CDK4 is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancer

Genes Chromosomes and Cancer

Volumn 42, Issue 2, 2005, Pages 193-199

  Wikman, Harriet ^a,b   Nymark, Penny ^a,b   Väyrynen, Aki ^a   Jarmalaite, Sonata ^a   Kallioniemi, Anne ^c   Salmenkivi, Kaisa ^b   Vainio Siukola, Katri ^a   Husgafvel Pursiainen, Kirsti ^a   Knuutila, Sakari ^b   Wolf, Maija ^d   Anttila, Sisko ^a,b  

^a FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIDIOL 1 MONOOXYGENASE; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; ELONGATION FACTOR TS; METHYLTRANSFERASE; PROTEIN P16INK4A;

AMPLICON; ARTICLE; CARCINOGENESIS; CHROMOSOME 12Q; COMPARATIVE GENOMIC HYBRIDIZATION; DNA MICROARRAY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE IDENTIFICATION; GENE TARGETING; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG CANCER; METHYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; UPREGULATION;

CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 12; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; DNA, NEOPLASM; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MICROARRAY ANALYSIS; NUCLEIC ACID HYBRIDIZATION; PROTO-ONCOGENE PROTEINS;

EID: 19944429304     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.20122     Document Type: Article

References (38)

1. Ahn J-Y, Hu Y, Kroll TG, Allard P, Ye K. 2004. PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proc Natl Acad Sci USA 101:6993-6998.
2. Bahr A, Hankeln T, Fiedler T, Hegemann J, Schmidt ER. 1999. Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation. Genomics 57:424-428.
3. Balsara B, Sonoda G, du Manoir S, Siegfried J, Gabrielson E, Testa J. 1997. Comparative genomic hybridization analysis detects frequent, often high-level, overrepresentation of DNA sequences at 3q, 5p, 7p, and 8q in human non-small cell lung carcinomas. Cancer Res 57:2116-2120.
4. Betticher D, White G, Vonlanthen S, Liu X, Kappeler A, Altermatt H, Thatcher N, Heighway J. 1997. G1 control gene status is frequently altered in resectable non-small cell lung cancer. Int J Can 74:556-562.
5. Björkqvist AM, Tammilehto L, Nordling S, Nurminen M, Anttila S, Mattson K, Knuutila S. 1998. Comparison of DNA copy number changes in malignant mesothelioma, adenocarcinoma and large-cell anaplastic carcinoma of the lung. Br J Cancer 77(2):260-269.
6. Borczuk AC, Gorenstein L, Walter KL, Assaad AA, Wang L, Powell CA. 2003. Non-small-cell lung cancer molecular signatures recapitulate lung developmental pathways. Am J Pathol 163:1949-1960.
7. Forus A, Larramendy ML, Meza-Zepeda LA, Bjerkehagen B, Godager LH, Dahlberg AB, Saeter G, Knuutila S, Myklebost O. 2001. Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases. Cancer Genet Cytogenet 125(2):100-111.
8. Hamada K, Kohno T, Kawanishi M, Ohwada S, Yokota J. 1998. Association of CDKN2A(p16)/CDKN2B(p15) alterations and homozygous chromosome arm 9p deletions in human lung carcinoma. Genes Chromosomes Cancer 22(3):232-240.
9. Hsu J-Y, Feldman D, McNeal JE, Peehl DM. 2001. Reduced 1alpha-hydroxylase activity in human prostate cancer cells correlates with decreased susceptibility to 25-hydroxyvitamin D3-induced growth inhibition. Cancer Res 61:2852-2856.
10. Huang DC, Papavasiliou V, Rhim JS, Horst RL, Kremer R. 2002. Targeted disruption of the 25-hydroxyvitamin D3 1 alpha-hydroxylase gene in ras-transformed keratinocytes demonstrates that locally produced 1 alpha,25-dihydroxyvitamin D3 suppresses growth and induces differentiation in an autocrine fashion. Mol Cancer Res 1(1):56-67.
11. Hyman E, Kauraniemi P, Hautaniemi S, Wolf M, Mousses S, Rozenblum E, Ringner M, Sauter G, Monni O, Elkahloun A and others. 2002. Impact of DNA Amplification on Gene Expression Patterns in Breast Cancer. Cancer Res 62:6240-6245.
12. Jarmalaite S, Kannio A, Anttila S, Lazutka J, Husgafvel-Pursiainen K. 2003. Aberrant p16 promoter methylation in smokers and former smokers with nonsmall cell lung cancer. Int J Can 106:913-918.
13. Jin M, Inoue S, Umemura T, Moriya J, Arakawa M, Nagashima K, Kato H. 2001. Cyclin D1, p16 and retinoblastoma gene product expression as a predictor for prognosis in non-small cell lung cancer at stages I and II. Lung Cancer 34:207-218.
14. Kettunen E, Anttila S, Seppänen JK, Karjalainen A, Edgren H, Lindström I, Salovaara R, Nissen A-M, Salo J, Mattson K. 2004. Differentially expressed genes in nonsmall cell lung cancer: expression profiling of cancer-related genes in squamous cell lung cancer. Cancer Genet Cytogenet 149:98-106.
15. Kubokura H, Tenjin T, Akiyama H, Koizumi K, Nishimura H, Yamamoto M, Tanaka S. 2001. Relations of the c-myc gene and chromosome 8 in non-small cell lung cancer: analysis by fluorescence in situ hybridization. Ann Thorac Cardiovasc Surg 7:197-203.
