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Volumn 32, Issue 7, 2007, Pages 601-606

Motexafin gadolinium. Apoptosis inducer radiation enhancer thioredoxin reductase inhibitor ribonucleotide reductase inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

DOCETAXEL; ENZYME INHIBITOR; GADOLINIUM TEXAPHYRIN; IBRITUMOMAB TIUXETAN; PEMETREXED; RADIOSENSITIZING AGENT; RIBONUCLEOTIDE REDUCTASE; RITUXIMAB; TEMOZOLOMIDE; THIOREDOXIN REDUCTASE; YTTRIUM 90;

EID: 34548681863     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2007.032.07.1113618     Document Type: Article
Times cited : (3)

References (32)
  • 1
    • 34548679507 scopus 로고    scopus 로고
    • Sessler, J.L, Miller, R.A, Harriman, A.M, Pharmacyclics, Inc, Univ. Texas, Radiation sensitization using texaphyrins. US 5622946
    • Sessler, J.L., Miller, R.A., Harriman, A.M. (Pharmacyclics, Inc.; Univ. Texas). Radiation sensitization using texaphyrins. US 5622946.
  • 2
    • 34548685504 scopus 로고    scopus 로고
    • Sessler, J.L, Ross, K.L, Wright, M. et al, Univ. Texas; Pharmacyclics, Inc, Texaphyrin metal complex mediated ester hydrolysis. WO 9429316
    • Sessler, J.L., Ross, K.L., Wright, M. et al. (Univ. Texas; Pharmacyclics, Inc.). Texaphyrin metal complex mediated ester hydrolysis. WO 9429316.
  • 3
    • 33751386168 scopus 로고
    • Synthesis and structural characterization of lanthanide(III) texaphyrins
    • Sessler, J.L., Mody, T.D., Hemmi, G.W., Lynch, V. Synthesis and structural characterization of lanthanide(III) texaphyrins. Inorg Chem 1993, 32(14): 3175-87.
    • (1993) Inorg Chem , vol.32 , Issue.14 , pp. 3175-3187
    • Sessler, J.L.1    Mody, T.D.2    Hemmi, G.W.3    Lynch, V.4
  • 4
    • 0030013113 scopus 로고    scopus 로고
    • Gadolinium(III) texaphyrin: A tumor selective radiation sensitizer that is detectable by MRI
    • Young, S.W., Qing, F., Harriman, A. et al. Gadolinium(III) texaphyrin: A tumor selective radiation sensitizer that is detectable by MRI. Proc Natl Acad Sci USA 1996, 93(13): 6610-5.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.13 , pp. 6610-6615
    • Young, S.W.1    Qing, F.2    Harriman, A.3
  • 6
    • 0000051161 scopus 로고    scopus 로고
    • One-electron reduction and oxidation studies of the radiation sensitizer gadolinium(III) texaphyrin (PCI-0120) and other water soluble metallotexaphyrins
    • Sessler, J.L., Tvermoes, N.A., Guldi, D.M., Mody, T.D., Allen, W.E. One-electron reduction and oxidation studies of the radiation sensitizer gadolinium(III) texaphyrin (PCI-0120) and other water soluble metallotexaphyrins. J Phys Chem A 1999, 103(7): 787-94.
    • (1999) J Phys Chem A , vol.103 , Issue.7 , pp. 787-794
    • Sessler, J.L.1    Tvermoes, N.A.2    Guldi, D.M.3    Mody, T.D.4    Allen, W.E.5
  • 7
    • 0035889348 scopus 로고    scopus 로고
    • Redox cycling by motexafin gadolinium enhances cellular response to ionizing radiation by forming reactive oxygen species
    • Magda, D., Lepp, C., Gerasimchuk, N. et al. Redox cycling by motexafin gadolinium enhances cellular response to ionizing radiation by forming reactive oxygen species. Int J Radiat Oncol Biol Phys 2001, 51(4): 1025-36.
