G. Yildirir, and P. T. Englund. 2006. Overexpression of a cytochrome b5 reduetase-like protein causes kinetoplast DNA loss in Trypanosoma brucei. J. Biol. Chem. 281:18499-18506.
65. Nichols, R. C., X. W. Wang, J. Tang, B. J. Hamilton, F. A. High, H. R. Herschman, and W. F. Rigby. 2000. The RGG domain in hnRNP A2 affects subcellular localization. Exp. Cell Res. 256:522-532.
66. Niewmierzycka, A., and S. Clarke. 1999. S-Adenosylmethionine-dependent methylation in Saccharomyces cerevisiae. Identification of a novel protein arginine methyltransferase. J. Biol. Chem. 274:814-824.
67. Noce, T., S. Okamoto-Ito, and N. Tsunekawa. 2001. Vasa homolog genes in mammalian germ cell development. Cell Struct. Funct. 26:131-136.
68. Obara-Ishihara, T., and H. Okayama. 1994. A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast. EMBO J. 13:1863-1872.
69. Pal, S., S. N. Vishwanath, H. Erdjument-Bromage, P. Tempst, and S. Sif. 2004. Human SWI/SNF-assoeiated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. MoL Cell. Biol. 24:9630-9645.
70. Pal, S., R. Yun, A. Datta, L. Lacomis, H. Erdjument-Bromage, J. Kumar, P. Tempst, and S. Sif. 2003. mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Mye target gene cad. Mol. Cell. Biol. 23:7475-7487.
71. Palfi, Z., S. Lücke, H. W. Lahm, W. S. Lane, V. Kruft, E. Bragado-Nilsson, B. Séraphin, and A. Bindereif. 2000. The spliceosomal snRNP core complex of Trypanosoma brucei: cloning and functional analysis reveals seven Sm protein constituents. Proc. Natl. Acad. Sei. USA 97:8967-8972.
72. Pelletier, M., D. A. Pasternack, and L. K. Read. 2005. In vitro and in vivo analysis of the major type I protein arginine methyltransferase from Trypanosoma brucei. Mol. Biochem. Parasitol. 144:206-217.
73. Pelletier, M., and L. K. Read. 2003. RBP16 is a multifunctional gene regulatory protein involved in editing and stabilization of specific mitochondrial mRNAs in Trypanosoma brucei. RNA 9:457-468.
74. Pelletier, M., Y. Xu, X. Wang, S. Zahariev, S. Pongor, J. M. Aletta, and L. K. Read. 2001. Arginine methylation of a mitochondrial guide RNA binding protein from Trypanosoma brucei. Mol. Biochem. Parasitol. 118:49-59.
75. Perreault, A., C. Lemieux, and F. Bachand. 2007. Regulation of the nuclear poly(A) binding protein by arginine methylation in fission yeast. J. Biol. Chem. 282:7552-7562.
76. Pollack, B. P., S. V. Kotenko, W. He, L. S. Izotova, B. L. Barnoski, and S. Pestka. 1999. The human homologue of the yeast proteins Skb1 and Hs17p interacts with Jak kinases and contains protein methyltransferase activity. J. Biol. Chem. 274:31531-31542.
77. Rho, J., S. Choi, Y. R. Seong, W. K. Cho, S. H. Kim, and D. S. Im. 2001. Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family. J. Biol. Chem. 276:11393- 11401.
78. Rigaut, G., A. Shevehenko, B. Rutz, M. Wilm, M. Mann, and B. Séraphin. 1999. A generic protein purification method for protein complex characterization and proteome exploration. Nat. Biotechnol. 17:1030-1032.
79. Roberts, T. G., N. R. Sturm, B. K. Yee, M. C. Yu, T. Hartshorne, N. Agabian, and D. A. Campbell. 1998. Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans. Mol. Cell. Biol. 18:4409-1417.
80. Ryan, C. M., K. T. Militello, and L. K. Read. 2003. Polyadenylation regulates the stability of Trypanosoma brucei mitochondrial RNAs. J. Biol. Chem. 278:32753-32762.
81. Saksouk, N., M. M. Bhatti, S. Kieffer, A. T. Smith, K. Musset, J. Garin, W. J. Sullivan, Jr., M. F. Cesbron-Delauw, and M. A. Hakimi. 2005. Histone-modifying complexes regulate gene expression pertinent to the differentiation of the protozoan parasite Toxoplasma gondii. Mol. Cell, Biol. 25:10301-10314.
