Candidate glioblastoma development gene identification using concordance between copy number abnormalities and gene expression level changes

Genes Chromosomes and Cancer

Volumn 46, Issue 10, 2007, Pages 875-894

  Lo, Ken C ^a   Rossi, Michael R ^a,c   LaDuca, Jeffrey ^a   Hicks, David G ^a   Turpaz, Yaron ^b   Hawthorn, Lesleyann ^a   Cowell, John K ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b Thermo Fisher Scientific   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPLICON; ARTICLE; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 11; CHROMOSOME 12; CHROMOSOME 14; CHROMOSOME 15; CHROMOSOME 4; CHROMOSOME 9; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DNA MICROARRAY; GENE AMPLIFICATION; GENE FREQUENCY; GENE IDENTIFICATION; GENE LOCATION; GENE LOSS; GENE OVEREXPRESSION; GENETIC SCREENING; GENOME ANALYSIS; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; TUMOR CELL;

BRAIN NEOPLASMS; CHROMOSOME ABERRATIONS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN; GENE DOSAGE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; GLIOBLASTOMA; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 34548726049     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20474     Document Type: Article

References (86)

1. Ahn JY, Hu Y, Kroll TG, Allard P, Ye K. 2004. PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proc Natl Acad Sci USA 101:6993-6998.
2. Allemeersch J, Durinck S, Vanderhaeghen R, Alard P, Maes R, Seeuws K, Bogaert T, Coddens K, Deschouwer K, Van Hummelen P, Vuylsteke M, Moreau Y, Kwekkeboom J, Wijfjes AH, May S, Beynon J, Hilson P, Kuiper MT. 2305. Benchmarking the CATMA microarray. A novel tool for Arabidopsis transcriptome analysis. Plant Physiol 137:588-601.
3. Aust DE, Muders M, Kohler A, Schmidt M, Diebold J, Muller C, Lohrs U, Waldman FM, Baretton GB. 2004. Prognostic relevance of 20q13 gains in sporadic colorectal cancers: A FISH analysis. Scand J Gastroenterol 39:766-772.
4. Bigner SH, Mark J, Burger PC, Mahaley MS, Jr, Bullard DE, Muhlbaier LH, Bigner DD. 1988. Specific chromosomal abnormalities in malignant human gliomas. Cancer Res 48:405-411.
5. Cairncross JG, Ueki K, Zlatescu MC, Lisb DK, Finkelstein DM, Hammond RR, Silver JS, Stark PC, Macdonald DR, Ino Y, Ramsay DA, Louis DN. 1998. Specific generic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst 90:1473-1479.
6. Chernova O, Cowell JK. 1998. Molecular Definition of chromosome translocations involving 10q24 and 19q13 in human malignant glioma cells. Cancer Genet Cytogenet 105:60-68.
7. Chernova OB, Hunyadi A, Malaj E, Pan H, Crooks C, Roe B, Cowell JK. 2001. A novel member of the WD-repeat gene family, VVDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells. Oncogene 20:5378-5392.
8. Cowell JK, Nowak NJ. 2003. High resolution analysis of genetic events in cancer cells using BAC arrays and CGHa. In: George F, Woude V, Klein G, editors. Advances in Cancer Ressearch. Oxford, UK: Elsevier Academic Press, Chapter 3, pp. 91-125.
9. Cowell JK, Matsui SI, Wang J, LaDuca J, Conroy J, McQuaid D, Nowak NJ. 2004. Application of comparative genome hybridization using BAC arrays and spectral karyotyping to the analysis of glioblastoma multiforme. Cancer Genet Cytogenet 151:36-51.
10. Deen DF, Chiarodo A, Grimm EA, Fike JR, Israel MA, Kun LE, Levin VA, Marton LJ, Packer RJ, Pegg AE. 1993. Brain Tumor Working Group report on the 9th International Conference on Brain Tumor Research and Therapy. Organ System Program, National Cancer Institute. J Neurooncol 16:243-272.
11. Dichamp CS, Taillibert L, Aguirre-Cruz J, Lejeune Y, Marie M, Kujas JY, Delattre K, Hoang-Xuan K, Sanson M. 2004. Loss of 14q chromosome in oligodendroglial and astrocytic tumors. J Neurooncol 67:281-285.
