-
1
-
-
33645526144
-
Cancer statistics
-
Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, et al. Cancer statistics. CA Cancer J Clin 2006;56:106-30.
-
(2006)
CA Cancer J Clin
, vol.56
, pp. 106-130
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Murray, T.4
Xu, J.5
Smigal, C.6
-
2
-
-
0038662614
-
Metastasis suppressor genes: Basic biology and potential clinical use
-
Steeg PS, Ouatas T, Halverson D, Palmieri D, Salerno M. Metastasis suppressor genes: Basic biology and potential clinical use. Clin Breast Cancer 2003;4:51-62.
-
(2003)
Clin Breast Cancer
, vol.4
, pp. 51-62
-
-
Steeg, P.S.1
Ouatas, T.2
Halverson, D.3
Palmieri, D.4
Salerno, M.5
-
3
-
-
12144286861
-
Perspectives on classic article: Metastasis suppressor genes
-
Steeg PS. Perspectives on classic article: Metastasis suppressor genes. J Natl Cancer Inst 2004;96:E4.
-
(2004)
J Natl Cancer Inst
, vol.96
-
-
Steeg, P.S.1
-
4
-
-
0037980379
-
Metastasis suppressor pathways - an evolving paradigm
-
Shevde LA, Welch DR. Metastasis suppressor pathways - an evolving paradigm. Cancer Lett 2003;198:1-20.
-
(2003)
Cancer Lett
, vol.198
, pp. 1-20
-
-
Shevde, L.A.1
Welch, D.R.2
-
6
-
-
27744480252
-
KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha
-
Jiang Y, Berk M, Singh LS, Tan H, Yin L, Powell CT, et al. KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha. Clin Exp Metastasis 2005;22:369-76.
-
(2005)
Clin Exp Metastasis
, vol.22
, pp. 369-376
-
-
Jiang, Y.1
Berk, M.2
Singh, L.S.3
Tan, H.4
Yin, L.5
Powell, C.T.6
-
7
-
-
0037264812
-
Metastasis suppressors alter the signal transduction of cancer cells
-
Steeg PS. Metastasis suppressors alter the signal transduction of cancer cells. Nat Rev Cancer 2003;3:55-63.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 55-63
-
-
Steeg, P.S.1
-
9
-
-
0037146735
-
Lysophosphatidic acid-regulated mitogenic ERK signaling in androgen-insensitive prostate cancer PC-3 cells
-
Kue PF, Taub JS, Harrington LB, Polakiewicz RD, Ullrich A, Daaka Y. Lysophosphatidic acid-regulated mitogenic ERK signaling in androgen-insensitive prostate cancer PC-3 cells. Int J Cancer 2002;102:572-9.
-
(2002)
Int J Cancer
, vol.102
, pp. 572-579
-
-
Kue, P.F.1
Taub, J.S.2
Harrington, L.B.3
Polakiewicz, R.D.4
Ullrich, A.5
Daaka, Y.6
-
10
-
-
0041508658
-
G protein-coupled receptors provide survival signals in prostate cancer
-
Yowell CW, Daaka Y. G protein-coupled receptors provide survival signals in prostate cancer. Clin Prostate Cancer 2002;1:177-81.
-
(2002)
Clin Prostate Cancer
, vol.1
, pp. 177-181
-
-
Yowell, C.W.1
Daaka, Y.2
-
11
-
-
0033757871
-
Essential role for G proteins in prostate cancer cell growth and signaling
-
Kue PF, Daaka Y. Essential role for G proteins in prostate cancer cell growth and signaling. J Urol 2000;164:2162-7.
-
(2000)
J Urol
, vol.164
, pp. 2162-2167
-
-
Kue, P.F.1
Daaka, Y.2
-
12
-
-
0034812072
-
The use of constitutively active receptors for drug discovery at the G protein-coupled receptor gene pool
-
Behan DP, Chalmers DT. The use of constitutively active receptors for drug discovery at the G protein-coupled receptor gene pool. Curr Opin Drug Discov Devel 2001;4:548-60.
-
(2001)
Curr Opin Drug Discov Devel
, vol.4
, pp. 548-560
-
-
Behan, D.P.1
Chalmers, D.T.2
-
13
-
-
0030586244
-
Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14
-
Xu Y, Casey G. Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14. Genomics 1996;35:397-402.
