Validation and use of three complementary analytical methods (LC-FLS, LC-MS/MS and ICP-MS) to evaluate the pharmacokinetics, biodistribution and stability of motexafin gadolinium in plasma and tissues

Analytical and Bioanalytical Chemistry

Volumn 385, Issue 2, 2006, Pages 345-356

  Miles, Dale R ^a   Mesfin, Mimi ^a   Mody, Tarak D ^a   Stiles, Mark ^b   Lee, Jean ^b   Fiene, John ^b   Denis, Bernie ^c   Boswell, Garry W ^a  

^a PHARMACYCLICS INC   (United States)

^b MDS Inc   (Canada)

^c Elemental Research Inc   (Canada)

Author keywords

Bioanalytical method; Liquid chromatography; Mass spectrometry; Motexafin gadolinium

Indexed keywords

BIOANALYTICAL METHOD; MOTEXAFIN GADOLINIUM; PROTEIN BINDING;

INDUCTIVELY COUPLED PLASMA; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PATIENT MONITORING; PLASMAS; PROTEINS; TISSUE;

PHARMACOKINETICS;

ANTINEOPLASTIC AGENT; GADOLINIUM TEXAPHYRIN; METALLOPORPHYRIN;

ANIMAL; CHEMICAL MODEL; CLINICAL CHEMISTRY; CONFERENCE PAPER; DRUG INTERACTION; HUMAN; KIDNEY; LIQUID CHROMATOGRAPHY; LIVER; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MOUSE; RAT; SENSITIVITY AND SPECIFICITY; TIME;

ANIMALS; ANTINEOPLASTIC AGENTS; CHEMISTRY, CLINICAL; CHROMATOGRAPHY, LIQUID; DRUG INTERACTIONS; HUMANS; KIDNEY; LIVER; MASS SPECTROMETRY; METALLOPORPHYRINS; MICE; MODELS, CHEMICAL; RATS; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 33646389271     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-006-0414-5     Document Type: Conference Paper

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