12. Dimova I, Yosifova A, Zaharieva B, Raitcheva S, Doganov N, Toncheva D. 2005. Association of 20q13.2 copy number changes with the advanced stage of ovarian cancer-tissue microarray analysis. Eur J Obstet Gynecol Reprod Biol 118:81-85.
13. Ekstrand AJ, James CD, Cavenee WK, Seliger B, Pettersson RF, Collins VP. 1991. Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res 51:2164-2172.
14. Fischer U, Hemmer D, Heckel D, Michel A, Feiden W, Steudel WI, Hulsebos T, Meese E. 2001. KUB3 amplification and overexpression in human gliomas. Glia 36:1-10.
15. Freije WA, Castro-Vargas FE, Fang Z, Horvath S, Cloughesy T, Liau LM, Mischel PS, Nelson SF. 2004. Gene expression profiling of gliomas strongly predicts survival. Cancer Res 64:6503-6510.
16. Fleming T, Saxena A, Clark C, Robertson J, Oldfield E, Aaronson S, Ali IU. 1992. Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res 52:4550-4553.
17. Haberler C, Gelpi E, Marosi C, Rossler K, Birner P, Budka H, Hainfellner JA. 2006. Immunohistochemical analysis of platelet-derived growth factor receptor-alpha, -beta, c-kit, c-abl, and arg proteins in glioblastoma: Possible implications for patient selection for imatinib mesylate therapy. J Neurooncol 76:105-109.
18. Haferlach T, Kohlmann A, Schnittger S, Dugas M, Hiddemann W, Kern W, Schoch C. 2005. Global approach to the diagnosis of leukemia using gene expression profiling. Blood 106:189-1198.
19. Hanks SK, Coleman S, Reid A, Plaja H, Firth D, Fitzpatrick A, Kidd K, Mehes R, Nash N, Robin N. 2004. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet 36:1159-1161.
20. Hawthorn L, Stein L, Varma R, Wiseman S, Loree T, Tan D. 2004. TIMP1 and SERPIN-A overexpression and TFF3 and CRABP1 underexpression as biomarkers for papillary thyroid carcinoma. Head Neck 26:1069-1083.
21. Hawthorn L, Stein L, Panzarella J, Loewen GM, Baumann H. 2006. Characterization of cell-type specific profiles in tissues and isolated cells from squamous cell carcinomas of the lung. Lung Cancer 53:129-142.
22. Hayashi M, Kawauchi S, Ueda K, Kaneda Y, Oga A, Furuya T, Hamano K, Sasaki K. 2005. Genomic alterations detected by comparative genomic hybridization in primary lung adenocarcinomas with special reference to the relationship with DNA ploidy. Oncol Rep 14:1429-1435.
23. Hermanson M, Funa K, Koopmann J, Maintz D, Waha A, Westermark B, Heldin CH, Wiestler OD, Louis DN, von Deimling A. 1996. Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas. Cancer Res 56:164-171.
24. Herold-Mende C, Steiner HH, Andl T, Riede D, Buttler A, Reisser C, Fusenig NE, Mueller MM. 1999. Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells. Lab Invest 79:1573-1582.
25. Hoheisel JD. 2006. Microarray technology: Beyond transcript profiling and genotype analysis. Nat Rev Genet 7:200-201.
26. Houillier C, Lejeune J, Benouaich-Amiel A, Laigle-Donadey F, Criniere E, Mokhtari K, Thillet J, Delattre JY, Hoang-Xuan K, Sanson M. 2006. Prognostic impact of molecular markers in a series of 220 primary glioblastomas. Cancer 106:2218-2223.
27. Hu J, Jiang C, Ng JK, Pang JC, Tong CY. 2002. Chromosome 14q may harbor multiple tumor suppressor genes in primary glioblastoma multiforme. Chin Med J (Engl) 115:1201-1204.
28. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. 2003a. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31:e15.
29. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP. 2003b. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4:249-264.
30. Irizarry RA, Warren D, Spencer F, Kim IF, Biswal S, Frank BC, Gabrielson E, Garcia JG, Geoghegan J, Germino G, Griffin C, Hilmer SC, Hoffman E, Jedlicka AE, Kawasaki E, Martãnez-Murillo F, Morsberger L, Lee H, Petersen D, Quackenbush J, Scott A, Wilson M, Yang Y, Ye SW, Yu W. 2005a. Multiple-laboratory comparison of microarray platforms. Nat Methods 2:345-355.
