Hypothalamus region-specific global gene expression profiling in early stages of early endocrine disruption in rat neonates injected with estradiol benzoate or flutamide

Developmental Neurobiology

Volumn 67, Issue 3, 2007, Pages 253-269

  Shibutani, Makoto ^a   Lee, Kyoung Youl ^a,b   Igarashi, Katsuhide ^a   Woo, Gye Hyeong ^a   Inoue, Kaoru ^a   Nishimura, Tetsuji ^a   Hirose, Masao ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b Occupational Safety and Health Research Institute   (South Korea)

Author keywords

Brain sexual differentiation; Estradiol benzoate; Flutamide; Microarray; Microdissection

Indexed keywords

COMPLEMENTARY RNA; ESTRADIOL BENZOATE; FLUTAMIDE; MESSENGER RNA; PARAFFIN; SESAME SEED OIL; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN REGION; CONTROLLED STUDY; DRUG MECHANISM; ENDOCRINE DISEASE; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; HORMONAL REGULATION; HORMONE ACTION; HYPOTHALAMUS; IN VITRO STUDY; MALE; MEDIAL PREOPTIC AREA; MICROARRAY ANALYSIS; MICRODISSECTION; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; SEX DIFFERENTIATION; TISSUE FIXATION; TRANSCRIPTION REGULATION; VALIDATION PROCESS;

ACETIC ACID; ANDROGEN ANTAGONISTS; ANIMALS; CHLOROFORM; CONTRACEPTIVE AGENTS; ESTRADIOL; FEMALE; FIXATIVES; FLUTAMIDE; FROZEN SECTIONS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HYPOTHALAMUS; MALE; METHANOL; MICROARRAY ANALYSIS; MICRODISSECTION; RATS; SEX DIFFERENTIATION;

EID: 34548623044     PISSN: 19328451     EISSN: 1932846X     Source Type: Journal    
DOI: 10.1002/dneu.20349     Document Type: Article

References (66)

