Mechanisms of prodigiosin cytotoxicity in human neuroblastoma cell lines

European Journal of Pharmacology

Volumn 572, Issue 2-3, 2007, Pages 111-119

  Francisco, Roser ^a   Pérez Tomás, Ricardo ^a   Gimènez Bonafé, Pepita ^a   Soto Cerrato, Vanessa ^a   Giménez Xavier, Pol ^a   Ambrosio, Santiago ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Apoptosis; Cisplatin; Neuroblastoma; Prodigiosin

Indexed keywords

CISPLATIN; PRODIGIOSIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ARTICLE; CANCER CELL CULTURE; CELL PH; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN CELL; MITOCHONDRION; NEUROBLASTOMA CELL; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CISPLATIN; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR FLUID; MITOCHONDRIA; NEUROBLASTOMA; OXYGEN CONSUMPTION; PRODIGIOSIN;

EID: 34548709748     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.06.054     Document Type: Article

References (32)

1. Bellosillo B., Piqué M., Barragán M., Castaño E., Villamor N., Colomer D., Montserrat E., Pons G., and Gil J. Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells. Blood 92 (1998) 1406-1414
2. Berthold F., and Hero B. Neuroblastoma - current drug therapy recommendations as a part of the total treatment approach. Drugs 59 (2000) 1261-1277
3. Boix J., Llecha N., Yuste V.J., and Comella J.X. Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines. Neuropharmacology 36 (1997) 811-821
4. Brodeur G.M. Neuroblastoma: biological insights into a clinical enigma. Nat. Rev., Cancer 3 (2003) 203-216
5. Campàs C., Dalmau M., Montaner B., Barragàn M., Bellosillo B., Colomer D., Pons G., Pérez-Tomás R., and Gil J. Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia. Leukemia 17 (2003) 746-750
6. - symporter) inhibit the acidification of lysosomes and induce cell cycle blockage in colon cancer cells. Life Sci. 78 (2005) 121-127
7. Díaz-Ruiz C., Montaner B., and Pérez-Tomás R. Prodigiosin induces cell death and morphological changes indicative of apoptosis in gastric cancer cell line HGT-1. Histol. Histopathol. 16 (2001) 415-421
8. Encinas M., Iglesias M., Liu Y., Wang H., Muhaisen A., Ceña V., Gallego C., and Comella J.X. Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J. Neurochem. 75 (2000) 991-1003
9. Giménez-Xavier P., Gómez-Santos C., Castaño E., Francisco R., Boada J., Unzeta M., Sanz E., and Ambrosio S. The decrease of NAD(P)H has a prominent role in dopamine toxicity. Biochim. Biophys. Acta 1762 (2006) 564-574
10. +-ATPase, inhibits vacuolar acidification and affects glycoprotein processing. FEBS Lett. 359 (1995) 53-59
11. Han S.B., Park S.H., Jeon Y.J., Kim Y.K., Kim H.M., and Yang K.H. Prodigiosin blocks T cell activation by inhibiting interleukin-2Ra expression and delays progression of autoimmune diabetes and collagen-induced arthritis. J. Pharmacol. Exp. Ther. 299 (2001) 415-425
12. - symport activity. J. Biochem. 124 (1998) 547-556
13. Llagostera E., Soto-Cerrato V., Joshi R., Montaner B., Giménez-Bonafé P., and Pérez-Tomás R. High cytotoxic sensitivity of the human small cell lung doxorubicin-resistant carcinoma (GLC4/ADR) cell line to prodigiosin through apoptosis activation. Anticancer Drugs 16 (2005) 393-399
14. Manderville R.A. Synthesis, proton-affinity and anti-cancer properties of the prodigiosin-group natural products. Curr. Med. Chem. - Anti-Cancer Agents 1 (2001) 195-218
