-
2
-
-
21744443319
-
-
Rubin JB, Gutmann DH. Neurofibromatosis type I - a model for nervous system tumour formation? Nat Cancer Rev 2005;5:557-64.
-
Rubin JB, Gutmann DH. Neurofibromatosis type I - a model for nervous system tumour formation? Nat Cancer Rev 2005;5:557-64.
-
-
-
-
3
-
-
0031044804
-
Optic pathway gliomas in children with neurofibromatosis 1: Consensus statement from the NF1 Optic Pathway Glioma Task Force
-
Listernick R, Louis DN, Packer RJ, Gutmann DH. Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 Optic Pathway Glioma Task Force. Ann Neurol 1997;41:143-9.
-
(1997)
Ann Neurol
, vol.41
, pp. 143-149
-
-
Listernick, R.1
Louis, D.N.2
Packer, R.J.3
Gutmann, D.H.4
-
4
-
-
0033864837
-
Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas
-
Gutmann DH, Donahoe J, Brown T, James CD, Perry A. Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas. Neuropathol Appl Neurobiol 2000;26:361-7.
-
(2000)
Neuropathol Appl Neurobiol
, vol.26
, pp. 361-367
-
-
Gutmann, D.H.1
Donahoe, J.2
Brown, T.3
James, C.D.4
Perry, A.5
-
5
-
-
0345305695
-
Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1
-
Gutmann DH, James CD, Poyhonen M, et al. Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1. Neurology 2003;61:1397-400.
-
(2003)
Neurology
, vol.61
, pp. 1397-1400
-
-
Gutmann, D.H.1
James, C.D.2
Poyhonen, M.3
-
6
-
-
0034837027
-
Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas
-
Kluwe L, Hagel C, Tatagiba M, et al. Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas. J Neuropathol Exp Neurol 2001;60:917-20.
-
(2001)
J Neuropathol Exp Neurol
, vol.60
, pp. 917-920
-
-
Kluwe, L.1
Hagel, C.2
Tatagiba, M.3
-
7
-
-
0346059618
-
Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity
-
Bajenaru ML, Hernandez MR, Perry A, et al. Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res 2003;63:8573-7.
-
(2003)
Cancer Res
, vol.63
, pp. 8573-8577
-
-
Bajenaru, M.L.1
Hernandez, M.R.2
Perry, A.3
-
8
-
-
11244344906
-
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
-
Dasgupta B, Li W, Perry A, Gutmann DH. Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes. Cancer Res 2005;65:236-45.
-
(2005)
Cancer Res
, vol.65
, pp. 236-245
-
-
Dasgupta, B.1
Li, W.2
Perry, A.3
Gutmann, D.H.4
-
9
-
-
0036293742
-
Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation
-
Bajenaru ML, Zhu Y, Hedrick NM, Donahoe J, Parada LF, Gutmann DH. Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol Cell Biol 2002;22:5100-13.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5100-5113
-
-
Bajenaru, M.L.1
Zhu, Y.2
Hedrick, N.M.3
Donahoe, J.4
Parada, L.F.5
Gutmann, D.H.6
-
10
-
-
11144230288
-
Natural history of neurofibromatosis 1-associated optic nerve glioma in mice
-
Bajenaru ML, Garbow JR, Perry A, Hernandez MR, Gutmann DH. Natural history of neurofibromatosis 1-associated optic nerve glioma in mice. Ann Neurol 2005;57:119-27.
-
(2005)
Ann Neurol
, vol.57
, pp. 119-127
-
-
Bajenaru, M.L.1
Garbow, J.R.2
Perry, A.3
Hernandez, M.R.4
Gutmann, D.H.5
-
11
-
-
0025201012
-
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins
-
Ballester R, Marchuk D, Boguski M, et al. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 1990;63:851-9.
-
(1990)
Cell
, vol.63
, pp. 851-859
-
-
Ballester, R.1
Marchuk, D.2
Boguski, M.3
-
12
-
-
0025251137
-
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21
-
Martin GA, Viskochil D, Bollag G, et al. The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. Cell 1990;63:843-9.
-
(1990)
Cell
, vol.63
, pp. 843-849
-
-
Martin, G.A.1
Viskochil, D.2
Bollag, G.3
-
13
-
-
0025091465
-
The neurofibromatosis type 1 gene encodes a protein related to GAP
-
Xu GF, O'Connell P, Viskochil D, et al. The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell 1990;62:599-608.
