Synthesis, DNA binding and in vitro antiproliferative activity of purinoquinazoline, pyridopyrimidopurine and pyridopyrimidobenzimidazole derivatives as potential antitumor agents

European Journal of Medicinal Chemistry

Volumn 33, Issue 9, 1998, Pages 685-696

  Da Settimo, Antonio ^a   Da Settimo, Federico ^a   Marini, Anna Maria ^a   Primofiore, Giampaolo ^a   Salerno, Silvia ^a   Viola, Giampietro ^b   Dalla Via, Lisa ^b   Marciani Magno, Sebastiano ^b  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Antipr oliferative properties; DNA binding agents; Purinoquinazolines; Pyridopyrimidobenzirnidazoles; Pyridopyrimidopurines

Indexed keywords

ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); PURINE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CIRCULAR DICHROISM; CONTROLLED STUDY; DNA CLEAVAGE; DNA DRUG COMPLEX; DRUG ACTIVITY; DRUG DNA BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THERMODYNAMICS;

EID: 0032425573     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(98)80027-5     Document Type: Article

References (26)

1. [1] Baguley B.C., Anti-Cancer Drug Des. 6 (1991) 1-35.
2. [2] Denny W.A., Anti-Cancer Drug Des. 4 (1989) 241-263.
3. [3] Chen A.Y., Liu L.F., Ann. Rev. Pharmacol. Tox. 34 (1994) 191-218.
4. [4] Da Settimo A., Primofiore G., Bertacchi M:C., Da Settimo F., Marini A.M., J. Heterocyclic Chem. 32 (1995) 941.
5. [5] Duesel B.F., Berman H., Schachter R.J., J. Am. Pharm. Ass. 43 (1954) 619.
6. [6] Jones J.W., Robins R.K., J. Am. Chem. Soc. 82 (1960) 3773.
7. [7] Bariana D.S., J. Med. Chem. 14 (1971) 543.
8. [8] Descours D., Festal D., Synthesis (1983) 1033.
9. [9] De Lucchi O., Miotti U., Modena G., In: Paquette L.A. (Ed.), Organic Reactions, Vol. 40, Wiley, New York, 1991, p. 157.
10. [10] Czuba W., Kasperek L., Prelicz D., Borkowska B., Bogdal M., Krzywosinski L., Przemyk B., Pol. J. Pharmacol. Pharm. 37 (1985) 533.
11. [11] Otto H.H., Pharm. Zentralh. 107 (1968) 444.
12. [12] Caroti P., Ceccotti C., Da Settimo A., Palla F., Primofiore G., J. Heterocyclic Chem. 23 (1986) 1833.
13. [13] Crothers D.J., Biopolymers 10 (1971) 2147-2158.
14. [14] Norden B., Appl. Spectroscop. Rev. 14 (1978) 157-248.
15. [15] Norden B., Kubista M., Kurucsev T., Q. Rev. Biophys. 25 (1992) 51-170.
16. [16] Scatchard G., Ann. NY Acad. Sci. 51 (1949) 660-672.
17. [17] McGhee J.D., von Hippel P.H., J. Mol. Biol. 86 (1974) 469-489.
18. [18] Cera C., Palù G., Marciani Magno S., Palumbo M., Nucleic Acids Res. 19 (1991) 2309-2314.
19. [19] Zegar I., Gräslund A., Bergman J., Eriksson M., Nordén B., Biopolymers 34 (1994) 599-609.
20. [20] Wilson W.D., Wang Y.H., Kusuma S., Chandrasekaran S., Yang N.C., Boykyn D.W., J. Am. Chem. Soc. 107 (1985) 4989-4995.
21. [21] Muller W., Gautier F., Eur. J. Biochem. 54 (1975) 385-394.
22. 22] Geacintov N.E., Shabaz M., Ibanez V., Moussaoui K., Harvey R.G., Biochemistry 27 (1988) 8380-8386.
23. 23] Liu L.F., Annu. Rev. Biochem. 58 (1989) 351-375.
24. 24] Capranico G., Zunino F., Eur. J. Cancer 28A (12) (1992) 2055-2060.
25. [25] Wada A., Kozawa S., J. Polim. Sci. 2 (1974) 853-864.
26. [26] Tewey K.M., Rowe T.C., Yang L., Halligan B.D., Liu L.F., Science 226 (1984) 466-468.