The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage

Biochemical Journal

Volumn 371, Issue 1, 2003, Pages 115-124

  Wikström, Katarina ^a   Juhas, Maria ^a   Sjölander, Anita ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Bad; Bcl XL; Cyclo oxygenase 2; Cytochrome c; Epithelial cell

Indexed keywords

MICROSCOPIC EXAMINATION; PROTEINS; SIGNALING; TUMORS;

ANTI-APOPTOTIC EFFECTS;

CELLS;

CASPASE 8; CYCLOOXYGENASE 2; CYTOCHROME C; LEUKOTRIENE D4; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANE SULFONAMIDE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN BCL XL; PROTEIN BID; SULFONAMIDE; UNCLASSIFIED DRUG; BAD PROTEIN, HUMAN; BID PROTEIN, HUMAN; CARRIER PROTEIN; CASP3 PROTEIN, HUMAN; CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE; CASPASE 3; CASPASE 9; CYCLOOXYGENASE 2 INHIBITOR; ISOENZYME; MEMBRANE PROTEIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANESULFONAMIDE; NITROBENZENE DERIVATIVE; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS2 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL DEATH; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; MICROSCOPY; MITOCHONDRION; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REGULATORY MECHANISM; WESTERN BLOTTING; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; EPITHELIUM CELL; INTESTINE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CELLS, CULTURED; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; CYTOCHROME C GROUP; ENZYME ACTIVATION; EPITHELIAL CELLS; HUMANS; INTESTINES; ISOENZYMES; LEUKOTRIENE D4; MEMBRANE PROTEINS; MITOCHONDRIA; NITROBENZENES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 0037393117     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021669     Document Type: Article

References (38)

