Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans

Journal of Lipid Research

Volumn 45, Issue 9, 2004, Pages 1594-1607

  Schwartz, Charles C ^a   VandenBroek, Julie M ^a   Cooper, Patricia S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cholesterol; High density lipoprotein; Kinetics; Low density lipoprotein; Reverse transport

Indexed keywords

CHOLESTEROL ESTER; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MEVALONIC ACID;

ADULT; AGED; ARTICLE; BILE DUCT FISTULA; CHOLESTEROL TRANSPORT; CLINICAL ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; HUMAN; LIPOPROTEIN SYNTHESIS; LIVER; MALE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL TRANSPORT; CHOLESTEROL; CHOLESTEROL ESTERS; EVOLUTION, MOLECULAR; FEMALE; HUMANS; LIPOPROTEINS; LIPOPROTEINS, HDL; LIPOPROTEINS, IDL; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; LIVER; MALE; MEVALONIC ACID; MIDDLE AGED; MODELS, BIOLOGICAL;

EID: 4544331579     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M300511-JLR200     Document Type: Article

References (47)

1. Glomset, J. A., and K. R. Norum. 1973. The metabolic role of lecithin:cholesterol acyltransferase: perspectives from pathology. Adv. Lipid Res. 11: 1-65.
2. Glomset, J. A., G. Assmann, E. Gjone, and K. R. Norum. 1995. Lecithin:cholesterol acyltransferase deficiency and fish eye disease. In The Metabolic and Molecular Basis of Inherited Disease. C. R. Scriver, A. L. Beaudet, W. S. Sly, D. Valle, J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson, editors. McGraw-Hill, New York. 1933-1951.
3. Brewer, H. B., Jr. 2000. The lipid-laden foam cell: an elusive target for therapeutic intervention. J. Clin. Invest. 105: 703-705.
4. Pattnaik, N. M., A. Montes, L. B. Hughes, and D. B. Zilversmit. 1978. Cholesteryl ester exchange protein in human plasma: isolation and characterization. Biochim. Biophys. Acta. 530: 428-438.
5. Tall, A. 1995. Plasma lipid transfer proteins. Annu. Rev. Biochem. 64: 235-257.
6. Brown, M. L., A. Inazu, C. B. Hesler, L. B. Agellon, C. Mann, M. E. Whitlock, Y. L. Marcel, R. W. Milne, J. Koizumi, H. Mabuchi, R. Takeda, and A. R. Tall. 1989. Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins. Nature. 342: 448-451.
7. Morton, R. E., and D. B. Zilversmit. 1983. Inter-relationship of lipids transferred by the lipid-transfer protein isolated from human lipoprotein-deficient plasma. J. Biol. Chem. 258: 11751-11757.
8. Barter, P. J., and M. E. Jones. 1979. Rate of exchange of esterified cholesterol between human plasma low and high density lipoproteins. Atherosclerosis. 34: 67-74.
9. Morton, R. E., and D. B. Zilversmit. 1981. A plasma inhibitor of triglyceride and cholesteryl ester transfer activities. J. Biol. Chem. 256: 11992-11995.
10. Pittman, R. C., T. P. Knecht, M. S. Rosenbaum, and C. A. Taylor, Jr. 1987. A nonendocytotic mechanism for the selective uptake of high density lipoprotein-associated cholesterol esters. J. Biol. Chem. 262: 2443-2450.
11. Rinninger, F., M. Brundert, S. Jackle, P. R. Galle, C. Busch, J. R. Izbicki, X. Rogiers, D. Henne-Bruns, B. Kremer, C. E. Broelsch, and H. Greten. 1994. Selective uptake of high-density lipoprotein-associated cholesteryl esters by human hepatocytes in primary culture. Hepatology. 19: 1100-1114.
12. Trigatti, B., A. Rigotti, and M. Krieger. 2000. The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism. Curr. Opin. Lipidol. 11: 123-131.
13. Schwartz, C. C., L. A. Zech, J. M. VandenBroek, and P. S. Cooper. 1993. Cholesterol kinetics in subjects with bile fistula: positive relationship between size of the bile acid precursor pool and bile acid synthetic rate. J. Clin. Invest. 91: 923-938.
