Metabonomics: The use of electrospray mass spectrometry coupled to reversed-phase liquid chromatography shows potential for the screening of rat urine in drug development

Rapid Communications in Mass Spectrometry

Volumn 16, Issue 20, 2002, Pages 1991-1996

  Plumb, Robert S ^a   Stumpf, Chris L ^a   Gorenstein, Marc V ^a   Castro Perez, Jose M ^b   Dear, Gordon J ^c   Anthony, Maria ^c   Sweatman, Brian C ^c   Connor, Susan C ^c   Haselden, John N ^c  

^a WATERS CORPORATION   (United States)

^b MICROMASS UK LTD   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRINCIPAL COMPONENT ANALYSIS; RATS;

CONTROL SAMPLES; DRUG DEVELOPMENT; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; MASS SPECTRA; METABONOMICS; PRINCIPAL-COMPONENT ANALYSIS; RAT URINE; REVERSED PHASE LIQUID-CHROMATOGRAPHY; REVERSED-PHASE LIQUID CHROMATOGRAPHY;

SCREENING;

DRUG;

ANIMAL; ARTICLE; CONTROLLED STUDY; DRUG RESEARCH; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSTRUMENTATION; MASS SPECTROMETRY; METABOLISM; METABONOMICS; METHODOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHARMACOLOGY; PRINCIPAL COMPONENT ANALYSIS; RAT; RESEARCH; REVERSED PHASE LIQUID CHROMATOGRAPHY; STATISTICAL ANALYSIS; TOXICOLOGY; URINALYSIS;

EID: 0036388279     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.813     Document Type: Article

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