1. 2. J Neurosci 22:8586-8596.
2. Aral Y, Sekine Y, Murakami S. 1996. Estrogen and apoptosis in the developing sexually dimorphic preoptic area in female rats. Neurosci Res 25:403-407.
3. Atanassova N, McKinnell C, Walker M, Turner KJ, Fisher JS, Morley M, Millar MR, et al. 1999. Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficiency of spermatogenesis in adulthood. Endocrinology 140:5364-5373.
4. Beltramini M, Zambenedetti P, Wittkowski W, Zatta P. 2004. Effects of steroid hormones on the Zn, Cu and MTI/II levels in the mouse brain. Brain Res 1013:134-141.
5. Chandrasekhar Y, Armstrong DT. 1989. Ability of progesterone to reverse anti-androgen (hydroxyflutamide)-induced interference with the preovulatory LH surge and ovulation in PMSG-primed immature rats. J Reprod Fertil 85:309-316.
6. Davis EC, Popper P, Gorski RA. 1996. The role of apoptosis in sexual differentiation of the rat sexually dimorphic nucleus of the preoptic area. Brain Res 734:10-18.
7. Diano S, Naftolin F, Horvath TL. 1997. Gonadal steroids target AMPA glutamate receptor-containing neurons in the rat hypothalamus, septum and amygdala: A morphological and biochemical study. Endocrinology 138:778-789.
8. Diano S, Naftolin F, Horvath TL. 1998. Kainate glutamate receptors (GluR5-7) in the rat arcuate nucleus: Relationship to tanycytes, astrocytes, neurons and gonadal steroid receptors. J Neuroendocrinol 10:239-247.
9. Dukes M, Furr BJ, Hughes LR, Tucker H, Woodburn JR. 2000. Nonsteroidal progestins and antiprogestins related to flutamide. Steroids 65:725-731.
10. Dunah AW, Hueske E, Wyszynski M, Hoogenraad CC, Jaworski J, Pak DT, Simonetta A, et al. 2005. LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses. Nat Neurosci 8:458-467.
11. Gray LE Jr, Kelce WR. 1996. Latent effects of pesticides and toxic substances on sexual differentiation of rodents. Toxicol Ind Health 12:515-531.
12. Gu G, Varoqueaux F, Simerly RB. 1999. Hormonal regulation of glutamate receptor gene expression in the anteroventral periventricular nucleus of the hypothalamus. J Neurosci 19:3213-3222.
13. Han JS, Boeke JD. 2005. LINE-1 retrotransposons: Modulators of quantity and quality of mammalian gene expression? Bioessays 27:775-784.
14. Haoudi A, Semmes OJ, Mason JM, Cannon RE. 2004. Retrotransposition- competent human LINE-1 induces apoptosis in cancer cells with intact p53. J Biomed Biotechnol 2004:185-194.
15. Hardy DO, Niu EM, Catterall JF. 2001. Kap promoter analysis in vivo: A regulatory role for a truncated L1 repeat. Mol Cell Endocrinol 181:57-67.
16. Heiss NS, Bächner D, Salowsky R, Kolb A, Kioschis P, Poustka A. 2000. Gene structure and expression of the mouse dyskeratosis congenita gene, dkc1. Genomics 67:153-163.
17. Hidalgo J, Aschner M, Zatta P, Vasak M. 2001. Roles of the metallothionein family of proteins in the central nervous system. Brain Res Bull 55:133-145.
18. Horie K, Urano T, Ikeda K, Inoue S. 2003. Estrogen-responsive RING finger protein controls breast cancer growth. J Steroid Biochem Mol Biol 85:101-104.
19. Ishitani K, Yoshida T, Kitagawa H, Ohta H, Nozawa S, Kato S. 2003. p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor. Biochem Biophys Res Commun 306:660-665.
20. Kim D, Kim EH, Kim C, Sun W, Kim HJ, Uhm CS, Park SH, et al. 2003. Differential regulation of metallothionein-I, II, and III mRNA expression in the rat brain following kainic acid treatment. Neuroreport 14:679-682.
21. Kim HS, Shin JH, Moon HJ, Kim TS, Kang IH, Seok JH, Kim IY, et al. 2002. Evaluation of the 20-day pubertal female assay in Sprague-Dawley rats treated with DES, tamoxifen, testosterone, and flutamide. Toxicol Sci 67:52-62.
22. Kocarek TA, Kraniak JM, Reddy AB. 1998. Regulation of rat hepatic cytochrome P450 expression by sterol biosynthesis inhibition: Inhibitors of squalene synthase are potent inducers of CYP2B expression in primary cultured rat hepatocytes and rat liver. Mol Pharmacol 54:474-484.
23. Koh DW, Dawson TM, Dawson VL. 2005. Poly(ADP-ribosyl)ation regulation of life and death in the nervous system. Cell Mol Life Sci 62:760-768.
24. Lund TD, Salyer DL, Fleming DE, Lephart ED. 2000. Pre or postnatal testosterone and flutamide effects on sexually dimorphic nuclei of the rat hypothalamus. Brain Res Dev Brain Res 120:261-266.
