The superficial layer of human articular cartilage is more susceptible to interleukin-1-induced damage than the deeper layers

Arthritis and Rheumatism

Volumn 39, Issue 3, 1996, Pages 478-488

  Hauselmann H J ^a,b,c   Flechtenmacher, J ^a,d   Michal, L ^a   Thonar, E J M A ^a   Shinmei, M ^e   Kuettner, K E ^a   Aydelotte, M B ^a  

^a RUSH MEDICAL COLLEGE   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY OF ULM   (Germany)

^e NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; PROSTAGLANDIN E2; PROTEOGLYCAN; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RECOMBINANT INTERLEUKIN 1ALPHA; RECOMBINANT INTERLEUKIN 1BETA; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE;

ADOLESCENT; ADULT; ARTICLE; ARTICULAR CARTILAGE; BINDING AFFINITY; BINDING SITE; CARTILAGE CELL; CELL CULTURE; CELL DAMAGE; CONTROLLED STUDY; ENZYME DEGRADATION; ENZYME SYNTHESIS; FEMALE; FEMUR CONDYLE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; RECEPTOR BINDING;

ADOLESCENT; ADULT; CARTILAGE, ARTICULAR; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; MIDDLE AGED; PROTEOGLYCANS; RECEPTORS, INTERLEUKIN-1; RECOMBINANT PROTEINS; SIALOGLYCOPROTEINS;

EID: 0029916803     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780390316     Document Type: Article

References (64)