31. Irizarry RA, Wu Z, Jaffee HA. 2005b. Comparison of Affymetrix GeneChip expression measures. Bioinformatics 1:1-7.
32. Joensuu H, Puputti M, Sihto H, Tynninen O, Nupponen NN. 2005. Amplification of genes encoding KIT, PDGFRalpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme. J Pathol 207:224-231.
33. Jones PA, Baylin SB. 2002. The fundamental role of epigenetic events in cancer. Nat Rev Genet 3:415-428.
34. Kawataki T, Naganuma H, Sasaki A, Yoshikawa H, Tasaka K, Nukui H. 2000. Correlation of thrombospondin-1 and transforming growth factor-beta expression with malignancy of glioma. Neuropathology 20:161-169.
35. Kimmelman AC, Ross DA, Liang BC. 1996. Loss of heterozygosity of studies on human gliomas have shown several regions on chromosome 10. Genomics 34:250-254.
36. Kitange G, Misra A, Law M, Passe S, Kollmeyer TM, Maurer M, Ballman K, Feuerstein BG, Jenkins RB. 2005. Chromosomal imbalances de-tected by array comparative genomic hybridization in human oligodendrogliomas and mixed oligoastrocytomas. Genes Chromosomes Cancer 42:68-77.
37. Kleihues P, Burger PC, Scheithauer BW. 1993. The new WHO classification of brain tumours. Brain Pathol 3:255-2568.
38. Kleihues P, Cavenee WK, editors. 2000. Pathology and genetics of tumors of the nervous system. Lyon, France: IARC Press.
39. Kunapuli P, Kasyapa C, Hawthorn L, Cowell JK. 2004. LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the Erk1/2 pathway. J Biol Chem 279:23151-23157.
40. Lamant L, Gascoyne RD, Duplantier MM, Armstrong F, Raghab A, Chhanabhai M, Rajcan-Separovic E, Raghab J, Delsol G, Espinos E. 2003. Non-muscle myosin heavy chain (MYH9): A new partner fused to ALK in anaplastic large cell lymphoma. Genes Chromosomes Cancer 37:427-432.
41. Larkin JE, Frank BC, Gavras H, Sultana R, Quackenbush J. 2005. Independence and reproducibility across microarray platforms. Nat Methods 2:337-344.
42. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis G, Rodgers L, McCombie R. 1997. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275:943-1947.
43. Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A, Schlessinger J. 1985. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumors of glial origin. Nature 313:144-147.
44. Liu G, Loraine AE, Shigeta R, Cline M, Cheng J, Valmeekam V, Sun S, Kulp D, Siani-Rose MA. 2003. NetAffx: Affymetrix probe-sets and annotations. Nucleic Acids Res 31:82-86.
45. Lo KC, Rossi MR, Pomeroy SL, Cowell JK. 2007a. Overlay analysis of the oligonucleotide array gene expression profiles and copy number abnormalities as determine by array comparative genomic hybridization in medulloblastomas. Genes Chromosomes Cancer. 46:53-66.
46. Lo KC, Shankar G, Turpaz Y, Bailey D, Rossi MR, Burkhardt T, Liang P, Cowell JK. 2007b. Overlay Tool© for aCGHViewer© an analysis module built for aCGHViewer© used to perform comparisons of data derived from different microarray platforms. Cancer Inf (in press).
47. Mark EB, Jonsson M, Asp J, Wennberg AM, Molne L, Lindahl A. 2006. Expression of genes involved in the regulation of CDKN2A in psoriatic involved skin. Arch Dermatol Res 297:459-467.
48. Mayr D, Kanitz V, Anderegg B, Luthardt B, Engel J, Lohrs U, Amann G, Diebold J. 2006. Analysis of gene amplification and prognostic markers in ovarian cancer using comparative genomic hybridization for microarrays and immunohistochemical analysis for tissue microarrays. Am J Clin Pathol 126:101-109.
49. Matsui SI, LaDuca J, Rossi MR, Nowak NJ, Cowell JK. 2005. Molecular characterization of a consistent 4.5 megabase deletion in 4q28 in prostate cancer cells. Cancer Genet Cytogenet 159:18-26.
50. Meech SJ, McGavran L, Odom LF, Liang X, Meltesen L, Gump J, Wei Q, Carlsen S, Hunger SP. 2001. Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4-anaplastic lymphoma kinase gene fusion. Blood 98:1209-1216.
