Advantages and disadvantages of using bovine serum albumin and/or Cremophor EL as extracellular additives during transport studies of lipophilic compounds across Caco-2 monolayers

Journal of Drug Delivery Science and Technology

Volumn 17, Issue 4, 2007, Pages 259-266

  Neuhoff, S ^a,b   Artursson, P ^a   Ungell, A L ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Bovine serum albumin; Caco 2; Cremophor EL; Drug absorption; Low recovery BCSII compounds; Low solubility; MDCK MDRI; Passive and active efflux; Polvoxyl 35 castor oil

Indexed keywords

ASIMADOLINE; BOVINE SERUM ALBUMIN; CREMOPHOR; DRUG ADDITIVE; FELODIPINE; GLYCOPROTEIN P; QUINIDINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG PENETRATION; DRUG SOLUBILITY; DRUG TRANSPORT; EFFUSION; HUMAN; HUMAN CELL; LIPOPHILICITY; MICELLE; NONHUMAN;

EID: 34548587728     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(07)50093-6     Document Type: Article

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