25. Maccioni RB, Cambiazo V. 1995. Role of microtubule-associated proteins in the control of microtubule assembly. Physiol Rev 75:835-864.
26. Marrone A, Walne A, Dokal I. 2005. Dyskeratosis congenita: Telomerase, telomeres and anticipation. Curr Opin Genet Dev 15:249-257.
27. Masutomi N, Shibutani M, Takagi H, Uneyama C, Takahashi N, Hirose M. 2003. Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life. Toxicology 192:149-170.
28. Matsumoto A, Sekine Y, Murakami S, Arai Y. 2000. Sexual differentiation of neuronal circuitry in the hypothalamus. In: Matsumoto A, editor. Sexual Differentiation of the Brain. Boca Raton: CRC Press, pp 203-227.
29. McCullough LD, Zeng Z, Blizzard KK, Debchoudhury I, Hurn PD. 2005. Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: Male toxicity, female protection. J Cereb Blood Flow Metab 25:502-512.
30. McEwen BS, Alves SE. 1999. Estrogen actions in the central nervous system. Endocr Rev 20:279-307.
31. Meisel RL, Sachs BD. 1994. The physiology of male sexual behavior. In: Knobil E, Neills JD, editors. The Physiology of Reproduction, 2nd ed. New York: Raven Press, pp 3-106.
32. Meredith JM, Bennett C, Scallet AC. 2001. A practical three-dimensional reconstruction method to measure the volume of the sexually-dimorphic central nucleus of the medial preoptic area (MPOC) of the rat hypothalamus. J Neurosci Methods 104:113-121.
33. Mooney RA, LeVea CM. 2003. The leukocyte common antigen-related protein LAR: Candidate PTP for inhibitory targeting. Curr Top Med Chem 3:809-819.
34. Morales JF, Snow ET, Murnane JP. 2002. Environmental factors affecting transcription of the human L1 retrotransposon. I. Steroid hormone-like agents. Mutagenesis 17:193-200.
35. Morales JF, Snow ET, Murnane JP. 2003. Environmental factors affecting transcription of the human L1 retrotransposon. II. Stressors. Mutagenesis 18:151-158.
36. Muotri AR, Chu VT, Marchetto MC, Deng W, Moran JV, Gage FH. 2005. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature 435:903-910.
37. Nagao T, Saito Y, Usumi K, Kuwagata M, Imai K. 1999. Reproductive function in rats exposed neonatally to bisphenol A and estradiol benzoate. Reprod Toxicol 13:303-311.
38. Numan M. 1994. Maternal behavior. In: Knobil E, Neills JD, editors. The Physiology of Reproduction, 2nd ed. New York: Raven Press, pp 221-302.
39. Odum J, Lefevre PA, Tinwell H, Van Miller JP, Joiner RL, Chapin RE, Wallis NY, et al. 2002. Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaning. Toxicol Sci 68:147-163.
40. Orikasa C, Kondo Y, Hayashi S, McEwen BS, Sakuma Y. 2002. Sexually dimorphic expression of estrogen receptor β in the anteroventral periventricular nucleus of the rat preoptic area: Implication in luteinizing hormone surge. Proc Natl Acad Sci USA 99:3306-3311.
41. Orimo A, Inoue S, Ikeda K, Noji S, Muramatsu M. 1995. Molecular cloning, structure, and expression of mouse estrogen-responsive finger protein Efp. Co-localization with estrogen receptor mRNA in target organs. J Biol Chem 270:24406-24413.
42. Pieper AA, Blackshaw S, Clements EE, Brat DJ, Krug DK, White AJ, Pinto-Garcia P, et al. 2000. Poly(ADP-ribosyl) ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission. Proc Natl Acad Sci USA 97:1845-1850.
43. Preuss U, Bierbaum H, Buchenau P, Scheidtmann KH. 2003. DAP-like kinase, a member of the death-associated protein kinase family, associates with centrosomes, centromers, and the contractile ring during mitosis. Eur J Cell Biol 82:447-459.
44. Proteau A, Blier S, Albert AL, Lavoie SB, Traish AM, Vincent M. 2005. The multifunctional nuclear protein p54nrb is multiphosphorylated in mitosis and interacts with the mitotic regulator Pin1. J Mol Biol 346:1163-1172.
45. Reyna-Neyra A, Arias C, Ferrera P, Morimoto S, Camacho-Arroyo I. 2004. Changes in the content and distribution of microtubule associated protein 2 in the hippocampus of the rat during the estrous cycle. J Neurobiol 60:473-480.
46. Reyna-Neyra A, Camacho-Arroyo I, Ferrera P, Arias C. 2002. Estradiol and progesterone modify microtubule associated protein 2 content in the rat hippocampus. Brain Res Bull 58:607-612.
