Brain concentrations of asimadoline in mice: The influence of coadministration of various P-glycoprotein substrates

International Journal of Clinical Pharmacology and Therapeutics

Volumn 36, Issue 2, 1998, Pages 76-79

  Bender, H M ^a   Dasenbrock, J ^a  

^a MERCK KGAA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASIMADOLINE; CYCLOSPORIN A; DEXAMETHASONE; DIGOXIN; GLYCOPROTEIN P; KAPPA OPIATE RECEPTOR AGONIST; ONDANSETRON; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BINDING SITE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG TRANSPORT; INTRAVENOUS DRUG ADMINISTRATION; LIQUID SCINTILLATION COUNTING; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; SUBCUTANEOUS DRUG ADMINISTRATION;

ACETAMIDES; ANALGESICS, OPIOID; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BRAIN; CARBON RADIOISOTOPES; CYCLOSPORINE; DEXAMETHASONE; DIGOXIN; DRUG INTERACTIONS; ENZYME INHIBITORS; GLUCOCORTICOIDS; IMMUNOSUPPRESSIVE AGENTS; MALE; MICE; ONDANSETRON; P-GLYCOPROTEIN; PILOT PROJECTS; PYRROLIDINES; SEROTONIN ANTAGONISTS; VINBLASTINE;

EID: 0031964820     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (6)

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2. Ford JM 1996 Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers. Eur J Cancer 32A: 991-1001
3. Sakata A et al 1994 In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier. Biochem Pharmacol 48: 1989-1992
4. Schinkel AH et al 1994 Disruption of the mouse mdrla P-glycoprotein gene leads to a dificiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77: 491-502
5. Schinkel AH et al 1995 Absence of the mdrla P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest 96: 1698-1705
6. Schinkel AH et al 1996 P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 97: 2517-2524