Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk

Cancer Research

Volumn 65, Issue 9, 2005, Pages 3548-3554

  Kimura, Makoto T ^a   Mori, Takahiro ^c   Conroy, Jeffrey ^a   Nowak, Norma J ^a,b   Satomi, Susumu ^c   Tamai, Katsuyuki ^d   Nagase, Hiroki ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d CycLex Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; ISOLEUCINE; PHENYLALANINE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CELL IMMORTALIZATION; CELL NUCLEUS; CELL STRUCTURE; CHROMOSOME SEGREGATION; CONFIDENCE INTERVAL; CONTROLLED STUDY; CYTOKINESIS; ENZYME ACTIVITY; ESOPHAGUS CANCER; FIBROBLAST; GENOMIC INSTABILITY; GENOTYPE; HAPLOTYPE; HOMOZYGOTE; HUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CELL NUCLEUS; CHROMOSOME ABERRATIONS; DNA, NEOPLASM; ESOPHAGEAL NEOPLASMS; GENE DOSAGE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; ISOENZYMES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; SUBCELLULAR FRACTIONS;

EID: 18144381030     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-2149     Document Type: Article

References (32)

1. Ponder BAJ. Cancer genetics. Nature 2001;411:336-41.
2. Peto J, Houlston RS. Genetics and the common cancer. Eur J Cancer 2001;37:S88-96.
3. Nagase H, Mao JH, Balmain B. A subset of skin tumor modifier loci determines survival time of tumor-bearing mice. Proc Natl Acad Sci U S A 1999;96:15032-7.
4. Nagase H, Mao JH, Balmain B. Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice. Cancer Res 2003;63:4849-53.
5. Ewart-Toland A, Briassouli P, de Koning JP, et al. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet 2003;34:403-12.
6. Miao X, Sun T, Wang Y, Zhang X, Tan W, Lin D. Functional STK15 Phe31Ile polymorphism is associated with the occurrence and advanced disease status of esophageal squamous cell carcinoma. Cancer Res 2004;64:2680-3.
7. DiCioccio RA, Song H, Waterfall C, et al. STK15 Polymorphisms and Association with Risk of Invasive Ovarian Cancer. Cancer Epidemiol Biomarkers Prev 2004;13:1589-94.
8. Egan KM, Newcomb PA, Ambrosone CB, et al. STK15 polymorphism and breast cancer risk in a population-based study. Carcinogenesis 2004;25:2149-53 [Epub 2004 Jul 22].
9. Nigg EA. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2001;2:21-32.
10. Sen S, Zhou H, White RA. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene 1997;14:2195-200.
11. Bischoff JR, Anderson L, Zhu Y, et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J 1998;17:3052-65.
12. Zhou H, Kuang J, Zhong L, et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 1998;20:189-93.
13. Dutertre S, Descamps S, Prigent C. On the role of aurora-A in centrosome function. Oncogene 2002;21:6175-83.
14. Hirota T, Kunitoku N, Sasayama T, et al. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 2003;114:585-98.
15. Sakakura C, Hagiwara A, Yasuoka R, et al. Tumor-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. Br J Cancer 2001;84:824-31.
16. Imyanitov EN, Togo AV, Hanson KP. Searching for cancer-associated gene polymorphisms: promises and obstacles. Canter Lett 2004;204:3-14.
17. Haga H, Yamada R, Ohnishi Y, Nakamura Y, Tanaka T. Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190,562 genetic variations in the human genome. J Hum Genet 2002;47:605-10.
18. Venter JC, Adams MD, Myers EW, et al. The sequence of the human genome. Science 2001;291:1304-51
19. Honda K, Mihara H, Kato Y, et al. Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway. Oncogene 2000;19:2812-9.
20. Pfleger CM, Kirschner MW. Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes Dev 2000;14:655-9.
21. Toji S, Yabuta N, Hosomi T, et al. The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells 2004;9:383-97.
22. Yabuta N, Fujii T, Copeland NG, et al. Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Genomics 2000;63:263-70.
23. Hori T, Takaori-Kondo A, Kamikubo Y, et al. Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. Oncogene 2000;19:3101-9.
24. Kamikubo Y, Takaori-Kondo A, Uchiyama T, et al. Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor. J Biol Chem 2003;278:17609-14.
25. Ishizaki K, Fujimoto J, Kumimoto H, et al. Frequent polymorphic changes but rare tumor specific mutations of the LATS2 gene on 13qtt-12 in esophageal squamous cell carcinoma. Int J Oncol 2002;21:1053-7.
26. Alderborn A, Kristfferon A, Hammerling U. Determination of single-nucleotide polymorphisms by real-time pyrophosphate DNA sequencing. Genome Res 2000;10:1249-58.
27. Cowell JK, Matsui S, Wang YD, et al. Application of bacterial artificial chromosome array-based comparative genomic hybridization and spectral karyotyping to the analysis of glioblastoma multiforme. Cancer Genet Cytogenet 2004;151:36-51.
28. Cleveland WS, Devlin SJ. Locally Weighted Regression: An Approach to Regression Analysis by Local Fitting. J Am Stat Assoc 1988;83:596-610.
29. Yang YH, Dudoit S, Luu P, et al. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res 2002;30:e15.
30. Kimura M, Kotani S, Hattori T, et al. Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast 1p11. J Biol Chem 1997;272:13766-71.
31. Hauf S, Cole RW, LaTerra S, et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol 2003;161:281-94.
32. Harrington EA, Bebbington D, Moore J, et al. VX-680, a potent selective small-molecule inhibitor of the Aurora kinases, suppresses tumot growth in vivo. Nat Med 2004;10:262-7.