Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 22, 2007, Pages 6920-6926

  Zhang, Lixia ^a   Ren, Lige ^a   Bai, Minghui ^a   Weng, Liwei ^a   Huang, Jing ^a   Wu, Lin ^a   Deng, Minggang ^a   Zhou, Xiang ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

DNA transcription; Phenol quaternary ammonium salt; Quinazoline derivatives

Indexed keywords

4 (2 CHLORO 6,7 DIMETHOXYQUINAZOLIN 4 YLAMINO) 2 [(DIMETHYLAMINO)METHYL]PHENOL; 4 (4 AMINO 6,7 DIMETHYLQUINAZOLIN 2 YLAMINO) 2 [(DIMETHYLAMINO)METHYL]PHENOL; 4,4' (6,7 DIMETHOXYQUINAZOLIN 2,4 DIYL) BIS(AZANEDIYL) BIS[2 [(DIMETHYLAMINO)METHYL]PHENOL]; [5 (2 CHLORO 6,7 DIMETHOXYQUINAZOLIN 4 YLAMINO) 2 HYDROXYPHENYL] N,N,N TRIMETHYLMETHANAMINIUM IODIDE; [5 (4 AMINO 6,7 DIMETHOXYQUINAZOLIN 2 YLAMINO) 2 HYDROXYPHENYL] N,N,N TRIMETHYLMETHANAMINIUM IODIDE; [5,5' (6,7 DIMETHOXYQUINAZOLIN 2,4 DIYL) BIS(AZANEDIYL) BIS(2 HYDROXY 5,1 PHENYLENE)] BIS(N,N,N TRIMETHYLMETHANAMINIUM)IODIDE; ANTINEOPLASTIC AGENT; DNA; QUATERNARY AMMONIUM DERIVATIVE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; DNA BINDING; DNA TRANSCRIPTION; DRUG EFFICACY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CROSS-LINKING REAGENTS; DNA; HYDROGEN-ION CONCENTRATION; MOLECULAR STRUCTURE; NUCLEIC ACID DENATURATION; PHENOLS; QUATERNARY AMMONIUM COMPOUNDS; QUINAZOLINES; SALTS; TEMPERATURE; TRANSCRIPTION, GENETIC;

EID: 34548848821     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.07.053     Document Type: Article

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