47. Rhees RW, Shryne JE, Gorski RA. 1990a. Onset of the hormone-sensitive perinatal period for sexual differentiation of the sexually dimorphic nucleus of the preoptic area in female rats. J Neurobiol 21:781-786.
48. Rhees RW, Shryne JE, Gorski RA. 1990b. Termination of the hormone-sensitive period for differentiation of the sexually dimorphic nucleus of the preoptic area in male and female rats. Dev Brain Res 52:17-23.
49. Rivas A, Fisher JS, McKinnell C, Atanassova N, Sharpe RM. 2002. Induction of reproductive tract developmental abnormalities in the male rat by lowering androgen production or action in combination with a low dose of diethylstilbestrol: Evidence for importance of the androgen-estrogen balance. Endocrinology 143:4797-4808.
50. Servomaa K, Rytomaa T. 1990. UV light and ionizing radiations cause programmed death of rat chloroleukaemia cells by inducing retropositions of a mobile DNA element (L1Rn). Int J Radiat Biol 57:331-343.
51. Sewer MB, Nguyen VQ, Huang CJ, Tucker PW, Kagawa N, Waterman MR. 2002. Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54nrb/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription. Endocrinology 143:1280-1290.
52. Shibutani M, Masutomi N, Uneyama C, Abe N, Takagi H, Lee KY, Hirose M. 2005. Down-regulation of GAT-1 mRNA expression in the microdissected hypothalamic medial preoptic area of rat offspring exposed maternally to ethinylestradiol. Toxicology 208:35-48.
53. Shibutani M, Uneyama C. 2002. Methacarn: A fixation tool for multipurpose genetic analysis from paraffin-embedded tissues. In: Conn M, editor. Methods in Enzymology, Vol. 356. New York: Academic Press, pp 114-125.
54. Shibutani M, Uneyama C, Miyazaki K, Toyoda K, Hirose M. 2000. Methacarn fixation: A novel tool for analysis of gene expressions in paraffin-embedded tissue specimens. Lab Invest 80:199-208.
55. Shimada N, Suzuki T, Inoue S, Kato K, Imatani A, Sekine H, Ohara S, et al. 2004. Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues. Mol Cell Endocrinol 218:147-153.
56. Skaper SD. 2003. Poly(ADP-ribose) polymerase-1 in acute neuronal death and inflammation: A strategy for neuroprotection. Ann NY Acad Sci 993:217-228; discussion 287-288.
57. Sogawa N, Sogawa CA, Oda N, Fujioka T, Onodera K, Furuta H. 2001. The effects of ovariectomy and female sex hormones on hepatic metallothionein-I gene expression after injection of cadmium chloride in mice. Pharmacol Res 44:53-57.
58. Suzuki K, Nakajima K, Otaki N, Kimura M. 1994. Metallothionein in developing human brain. Biol Signals 3:188-192.
59. Takagi H, Shibutani M, Kato N, Fujita H, Lee KY, Takigami S, Mitsumori K, et al. 2004. Microdissected region-specific gene expression analysis with methacarn-fixed, paraffin-embedded tissues by real-time RT-PCR. J Histochem Cytochem 52:903-913.
60. Tena-Sempere M, Gonzalez LC, Pinilla L, Huhtaniemi I, Aguilar E. 2001. Neonatal imprinting and regulation of estrogen receptor α and β mRNA expression by estrogen in the pituitary and hypothalamus of the male rat. Neuroendocrinology 73:12-25.
61. Thornton JE, Irving S, Goy RW. 1991. Effects of prenatal antiandrogen treatment on masculinization and defeminization of Guinea pigs. Physiol Behav 50:471-475.
62. Tsukahara S, Ezawa N, Yamanouchi K. 2003. Neonatal estrogen decreases neural density of the septum-midbrain central gray connection underlying the lordosis-inhibital system in female rats. Neuroendocrinology 78:226-233.
63. Uneyama C, Shibutani M, Masutomi N, Takagi H, Hirose M. 2002. Methacarn fixation for genomic DNA analysis in microdissected, paraffin-embedded tissue specimens. J Histochem Cytochem 50:1237-1245.
64. Urano T, Saito T, Tsukui T, Fujita M, Hosoi T, Muramatsu M, Ouchi Y, et al. 2002. Efp targets 14-3-3σ for proteolysis and promotes breast tumour growth. Nature 417:871-875.
65. Wolf CJ, LeBlanc GA, Gray LE Jr. 2004. Interactive effects of vinclozolin and testosterone propionate on pregnancy and sexual differentiation of the male and female SD rat. Toxicol Sci 78:135-143.
66. Xie T, Tong L, McCann UD, Yuan J, Becker KG, Mechan AO, Cheadle C, et al. 2004. Identification and characterization of metallothionein-1 and -2 gene expression in the context of (±)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons. J Neurosci 24:7043-7050.