14. Burstein, M., and H. R. Scholnick. 1973. Lipoprotein-polyanion-metal interactions. Adv. Lipid Res. 11: 67-108.
15. Hirsch, J., and E. H. Ahrens. 1958. The separation of complex lipid mixtures by the use of silicic acid chromatography. J. Biol. Chem. 233: 311-320.
16. Schwartz, C. C., Z. R. Vlahcevic, M. Berman, J. G. Meadows, R. M. Nisman, and L. Swell. 1982. Central role of high density lipoprotein in plasma free cholesterol metabolism. J. Clin. Invest. 70: 105-116.
17. Sperry, W., and M. Webb. 1950. Revision of Schoenheimer-Sperry method for cholesterol determination. J. Biol. Chem. 187: 97-106.
18. Schwartz, C. C., M. Berman, Z. R. Vlahcevic, and L. Swell. 1982. Multicompartmental analysis of cholesterol metabolism in man. Quantitative kinetic evaluation of precursor sources and turnover of high density lipoprotein cholesterol esters. J. Clin. Invest. 70: 863-867.
19. Schwartz, C. C., M. Berman, Z. R. Vlahcevic, L. G. Halloran, D. H. Gregory, and L. Swell. 1978. Multicompartmental analysis of cholesterol metabolism in man: characterization of the hepatic bile acid and biliary cholesterol precursor sites. J. Clin. Invest. 61: 408-423.
20. Greif, P., M. Wastney, O. Linares, and R. Boston. 1998. Balancing needs, efficiency, and functionality in the provision of modeling software: a perspective of the NIH WinSAAM Project. Adv. Exp. Med. Biol. 445: 3-20.
21. Monroe, P., Z. R. Vlahcevic, and L. Swell. 1983. In vivo evaluation of lipoprotein cholesterol ester metabolism in patients with liver disease. Gastroenterology. 85: 820-829.
22. Grundy, S. M., and E. H. Ahrens, Jr. 1969. Measurements of cholesterol turnover, synthesis, and absorption in man, carried out by isotope kinetic and sterol balance methods. J. Lipid Res. 10: 91-107.
23. Barter, P.J. 1983. Evidence that lecithin:cholesterol acyltransferase acts on both high-density and low-density lipoproteins. Biochim. Biophys. Acta. 751: 261-270.
24. Carlson, L. A., and L. Holmquist. 1985. Evidence for deficiency of high density lipoprotein lecithin:cholesterol acyltransferase activity (alpha-LCAT) in fish eye disease. Acta Med. Scand. 218: 189-196.
25. Subbaiah, P. V., B. Banerji, R. E. Gregg, and J. D. Bagdade. 1990. Molecular species of cholesteryl esters formed in abetalipoproteinemia: effect of apoprotein B-containing lipoproteins. J. Lipid Res. 31: 927-932.
26. Yen, F. T., R. J. Deckelbaum, C. J. Mann, Y. L. Marcel, R. W. Milne, and A. R. Tall. 1989. Inhibition of cholesteryl ester transfer protein activity by monoclonal antibody. Effects on cholesteryl ester formation and neutral lipid mass transfer in human plasma. J. Clin. Invest. 83: 2018-2024.
27. Dobiasova, M. 1983. Lecithin:cholesterol acyltransferase and the regulation of endogenous cholesterol transport. Adv. Lipid Res. 20: 107-194.
28. Clifton-Bligh, P., N. E. Miller, and P. J. Nestel. 1974. Increased plasma cholesterol esterifying activity during colestipol resin therapy in man. Metabolism. 23: 437-444.
29. Kane, J. P., and R. J. Havel. 1995. Disorders of the biogenesis and secretion of lipoproteins containing the B apolipoproteins. In The Metabolic and Molecular Basis of Inherited Disease. C. R. Scriver, A. L. Beaudet, W. S. Sly, D. Valle, J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson, editors. McGraw-Hill, New York. 1853-1885.
30. Anderson, R. A., C. Joyce, M. Davis, J. W. Reagan, M. Clark, G. S. Shelness, and L. L. Rudel. 1998. Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates. J. Biol. Chem. 273: 26747-26754.