1. Ratcliffe A, Tyler JA, Hardingham TE: Articular cartilage cultured with interleukin 1: increased release of link protein, hyaluronate-binding region and other proteoglycan fragments. Biochem J 238:571-580, 1986
2. 2 release from cartilage in organ culture. Arthritis Rheum 32:288-297, 1989
3. Hutchinson NI, Lark MW, MacNaul KL, Harper C, Hoerrner LA, McDonnell J, Donatelli S, Moore V, Bayne EK: In vivo expression of stromelysin in synovium and cartilage of rabbits injected intraarticularly with interleukin-1β. Arthritis Rheum 35:1227-1233, 1992
4. Van Beuningen HM, Arntz OJ, van den Berg WB: In vivo effects of interleukin-1 on articular cartilage: prolongation of proteoglycan metabolic disturbances in old mice. Arthritis Rheum 34:606-615, 1991
5. Tyler JA: Articular cartilage cultured with catabolin (pig interleukin 1) synthesizes a decreased number of normal proteoglycan molecules. Biochem J 227:869-878, 1985
6. Benton HP, Tyler JA: Inhibition of cartilage proteoglycan synthesis by interleukin 1. Biochem Biophys Res Commun 154:421-428, 1988
7. Tyler JA: Chondrocyte-mediated depletion of articular cartilage proteoglycans in vitro. Biochem J 225:493-507, 1985
8. Morales TI, Hascall VC: Effects of interleukin-1 and lipopolysaccharides on protein and carbohydrate metabolism in bovine articular cartilage organ cultures. Connect Tissue Res 19:255-275, 1989
9. Aydelotte MB, Raiss RX, Caterson B, Kuettner KE: Influence of interleukin-1 on the morphology and proteoglycan metabolism of cultured bovine articular chondrocytes. Connect Tissue Res 28:143-159, 1992
10. 2 production by an interleukin 1-like factor. Eur J Immunol 14:490-495, 1984
11. Gowen M, Wood DD, Ihrie EJ, Meats JE, Russell RGG: Stimulation by human interleukin 1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro. Biochim Biophys Acta 797:186-193, 1984
12. Wood DD, Ihrie EJ, Dinarello CA, Cohen PL: Isolation of an interieukin-1-like factor from human joint effusions. Arthritis Rheum 26:975-983, 1983
13. Walakovits LA, Moore VL, Bhardwaj N, Gallick GS, Lark MW: Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injury. Arthritis Rheum 35:35-42, 1992
14. Lohmander LS, Walakovits LA, Lark MW: Metalloproteinase, tissue inhibitor and proteoglycan fragments in knee synovial fluid in human osteoarthritis (abstract). Trans Orthop Res Soc 17:273, 1992
15. Muir H: Current and future trends in articular cartilage research and osteoarthritis. In, Articular Cartilage and Osteoarthritis. Edited by KE Kuettner, R Schleyerbach, JG Peyron, VC Hascall, New York, Raven Press, 1992
16. Martel-Pelletier J, McCollum R, DiBattista J, Faure M-P, Chin JA, Fournier S, Sarfati M, Pelletier J-P: The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes: identification as the type I receptor and analysis of binding kinetics and biologic function. Arthritis Rheum 35:530-540, 1992
17. Lomedico PT, Kilian PL, Gubler U, Stern AS, Chizzonite R: Molecular biology of interleukin-1 (abstract). Cold Spring Harb Symp Quant Biol 51:631-635, 1986
18. March CJ, Mosley B, Larsen A, Cerretti AP, Braedt G, Price V, Gillis S, Henney CS, Kronheim SR, Grabstein K, Conlon PJ, Hopp TP, Cosman D: Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 315:641-647, 1985
19. Lomedico PT, Gubler U, Hellmann C, Dukovich M, Giri JG, Pan Y-CE, Collier K, Semionow R, Chua AO, Mizel SB: Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature 312:458-462, 1984
20. Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, Elliston KO, Ayala JM, Casano FJ, Chin J, Ding GJ-F, Egger LA, Gaffney EP, Limjuco G, Palyha OC, Raju SM, Rolando AM, Salley JP, Yamin T-T, Lee TD, Shively JE, MacCross M, Mumford RA, Schmidt JA, Tocci MJ: A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature 356:768-774, 1992
21. Dinarello CA, Wolff SM: The role of interteukin-1 in disease. N Engl J Med 328:106-113, 1993
22. Chin JE, Horuk R: Interleukin 1 receptors on rabbit articular chondrocytes: relationship between biological activity and receptor binding kinetics. FASEB J 4:1481-1487, 1990
23. Smith RJ, Chin JE, Sam LM, Justen JM: Biologic effects of an interleukin-1 receptor antagonist protein on interleukin-1-stimulated cartilage erosion and chondrocyte responsiveness. Arthritis Rheum 34:78-83, 1991