-
(1990)
Cell
, vol.62
, pp. 599-608
-
-
Xu, G.F.1
O'Connell, P.2
Viskochil, D.3
-
14
-
-
0026319619
-
cDNA cloning of the type 1 neurofibromatosis gene: Complete sequence of the NF1 gene product
-
Marchuk DA, Saulino AM, Tavakkol R, et al. cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product. Genomics 1991;11:931-40.
-
(1991)
Genomics
, vol.11
, pp. 931-940
-
-
Marchuk, D.A.1
Saulino, A.M.2
Tavakkol, R.3
-
16
-
-
0027395503
-
A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity
-
Andersen LB, Ballester R, Marchuk DA, et al. A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. Mol Cell Biol 1993;13:487-95.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 487-495
-
-
Andersen, L.B.1
Ballester, R.2
Marchuk, D.A.3
-
18
-
-
0026528368
-
Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis
-
DeClue JE, Papageorge AG, Fletcher JA, et al. Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis. Cell 1992;69:265-73.
-
(1992)
Cell
, vol.69
, pp. 265-273
-
-
DeClue, J.E.1
Papageorge, A.G.2
Fletcher, J.A.3
-
19
-
-
0032492762
-
Contrasting levels of p21ras activation and expression of neurofibromin in peripheral primitive neuroectodermal tumour and neuroblastoma cells, and their response to retinoic acid
-
Burchill SA, Berry PA, Bradbury FM, Lewis IJ. Contrasting levels of p21ras activation and expression of neurofibromin in peripheral primitive neuroectodermal tumour and neuroblastoma cells, and their response to retinoic acid. J Neurol Sci 1998;157:129-37.
-
(1998)
J Neurol Sci
, vol.157
, pp. 129-137
-
-
Burchill, S.A.1
Berry, P.A.2
Bradbury, F.M.3
Lewis, I.J.4
-
20
-
-
9044251606
-
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells
-
Bollag G, Clapp DW, Shih S, et al. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat Genet 1996;12:144-8.
-
(1996)
Nat Genet
, vol.12
, pp. 144-148
-
-
Bollag, G.1
Clapp, D.W.2
Shih, S.3
-
21
-
-
0031771187
-
Ras activation in astrocytomas and neurofibromas
-
Guha A. Ras activation in astrocytomas and neurofibromas. Can J Neurol Sci 1998;25:267-81.
-
(1998)
Can J Neurol Sci
, vol.25
, pp. 267-281
-
-
Guha, A.1
-
22
-
-
0033083796
-
Neurofibromatosis type 1 peripheral nerve tumors: Aberrant activation of the Ras pathway
-
Feldkamp MM, Angelov L, Guha A. Neurofibromatosis type 1 peripheral nerve tumors: aberrant activation of the Ras pathway. Surg Neurol 1999;51:211-8.
-
(1999)
Surg Neurol
, vol.51
, pp. 211-218
-
-
Feldkamp, M.M.1
Angelov, L.2
Guha, A.3
-
23
-
-
0034960830
-
SDF-1 α induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells
-
Klein RS, Rubin JB, Gibson HD, et al. SDF-1 α induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells. Development 2001;128:1971-81.
-
(2001)
Development
, vol.128
, pp. 1971-1981
-
-
Klein, R.S.1
Rubin, J.B.2
Gibson, H.D.3
-
24
-
-
0344823964
-
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
-
Rubin JB, Kung AL, Klein RS, et al. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci U S A 2003;100:13513-8.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 13513-13518
-
-
Rubin, J.B.1
Kung, A.L.2
Klein, R.S.3
-
25
-
-
1842584928
-
Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells
-
Peng H, Huang Y, Rose J, et al. Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells. J Neurosci Res 2004;76:35-50.
-
(2004)
J Neurosci Res
, vol.76
, pp. 35-50
-
-
Peng, H.1
Huang, Y.2
Rose, J.3
-
26
-
-
0030996903
-
-
The I, Hannigan GE, Cowley GS, et al. Rescue of a Drosophila NF1 mutant phenotype by protein kinase A. Science 1997;276:791-4.
-
The I, Hannigan GE, Cowley GS, et al. Rescue of a Drosophila NF1 mutant phenotype by protein kinase A. Science 1997;276:791-4.
-
-
-
-
27
-
-
0031007708
-
-
Guo HF, The I, Hannan F, Bernards A, Zhong Y. Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides. Science 1997;276:795-8.
-
Guo HF, The I, Hannan F, Bernards A, Zhong Y. Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides. Science 1997;276:795-8.