    • (2001) Int J Radiat Oncol Biol Phys , vol.51 , Issue.4 , pp. 1025-1036
    • Magda, D.1    Lepp, C.2    Gerasimchuk, N.3
  • 8
    • 12844283848 scopus 로고    scopus 로고
    • Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells
    • Evens, A.M., Lecane, P., Magda, D. et al. Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells. Blood 2005, 105(3): 1265-73.
    • (2005) Blood , vol.105 , Issue.3 , pp. 1265-1273
    • Evens, A.M.1    Lecane, P.2    Magda, D.3
  • 9
    • 20944432604 scopus 로고    scopus 로고
    • Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines
    • Magda, D., Lecane, P., Miller, R.A. et al. Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines. Cancer Res 2005, 65(9): 3837-45.
    • (2005) Cancer Res , vol.65 , Issue.9 , pp. 3837-3845
    • Magda, D.1    Lecane, P.2    Miller, R.A.3
  • 10
    • 33744956073 scopus 로고    scopus 로고
    • Motexafin gadolinium, a tumor selective drug targeting thioredoxin reductase and ribonucleotide reductase
    • Hashemy, S.I., Ungerstedt, J.S., Zahedi Avval, F., Holmgren, A. Motexafin gadolinium, a tumor selective drug targeting thioredoxin reductase and ribonucleotide reductase. J Biol Chem 2006, 281(16): 10691-7.
    • (2006) J Biol Chem , vol.281 , Issue.16 , pp. 10691-10697
    • Hashemy, S.I.1    Ungerstedt, J.S.2    Zahedi Avval, F.3    Holmgren, A.4
  • 11
    • 33845881174 scopus 로고    scopus 로고
    • Motexafin gadolinium-induced cell death correlates with heme oxygenase-1 expression and inhibition of P450 reductase-dependent activities
    • Evans, J.P., Xu, F., Sirisawad, M., Miller, R., Naumovski, L., Ortiz de Montellano, P.R. Motexafin gadolinium-induced cell death correlates with heme oxygenase-1 expression and inhibition of P450 reductase-dependent activities. Mol Pharmacol 2007, 71(1): 193-200.
    • (2007) Mol Pharmacol , vol.71 , Issue.1 , pp. 193-200
    • Evans, J.P.1    Xu, F.2    Sirisawad, M.3    Miller, R.4    Naumovski, L.5    Ortiz de Montellano, P.R.6
  • 12
    • 0032874534 scopus 로고    scopus 로고
    • Phases IB and II multidose trial of gadolinium texaphyrin, a radiation sensitizer detectable at MR imaging: Preliminary results in brain metastases
    • Viala, J., Vanel, D., Meingan, P., Lartigau, E., Carde, P., Renschler, M. Phases IB and II multidose trial of gadolinium texaphyrin, a radiation sensitizer detectable at MR imaging: Preliminary results in brain metastases. Radiology 1999, 212(3): 755-9.
    • (1999) Radiology , vol.212 , Issue.3 , pp. 755-759
    • Viala, J.1    Vanel, D.2    Meingan, P.3    Lartigau, E.4    Carde, P.5    Renschler, M.6
  • 13
    • 0034998914 scopus 로고    scopus 로고
    • Intracellular localization of the radiation enhancer motexafin gadolinium using interferometric Fourier fluorescence microscopy
    • Woodburn, K.W. Intracellular localization of the radiation enhancer motexafin gadolinium using interferometric Fourier fluorescence microscopy. J Pharmacol Exp Ther 2001, 297(3): 888-94.
    • (2001) J Pharmacol Exp Ther , vol.297 , Issue.3 , pp. 888-894
    • Woodburn, K.W.1
  • 14
    • 33646559565 scopus 로고    scopus 로고
    • Population pharmacokinetics and bioavailability of motexafin gadolinium (Xcytrin) in CD1 mice following intravenous and intraperitoneal injection
    • Boswell, G.W., Miles, D.R., Thiemann, P.A., Mesfin, M. Population pharmacokinetics and bioavailability of motexafin gadolinium (Xcytrin) in CD1 mice following intravenous and intraperitoneal injection. Invest New Drugs 2006, 24(4): 281-9.