16. Lingfei K, Pingzhang Y, Zhengguo L, Jianhua G, Yaowu Z. 1998. A study on p16, pRb, cdk4 and cyclinD1 expression in non-small cell lung cancers. Cancer Lett 130:93-101.
17. Malusecka E, Zborek A, Krzyzovvska-Gruca S. 1999. Changes in expression of pRb, p16 and cyclin D1 in non-small cell lung cancer: an immunohistochemical study. Folia Histochem Cyto 37:19-24.
18. Mariatos G, Gorgoulis V, Zacharatos P, Kotsinas A, Vogiatzi T, Rassidakis G, Foukas P, Liloglou T, Tiniakos D, Angelou N and others. 2000. Expression of p16(INK4A) and alterations of the 9p21-23 chromosome region in non-small-cell lung carcinomas: relationship with tumor growth parameters and ploidy status. Int J Can 89:133-141.
19. Mawer E, Haves M, Heys S, Davies M, White A, Stewart M, Smith G. 1994. Constitutive synthesis of 1,25-dihydroxyvitamin D3 by a human small cell lung cancer cell line. J ClinEndocr Metab 79:554-560.
20. Miliani de Marval P, Macias E, Conti C, Rodriguez-Puebla M. 2004. Enhanced malignant tumorigenesis in Cdk4 transgenic mice. Oncogene 23:1863-1873.
21. Miller CT, Aggarwal S, Lin TK, Dagenais SL, Contreras JI, Orringer MB, Glover TW, Beer DG, Lin L. 2003. Amplification and overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas. Cancer Res 63:4136-4143.
22. Moller M. 2003. Molecular control of the cell cycle in cancer: biological and clinical aspects. Dan Med Bull 50:118-138.
23. Otterson G, Kratzke R, Coxon A, Kim Y, Kaye F. 1994. Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB. Oncogene 9:3375-3378.
24. Petersen I, Bujard M, Petersen S, Wolf G, Goeze A, Schwendel A, Langreck H, Gellert K, Reichel M, Just K and others. 1997. Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung. Cancer Res 57:2331-2335.
25. Piipari R, Nurminen T, Savela K, Hirvonen A, Mäntylä T, Anttila S. 2003. Glutathione S-transferases and aromatic DNA adducts in smokers' bronchoalveolar macrophages. Lung Cancer 39:265-272.
26. Ratschiller D, Heighway J, Gugger M, Rappeler A, Pirnia F, Schmid RA, Borner MM, Betticher DC. 2003. Cyclin D1 overexpression in bronchial epithelia of patients with lung cancer is associated with smoking and predicts survival. J Clin Oncol 21:2085-2093.
27. Reifenberger G, Reifenberger J, Ichimura K, Collins V. 1995. Amplification at 12q13-14 in human malignant gliomas is frequently accompanied by loss of heterozygosity at loci proximal and distal to the amplification site. Cancer Res 55:731-734.
28. Reissmann P, Koga H, Figlin R, Holmes E, Slamon D. 1999. Amplification and overexpression of the cyclin D1 and epidermal growth factor receptor genes in non-small-cell lung cancer. J Cancer Res Clin 125:61-70.
29. Ried T, Petersen I, Holtgreve-Grez H, Speicher M, Schrock E, du Manoir S, Cremer T. 1994. Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization. Cancer Res 54:1801-1806.
30. Schraml P, Kononen J, Bubendorf L, Moch H, Bissig H, Nocito A, Mihatsch MJ, Kallioniemi O-P, Sauter G. 1999. Tissue microarrays for gene amplification surveys in many different tumor types. Clin Cancer Res 5:1966-1975.
31. Szymanska J, Serra M, Skytting B, Larsson O, Virolainen M, Akerman M, Tarkkanen M, Huuhtanen R, Picci P, Bacchini P and others. 1998. Genetic imbalances in 67 synovial sarcomas evaluated by comparative genomic hybridization. Genes Chromosomes Cancer 23:213-219.
32. Tangpricha V, Flanagan JN, Whitlatch LW, Tseng CC, Chen TC, Holt PR, Lipkin MS, Holick MF. 2001. 25-hydroxyvitamin D-1α-hydroxylase in normal and malignant colon tissue. The Lancet 357:1673-1674.
33. Weber-Hall S, McManus A, Anderson J, Nojima T, Abe S, Pritchard-Jones K, Shipley J. 1996. Novel formation and amplification of the PAX7-FKHR fusion gene in a case of alveolar rhabdomyosarcoma. Genes Chromosomes Cancer 17:7-13.
34. Wikman H, Kettunen E, Seppänen J, Karjalainen A, Hollmén J, Anttila S, Knuutila S. 2002. Identification of differentially expressed genes in pulmonary adenocarcinoma by using cDNA array. Oncogene 22:5804-5813.
35. Wikman H, Seppänen JK, Sarhadi VK, Kettunen E, Salmenkivi K, Kuosma E, Vainio-Siukola K, Nagy B, Karjalainen A, Sioris T, Salo J, Hollmén J, Knuutila S, Anttila S. 2004. Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarrays. J Pathol 203:584-593.
36. Wolf M, Aaltonen L, Szymanska J, Tarkkanen M, Blomqvist C, Berner J, Myklebost O, Knuutila S. 1997. Complexity of 12q13-22 amplicon in liposarcoma: microsatellite repeat analysis. Genes Chromosomes Cancer 18:66-70.
37. Xin H, Woriax V, Burkhart W, Spremulli LL. 1995. Cloning and expression of mitochondrial translational elongation factor Ts from bovine and human liver. J Biol Chem 270:17243-17249.
38. Yokomura K, Suda T, Sasaki S, Inui N, Chida K, Nakamura H. 2003. Increased Expression of the 25-hydroxyvitamin D3-1α-hydroxylase gene in alveolar macrophages of patients with lung cancer. J Clin Endocrinol Metab 88:5704-5709.