-
(1996)
Genomics
, vol.35
, pp. 397-402
-
-
Xu, Y.1
Casey, G.2
-
14
-
-
33745686063
-
Lysophosphatidylcholine impairs endothelial barrier function through the G Protein-coupled receptor, GPR4
-
Qiao J, Huang F, Naikawadi RP, Kim KS, Said T, Lum H. Lysophosphatidylcholine impairs endothelial barrier function through the G Protein-coupled receptor, GPR4. Am J Physiol Lung Cell Mol Physiol 2006;291:L91-101.
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.291
-
-
Qiao, J.1
Huang, F.2
Naikawadi, R.P.3
Kim, K.S.4
Said, T.5
Lum, H.6
-
15
-
-
20944433323
-
GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine
-
Kim KS, Ren J, Jiang Y, Ebrahem. Q, Tipps R, Cristina K, et al. GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. Faseb J 2005;19:819-21.
-
(2005)
Faseb J
, vol.19
, pp. 819-821
-
-
Kim, K.S.1
Ren, J.2
Jiang, Y.3
Ebrahem, Q.4
Tipps, R.5
Cristina, K.6
-
16
-
-
0037944248
-
Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis
-
Tosa N, Murakami M, Jia WY, Yokoyama M, Masunaga T, Iwabuchi C, et al. Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis. Int Immunol 2003;15:741-9.
-
(2003)
Int Immunol
, vol.15
, pp. 741-749
-
-
Tosa, N.1
Murakami, M.2
Jia, W.Y.3
Yokoyama, M.4
Masunaga, T.5
Iwabuchi, C.6
-
17
-
-
13444250893
-
Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells
-
Radu CG, Nijagal A, McLaughlin J, Wang L, Witte ON. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proc Natl Acad Sci U S A 2005; 102:1632-7.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 1632-1637
-
-
Radu, C.G.1
Nijagal, A.2
McLaughlin, J.3
Wang, L.4
Witte, O.N.5
-
18
-
-
0035897409
-
Identification of a molecular target of psychosine and its role in globoid cell formation
-
Im DS, Heise CE, Nguyen T, O'Dowd BF, Lynch KR. Identification of a molecular target of psychosine and its role in globoid cell formation. J Cell Biol 2001;153:429-34.
-
(2001)
J Cell Biol
, vol.153
, pp. 429-434
-
-
Im, D.S.1
Heise, C.E.2
Nguyen, T.3
O'Dowd, B.F.4
Lynch, K.R.5
-
19
-
-
29044447488
-
Two ligands for a GPCR, proton vs lysolipid
-
Im DS. Two ligands for a GPCR, proton vs lysolipid. Acts Pharmacol Sin 2005;26:1435-41.
-
(2005)
Acts Pharmacol Sin
, vol.26
, pp. 1435-1441
-
-
Im, D.S.1
-
20
-
-
24344474845
-
Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: A novel type of multi-functional receptors
-
Tomura H, Mogi C, Sato K, Okajima F. Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: A novel type of multi-functional receptors. Cell Signal 2005;17:1466-76.
-
(2005)
Cell Signal
, vol.17
, pp. 1466-1476
-
-
Tomura, H.1
Mogi, C.2
Sato, K.3
Okajima, F.4
-
21
-
-
0036033424
-
Constitutive activity of G-protein-coupled receptors: Cause of disease and common property of wild-type receptors
-
Seifert R, Wenzel-Seifert K. Constitutive activity of G-protein-coupled receptors: Cause of disease and common property of wild-type receptors. Naunyn Schmiedebergs Arch Pharmacol 2002;366:381-416.
-
(2002)
Naunyn Schmiedebergs Arch Pharmacol
, vol.366
, pp. 381-416
-
-
Seifert, R.1
Wenzel-Seifert, K.2
-
22
-
-
0033389561
-
Constitutively active mutations of G protein-coupled receptors: The case of the human luteinizing hormone and follicle-stimulating hormone receptors
-
Nordhoff V, Gromoll J, Simoni M. Constitutively active mutations of G protein-coupled receptors: The case of the human luteinizing hormone and follicle-stimulating hormone receptors. Arch Med Res 1999;30:501-9.
