Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2′-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs

Journal of Medicinal Chemistry

Volumn 50, Issue 19, 2007, Pages 4630-4641

  Pellicciari, Roberto ^a   Marinozzi, Maura ^a   Macchiarulo, Antonio ^a   Fulco, Maria Carmela ^a   Gafarova, Julia ^a,d   Serpi, Michaela ^a   Giorgi, Gianluca ^b   Nielsen, Søren ^c   Thomsen, Christian ^c  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c H LUNDBECK A S   (Denmark)

^d INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2' SULFONOCYCLOPROPYL)GLYCINE; AMPA RECEPTOR; CARBON; GLYCINE DERIVATIVE; HOMOCYSTEIC ACID; HOMOCYSTEIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; CALCULATION; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC POTENTIAL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STEREOISOMERISM; STRUCTURE ANALYSIS;

ANIMALS; BRAIN; CELL LINE; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; CYCLOPROPANES; GLYCINE; HOMOCYSTEINE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PRINCIPAL COMPONENT ANALYSIS; RATS; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; THERMODYNAMICS;

EID: 34648827084     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070322e     Document Type: Article

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