31. Chang, C. C. Y., N. Sakashita, K. Ornvold, O. Lee, E. T. Chang, R. Dong, S. Lin, C. G. Lee, S. C. Strom, R. Kashyap, J. J. Fung, R. V. Farese, Jr., J. F. Patoiseau, A. Delhon, and T. Y. Chang. 2000. Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine. J. Biol. Chem. 275: 28083-28092.
32. Nilsson, A., and D. B. Zilversmit. 1972. Fate of intravenously administered particulate and lipoprotein cholesterol in the rat. J. Lipid Res. 13: 32-37.
33. McPherson, R., C. J. Mann, A. R. Tall, M. Hogue, L. Martin, R. W. Milne, and Y. L. Marcel. 1991. Plasma concentrations of cholesteryl ester transfer protein in hyperlipoproteinemia: relation to cholesteryl ester transfer protein activity and other lipoprotein variables. Arterioscler. Thromb. 11: 797-804.
34. Bagdade, J. D., M. C. Ritter, and P. V. Subbaiah. 1991. Accelerated cholesteryl ester transfer in plasma of patients with hypercholesterolemia. J. Clin. Invest. 87: 1259-1265.
35. Guerin, M., T. S. Lassel, W. Le Goff, M. Farnier, and M. J. Chapman. 2000. Action of atorvastatin in combined hyperlipidemia: preferential reduction of cholesteryl ester transfer from HDL to VLDL1 particles. Arterioscler. Thromb. Vasc. Biol. 20: 189-197.
36. Shamburek, R. D., P. G. Pentchev, L. A. Zech, J. Blanchette-Mackie, E. D. Carstea, J. M. VandenBroek, P. S. Cooper, E. B. Neufeld, R. D. Phair, H. B. Brewer, Jr., R. O. Brady, and C. C. Schwartz. 1997. Intracellular trafficking of the free cholesterol derived from LDL cholesteryl ester is defective in vivo in Niemann-Pick C disease: insights on normal metabolism of HDL and LDL gained from the NP-C mutation. J. Lipid Res. 38: 2422-2435.
37. Blum, C. B., R. I. Levy, S. Eisenberg, M. Hall III, R. H. Goebel, and M. Berman. 1977. High density lipoprotein metabolism in man. J. Clin. Invest. 60: 795-807.
38. Langer, T., W. Strober, and R. I. Levy. 1972. The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia. J. Clin. Invest. 51: 1528-1536.
39. Kesaniemi, Y. A., W. F. Beltz, and S. M. Grundy. 1985. Comparisons of metabolism of apolipoprotein B in normal subjects, obese patients, and patients with coronary heart disease. J. Clin. Invest. 76: 586-595.
40. Parhofer, K. G., P. H. R. Barrett, D. M. Bier, and G. Schonfeld. 1991. Determination of kinetic parameters of apolipoprotein B metabolism using amino acids labeled with stable isotopes. J. Lipid Res. 32: 1311-1323.
41. Packard, C. J., T. Demant, J. P. Stewart, D. Bedford, M. J. Caslake, G. Schwertfeger, A. Bedynek, J. Shepherd, and D. Seidel. 2000. Apolipoprotein B metabolism and the distribution of VLDL and LDL subfractions. J. Lipid Res. 41: 305-317.
42. 3H]leucine tracer. J. Lipid Res. 32: 1823-1836.
43. Welty, F. K., A. H. Lichtenstein, P. H. R. Barrett, G. G. Dolnikowski, and E. J. Schaefer. 1999. Human apolipoprotein (Apo) B-48 and ApoB-100 kinetics with stable isotopes. Arterioscler. Thromb. Vasc. Biol. 19: 2966-2974.
44. Welty, F. K., A. H. Lichtenstein, P. H. R. Barrett, G. G. Dolnikowski, J. M. Ordovas, and E. J. Schaefer. 1997. Decreased production and increased catabolism of apolipoprotein B-100 in apolipoprotein B-67/B-100 heterozygotes. Arterioscler. Thromb. Vasc. Biol. 17: 881-888.
45. Ji, Y., N. Wang, R. Ramakrishnan, E. Sehayek, D. Huszar, J. L. Breslow, and A. R. Tall. 1999. Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile. J. Biol. Chem. 274: 33398-33402.
46. Dietschy, J. M., and S. D. Turley. 2002. Control of cholesterol turnover in the mouse. J. Biol. Chem. 277: 3801-3804.
47. Goldberg, D. I., W. F. Beltz, and R. C. Pittman. 1991. Evaluation of pathways for the cellular uptake of high density lipoprotein cholesterol esters in rabbits. J. Clin. Invest. 87: 331-346.