-
(1999)
Arch Med Res
, vol.30
, pp. 501-509
-
-
Nordhoff, V.1
Gromoll, J.2
Simoni, M.3
-
23
-
-
27744489232
-
The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer
-
Boddy JL, Fox SB, Han C, Campo L, Turley H, Kanga S, et al. The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer. Clin Cancer Res 2005;11:7658-63.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7658-7663
-
-
Boddy, J.L.1
Fox, S.B.2
Han, C.3
Campo, L.4
Turley, H.5
Kanga, S.6
-
24
-
-
0036682002
-
Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease
-
LaTulippe E, Satagopan J, Smith A, Scher H, Scardino P, Reuter V, et al. Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Res 2002;62:4499-506.
-
(2002)
Cancer Res
, vol.62
, pp. 4499-4506
-
-
LaTulippe, E.1
Satagopan, J.2
Smith, A.3
Scher, H.4
Scardino, P.5
Reuter, V.6
-
25
-
-
0042322842
-
Proton-sensing G-protein-coupled receptors
-
Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junket U, et al. Proton-sensing G-protein-coupled receptors. Nature 2003;425:93-8.
-
(2003)
Nature
, vol.425
, pp. 93-98
-
-
Ludwig, M.G.1
Vanek, M.2
Guerini, D.3
Gasser, J.A.4
Jones, C.E.5
Junket, U.6
-
26
-
-
33845261493
-
A rapid method of total lipid extraction and purification
-
Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-7.
-
(1959)
Can J Biochem Physiol
, vol.37
, pp. 911-917
-
-
Bligh, E.G.1
Dyer, W.J.2
-
28
-
-
0035869447
-
Electrospray ionization mass spectrometry analysis of lysophospholipids in human ascitic fluids: Comparison of the lysophospholipid contents in malignant vs nonmalignant ascitic fluids
-
Xiao YJ, Schwartz B, Washington M, Kennedy A, Webster K, Belinson J, et al. Electrospray ionization mass spectrometry analysis of lysophospholipids in human ascitic fluids: Comparison of the lysophospholipid contents in malignant vs nonmalignant ascitic fluids. Anal Biochem 2001;290:302-13.
-
(2001)
Anal Biochem
, vol.290
, pp. 302-313
-
-
Xiao, Y.J.1
Schwartz, B.2
Washington, M.3
Kennedy, A.4
Webster, K.5
Belinson, J.6
-
29
-
-
0034015340
-
Evaluation of plasma lysophospholipids for diagnostic significance using electrospray ionization mass spectrometry (ESI-MS) anayles
-
Xiao Y, Chen Y, Kennedy AW, Belinson J, Xu Y. Evaluation of plasma lysophospholipids for diagnostic significance using electrospray ionization mass spectrometry (ESI-MS) anayles. Ann N Y Acad Sci 2000;905: 242-59.
-
(2000)
Ann N Y Acad Sci
, vol.905
, pp. 242-259
-
-
Xiao, Y.1
Chen, Y.2
Kennedy, A.W.3
Belinson, J.4
Xu, Y.5
-
30
-
-
0023747344
-
Development of skeletal metastasis by human prostate cancer in athymic nude mice
-
Shevrin DH, Kukreja SC, Ghosh L, Lad TE. Development of skeletal metastasis by human prostate cancer in athymic nude mice. Clin Exp Metastasis 1988;6:401-9.
-
(1988)
Clin Exp Metastasis
, vol.6
, pp. 401-409
-
-
Shevrin, D.H.1
Kukreja, S.C.2
Ghosh, L.3
Lad, T.E.4
-
31
-
-
0036968494
-
-
Bastide C, Bagnis C, Mannoni P, Hassoun J, Bladou F. A Nod Scid mouse model to study human prostate cancer. Prostate Cancer Prostatic Dis 2002;5: 311-5.
-
Bastide C, Bagnis C, Mannoni P, Hassoun J, Bladou F. A Nod Scid mouse model to study human prostate cancer. Prostate Cancer Prostatic Dis 2002;5: 311-5.
