Altered processing of pro-orphanin FQ/nociceptin and pro-opiomelanocortin-derived peptides in the brains of mice expressing defective prohormone convertase 2

Journal of Neuroscience

Volumn 21, Issue 16, 2001, Pages 5864-5870

  Allen, Richard G ^b   Peng, Bonnie ^a   Pellegrino, Michael J ^b   Miller, Emilie D ^b   Grandy, David K ^b   Lundblad, James R ^b   Washburn, Carrie L ^b   Pintar, John E ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Gene targeting; Neuropeptide; PC2; POMC; Proorphanin FQ nociceptin; Proteolytic processing

Indexed keywords

BETA ENDORPHIN; BETA LIPOTROPIN; BRAIN PEPTIDE; FURIN; LIPOTROPIN; NEUROPEPTIDE; NOCICEPTIN; PROOPIOMELANOCORTIN; PROORPHANIN FQ; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; GENE TARGETING; HYPOTHALAMUS; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; RADIOIMMUNOASSAY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 0035882519     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-16-05864.2001     Document Type: Article

References (31)

1. Altered POMC processing in SPC2 KO mice
2. Defective prodynorphin processing in mice lacking prohormone convertase PC2
3. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ, or κ opioid receptor type
4. Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary
5. Structure and biosynthesis of pro-adrenocorticotropin/endorphin and related peptides
6. Further analysis of post-translational processing of β-endorphin in rat intermediate pituitary
7. Characterization of pro-ACTH/endorphin-derived peptides in rat hypothalamus
8. Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing
9. Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2
10. Post-translational processing of pro-opiomelanocortin (POMC)-derived peptides during fetal monkey pituitary development II: β-endorphins, β-melanotropins
11. Distribution of nociceptin/orphanin FQ precursor protein and receptor in brain and spinal cord: A study using in situ hybridization and X-Gal histochemistry in receptor-deficient mice
12. Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress
13. Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice
14. The proteolytic maturation of prohormone convertase 2 (PC2) is a pH-driven process
15. Differences in the post-translational processing of β-endorphin in rat anterior and intermediate pituitary
16. Common precursor to corticotropins and endorphins
17. Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and α-melanotropin
18. Carboxyl terminal peptides derived from prepro-orphanin FQ/nociceptin (ppOFZ/N) are produced in the hypothalamus and possess analgesic bioactivities
19. Isolation and structure of the endogenous agonist of opioid receptor-like ORL-receptor
20. A cellular mechanism for the bidirectional pain-modulating actions of orphanin FQ/nociceptin
21. Orphanin FQ is the major OFQl-17-containing peptide produced in the rodent and monkey hypothalamus
22. Orphanin FQ: A neuropeptide that activates an opioidlike G proteincoupled receptor
23. Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: The subtilisin-like proprotein convertases
24. Proprotein and prohormone convertase of the subtilisin family
25. Cellular and molecular biology of neuropeptide processing and packaging
26. An in vitro characterization of the cleavage site specificity of the insulin cell prohormone processing enzymes
27. Actions of the ORL receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro
28. Orphanin FQ inhibits synaptic transmission and long-term potentiation in rat hippocampus
29. The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: Implications for early maturation of proteolytic processing capacity
30. Endoproteolytic processing of proopiomelayynocortin and prohormone convertases 1 and 2 in neuroendocrine cells overexpressing prohormone convertases 1 or 2
31. Proteolytic processing in the secretory pathway