82. Shen, E. C., M. F. Henry, V. H. Weiss, S. R. Valentini, P. A. Silver, and M. S. Lee. 1998. Arginine methylation facilitates the nuclear export of hnRNP proteins. Genes Dev. 12:679-691.
83. Shire, E., P. Kapoor, K. Jiang, M. N. Hing, N. Sivachandran, T. Nguyen, and L. Frappier. 2006. Regulation of the EBNA1 Epstein-Barr virus protein by serine phosphorylation and arginine methylation. J. Virol. 80:5261-5272.
84. Sogin, M. L., J. H. Gunderson, H. J. Elwood, R. A. Alonso, and D. A. Peattie. 1989. Phylogenetic meaning of the kingdom concept: an unusual ribosomal RNA from Giardia lamblia. Science 243:75-77.
85. Stallcup, M. R., D. Chen, S. S. Koh, H. Ma, Y. H. Lee, H. Li, B. T. Schurter, and D. W. Aswad. 2000. Co-operation between protein-acetylating and protein-methylating co-activators in transcriptional activation. Biochem. Soc. Trans. 28:415-418.
86. Stetler, A., C. Winograd, J. Sayegh, A. Cheever, E. Patton, X. Zhang, S. Clarke, and S. Ceman. 2006. Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp. Hum. Mol. Genet. 15:87-96.
87. Strahl, B. D., S. D. Briggs, C. J. Brame, J. A. Caldwell, S. S. Koh, H. Ma, R. G. Cook, J. Shabanowitz, D. F. Hunt, M. R. Stallcup, and C. D. Allis. 2001. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coaetivator PRMT1. Curr. Biol. 11:996-1000.
88. Stuart, K., E. Gobright, L. Jenni, M. Milhausen, L. Thomashow, and N. Agabian. 1984. The IsTaR 1 serodeme of Trypanosoma brucei: development of a new serodeme. J. Parasitol. 70:747-754.
89. Stuart. K. D., A. Schnaufer, N. L. Ernst, and A. K. Panigrahi. 2005. Complex management: RNA editing in trypanosomes. Trends Biochem. Sci. 30:97-105.
90. Tetaud, E., C. Giroud, A. R. Prescott, D. W. Parkin, D. Baltz, N. Biteau, T. Baltz, and A. H. Fairlamb. 2001. Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei. Mol. Biochem. Parasitol. 116:171-183.
91. Vanhamme, L., D. Perez-Morga, C. Marchal, D. Speijer, L. Lambert, M. Geuskens, S. Alexandre, N. Ismaïli, U. Göringer, R. Benne, and E. Pays. 1998. Trypanosoma brucei TBRGG1, a mitochondrial oligo(U)-binding protein that co-localizes with an in vitro RNA editing activity. J. Biol. Chem. 273:21825-21833.
92. Wang, X., Y. Zhang, Q. Ma, Z. Zhang, Y. Xue, S. Bao, and K. Chong. 2007. SKB1-mediated symmetric dimethylation of histone H4R3 controls flowering time in Arabidopsis. EMBO J. 26:1934-1941.
93. Wang, Z., J. C. Morris, M. E. Drew, and P. T. Englund. 2000. Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters. J. Biol. Chem. 275:40174-40179.
94. Wirtz, E., S. Leal, C. Ochatt, and G. A. Cross. 1999. A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Mol. Biochem. Parasitol. 99:89-101.
95. Wysocka, J., C., D. Allis, and S. Coonrod. 2006. Histone arginine methylation and its dynamic regulation. Front. Biosci. 11:344-355.
96. Xu, W., H. Chen, K. Du, H. Asahara, M. Tini, B. M. Emerson, M. Montminy, and R. M. Evans. 2001. A transcriptional switch mediated by cofactor methylation. Science 294:2507-2511.
97. Zhang, X., and X. Cheng. 2003. Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides. Structure 11:509-520.
98. Zhang, X., L. Zhou, and X. Cheng. 2000. Crystal structure of the conserved core of protein arginine methyltransferase PRMT3. EMBO J. 19:3509-3519.
99. Zobel-Thropp, P., J. D. Gary, and S. Clarke. 1998. δ-N-Methylarginine is a novel posttranslational modification of arginine residues in yeast proteins.