24. Hannum CH, Wilcox CJ, Arend WP, Joslin FG, Dripps DJ, Heimdal PL, Armes LG, Sommer A, Eisenberg SP, Thompson RC: Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 343:336-340, 1990
25. Slack J, McMahan CJ, Waugh S, Schooley K, Spriggs MK, Sims JE, Dower SK: Independent binding of IL-1α and IL-1β to type I and type II IL-1 receptors. J Biol Chem 268:2513-2524, 1993
26. Eisenberg SP, Evans RJ, Arend WP, Verderbe E, Brewer MT, Hannum CH, Thompson RC: Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature 343:341-346, 1990
27. Dripps DJ, Verderber E, Ng RK, Thompson RC, Eisenberg SP: Interleukin-1 receptor antagonist binds to the type II interleukin-1 receptor on B cells and neutrophils. J Biol Chem 266:20311-20315, 1991
28. Arend WP, Welgus HP, Thompson RC, Eisenberg SP: Biological properties of recombinant human monocyte-derived interleukin-1 receptor antagonist. J Clin Invest 85:1694-1697, 1990
29. Sims JE, March CJ, Cosman D, Widmer MB, MacDonald HR, McMahan CJ, Grubin CE, Wignall JM, Jackson JL, Call SM, Friend D, Alpert AR, Gillis S, Urdal DL, Dower SK: cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science 241:585-589, 1988
30. Horuk R, McCubrey JA: The interleukin-1 receptor in Raji human B-lymphoma cells. Biochem J 260:657-663, 1989
31. Scapigliati G, Ghiara P, Bartalini M, Tagliabue A, Boraschi D: Differential binding of IL-1α and IL-1β to receptors on B and T cells. FEBS Lett 243:394-398, 1989
32. Sims JE, Acres RB, Grubin CE, McMahan CJ, Wignall JM, March CJ, Dower SK: Cloning the interleukin 1 receptor from human T cells. Proc Natl Acad Sci U S A 86:8946-8950, 1989
33. Saklatvala J, Bird T: A common class of high affinity receptors for the two types of porcine interleukin-1 on articular chondrocytes. Lymphokine Res 5 (Suppl 1):99-104, 1986
34. McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, Grubin CE, Wignall JM, Jenkins NA, Brannan CI, Copeland NG, Huebner K, Croce CM, Cannizzarro LA, Benjamin D, Dower SK, Spriggs MK, Sims JE: A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J 10:2821-2832, 1991
35. Dinarello CA, Thompson RC: Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol Today 12:404-410, 1991
36. Martel-Pelletier J, Sadouk MB, Mineau F, Kiansa K, Tardif G, and Martel-Pelletier J-P: Human synovial fibroblast coexpress interleukin-1 receptor type I and type II: the enhanced binding to interleukin-1 in osteoarthritic cells is related to an increased level of type I receptor (abstract). Trans Orthop Res Soc 20:306, 1995
37. Bomsztyk K, Sims JE, Stanton TH, Slack J, McMahan CJ, Valentine MA, Dower SK: Evidence for different interleukin 1 receptors in murine B- and T-cell lines. Proc Natl Acad Sci USA 86:8034-8038, 1989
38. Chizzonite R, Truitt T, Kilian PL, Stern AS, Nunes P, Parker KP, Kaffka KL, Chua AO, Lugg DK, Gubler U: Two high-affinity interleukin 1 receptors represent separate gene products. Proc Natl Acad Sci U S A 86:8029-8033, 1989
39. Colotta F, Re F, Muzio M, Bertini R, Polentarutti N, Sironi M, Giri JG, Dower SK, Sims JE, Mantovani A: Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science 261:472-475, 1993
40. Dower SK, Call SM, Gillis S, Urdal DL: Similarity between the interleukin-1 receptors on a murine T-lymphoma cell line and on a murine fibroblast cell line. Proc Natl Acad Sci U S A 83:1060-1064, 1986
41. Horak R, Huang JJ, Covington M, Newton RC: A biochemical and kinetic analysis of the interleukin-1 receptor. J Biol Chem 262:16275-16278, 1987
42. Carter DB, Deibel MR Jr, Dunn CJ, Tomich CS, Laborde AL, Slightom JL, Berger AE, Bienkowski MJ, Sun FF, McEwan RN, Harris PKW, Yem AW, Waszak GA, Chosay JG, Sieu LC, Hardee MM, Zurcher-Neely HA, Reardon IM, Heinrickson RL, Truesdell SE, Shelly JA, Eessalu TE, Taylor BM, Tracey DE: Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature 344:633-638, 1990
43. Granowitz EV, Clark BD, Mancilla J, Dinarello CA: Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor. J Biol Chem 266:14147-14150, 1991
44. Aydelotte MB, Kuettner KE: Heterogeneity of articular chondrocytes and cartilage matrix. In, Joint Cartilage Degradation. Edited by JF Woessner, DS Howell. New York, Marcel Dekker, 1993