-
-
-
-
32
-
-
0031010232
-
Orthetopic implantation of human prostate cancer cell lines a clinically relevant animal model for metastatic prostate cancer
-
Rembrink K, Remijn JC, van der Kwast TH, Rubben H, Schroder FH. Orthetopic implantation of human prostate cancer cell lines a clinically relevant animal model for metastatic prostate cancer. Prostate 1997; 31:168-74.
-
(1997)
Prostate
, vol.31
, pp. 168-174
-
-
Rembrink, K.1
Remijn, J.C.2
van der Kwast, T.H.3
Rubben, H.4
Schroder, F.H.5
-
33
-
-
0037853135
-
The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis
-
Lin P, Ye RD. The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis. J. Biol Chem 2003; 278:14379-86.
-
(2003)
J. Biol Chem
, vol.278
, pp. 14379-14386
-
-
Lin, P.1
Ye, R.D.2
-
34
-
-
0346458668
-
T cell chemotaxis to lysophosphatidylcholine through the G2A receptor
-
Radu CG, Yang LV, Riedinger M, Au M, Witte ON. T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. Proc Natl Acad Sci U S A 2004;101:245-50.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 245-250
-
-
Radu, C.G.1
Yang, L.V.2
Riedinger, M.3
Au, M.4
Witte, O.N.5
-
35
-
-
0142063418
-
The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner
-
Bektas M, Barak LS, Jolly PS, Liu H, Lynch KR, Lacana E, et al. The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. Biochemistry 2003;42:12181-91.
-
(2003)
Biochemistry
, vol.42
, pp. 12181-12191
-
-
Bektas, M.1
Barak, L.S.2
Jolly, P.S.3
Liu, H.4
Lynch, K.R.5
Lacana, E.6
-
36
-
-
0037162029
-
Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction
-
Xu Y. Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction. Biochim. Biophys Acta 2002;1582:81-8.
-
(2002)
Biochim. Biophys Acta
, vol.1582
, pp. 81-88
-
-
Xu, Y.1
-
37
-
-
0042471532
-
Unfolding the pathophysiological role of bioactive lysophospholipids
-
Xu Y, Xiao YJ, Zhu K, Baudhuin LM, Lu J, Hong G, et al. Unfolding the pathophysiological role of bioactive lysophospholipids. Curr Drug Targets Immune Endocr Metabol Disord 2003;3:23-32.
-
(2003)
Curr Drug Targets Immune Endocr Metabol Disord
, vol.3
, pp. 23-32
-
-
Xu, Y.1
Xiao, Y.J.2
Zhu, K.3
Baudhuin, L.M.4
Lu, J.5
Hong, G.6
-
38
-
-
4344643652
-
G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers
-
Sin WC, Zhang Y, Zhong W, Adhikarakunnathu S, Powers S, Hoey T, et al. G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers. Oncogene 2004;23:6299-303.
-
(2004)
Oncogene
, vol.23
, pp. 6299-6303
-
-
Sin, W.C.1
Zhang, Y.2
Zhong, W.3
Adhikarakunnathu, S.4
Powers, S.5
Hoey, T.6
-
39
-
-
2642530312
-
Effects of tumour acidification with glucose-MIBG on the spontaneous metastatic potential of two murine cell lines
-
Kalliomaki T, Hill RP. Effects of tumour acidification with glucose-MIBG on the spontaneous metastatic potential of two murine cell lines. Br J Cancer 2004;90:1842-9.
-
(2004)
Br J Cancer
, vol.90
, pp. 1842-1849
-
-
Kalliomaki, T.1
Hill, R.P.2
-
40
-
-
34548560654
-
RGS18 acts as a negative regulator of osteoclastogenesis by modulating acid-sensing OGR1/NFAT signaling pathway
-
Jun 18 Epub ahead of print
-
Iwai K, Koike M, Ohshima S, Miyatake K, Uchiyama Y, Saeki Y, et al. RGS18 acts as a negative regulator of osteoclastogenesis by modulating acid-sensing OGR1/NFAT signaling pathway. J Bone Miner Res 2007. [Jun 18 Epub ahead of print].
