Amplification and overexpression of Aurora-A in esophageal squamous cell carcinoma

Oncology Reports

Volumn 17, Issue 5, 2007, Pages 1083-1088

  Yang, Shang Bin ^a   Zhou, Xiao Bo ^a   Zhu, Hong Xia ^a   Quan, Lan Ping ^a   Bai, Jin Feng ^a   He, Jie ^a   Gao, Yan Ning ^a   Cheng, Shu Jun ^a   Xu, Ning Zhi ^a  

^a CANCER HOSPITAL   (China)

Author keywords

Amplification; Aurora A; Esophageal squamous cell carcinoma; Overexpression

Indexed keywords

AURKA PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; DNA PROBE; ESOPHAGUS TUMOR; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE DOSAGE; GENETICS; HUMAN; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DNA PROBES; ESOPHAGEAL NEOPLASMS; GENE AMPLIFICATION; GENE DOSAGE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 34548575188     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.17.5.1083     Document Type: Article

References (31)

1. Marumoto T, Hirota T, Morisaki T, et al: Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells. Genes Cells 7: 1173-1182, 2002. (Pubitemid 35256338)
2. Dutertre S, Descamps S and Prigent C: On the role of aurora-A in centrosome function. Oncogene 21: 6175-6183, 2002.
3. Schlegel J, Stumm G, Scherthan H, Bocker T, Zirngibl H, Ruschoff J and Hofstadter F: Comparative genomic in situ hybridization of colon carcinomas with replication error. Cancer Res 55: 6002-6005, 1995.
4. Reznikoff CA, Belair CD, Yeager TR, Savelieva E, Blelloch RH, Puthenveettil JA and Cuthill S: A molecular genetic model of human bladder cancer pathogenesis. Semin Oncol 23: 571-584, 1996. (Pubitemid 26362217)
5. Forozan F, Mahlamaki EH, Monni O, et al: Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data. Cancer Res 60: 4519-4525, 2000. (Pubitemid 32103634)
6. Jazaeri AA, Lu K, Schmandt R, et al: Molecular determinants of tumor differentiation in papillary serous ovarian carcinoma. Mol Carcinog 36: 53-59, 2003. (Pubitemid 36183896)
7. Klein A, Reichardt W, Jung V, Zang KD, Meese E and Urbschat S: Overexpression and amplification of STK15 in human gliomas. Int J Oncol 25: 1789-1794, 2004.
8. Jeng YM, Peng SY, Lin CY and Hsu HC: Overexpression and amplification of Aurora-A in hepatocellular carcinoma. Clin Cancer Res 10: 2065-2071, 2004.
9. Li D, Zhu J, Firozi PF, et al: Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clin Cancer Res 9: 991-997, 2003. (Pubitemid 36323702)
10. Sen S, Zhou H, Zhang RD, et al: Amplification/overexpression of a mitotic kinase gene in human bladder cancer. J Natl Cancer Inst 94: 1320-1329, 2002.
11. Kamada K, Yamada Y, Hirao T, et al: Amplification/overexpression of Aurora-A in human gastric carcinoma: potential role in differentiated type gastric carcinogenesis. Oncol Rep 12: 593-599, 2004.
12. Tanaka E, Hashimoto Y, Ito T, et al: The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma. Clin Cancer Res 11: 1827-1834, 2005. (Pubitemid 40471846)
13. Zhou H, Kuang J, Zhong L, et al: Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 20: 189-193, 1998. (Pubitemid 28455454)
14. Ewart-Toland A, Briassouli P, De Koning JP, et al: Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet 34: 403-412, 2003. (Pubitemid 36935333)
15. Wang X, Zhou YX, Qiao W, Tominaga Y, Ouchi M, Ouchi T and Deng CX: Overexpression of Aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene (In press).
16. Wei F, Ni J, Wu SS, et al: Cytogenetic studies of esophageal squamous cell carcinomas in the northern Chinese population by comparative genomic hybridization. Cancer Genet Cytogenet 138: 38-43, 2002. (Pubitemid 35292598)
17. Fujita Y, Sakakura C, Shimomura K, et al: Chromosome arm 20q gains and other genomic alterations in esophageal squamous cell carcinoma, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization. Hepatogastroenterology 50: 1857-1863, 2003. (Pubitemid 37467948)
18. Moskaluk CA, Hu J and Perlman EJ: Comparative genomic hybridization of esophageal and gastroesophageal adenocarcinomas shows consensus areas of DNA gain and loss. Genes Chromosomes Cancer 22: 305-311, 1998. (Pubitemid 28304521)
19. Yen CC, Chen YJ, Chen JT, et al: Comparative genomic hybridization of esophageal squamous cell carcinoma: correlations between chromosomal aberrations and disease progression/prognosis. Cancer 92: 2769-2777, 2001.
20. Yen CC, Chen YJ, Lu KH, et al: Genotypic analysis of esophageal squamous cell carcinoma by molecular cytogenetics and real-time quantitative polymerase chain reaction. Int J Oncol 23: 871-881, 2003.
21. Tong T, Zhong Y, Kong J, et al: Overexpression of Aurora-A contributes to malignant development of human esophageal squamous cell carcinoma. Clin Cancer Res 10: 7304-7310, 2004. (Pubitemid 39487719)
22. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005. (Pubitemid 40372904)
23. Klein A, Jung V, Zang KD, et al: Detailed chromosomal characterization of the breast cancer cell line MCF7 with special focus on the expression of the serine-threonine kinase 15. Oncol Rep 14: 23-31, 2005.
24. Fraizer GC, Diaz MF, Lee IL, Grossman HB and Sen S: Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells. Int J Oncol 25: 1631-1639, 2004.
25. Miao X, Sun T, Wang Y, Zhang X, Tan W and Lin D: Functional STK15 Phe31Ile polymorphism is associated with the occurrence and advanced disease status of esophageal squamous cell carcinoma. Cancer Res 64: 2680-2683, 2004. (Pubitemid 38500601)
26. Kimura MT, Mori T, Conroy J, Nowak NJ, Satomi S, Tamai K and Nagase H: Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk. Cancer Res 65: 3548-3554, 2005. (Pubitemid 40616329)
27. Sun T, Miao X, Wang J, Tan W, Zhou Y, Yu C and Lin D: Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma. Carcinogenesis 25: 2225-2230, 2004. (Pubitemid 39534861)
28. Mahadevan D, Bearss DJ and Vankayalapati H: Structure-based design of novel anti-cancer agents targeting aurora kinases. Curr Med Chem Anti-Cancer Agents 3: 25-34, 2003. (Pubitemid 36131632)
29. Vankayalapati H, Bearss DJ, Saldanha JW, Munoz RM, Rojanala S, von Hoff DD and Mahadevan D: Targeting aurora2 kinase in oncogenesis: a structural bioinformatics approach to target validation and rational drug design. Mol Cancer Ther 2: 283-294, 2003.
30. Hata T, Furukawa T, Sunamura M, et al: RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity inhuman pancreatic cancer cells. Cancer Res 65: 2899-2905, 2005. (Pubitemid 40490094)
31. Harrington EA, Bebbington D, Moore J, et al: VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med 10: 262-267, 2004. (Pubitemid 38667616)