Extended haplotypes and linkage disequilibrium in the IL1R1-IL1A-IL1B-IL1RN gene cluster: Association with knee osteoarthritis

Genes and Immunity

Volumn 5, Issue 6, 2004, Pages 451-460

  Smith, Andrew J P ^a   Keen, L J ^a   Billingham, M J ^a   Perry, M J ^b   Elson, C J ^a   Kirwan, J R ^c   Sims, J E ^d   Doherty, M ^e   Spector, T D ^f   Bidwell, J L ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b SOUTHMEAD HOSPITAL   (United Kingdom)

^c BRISTOL ROYAL INFIRMARY   (United Kingdom)

^d AMGEN INC   (United States)

^e UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^f ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Interleukin 1; Linkage disequilibrium; Osteoarthritis; Polymorphism

Indexed keywords

INTERLEUKIN 1 RECEPTOR;

ADULT; ARTICLE; CONTROLLED STUDY; EXON; FEMALE; GENE CLUSTER; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOME; GENOTYPE; HAPLOTYPE; HUMAN; INFLAMMATION; KNEE OSTEOARTHRITIS; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POLYMORPHIC LOCUS; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; RISK REDUCTION; STATISTICAL ANALYSIS; UNITED KINGDOM;

AGED; BASE SEQUENCE; CASE-CONTROL STUDIES; FEMALE; GENOTYPE; HAPLOTYPES; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; OSTEOARTHRITIS, KNEE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RECEPTORS, INTERLEUKIN-1; RECEPTORS, INTERLEUKIN-1 TYPE I; RISK FACTORS; SEQUENCE HOMOLOGY, NUCLEIC ACID; SIALOGLYCOPROTEINS; TANDEM REPEAT SEQUENCES;

EID: 4644247122     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6364107     Document Type: Article

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