-
(2007)
J Bone Miner Res
-
-
Iwai, K.1
Koike, M.2
Ohshima, S.3
Miyatake, K.4
Uchiyama, Y.5
Saeki, Y.6
-
41
-
-
33747742467
-
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis
-
Yang M, Mailhot G, Birnbaum MJ, Mackay CA, Mason-Savas A, Odgren PR. Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis. J Biol Chem 2006;281:23598-605.
-
(2006)
J Biol Chem
, vol.281
, pp. 23598-23605
-
-
Yang, M.1
Mailhot, G.2
Birnbaum, M.J.3
Mackay, C.A.4
Mason-Savas, A.5
Odgren, P.R.6
-
42
-
-
27344451242
-
Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation
-
Mogi C, Tomura H, Tobo M, Wang JQ, Damirin A, Kon J, et al. Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation. J Pharmacol. Sci 2005;99:160-7.
-
(2005)
J Pharmacol. Sci
, vol.99
, pp. 160-167
-
-
Mogi, C.1
Tomura, H.2
Tobo, M.3
Wang, J.Q.4
Damirin, A.5
Kon, J.6
-
43
-
-
0034746927
-
Low expression of Galpha protein subunits in human prostate cancer
-
Garcia-Fernandez MO, Solano RM, Sanchez-Chapado M, Ruiz-Villaespesa A, Prieto JC, Carmena MJ. Low expression of Galpha protein subunits in human prostate cancer. J Urol 2001;166:2512-7.
-
(2001)
J Urol
, vol.166
, pp. 2512-2517
-
-
Garcia-Fernandez, M.O.1
Solano, R.M.2
Sanchez-Chapado, M.3
Ruiz-Villaespesa, A.4
Prieto, J.C.5
Carmena, M.J.6
-
44
-
-
0037162066
-
Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells
-
Panetti TS. Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells. Biochim Biophys Acta 2002;1582: 190-6.
-
(2002)
Biochim Biophys Acta
, vol.1582
, pp. 190-196
-
-
Panetti, T.S.1
-
45
-
-
33744986180
-
Rho kinase-independent inhibitory regulation of Rac and cell migration by LPA1 receptor in Gi-inactivated CHO cells
-
Sugimoto N, Takuwa N, Yoshioka K, TakuwaRho-dependent Y. Rho kinase-independent inhibitory regulation of Rac and cell migration by LPA1 receptor in Gi-inactivated CHO cells. Exp Cell Res 2006;312:1899-908.
-
(2006)
Exp Cell Res
, vol.312
, pp. 1899-1908
-
-
Sugimoto, N.1
Takuwa, N.2
Yoshioka, K.3
TakuwaRho-dependent, Y.4
-
46
-
-
0037370012
-
Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform
-
Sugimoto N, Takuwa N, Okamoto H, Sakurada S, Takuwa Y. Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol Cell Biol 2003;23:1534-45.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 1534-1545
-
-
Sugimoto, N.1
Takuwa, N.2
Okamoto, H.3
Sakurada, S.4
Takuwa, Y.5
-
47
-
-
0034974903
-
Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha.2)-linked Rho kinase activity
-
Liu F, Verin AD, Wang P, Day R, Wersto RP, Chrest FJ, et al. Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha.2)-linked Rho kinase activity. Am J Respir Cell Mol Biol 2001;24:711-9.
-
(2001)
Am J Respir Cell Mol Biol
, vol.24
, pp. 711-719
-
-
Liu, F.1
Verin, A.D.2
Wang, P.3
Day, R.4
Wersto, R.P.5
Chrest, F.J.6
-
48
-
-
0028931050
-
Angiopeptin (BIM23014C) inhibits vascular smooth muscle cell migration in vitro through a G-protein-mediated pathway and is associated with inhibition of adenylyl cyclase and cyclic AMP accumulation
-
Mooradian DL, Fernandes B, Diglio CA, Lester BR. Angiopeptin (BIM23014C) inhibits vascular smooth muscle cell migration in vitro through a G-protein-mediated pathway and is associated with inhibition of adenylyl cyclase and cyclic AMP accumulation. J Cardiovasc Pharmacol 1995;25:611-8.
-
(1995)
J Cardiovasc Pharmacol
, vol.25
, pp. 611-618
-
-
Mooradian, D.L.1
Fernandes, B.2
Diglio, C.A.3
Lester, B.R.4
|