    • (2006) Invest New Drugs , vol.24 , Issue.4 , pp. 281-289
    • Boswell, G.W.1    Miles, D.R.2    Thiemann, P.A.3    Mesfin, M.4
  • 16
    • 33646389271 scopus 로고    scopus 로고
    • Validation and use of three complementary analytical methods (LC-FLS, LC-MS/MS and ICP-MS) to evaluate the pharmacokinetics, biodistribution and stability of motexafin gadolinium in plasma and tissues
    • Miles, D.R., Mesfin, M., Mody, T.D. et al. Validation and use of three complementary analytical methods (LC-FLS, LC-MS/MS and ICP-MS) to evaluate the pharmacokinetics, biodistribution and stability of motexafin gadolinium in plasma and tissues. Anal Bioanal Chem 2006, 385(2): 345-56.
    • (2006) Anal Bioanal Chem , vol.385 , Issue.2 , pp. 345-356
    • Miles, D.R.1    Mesfin, M.2    Mody, T.D.3
  • 17
    • 30644470141 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the novel redox-active agent, motexafin gadolinium, with concurrent radiation therapy in patients with locally advanced pancreatic or biliary cancers
    • Ramanathan, R.K., Fakih, M., Mani, S. et al. Phase I and pharmacokinetic study of the novel redox-active agent, motexafin gadolinium, with concurrent radiation therapy in patients with locally advanced pancreatic or biliary cancers. Cancer Chemother Pharmacol 2006, 57(4): 465-74.
    • (2006) Cancer Chemother Pharmacol , vol.57 , Issue.4 , pp. 465-474
    • Ramanathan, R.K.1    Fakih, M.2    Mani, S.3
  • 18
    • 16444383795 scopus 로고    scopus 로고
    • Reductase-mediated metabolism of motexafin gadolinium (Xcytrin) in rat and human liver subcellular fractions and purified enzyme preparations
    • Mani, C., Upadhyay, S., Lacy, S., Boswell, G.W., Miles, D.R. Reductase-mediated metabolism of motexafin gadolinium (Xcytrin) in rat and human liver subcellular fractions and purified enzyme preparations. J Pharm Sci 2005, 94(3): 559-70.
    • (2005) J Pharm Sci , vol.94 , Issue.3 , pp. 559-570
    • Mani, C.1    Upadhyay, S.2    Lacy, S.3    Boswell, G.W.4    Miles, D.R.5
  • 19
    • 33751181914 scopus 로고    scopus 로고
    • Motexafin gadolinium: A novel redox active drug for cancer therapy
    • Magda, D., Miller, R.A. Motexafin gadolinium: A novel redox active drug for cancer therapy. Semin Cancer Biol 2006, 16(6): 466-76.
    • (2006) Semin Cancer Biol , vol.16 , Issue.6 , pp. 466-476
    • Magda, D.1    Miller, R.A.2
  • 20
    • 0032907689 scopus 로고    scopus 로고
    • A phase I single-dose trial of gadolinium texaphyrin (Gd-Tex), a tumor selective radiation sensitizer detectable by magnetic resonance imaging
    • Rosenthal, D.I., Nurenberg, P., Becerra, C.R. et al. A phase I single-dose trial of gadolinium texaphyrin (Gd-Tex), a tumor selective radiation sensitizer detectable by magnetic resonance imaging. Clin Cancer Res 1999, 5(4): 739-45.
    • (1999) Clin Cancer Res , vol.5 , Issue.4 , pp. 739-745
    • Rosenthal, D.I.1    Nurenberg, P.2    Becerra, C.R.3
  • 21
    • 0037676125 scopus 로고    scopus 로고
    • Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases
    • Mehta, M.P., Rodrigus, P., Terhaard, C.H. et al. Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases. J Clin Oncol 2003, 21(13): 2529-36.
    • (2003) J Clin Oncol , vol.21 , Issue.13 , pp. 2529-2536
    • Mehta, M.P.1    Rodrigus, P.2    Terhaard, C.H.3
  • 22
    • 0035300617 scopus 로고    scopus 로고
    • Multicenter phase Ib/II trial of the radiation enhancer motexafin gadolinium in patients with brain metastases
    • Carde, P., Timmerman, R., Mehta, M.P. et al. Multicenter phase Ib/II trial of the radiation enhancer motexafin gadolinium in patients with brain metastases. J Clin Oncol 2001, 19(7): 2074-83.