-
-
-
-
28
-
-
0141529951
-
The neurofibromatosis 1 gene product neurofibromin regulates pituitary adenylate cyclase-activating polypeptide-mediated signaling in astrocytes
-
Dasgupta B, Dugan LL, Gutmann DH. The neurofibromatosis 1 gene product neurofibromin regulates pituitary adenylate cyclase-activating polypeptide-mediated signaling in astrocytes. J Neurosci 2003;23:8949-54.
-
(2003)
J Neurosci
, vol.23
, pp. 8949-8954
-
-
Dasgupta, B.1
Dugan, L.L.2
Gutmann, D.H.3
-
29
-
-
29244445813
-
Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies
-
Woerner BM, Warrington NM, Kung AL, Perry A, Rubin JB. Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies. Cancer Res 2005;65:11392-9.
-
(2005)
Cancer Res
, vol.65
, pp. 11392-11399
-
-
Woerner, B.M.1
Warrington, N.M.2
Kung, A.L.3
Perry, A.4
Rubin, J.B.5
-
30
-
-
0344013138
-
High-yield isolation of murine microglia by mild trypsinization
-
Saura J, Tusell JM, Serratosa J. High-yield isolation of murine microglia by mild trypsinization. Glia 2003;44:183-9.
-
(2003)
Glia
, vol.44
, pp. 183-189
-
-
Saura, J.1
Tusell, J.M.2
Serratosa, J.3
-
31
-
-
33846670549
-
Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo
-
Yang L, Jackson E, Woerner BM, Perry A, Piwnica-Worms D, Rubin JB. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res 2007;67:651-8.
-
(2007)
Cancer Res
, vol.67
, pp. 651-658
-
-
Yang, L.1
Jackson, E.2
Woerner, B.M.3
Perry, A.4
Piwnica-Worms, D.5
Rubin, J.B.6
-
32
-
-
2342545918
-
Immune and nervous system CXCL12 and CXCR4: Parallel roles in patterning and plasticity
-
Klein RS, Rubin JB. Immune and nervous system CXCL12 and CXCR4: parallel roles in patterning and plasticity. Trends Immunol 2004;25:306-14.
-
(2004)
Trends Immunol
, vol.25
, pp. 306-314
-
-
Klein, R.S.1
Rubin, J.B.2
-
33
-
-
1642366238
-
Differential processing of stromal-derived factor-1α and stromal-derived factor-1β explains functional diversity
-
De La Luz Sierra M, Yang F, Narazaki M, et al. Differential processing of stromal-derived factor-1α and stromal-derived factor-1β explains functional diversity. Blood 2004;103:2452-9.
-
(2004)
Blood
, vol.103
, pp. 2452-2459
-
-
De La Luz Sierra, M.1
Yang, F.2
Narazaki, M.3
-
34
-
-
0036902811
-
Microarray analysis of selected genes in neural stem and progenitor cells
-
Luo Y, Cai J, Liu Y, et al. Microarray analysis of selected genes in neural stem and progenitor cells. J Neurochem 2002;83:1481-97.
-
(2002)
J Neurochem
, vol.83
, pp. 1481-1497
-
-
Luo, Y.1
Cai, J.2
Liu, Y.3
-
35
-
-
2442687810
-
Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4
-
Ehtesham M, Yuan X, Kabos P, et al. Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4. Neoplasia 2004;6:287-93.
-
(2004)
Neoplasia
, vol.6
, pp. 287-293
-
-
Ehtesham, M.1
Yuan, X.2
Kabos, P.3
-
36
-
-
1942520401
-
Astrocyte apoptosis: Implications for neuroprotection
-
Takuma K, Baba A, Matsuda T. Astrocyte apoptosis: implications for neuroprotection. Prog Neurobiol 2004;72:111-27.
-
(2004)
Prog Neurobiol
, vol.72
, pp. 111-127
-
-
Takuma, K.1
Baba, A.2
Matsuda, T.3
-
37
-
-
0037184060
-
Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway
-
Gomez Del Pulgar T, De Ceballos ML, Guzman M, Velasco G. Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2002;277:36527-33.
-
(2002)
J Biol Chem
, vol.277
, pp. 36527-36533
-
-
Gomez Del Pulgar, T.1
De Ceballos, M.L.2
Guzman, M.3
Velasco, G.4
-
38
-
-
0034094242
-
Inhibition of cell growth and proliferation in human glioma cells and normal human astrocytes induced by 8-Cl-cAMP and tiazofurin
-
Pesic M, Drabek K, Esler C, Ruzdijic S, Pejanovic V, Pietrzkowski Z. Inhibition of cell growth and proliferation in human glioma cells and normal human astrocytes induced by 8-Cl-cAMP and tiazofurin. Nucleosides Nucleotides Nucleic Acids 2000;19:963-75.