1. Samuelsson, B., Dahlen, S. E., Lindgren, J. Å., Rouzer, C. A. and Serhan, C. N. (1987) Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 237, 1171-1176
2. 1 receptor. Nature (London) 399, 789-793
3. Heise, C. E., O'Dowd, B. F., Figueroa, D. J., Sawyer, N., Nguyen, T., Im, D. S., Stocco, R., Bellefeuille, J. N., Abramovitz, M., Cheng, R. et al. (2000) Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275, 30531-30536
4. 2+. J. Biol. Chem. 265, 20976-20981
5. Horwitz, R. J., McGill, K. A. and Busse, W. W. (1998) The role of leukotriene modifiers in the treatment of asthma. Am. J. Respir. Crit. Care Med. 157, 1363-1371
6. Ekbom, A., Helmick, C., Zack, M. and Adami, H. O. (1990) Ulcerative colitis and colorectal cancer. A population-based study. N. Engl. J. Med. 323, 1228-1233
7. Smalley, W. E. and DuBois, R. N. (1997) Colorectal cancer and nonsteroidal anti-inflammatory drugs. Adv. Pharmacol. 39, 1-20
8. Vane, J. R. and Botting, R. M. (1998) Mechanism of action of nonsteroidal anti-inflammatory drugs. Am. J. Med. 104, 2S-8S
9. Sheng, H., Shao, J., Kirkland, S. C., Isakson, P., Coffey, R. J., Morrow, J., Beauchamp, R. D. and DuBois, R. N. (1997) Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J. Clin. Invest. 99, 2254-2259
10. Öhd, J. F., Wikström, K. and Sjölander, A. (2000) Leukotrienes induce cell-survival signaling in intestinal epithelial cells. Gastroenterology 119, 1007-1018
11. 1, COX-2 and other cell survival factors in colorectal adenocarcinomas. Gastroenterology 124, 57-70
12. 2 in human colon cancer cells. Cancer Res. 58, 362-366
13. Shimizu, S., Narita, M. and Tsujimoto, Y. (1999) Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature (London) 399, 483-487
14. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S. and Wang, X. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (Cambridge, Mass.) 91, 479-489
15. Luo, X., Budihardjo, I., Zou, H., Slaughter, C. and Wang, X. (1998) Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell (Cambridge, Mass.) 94, 481-490
16. Korsmeyer, S. J., Wei, M. C., Saito, M., Weiler, S., Oh, K. J. and Schlesinger, P. H. (2000) Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 7, 1166-1173
17. Besnault, L., Schrantz, N., Auffredou, M. T., Leca, G., Bourgeade, M. F. and Vazquez, A. (2001) B cell receptor cross-linking triggers a caspase-8-dependent apoptotic pathway that is independent of the death effector domain of fas-associated death domain protein. J. Immunol. 167, 733-740
18. Vanderheyde, N., Aksoy, E., Amraoui, Z., Vandenabeele, P., Goldman, M. and Willems, F. (2001) Tumoricidal activity of monocyte-derived dendritic cells: evidence for a caspase-8-dependent, Fas-associated death domain-independent mechanism. J. Immunol. 167, 3565-3569
19. Liu, X. H., Yao, S., Kirschenbaum, A. and Levine, A. C. (1998) NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates Bcl-2 expression in LNCaP cells. Cancer Res. 58, 4245-4249
20. Futaki, N., Takahashi, S., Yokoyama, M, Arai, I., Higuchi, S. and Otomo, S. (1994) NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47, 55-59
21. Lizcano, J. M., Morrice, N. and Cohen, P. (2000) Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem. J. 349, 547-557
22. Breitschopf, K., Zeiher, A. M. and Dimmeler, S. (2000) Ubiquitin-mediated degradation of the proapoptotic active form of Bid. A functional consequence on apoptosis induction. J. Biol. Chem. 275, 21648-21552
23. Mandic, A., Viktorsson, K., Strandberg, L., Heiden, T., Hansson, J., Linder, S. and Shoshan, M. C. (2002) Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis. Mol. Cell. Biol. 22, 3003-3013
24. Cao, Y. and Prescott, S. M. (2002) Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. J. Cell. Physiol. 190, 279-286
25. Elder, D. J., Halton, D. E., Playle, L. C. and Paraskeva, C. (2002) The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. Int. J. Cancer 99, 323-327
26. Li, M., Wu, X. and Xu, X. C. (2001) Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway. Clin. Cancer Res. 7, 1010-1016
27. Li, M., Wu, X. and Xu, X. C. (2001) Induction of apoptosis by cyclo-oxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway in esophageal cancer cells. Int. J. Cancer 93, 218-223
28. Hague, A., Bracey, T. S., Hicks, D. J., Reed, J. C. and Paraskeva, C. (1998) Decreased levels of p26-Bcl-2, but not p30 phosphorylated Bcl-2, precede TGFβ1-induced apaptosis in colorectal adenoma cells. Carcinogenesis 19, 1691-1695
29. Zhang, L., Yu, J., Park, B. H., Kinzler, K. W. and Vogelstein, B. (2000) Role of BAX in the apoptotic response to anticancer agents. Science 290, 989-992
30. Rosen, K., Rak, J., Jin, J., Kerbel, R. S., Newman, M. J. and Filmus, J. (1998) Downregulation of the pro-apoptotic protein Bak is required for the Ras-induced transformation of intestinal epithelial cells. Curr. Biol. 8, 1331-1334
31. L and reduced Bak in primary colorectal adenocarcinomas. Cancer Res. 56, 2422-2427
32. Virdee, K., Parone, P. A. and Tolkovsky, A. M. (2000) Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival. Curr. Biol. 10, 1151-1154
33. L. Cell (Cambridge, Mass.) 87, 619-628
34. 4 activates MAPK through a Ras-independent but PKCε-dependent pathway in intestinal epithelial cells. J. Cell Sci. 115, 1883-1893
35. Grossmann, J., Walther, K., Artinger, M., Kiessling, S. and Scholmerich, J. (2001) Apoptotic signaling during initiation of detachment-induced apoptosis ('anoikis') of primary human intestinal epithelial cells. Cell Growth Differ. 12, 147-155
36. Rytömaa, M., Martins, L. M. and Downward, J. (1999) Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis. Curr. Biol. 9, 1043-1046
37. Han, Z., Pantazis, P., Wyche, J. H., Kouttab, N., Kidd, V. J. and Hendrickson, E. A. (2001) A Fas-associated death domain protein-dependent mechanism mediates the apoptotic action of non-steroidal anti-inflammatory drugs in the human leukemic Jurkat cell line. J. Biol. Chem. 276, 38748-38754
38. Desagher, S., Osen-Sand, A., Montessuit, S., Magnenat, E., Vilbois, F., Hochmann, A., Journot, L., Antonsson, B. and Martinou, J. C. (2001) Phosphorylation of Bid by casein kinases I and II regulates its cleavage by caspase 8. Mol. Cell 8, 601-611