45. Akizuki S, Mow VC, Müller F, Pita JC, Howell DS, Manicourt DH: Tensile properties of human knee joint cartilage. I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus. J Orthop Res 4:379-392, 1986
46. Aydelotte MB, Kuettner KE: Differences between subpopulations of cultured bovine articular chondrocytes. I. Morphology and cartilage matrix production. Connect Tissue Res 18:205-222, 1988
47. Aydelotte MB, Greenhill RR, Kuettner KE: Differences between sub-populations of cultured bovine articular chondrocytes. II. Proteoglycan metabolism. Connect Tissue Res 18: 223-234, 1988
48. Aydelotte MB, Raiss RX, Schleyerbach R, Kuettner KE: Effects of interleukin-1 on metabolism of proteoglycans by cultured bovine articular chondrocytes (abstract). J Bone Joint Surg [Am] 12:359, 1988
49. Häuselmann HJ, Mok-Loh SS, Schumacher BL, Aydelotte MB, Kuettner KE: Different IL-1 and IRAP responses of subpopulations of human articular chondrocytes (abstract). Trans Orthop Res Soc 17:61, 1992
50. Häuselmann HJ, Flechtenmacher J, Mollenhauer J, Kuettner KE, Aydelotte MB: Differences in responsiveness and in receptor numbers for interleukin-1 between adult human chondrocytes from superficial and deep zones of articular cartilage (abstract). Trans Orthop Res Soc 19:363, 1994
51. Häuselmann HJ, Fernandas RJ, Mok SS, Schmid TM, Block JA, Aydelotte MB, Kuettner KE, Thonar EJ-MA: Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads. J Cell Sci 107:17-27, 1994
52. Häuselmann HJ, Aydelotte MB, Schumacher BL, Kuettner KE, Gitelis SH, Thonar EJ-MA: Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads. Matrix 12:116-129, 1992
53. Kim Y-J, Sah RLY, Doong J-YH, Grodzinsky AJ: Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 174:168-176, 1988
54. Chandrasekhar S, Harvey AK: Induction of interleukin-1 receptors on chondrocytes by fibroblast growth factor: a possible mechanism for modulation of interleukin-1 activity. J Cell Physiol 138:236-246, 1989
55. Harvey AK, Hrubey PS, Chandrasekhar S: Transforming growth factor-β inhibition of interleukin-1 activity involves down regulation of interleukin-1 receptors on chondrocytes. Exp Cell Res 195:376-385, 1991
56. Kodama S, Iwata K, Iwata H, Yamashita K, Hayakawa T: Rapid one-step sandwich enzyme immunoassay for tissue inhibitor of metalloproteinases: an application for rheumatoid arthritis serum and plasma. J Immunol Methods 127:103-108, 1990
57. Cooksley S, Hipkiss HJB, Tickle SB, Holmesievers E, Docherty AJP, Murphy G, Lawson ADG: Immunoassay for the detection of human collagenase; stromelysin; tissue inhibitor of metalloproteinase (TIMP) and enzyme-inhibitor complexes. Matrix 10:285-291, 1990
58. Hauselmann HJ, Oppliger L, Michel BA, Stefanovic-Racic M, Evans CH: Nitric oxide and proteoglycan biosynthesis by human articular chondrocytes in alginate culture. FEBS Lett 352:361-364, 1994
59. Knott I, Dieu M, Burton M, Lecomte V, Remacle J, Raes M: Differential effects of interleukin-1 alpha and beta on the arachidonic acid cascade in human synovial cells and chondrocytes in culture. Agents Actions 39:126-131, 1993
60. Tyler JA, Bolis S, Dingle JT, Middleton JFS: Mediators of matrix catabolism. In, Articular Cartilage and Osteoarthntis. Edited by KE Kuettner, R Schleyerbach, JG Peyron, VC Hascal. New York, Raven Press, 1992
61. Bird TA, Saklatvala J: Identification of a common class of high affinity receptors for both types of porcine interleukin-1 on connective tissue cells. Nature (London) 324:263-266, 1986
62. Nguyen Q, Murphy G, Roughley PJ, Mort JS: Degradation of proteoglycan aggregate by a cartilage metalloproteinase: evidence for the involvement of strometysin in the generation of link protein heterogeneity in situ. Biochem J 259:61-67, 1989
63. McDonnell J, Hoerrner LA, Lark MW, Harper C, Dey T, Lobner J, Eiermann G. Kazazis D, Singer II, Moore VL: Recombinant human interleukin-1β-induced increase in levels of proteoglycans, stromelysin, and leukocytes in rabbit synovial fluid. Arthritis Rheum 35:799-805, 1992
64. Lohmander LS, Roos H, Dahlberg L, Hoerrner LA, Lark MW: Temporal patterns of stromelysin-1, tissue inhibitor, and proteoglycan fragments in human knee joint fluid after injury to the cruciate ligament or meniscus. J Orthop Res 12:21-28, 1994