51. Mohapatra G, Bollen AW, Kim DH, Lamborn K, Moore DH, Prados MD, Feuerstein BG. 1998. Analyses of brain tumor cell lines confirm a simple model of relationships among fluorescence in situ hybridization, DNA index, and comparative genomic hybridization. Genes Chromosomes Cancer 21:195-206.
52. Naef F, Hacker CR, Patil N, Magnasco M. 2002. Empirical characterization of the expression ratio noise structure in high-density oligonucleotide arrays. Genome Biol 3(4):RESEARCH 0018. Epub 3(4).
53. Nakahara Y, Shiraishi T, Okamoto H, Mineta T, Oishi T, Sasaki K, Tabuch K. 2004. Detrended fluctuation analysis of genome-wide copy number profiles of glioblastomas using array-based comparative genomic hybridization. Neurooncol 6:281-289.
54. Nakopoulou L, Tsirmpa I, Giannopoulou I, Trafalis D, Katsarou S, Davaris P. 2002. Aneuploidy of chromosome 20 in invasive breast cancer correlates with poor outcome. Cancer Genet Cytogenet 134:127-132.
55. Natrajan R, Louhelainen J, Williams S, Laye J, Knowles MA. 2003. High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder. Cancer Res 63:7657-7662.
56. Nishizuka M, Arimoto E, Tsuchiya T, Nishihara T, Imagawa M. 2003. Crucial role of TCL/TC10beta L, a subfamily of Rho GTPase, in adipocyte differentiation. J Biol Chem 278:15279-15284.
57. Ohgaki H, Dessen P, Jourde B, Horstmann S, Nishikawa T, Di Patre PL, Burkhard C, Schuler D, Probst-Hensch NM, Maiorka PC. 2004. Genetic pathways to glioblastoma: A population based study. Cancer Res 64:6892-6899.
58. Olshen AB, Venkatraman ES, Lucito R, Wigler M. 2004. Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics 5:557-572.
59. Paunu N, Lahermo P, Onkamo P, Ollikainen V, Rantala I, Helen P, Simola KO, Kere J, Haapasalo H. 2002. A novel low-penetrance locus for familial glioma at 15q23-q26.3. Cancer Res 62:3798-3802.
60. Pershouse MA, Stubblefield E, Hadi A, Killary AM, Yung WK, Steck PA. 1993. Analysis of the functional role of chromosome 10 loss in human glioblastomas. Cancer Res 53:5043-5050.
61. Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, Kim JY, Goumnerova LC, Black PM, Lau C. 2002. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415:436-442.
62. Ramirez T, Thoma K, Taja-Chayeb L, Efferth T, Herrera LA, Halatsch ME, Gebhart E. 2003. Specific patterns of DNA copy number gains and losses in eight new glioblastoma multiforme cell lines. Int J Oncol 23:453-460.
63. Rasheed BK, McLendon RE, Friedman HS, Friedman AH, Fuchs HE, Bigner DD, Bigner SH. 1995. Chromosome 10 deletion mapping in human gliomas: A common deletion region in 10q25. Oncogene 10:2243-2246.
64. Reifenberger G, Reifenberger J, Ichimura K, Meltzer PS, Collins VP. 1994. Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2. Cancer Res 54:4299-4303.
65. Riemenschneider MJ, Knobbe CB, Reifenberger G. 2003. Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target. Int J Cancer 104:752-757.
66. Rossi MR, LaDuca J, Matsui SI, Nowak NJ, Hawthorn L, Cowell JK. 2005a. Novel amplicons on the short arm of chromosome 7 identified using high resolution array CGH contain over expressed genes in addition to EGFR in glioblastoma multiiforme. Genes Chromosomes Cancer 44:392-404.
67. Rossi MR, Gaile D, LaDuca J, Matsui SI, Conroy J, McQuaid D, Chervinsky D, Eddy R, Chen HS, Barnett G, Nowak NJ, Cowell JK. 2005b. Identification of consistent novel megabase deletions in low-grade oligodendrogliomas using array-based comparative genomic hybridization. Genes Chromosomes Cancer 44:85-96.
68. Sanchez-Carbayo M, Socci ND, Lozano J, Saint F, Cordon-Cardo C. 2006. Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. J Clin Oncol 24:778-789.