15. Melvin M.S., Ferguson D.C., Lindquist N., and Manderville R.A. DNA binding by 4-methoxypyrrolic natural products. Preference for intercalation at AT sites by tambjamine E and prodigiosin. J. Org. Chem. 64 (1999) 6861-6869
16. Melvin M.S., Wooton K.E., Rich C.C., Saluta G.R., Kucera G.L., Lindquist N., and Manderville R.A. Copper-nuclease efficiency correlates with cytotoxicity for the 4-methoxypyrrolic natural products. J. Inorg. Biochem. 87 (2001) 129-135
17. Montaner B., and Pérez-Tomás R. Prodigiosin-induced apoptosis in human colon cancer cells. Life Sci. 68 (2001) 2025-2036
18. Montaner B., and Pérez-Tomás R. The prodigiosins: a new family of anticancer drugs. Curr. Cancer Drug Targ. 3 (2003) 57-65
19. Montaner B., Navarro S., Piqué M., Vilaseca M., Martinell M., Giralt E., Gil J., and Pérez-Tomás R. Prodigiosin from the supernatant of Serratia marcescens induces apoptosis in haematopoietic cancer cell lines. Br. J. Pharmacol. 131 (2000) 585-593
20. Montaner B., Castillo-Ávila W., Martinell M., Ollinger R., Aymami J., Giralt E., and Pérez-Tomás R. DNA interactions and dual topoisomerase I and II inhibition properties of the anti-tumor drug prodigiosin. Toxicol. Sci. 85 (2005) 870-879
21. Nakashima T., Tamura T., Kurachi M., Yamaguchi K., and Oda T. Apoptosis-mediated cytotoxicity of prodigiosin-like red pigment produced by γ-Proteobacterium and its multiple bioactivities. Biol. Pharm. Bull. 28 (2005) 2289-2295
22. Pérez-Tomás R., Montaner B., Llagostera E., and Soto-Cerrato V. The prodigiosins, proapoptotic drugs with anticancer properties. Biochem. Pharmacol. 66 (2003) 1447-1452
23. Rizzo V., Morelli A., Pinciroli V., Sciangula D., and D'Alessio R. Equilibrium and kinetics of rotamer interconversion in immusuppressant prodigiosin derivatives in solution. J. Pharmacol. Sci. 88 (1998) 73-78
24. - symporters that uncouple proton translocators. J. Biol. Chem. 273 (1998) 21455-21462
25. Soto-Cerrato V., Llagostera E., Montaner B., Scheffer G.L., and Pérez-Tomás R. Mitochondria-mediated apoptosis operating irrespective of multidrug resistance in breast cancer cells by the anticancer agent prodigiosin. Biochem. Pharmacol. 68 (2004) 1345-1352
26. Williamson N.R., Fineran P.C., Leeper F.J., and Salmond G.P.C. The biosynthesis and regulation of bacterial prodigiosines. Nat. Rev. Microbiol. 4 (2006) 887-899
27. - symporter, induces apoptosis in human and rat hepatocellular cancer cell lines in vitro and inhibits the growth of hepatocellular carcinoma xenografts in nude mice. Hepatology 30 (1999) 894-902
28. - symporter, induces apoptosis and differentiation in HL-60 cells. Int. J. Cancer 88 (2000) 121-128
29. Yamamoto D., Tanaka K., Nakai K., Baden T., Inoue K., Yamamoto C., Takemoto H., Kamato K., Hirata H., Morikawa S., Inubushi T., and Hioki K. Synergistic effects induced by cycloprodigiosin hydrochloride and epirubicin on human breast cancer cells. Breast Cancer Res. Treat. 72 (2002) 1-10
30. Yuste V.J., Bayascas J.R., Llecha N., Sanchez-Lopez I., Boix J., and Comella J.X. The absence of oligonucleosomal DNA fragmentation during apoptosis of IMR-5 neuroblastoma cells: disappearance of the caspase-activated DNase. J. Biol. Chem. 276 (2001) 22323-22331
31. Zaizen Y., Taniguchi S., and Suita S. The role of cellular motility in the invasion of human neuroblastoma cells with or without N-myc amplification and expression. J. Pediatr. Surg. 33 (1998) 1765-1770
32. Zhang J., Shen Y., Liu J., and Wei D. Antimetastatic effect of prodigiosin through inhibition of tumor invasion. Biochem. Pharmacol. 69 (2005) 407-414