    • (2001) J Clin Oncol , vol.19 , Issue.7 , pp. 2074-2083
    • Carde, P.1    Timmerman, R.2    Mehta, M.P.3
  • 23
    • 3042787102 scopus 로고    scopus 로고
    • Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: Results of a randomized phase III trial
    • Meyers, C.A., Smith, J.A., Bezjak, A. et al. Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: Results of a randomized phase III trial. J Clin Oncol 2004, 22(1): 157-65.
    • (2004) J Clin Oncol , vol.22 , Issue.1 , pp. 157-165
    • Meyers, C.A.1    Smith, J.A.2    Bezjak, A.3
  • 24
    • 34548700725 scopus 로고    scopus 로고
    • Motexafin gadolinium (MGd) combined with prompt whole brain radiation therapy (RT) prolongs time to neurologic progression in non-small cell lung cancer (NSCLC) patients with brain metastases: Results of a phase III trial
    • Abst 7014
    • Mehta, M.P., Gervais, R., Chabot, P. et al. Motexafin gadolinium (MGd) combined with prompt whole brain radiation therapy (RT) prolongs time to neurologic progression in non-small cell lung cancer (NSCLC) patients with brain metastases: Results of a phase III trial. J Clin Oncol [42nd Annu Meet Am Soc Clin Oncol (ASCO) (June 3-6, Atlanta) 2006] 2006, 24(18, Suppl): Abst 7014.
    • J Clin Oncol [42nd Annu Meet Am Soc Clin Oncol (ASCO) (June 3-6, Atlanta) 2006] 2006, 24(18, Suppl)
    • Mehta, M.P.1    Gervais, R.2    Chabot, P.3
  • 25
    • 34548698573 scopus 로고    scopus 로고
    • Motexafin gadolinium (MGd) combined with whole brain radiation therapy prolongs time to neurologic progression in non-small cell lung cancer (NSCLC) patients with brain metastases: Pooled analysis of two randomized phase III trials
    • Abst 2010
    • Shapiro, W.R., Mehta, M.P., Langer, C. et al. Motexafin gadolinium (MGd) combined with whole brain radiation therapy prolongs time to neurologic progression in non-small cell lung cancer (NSCLC) patients with brain metastases: Pooled analysis of two randomized phase III trials. J Clin Oncol [43rd Annu Meet Am Soc Clin Oncol (ASCO) (June 1-5, Chicago) 2007] 2007, 25(18, Suppl.): Abst 2010.
    • J Clin Oncol [43rd Annu Meet Am Soc Clin Oncol (ASCO) (June 1-5, Chicago) 2007] 2007, 25(18, Suppl.)
    • Shapiro, W.R.1    Mehta, M.P.2    Langer, C.3
  • 29
    • 34548696283 scopus 로고    scopus 로고
    • Motexafin gadolinium, rituximab, and yttrium Y 90 ibritumomab tiuxetan in treating patients with stage II, stage III, or stage IV relapsed or refractory non-Hodgkin's lymphoma (NCT00089284). ClinicalTrials.gov Web site, June 25, 2007.
    • Motexafin gadolinium, rituximab, and yttrium Y 90 ibritumomab tiuxetan in treating patients with stage II, stage III, or stage IV relapsed or refractory non-Hodgkin's lymphoma (NCT00089284). ClinicalTrials.gov Web site, June 25, 2007.
  • 31
    • 34548687826 scopus 로고    scopus 로고
    • Study of the effect on non-small cell lung cancer of the investigational drug motexafin gadolinium when used in combination with docetaxel (Taxotere) (NCT00373204). ClinicalTrials.gov Web site, June 25, 2007.
    • Study of the effect on non-small cell lung cancer of the investigational drug motexafin gadolinium when used in combination with docetaxel (Taxotere) (NCT00373204). ClinicalTrials.gov Web site, June 25, 2007.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.