69. Sasaki T, Arai H, Beppu T, Ogasawara K. 2003. Detection of gene amplification and deletion in high-grade gliomas using a genome DNA microarrav (GenoSensor Arrav 300). Brain Tumor Pathol 20:59-63.
70. Shin KH, Kang MK, Kim RH, Christensen R, Park NH. 2006. Heterogeneous nuclear ribonucleoprotein G shows tumor suppressive effect against oral squamous cell carcinoma cells. Clin Cancer Res 12:3222-3228.
71. Sonoda Y, Murakami Y, Tominaga T, Kayama T, Yoshimoto T, Sekiya T. 1996. Deletion mapping of chromosome 10 in human glioma. Jpn J Cancer Res 87:363-367.
72. Sotiriou C, Neo SY, McShane LM, Korn EL, Long PM, Jazaeri A, Martiat P, Fox SB, Harris AL, Liu ET 2003. Breast cancer classification and prognosis based on gene egression profiles from a population-based study. Proc Natl Acad Sci USA 100:10393-10398.
73. Steck PA, Ligon AH, Cheong P, Yung WK, Pershouse MA. 1995. Two tumor suppressive loci on chronosome 10 involved in human glioblastomas. Genes Chromosomes Cancer 12:255-261.
74. Steck PA, Pershouse MA, Jasser SA, Yung WKA, Lin H, Lignon AH, Langford LA, Baumgard ML, Hattier T, Davies T. 1997. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15:356-362.
75. Su YA, Lee MM, Hutter CM, Meltzer PS. 1997. Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas. Oncogene 15:1289-1294.
76. Suzuki T, Maruno M, Wada K, Kagawa N, Fujimoto Y, Hashimoto N, Izumoto S, Yoshimine T 2004. Genetic analysis of human glioblastomas using a genomic microarray system. Brain Tumor Pathol 21:27-34.
77. Tomlinson I, Rahman N, Frayling I, Mangion J, Barfoot R, Hamoudi R, Seal S, Northover J, Thomas HJ, Neale K. 1999. Inherited susceptibility to colorectal ac enomas and carcinomas: Evidence for a new predisposition gene on 15q14-q22. Gastroenterology 116:789-795.
78. Vignal E, De Toledo M, Comunale F, Ladcpoulou A, Gauthier-Rouviere C, Blangv A, Fort P. 2000. Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42. J Biol Chem 275:36457-36464.
79. Volpert OV, Pili R, Sikder HA, Nelius T, Zaichuk T, Morris C, Shiflett CB, Devlin MK, Conant K, Alani RM. 2002. Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1. Cancer Cell 2:473-483.
80. Wick W, Petersen I, Schmutzler RK, Wolfarth B, Lenartz D, Bierhoff E, Hummerich J, Muller DJ, Stangl AP, Schramm J. 1996. Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastatic stage in breast cancer. Oncogene 12:973-978.
81. Wikman H, Nymark P, Vayrynen A, Jarmalaite S, Kallioniemi A, Salmenkivi K, Vainio-Siukola K, Husgafvel-Pursiainen K, Knuutila S, Wolf M, Anttila S. 2005. CDK4 is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancer. Genes Chromosomes Cancer 42:193-199.
82. Wong AJ, Bigner SH, Bigner DD, Kinzler KW, Hamilton SR, Vogelstein B. 1987. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci USA 84:6899-6903.
83. Wooten EC, Fults D, Duggirala R, Williams K, Kyritsis AP, Bondy ML, Levin VA, O'Connell P. 1999. A study of loss of heterozygosity at 70 loci in anaplastic astrocytoma and glioblastoma multiforme with implications for tumor evolution. Neurooncol 3:169-176.
84. Wu Z, Irizarry RA, Gentleman R, Martinez Murillo F, Spencer F. 2004. A model based background adjustment for oligonucleotide expression arrays. J Am Stat Assoc 99:909-917.
85. Yang XJ, Tan MH, Kim HL, Ditlev JA, Betten MW, Png CE, Kort EJ, Futami K, Furge KA, Takahash.i M. 2005. A molecular classification of papillary renal cell carcinoma. Cancer Res 65:5628-5637.
86. Zhou Y, Abagyan R. 2002. Match-only integral distribution (MOID) algorithm for high-density oligonucleotide array analysis. BMC Bioinformatics 3(3): Epub.