-
(2000)
Nucleosides Nucleotides Nucleic Acids
, vol.19
, pp. 963-975
-
-
Pesic, M.1
Drabek, K.2
Esler, C.3
Ruzdijic, S.4
Pejanovic, V.5
Pietrzkowski, Z.6
-
39
-
-
0033520311
-
Differential effects of cAMP in neurons and astrocytes. Role of B-raf
-
Dugan LL, Kim JS, Zhang Y, et al. Differential effects of cAMP in neurons and astrocytes. Role of B-raf. J Biol Chem 1999;274:25842-8.
-
(1999)
J Biol Chem
, vol.274
, pp. 25842-25848
-
-
Dugan, L.L.1
Kim, J.S.2
Zhang, Y.3
-
40
-
-
1642292051
-
Desensitization of G protein-coupled receptors and neuronal functions
-
Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, Caron MG. Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci 2004;27:107-44.
-
(2004)
Annu Rev Neurosci
, vol.27
, pp. 107-144
-
-
Gainetdinov, R.R.1
Premont, R.T.2
Bohn, L.M.3
Lefkowitz, R.J.4
Caron, M.G.5
-
41
-
-
0030460743
-
Gprotein-coupled receptor regulation: Role of G-protein-coupled receptor kinases and arrestins
-
Ferguson SS, Barak LS, Zhang J, Caron MG. Gprotein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins. Can J Physiol Pharmacol 1996;74:1095-110.
-
(1996)
Can J Physiol Pharmacol
, vol.74
, pp. 1095-1110
-
-
Ferguson, S.S.1
Barak, L.S.2
Zhang, J.3
Caron, M.G.4
-
43
-
-
0032742818
-
Trafficking of the HIV coreceptor CXCR4: Role of arrestins and identification of residues in the C-terminal tail that mediate receptor internalization
-
Orsini MJ, Parent JL, Mundell SJ, Marchese A, Benovic JL. Trafficking of the HIV coreceptor CXCR4: role of arrestins and identification of residues in the C-terminal tail that mediate receptor internalization. J Biol Chem 1999;274:31076-86.
-
(1999)
J Biol Chem
, vol.274
, pp. 31076-31086
-
-
Orsini, M.J.1
Parent, J.L.2
Mundell, S.J.3
Marchese, A.4
Benovic, J.L.5
-
44
-
-
0033521109
-
Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases
-
Pitcher JA, Tesmer JJ, Freeman JL, Capel WD, Stone WC, Lefkowitz RJ. Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. J Biol Chem 1999;274:34531-4.
-
(1999)
J Biol Chem
, vol.274
, pp. 34531-34534
-
-
Pitcher, J.A.1
Tesmer, J.J.2
Freeman, J.L.3
Capel, W.D.4
Stone, W.C.5
Lefkowitz, R.J.6
-
45
-
-
0035075794
-
Neurofibromatosis 1 (NF1) heterozygosity results in a cell autonomous growth advantage for astrocytes
-
Bajenaru ML, Donahoe J, Corral T, et al. Neurofibromatosis 1 (NF1) heterozygosity results in a cell autonomous growth advantage for astrocytes. Glia 2001;33:314-23.
-
(2001)
Glia
, vol.33
, pp. 314-323
-
-
Bajenaru, M.L.1
Donahoe, J.2
Corral, T.3
-
46
-
-
31144472425
-
Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation
-
Zhu Y, Harada T, Liu L, et al. Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development 2005;132:5577-88.
-
(2005)
Development
, vol.132
, pp. 5577-5588
-
-
Zhu, Y.1
Harada, T.2
Liu, L.3
-
47
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
48
-
-
34447320760
-
Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth
-
Daginakatte GC, Gutmann DH. Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth. Hum Mol Genet 2007;16:1098-112.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 1098-1112
-
-
Daginakatte, G.C.1
Gutmann, D.H.2
-
49
-
-
9144260570
-
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells
-
Yang FC, Ingram DA, Chen S, et al. Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. J Clin Invest 2003;112:1851-61.
-
(2003)
J Clin Invest
, vol.112
, pp. 1851-1861
-
-
Yang, F.C.1
Ingram, D.A.2
Chen, S.3
|